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Carmen de Sena Tomás obtained her degree in Biology from the Universidad de Salamanca, Spain in 2006. Then, she moved to the Centro Nacional de Biotecnología (CNB-CSIC) in Madrid where she performed her PhD sutdies under the supervision of Prof. Dr. José Pérez-Martín. During her PhD, she demonstrated how in absence of DNA damage, the DNA damage response pathway (Atr1/Chk1) controls cell cycle progression in dikaryons, an essential cellular stage in the life cycle of most Basidiomycetes. In addition she characterized the role of Ku proteins which play and essential role in the telomeres to avoid unwanted recombination in U. maydis. After earning her PhD degree in 2012, she performed a first postdoc on genome stability in Prof. Dr. William K. Holloman's lab at Cornell University (New York, USA), where she showed the role of a LAMMER kinase in cell cycle regulation and chromosome segregation during meiosis in U. maydis. Subsequently, she joined Dr. Kimara Targoff’s lab at Columbia University (New York, USA) to study heart development and regeneration in zebrafish. During this second postdoc, she demonstrated a previously unrecognized Nkx2.5-dependent regenerative circuit that invokes myocardial proliferation and dedifferentiation to ensure effective regeneration in the zebrafish heart. Currently, she works as a senior postdoctoral researcher in Dr. Leonor Saúde's lab at Instituto de Medicina Molecular (IMM-JLA) in Lisboa, studying the role of the immune system in spinal cord regeneration in zebrafish. She has participated in international collaborations and published several research articles in international peer-reviewed Q1 journals and attended international epecialized conferences where her work has been recognized.
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Identificação

Identificação pessoal

Nome completo
Carmen De Sena Tomas

Nomes de citação

  • de Sena-Tomás, Carmen

Identificadores de autor

Ciência ID
9C19-402D-4AAA
ORCID iD
0000-0002-0477-6135

Endereços de correio eletrónico

  • cdesena@medicina.ulisboa.pt (Profissional)

Moradas

  • Avenida Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia do Desenvolvimento
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Microbiologia
  • Ciências Naturais - Ciências Biológicas - Fitologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Espanhol; Castelhano (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Português Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2007/09/01 - 2012/03/02
Concluído
 Molecular Biology (Doutoramento)
Universidad Autónoma de Madrid, Espanha
"Roles of the Atr1-Chk1 pathway in the phytopathogenic fungus Ustilago maydis" (TESE/DISSERTAÇÃO)
 sobresaliente cum laude
2007 - 2009
Concluído
 Molecular Biology (DEA)
Universidad Autónoma de Madrid, Espanha
"Characterization of atr1 in Ustilago maydis" (TESE/DISSERTAÇÃO)
2001/09/01 - 2006/10/05
Concluído
 Biology (Licence)
Universidad de Salamanca Facultad de Biología, Espanha
"Molecular analysis of the regulation of fas gene expression in Rhodococcus fascians" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02/01 - Atual Pós-doutorado (Investigação) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2015/01/05 - 2018/12/31 Pós-doutorado (Investigação) Columbia University, Estados Unidos
Columbia University, Estados Unidos
2012/06/01 - 2015/01/04 Pós-doutorado (Investigação) Weill Cornell Medicine, Estados Unidos
Weill Cornell Medicine, Estados Unidos
2011/04/01 - 2011/06/30 Estagiário de Investigação (Investigação) Georg August Universität Büsgen Institut, Alemanha
2010/05/01 - 2010/07/31 Estagiário de Investigação (Investigação) Georg August Universität Büsgen Institut, Alemanha
2008/09/12 - 2008/12/12 Estagiário de Investigação (Investigação) Weill Cornell Medicine, Estados Unidos
2005/09/30 - 2006/07/01 Estagiário de Investigação (Investigação) Vlaams Instituut voor Biotechnologie Department of Plant Systems Biology, Bélgica

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/09/01 - 2012/02/28 PhD student Centro Nacional de Biotecnología, Espanha
Projetos

Bolsa

Designação Financiadores
2022/01/01 - Atual Improving spinal cord regeneration by modulating neutrophil inflammation: lessons from a zebrafish perspective
2022.02766.PTDC
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/01/01 - 2018/12/31 Mechanisms of the second heart field development regulated by Nkx genes
1R01HL131438-01A1
Investigador Pós-doutorado
Columbia University, Estados Unidos
 National Institute of Health (NIH), National Heart, Lung and Blood Institute (NHLBI)
Em curso

Projeto

Designação Financiadores
2019/02/01 - Atual Modulation of vascular repair during spinal cord regeneration
PTDC/BIA-BID/28572/2017
Investigador Pós-doutorado
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2023/08/31 Senescent cells and their secretory phenotype: novel targets for spinal cord repair
MC36-2020
Investigador Pós-doutorado
Instituto de Medicina Molecular, Portugal
 Santa Casa da Misericórdia de Lisboa
Em curso
2019/09/15 - 2023/03/14 Targeting induced-senescent cells: a novel approach to promote spinal cord regeneration in mammals
HR18-00187
Bolseiro de Investigação
Instituto de Medicina Molecular, Portugal
 Obra Social La Caixa
Concluído
2014/07/01 - 2015/01/04 Mechanisms in Brh2-promoted recombinational repair
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES/5R01GM079859-06/US
Investigador Pós-doutorado
Weill Cornell Medicine, Estados Unidos
 National Institutes of Health
Concluído
2012/06/01 - 2014/06/30 BRCA2 model system
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES/5R01GM042482-19/US
Investigador Pós-doutorado
Weill Cornell Medicine, Estados Unidos
 National Institutes of Health
Concluído
2007/09/01 - 2011/08/31 Analysis of the formation of the infective filament of Ustilago maydis: a model to define cell cycle regulators and morphogenesis regulators as virulence factors in pathogenic fungi
BIO2005-02998
Bolseiro de Doutoramento
Centro Nacional de Biotecnología, Espanha
 Ministerio de Educación y Ciencia
Concluído
Produções

Publicações

Artigo em revista
  1. de Sena-Tomás, Carmen; Aleman, Angelika G.; Ford, Caitlin; Varshney, Akriti; Yao, Di; Harrington, Jamie K.; Saúde, Leonor; Ramialison, Mirana; Targoff, Kimara L.. "Activation of Nkx2.5 transcriptional program is required for adult myocardial repair". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-30468-4.
    10.1038/s41467-022-30468-4
  2. Budine, Terin E.; de Sena-Tomás, Carmen; Williams, Margot L.K.; Sepich, Diane S.; Targoff, Kimara L.; Solnica-Krezel, Lila. "Gon4l/Udu regulates cardiomyocyte proliferation and maintenance of ventricular chamber identity during zebrafish development". Developmental Biology 462 2 (2020): 223-234. http://dx.doi.org/10.1016/j.ydbio.2020.03.002.
    Publicado • 10.1016/j.ydbio.2020.03.002
  3. Morikawa, Kumi; Furuhashi, Kazuhiro; de Sena-Tomás, Carmen; Garcia-Garcia, Alvaro L.; Bekdash, Ramsey; Klein, Alison D.; Gallerani, Nicholas; et al. "Photoactivatable Cre recombinase 3.0 for in vivo mouse applications". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-16030-0.
    Publicado • 10.1038/s41467-020-16030-0
  4. Shi, Lingyan; Zheng, Chaogu; Shen, Yihui; Chen, Zhixing; Silveira, Edilson S.; Zhang, Luyuan; Wei, Mian; et al. "Optical imaging of metabolic dynamics in animals". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-05401-3.
    Publicado • 10.1038/s41467-018-05401-3
  5. Colombo, Sophie; de Sena-Tomás, Carmen; George, Vanessa; Werdich, Andreas A.; Kapur, Sunil; MacRae, Calum A.; Targoff, Kimara L.. "Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression". Development 145 3 (2017): dev161497. http://dx.doi.org/10.1242/dev.161497.
    Publicado • 10.1242/dev.161497
  6. Tenorio-Gómez, María; de Sena-Tomás, Carmen; Pérez-Martín, Jose. "MRN- and 9-1-1-Independent Activation of the ATR-Chk1 Pathway during the Induction of the Virulence Program in the Phytopathogen Ustilago maydis". PLOS ONE 10 9 (2015): e0137192. http://dx.doi.org/10.1371/journal.pone.0137192.
    Publicado • 10.1371/journal.pone.0137192
  7. de Sena-Tomás, Carmen; Sutherland, Jeanette H.; Milisavljevic, Mira; Nikolic, Dragana B.; Pérez-Martín, José; Kojic, Milorad; Holloman, William K.. "LAMMER kinase contributes to genome stability in Ustilago maydis". DNA Repair 33 (2015): 70-77. http://dx.doi.org/10.1016/j.dnarep.2015.05.011.
    Publicado • 10.1016/j.dnarep.2015.05.011
  8. de Sena-Tomás, Carmen; Yu, Eun Young; Calzada, Arturo; Holloman, William K.; Lue, Neal F.; Pérez-Martín, José. "Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres". Nucleic Acids Research 43 4 (2015): 2138-2151. http://dx.doi.org/10.1093/nar/gkv082.
    Publicado • 10.1093/nar/gkv082
  9. de Sena-Tomás, Carmen; Navarro-González, Mónica; Kües, Ursula; Pérez-Martín, José. "A DNA Damage Checkpoint Pathway Coordinates the Division of Dikaryotic Cells in the Ink Cap Mushroom Coprinopsis cinerea". Genetics 195 1 (2013): 47-57. http://dx.doi.org/10.1534/genetics.113.152231.
    Publicado • 10.1534/genetics.113.152231
  10. Pérez-Martín, Jose; de Sena-Tomás, Carmen. "Dikaryotic cell cycle in the phytopathogenic fungusUstilago maydisis controlled by the DNA damage response cascade". Plant Signaling & Behavior 6 10 (2011): 1574-1577. http://dx.doi.org/10.4161/psb.6.10.17055.
    Publicado • 10.4161/psb.6.10.17055
  11. de Sena-Tomás, Carmen; Fernández-Álvarez, Alfonso; Holloman, William K.; Pérez-Martín, José. "The DNA Damage Response Signaling Cascade Regulates Proliferation of the Phytopathogenic Fungus Ustilago maydis in Planta". The Plant Cell 23 4 (2011): 1654-1665. http://dx.doi.org/10.1105/tpc.110.082552.
    Publicado • 10.1105/tpc.110.082552
Poster em conferência
  1. Ford, Caitlin; de Sena-Tomás, Carmen; Gao, Cynthia; Rangaswami, Uday; See, Michael; Nim, Hieu; Sanges, Remo; Ramialison, Mirana; Targoff, Kimara L.. "Nkx2.7 is a novel regulator of pharyngeal arch development". Trabalho apresentado em Weinstein Cardiovascular Development and Regeneration Meeting, 2022.
  2. Yao, Di; Aleman, Angelika G.; Ford, Caitlin; Woodard, Micah; de Sena-Tomás, Carmen; Targoff, Kimara L.. "Fibulin genes regulate outflow track caliber and extracellular matrix integrity". Trabalho apresentado em Weinstein Cardiovascular Development and Regeneration Meeting, 2022.
  3. Neves-Silva, Dalila; Martins, Isaura; de Sena-Tomás, Carmen; Rebocho da Costa, Mariana; Quitéria, Raquel; Matthiesen, Rune; Carvalho, A. S.; et al. "Mimicking the Zebrafish Extracellular Matrix Profile in Mammals to Promote Spinal Cord Repair.". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN2021), 2021.
  4. de Sena-Tomás, Carmen; Yao, Di; Aleman, Angelika G.; Harrington, Jamie; Varshney, Akriti; Saúde, Leonor; Ramialison, Mirana; Targoff, Kimara L.. "Activation of Nkx2.5 transcriptional program is required for adult myocardial repair". Trabalho apresentado em 16th International Zebrafish Conference, 2021.
  5. Ribeiro, Ana; Rebocho da Costa, Mariana; de Sena-Tomás, Carmen; Saúde, Leonor. "Vascular repair after spinal cord injury in zebrafish". Trabalho apresentado em 16th International Zebrafish Conference, 2021.
  6. Ford, Caitlin; de Sena-Tomás, Carmen; Targoff, Kimara L.. "Nkx2.7 is a novel regulator of craniofacial muscle and cartilage development". Trabalho apresentado em 16th International Zebrafish Conference, 2021.
  7. de Sena-Tomás, Carmen; Harrington, Jamie; Targoff, Kimara L.. "Nkx2.5 is required for proliferation and extracellular matrix patterning during myocardial repair". Trabalho apresentado em Weinstein Cardiovascular Development and Regeneration Conference, 2018.
  8. de Sena-Tomás, Carmen; Harrington, Jamie; Targoff, Kimara L.. "Nkx2.5 is required for proliferation during myocardial repair". Trabalho apresentado em Weinstein Cardiovascular Development and Regeneration Meeting, 2017.
  9. de Sena-Tomás, Carmen; Harrington, Jamie; Targoff, Kimara L.. "Nkx2.5 is required for proliferation during ventricular regeneration". Trabalho apresentado em Weinstein Cardiovascular Development and Regeneration Conference, 2016.
  10. de Sena-Tomás, Carmen; Pérez-Martín, José. "Essentiality of Ku70/80 in Ustilago maydis is related to its ability to suppress DNA damage signaling at telomeres". Trabalho apresentado em UNIA workshop “The enemy within: endogenous DNA damage as a source of cancer and ageing”, 2011.
  11. de Sena-Tomás, Carmen; Pérez-Martín, José. "Ku70/80 avoid DNA damage checkpoint activation at telomeres in Ustilago maydis". Trabalho apresentado em EMBO workshop “Chromosome structure, damage & repair”, 2011.
Pré-impressão
  1. Ana Ribeiro; Mariana Rebocho da Costa; Carmen de Sena-Tomás; Elsa Charas Rodrigues; Raquel Quitéria; Tiago Maçarico; Susana Constantino Rosa Santos; Leonor Saúde. "New functional vessels form after spinal cord injury in zebrafish". 2022. https://doi.org/10.1101/2022.06.09.495446.
    10.1101/2022.06.09.495446
Tese / Dissertação
  1. "Roles of the Atr1-Chk1 pathway in the phytopathogenic fungus Ustilago maydis". Doutoramento, Universidad Autónoma de Madrid, 2012.
  2. "Characterization of atr1 in Ustilago maydis". Mestrado, Universidad Autónoma de Madrid, 2009.
  3. "Molecular analysis of the regulation of fas gene expression in Rhodococcus fascians". Licenciatura, Universidad de Salamanca, 2006.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2017/09/22 Nkx2.5 is required for proliferation during myocardial repair 2017 Fall MARZ (Mid Atlantic Region Zebrafish) meeting
NYU Langone Medical Center (New York, Estados Unidos)
2010/09 Atr1, a DNA damage response kinase and its role in virulence in Ustilago maydis ZYMOMADRID XXIV
Universidad Complutense de Madrid (Madrid, Espanha)
2008/02 Implication of the DNA damage response pathway in the virulence program of the phytopathogen Ustilago maydis ZYMOMADRID XXII
Universidad Complutense de Madrid (Madrid, Espanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/09 - 2022/01 Unraveling the role of neutrophils during spinal cord regeneration in zebrafish
Orientador
 Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018/10 - 2018/10 Welcusa NY (networking) (2018/10 - 2018/10)
Outro (Coorganizador)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2018/08 - 2018/08 Epigenetics in health and disease and discussion on the future of biomedicine in Europe and Spain by Manel Esteller (2018/08 - 2018/08)
Seminário (Coorganizador)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2018/06 - 2018/06 How to discover a new particle? Chasing Higgs Boson by Javier Santaolalla (2018/06 - 2018/06)
Outro (Coorganizador)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2018/05 - 2018/05 ECUSA-NY, 3rd anniversary science fair and networking event (2018/05 - 2018/05)
Outro (Presidente da Comissão Organizadora)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2018/03 - 2018/03 "Champions of illusion" by Stephen Macknik and Susana Martínez-Conde. Book presentation (2018/03 - 2018/03)
Outro (Coorganizador)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2018/02 - 2018/02 The challenges of a scientific career inside academia (2018/02 - 2018/02)
Mesa-redonda (Coorganizador)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2017/10 - 2017/10 Welcusa NY (networking) (2017/10 - 2017/10)
Outro (Coorganizador)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2017/05 - 2017/05 Immigration info session (2017/05 - 2017/05)
Mesa-redonda (Membro da Comissão Organizadora)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2016/10 - 2016/10 Alternatives for Science professionals to return to Spain (2016/10 - 2016/10)
Mesa-redonda (Coorganizador)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2016/09 - 2016/09 Welcusa NY (networking) (2016/09 - 2016/09)
Outro (Coorganizador)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos
2015/11 - 2015/11 Taxation for Spanish Scientists in the USA (2015/11)
Mesa-redonda (Coorganizador)
 ECUSA - NY (Spanish Scientists in USA, New York Chapter), Estados Unidos

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2021/06 - 2021/06 Participation at the 16th International Zebrafish Conference
Conferência
 16th International Zebrafish Conference
2020/03/02 - 2020/03/06 Participation in the workshop "Recent Trends in CNS Regenerative Medicine: from injury and disease to advanced therapies"
Oficina (workshop)
 Recent Trends in CNS Regenerative Medicine: from injury and disease to advanced therapies
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/05/16 - 2018/05/18 Participation in Weinstein Cardiovascular Development and Regeneration Conference 2018
Conferência
 Weinstein Cardiovascular Development and Regeneration Conference
Weinstein Cardiovascular Development Conference, Estados Unidos
2017/05/04 - 2017/05/06 Participation in Weinstein Cardiovascular Development and Regeneration Meeting 2017
Conferência
 Weinstein Cardiovascular Development and Regeneration Meeting
Weinstein Cardiovascular Development Conference, Estados Unidos
2016/05/19 - 2016/05/21 Participation in Weinstein Cardiovascular Development and Regeneration Conference 2016
Conferência
 Weinstein Cardiovascular Development and Regeneration Conference
Weinstein Cardiovascular Development Conference, Estados Unidos
2011/11/17 - 2011/11/19 Participation in UNIA workshop "The enemy within: endogenous DNA damage as a source of cancer and aging"
Oficina (workshop)
 The enemy within: endogenous DNA damage as a source of cancer and ageing
Universidad Internacional de Andalucía, Espanha
2011/09/25 - 2011/09/28 Participation in EMBO workshop "Chromosome structure, damage & repair"
Oficina (workshop)
 Chromosome structure, damage & repair
EMBO Press, Alemanha

Membro de associação

Nome da associação Tipo de participação
2021/04 - Atual International Zebrafish Society
2021/03/09 - Atual International Society for Regenerative Biology Postdoctoral Member
2017/01 - 2018/12 ECUSA - NY (Spanish Scientists in the USA) President
2014/12 - 2017/01 ECUSA-NY (Spanish Scientists in the USA, New York Chapter) Founding member of ECUSA-NY and board member
2014/12 - 2017/01 ECUSA (Spanish Scientists in the USA) Advisory director
Distinções

Prémio

2022 Travel award
Weinstein Cardiovascular Development Conference, Estados Unidos
2017 Honorable mention award
Weinstein Cardiovascular Development Conference, Estados Unidos

Outra distinção

2007 PhD fellowship grant - BES-2007-16813
Ministerio de Educación y Ciencia, Espanha
2005 Erasmus grant
Universidad de Salamanca, Espanha