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Antigny Fabrice. Is Invited Auxiliary Researcher in INSERM U999.
Identification

Personal identification

Full name
Antigny Fabrice

Citation names

  • Fabrice, Antigny

Author identifiers

Ciência ID
AA1F-B051-F467
ORCID iD
0000-0002-9515-6571

Telephones

Telephone
  • (+33) 0140942299 (Professional)

Websites

  • http://www.u999.universite-paris-saclay.fr/en/ (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Physiology

Languages

Language Speaking Reading Writing Listening Peer-review
French (Mother tongue)
English Intermediate (B1) Advanced (C1) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Education
Degree Classification
2005/10/01 - 2008/11/30
Concluded
PhD thesis (Doctorat)
Université de Poitiers, France
"Homéostasie calcique dans les cellules épithéliales mucoviscidosiques (F508del-CFTR)" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution
Employer
2013/09/01 - Current Principal Investigator (Research) INSERM U999, France
Université Paris-Saclay, France
Projects

Grant

Designation Funders
2018/10/01 - 2022/06/01 KCNK3 channel A new therapeutic target in Pulmonary Arterial Hypertension – KAPAH
Principal investigator
Agence nationale de la recherche
Ongoing
Outputs

Publications

Journal article
  1. Yegen CH; Lambert M; Beurnier A; Montani D; Humbert M; Planès C; Boncoeur E; Voituron N; Antigny F. "KCNK3 channel is important for the ventilatory response to hypoxia in rats.". Respiratory physiology & neurobiology (2023): https://doi.org/10.1016/j.resp.2023.104164.
    10.1016/j.resp.2023.104164
  2. Anaïs Saint-Martin Willer; Santos-Gomes J; Adão R; Bras-Silva C; Eyries M; Francisco Perez-Vizcaino; Capuano V; Montani D; Fabrice Antigny. "Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart.". The Journal of physiology (2023): https://doi.org/10.1113/JP284936.
    10.1113/jp284936
  3. Bastien Masson; Anaïs Saint-Martin Willer; Dutheil M; Penalva L; Le Ribeuz H; El Jekmek K; Ruchon Y; et al. "Contribution of transient receptor potential canonical channels in human and experimental pulmonary arterial hypertension.". American journal of physiology. Lung cellular and molecular physiology (2023): https://doi.org/10.1152/ajplung.00011.2023.
    10.1152/ajplung.00011.2023
  4. Hélène Le Ribeuz; Bastien Masson; Mary Dutheil; Angèle Boët; Antoine Beauvais; Jessica Sabourin; Vincent Thomas De Montpreville; et al. "Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension". Frontiers in Cardiovascular Medicine 9 (2023): http://dx.doi.org/10.3389/fcvm.2022.1066047.
    10.3389/fcvm.2022.1066047
  5. Spiro KHOURY; Antoine Beauvais; Jenny Colas; Anaïs Saint-Martin Willer; Frédéric Perros; Marc Humbert; clarisse Vandebrouck; et al. "Lipidomic Profile Analysis of Lung Tissues Revealed Lipointoxication in Pulmonary Veno-Occlusive Disease". Biomolecules (2022): https://www.mdpi.com/2218-273X/12/12/1878.
    10.3390/biom12121878
  6. Bastien Masson; Hélène Le Ribeuz; Jessica Sabourin; Loann Laubry; Emily Woodhouse; Richard Foster; Yann; et al. "Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension". Circulation Research 131 9 (2022): http://dx.doi.org/10.1161/circresaha.122.321041.
    10.1161/circresaha.122.321041
  7. Jessica Sabourin; Antoine Beauvais; Rui Luo; David Montani; Jean-Pierre Benitah; Bastien Masson; Fabrice Antigny. "The SOCE Machinery: An Unbalanced Knowledge between Left and Right Ventricular Pathophysiology". Cells (2022): https://www.mdpi.com/2073-4409/11/20/3282.
    10.3390/cells11203282
  8. Benoît Chevalier; Nesrine Baatallah; Matthieu Najm; Solène Castanier; Vincent Jung; Iwona Pranke; Anita Golec; et al. "Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/16/8937.
    10.3390/ijms23168937
  9. Joana Gomes; Hélène Le Ribeuz; Bras-Silva C; Fabrice Antigny; Adão R. "Role of Ion Channel Remodeling in Endothelial Dysfunction Induced by Pulmonary Arterial Hypertension". Biomolecules (2022): https://www.mdpi.com/2218-273X/12/4/484.
    10.3390/biom12040484
  10. Le Ribeuz, Hélène; Masson, Bastien; Capuano, Véronique; Dutheil, Mary; Gooroochurn, Hans; Boët, Angèle; Ghigna, Maria-Rosa; et al. Corresponding author: Antigny, Fabrice. "SUR1 as a New Therapeutic Target for Pulmonary Arterial Hypertension". American Journal of Respiratory Cell and Molecular Biology (2022): http://dx.doi.org/10.1165/rcmb.2021-0180oc.
    10.1165/rcmb.2021-0180oc
  11. Cheron, Céline; McBride, Susan Ainslie; Antigny, Fabrice; Girerd, Barbara; Chouchana, Margot; Chaumais, Marie-Camille; Jaïs, Xavier; et al. "Sex and gender in pulmonary arterial hypertension". European Respiratory Review 30 162 (2021): 200330. http://dx.doi.org/10.1183/16000617.0330-2020.
    10.1183/16000617.0330-2020
  12. Bastien Masson; David Montani; Marc Humbert; Véronique Capuano; Fabrice Antigny. Corresponding author: Fabrice Antigny. "Role of Store-Operated Ca2+ Entry in the Pulmonary Vascular Remodeling Occurring in Pulmonary Arterial Hypertension". Biomolecules (2021): https://www.mdpi.com/2218-273X/11/12/1781.
    10.3390/biom11121781
  13. Antigny, Fabrice; Le Ribeuz, Hélène; Humbert, Marc; Montani, David. Corresponding author: Antigny, Fabrice. "Comment on: Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype". European Respiratory Journal 58 2 (2021): 2101365. http://dx.doi.org/10.1183/13993003.01365-2021.
    10.1183/13993003.01365-2021
  14. Thaïs Hautbergue; Fabrice Antigny; Angèle Boët; François Haddad; Bastien Masson; Melanie Lambert; Amélie Delaporte; et al. "Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure". Cells (2021): https://www.mdpi.com/2073-4409/10/6/1559.
    10.3390/cells10061559
  15. Le Ribeuz, Hélène; To, Lucie; Ghigna, Maria-Rosa; Martin, Clémence; Nagaraj, Chandran; Dreano, Elise; Rucker-Martin, Catherine; et al. "Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension". European Respiratory Journal 58 5 (2021): 2000653. http://dx.doi.org/10.1183/13993003.00653-2020.
    10.1183/13993003.00653-2020
  16. Le Ribeuz, Hélène; Montani, David; Antigny, Fabrice. Corresponding author: Antigny, Fabrice. "The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model". Frontiers in Physiology 12 (2021): http://dx.doi.org/10.3389/fphys.2021.668267.
    10.3389/fphys.2021.668267
  17. Burgos, Miguel; Philippe, Reginald; Antigny, Fabrice; Buscaglia, Paul; Masson, Emmanuelle; Mukherjee, Sreya; Dubar, Pauline; et al. "The p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis". Journal of Cell Science 134 3 (2021): http://dx.doi.org/10.1242/jcs.244012.
    10.1242/jcs.244012
  18. Lambert, Mélanie; Mendes-Ferreira, Pedro; Ghigna, Maria-Rosa; LeRibeuz, Hélène; Adão, Rui; Boet, Angèle; Capuano, Véronique; et al. Corresponding author: Antigny, Fabrice. "Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload". Cardiovascular Research 117 12 (2021): 2474-2488. http://dx.doi.org/10.1093/cvr/cvab016.
    10.1093/cvr/cvab016
  19. Hélène Le Ribeuz; Florent Dumont; Guillaume Ruellou; Mélanie Lambert; Thierry Balliau; Marceau Quatredeniers; Barbara Girerd; et al. Corresponding author: Fabrice Antigny. "Proteomic Analysis of KCNK3 Loss of Expression Identified Dysregulated Pathways in Pulmonary Vascular Cells". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/19/7400.
    10.3390/ijms21197400
  20. Hélène Le Ribeuz; Véronique Capuano; Barbara Girerd; Marc Humbert; David Montani; Fabrice Antigny. "Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension". Biomolecules (2020): https://www.mdpi.com/2218-273X/10/9/1261.
    10.3390/biom10091261
  21. Le Ribeuz H; Courboulin A; Ghigna MR; Lambert M; Hautefort A; Humbert M; David Montani; et al. "In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression.". Respiratory research (2020): https://europepmc.org/articles/PMC7364627.
    10.1186/s12931-020-01444-7
  22. Fabrice, Antigny. "Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease.". American journal of respiratory cell and molecular biology (2020): https://doi.org/10.1165/rcmb.2019-0015OC.
    10.1165/rcmb.2019-0015oc
  23. Fabrice, Antigny. Corresponding author: Fabrice, Antigny. "Excitation-contraction coupling and relaxation alteration in right ventricular remodelling caused by pulmonary arterial hypertension.". Archives of cardiovascular diseases (2020): https://doi.org/10.1016/j.acvd.2019.10.009.
    10.1016/j.acvd.2019.10.009
  24. Fabrice, Antigny. "Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload.". Circulation (2020): https://europepmc.org/articles/PMC6970549.
    10.1161/CIRCULATIONAHA.118.038891
  25. Fabrice, Antigny. "Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes.". Cells (2019): https://europepmc.org/articles/PMC7017140.
    10.3390/cells9010047
  26. Fabrice, Antigny. Corresponding author: Fabrice, Antigny. "Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension.". Circulation research (2019): https://doi.org/10.1161/CIRCRESAHA.119.314793.
    10.1161/circresaha.119.314793
  27. Fabrice, Antigny. Corresponding author: Fabrice, Antigny. "Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective.". Fundamental & clinical pharmacology (2019): https://doi.org/10.1111/fcp.12493.
    10.1111/fcp.12493
  28. Fabrice, Antigny. Corresponding author: Fabrice, Antigny. "Pulmonary arterial hypertension in patient treated for multiple sclerosis with 4-aminopyridine.". Fundamental & clinical pharmacology (2019): https://doi.org/10.1111/fcp.12489.
    10.1111/fcp.12489
  29. Fabrice, Antigny. "The BET Bromodomain Inhibitor I-BET-151 Induces Structural and Functional Alterations of the Heart Mitochondria in Healthy Male Mice and Rats.". International journal of molecular sciences (2019): https://europepmc.org/articles/PMC6480532.
    10.3390/ijms20071527
  30. Quatredeniers M; Nakhleh MK; Dumas SJ; Courboulin A; Vinhas MC; Antigny F; Phan C; et al. "Functional interaction between PDGF and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension.". American journal of physiology. Lung cellular and molecular physiology (2018): http://europepmc.org/abstract/med/30543306.
    10.1152/ajplung.00537.2017
  31. Lambert M; Capuano V; Olschewski A; Sabourin J; Nagaraj C; Girerd B; Weatherald J; Humbert M; Antigny F. Corresponding author: Antigny F. "Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?". International journal of molecular sciences (2018): http://europepmc.org/abstract/med/30322215.
    10.3390/ijms19103162
  32. Hautefort A; Mendes-Ferreira P; Sabourin J; Manaud G; Bertero T; Rücker-Martin C; Riou M; et al. "Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension.". Circulation (2018): http://europepmc.org/abstract/med/30586714.
    10.1161/circulationaha.118.033744
  33. Lambert, Melanie; Boet, Angele; Rucker-Martin, Catherine; Mendes-Ferreira, Pedro; Capuano, Veronique; Hatem, Stephane; Adao, Rui; et al. Corresponding author: Antigny, Fabrice. "Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension.". Cardiovascular research (2018): http://europepmc.org/abstract/med/29360952.
    10.1093/cvr/cvy016
  34. Sabourin, Jessica; Boët, Angèle; Lambert, Mélanie; Lambert, Melanie; Gomez, Ana-Maria; Benitah, Jean-Pierre; Perros, Frederic; Humbert, Marc; Antigny, Fabrice. Corresponding author: Antigny, Fabrice. "Ca2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.". Journal of molecular and cellular cardiology (2018): http://europepmc.org/abstract/med/29634917.
    10.1016/j.yjmcc.2018.04.003
  35. Dumas, Sebastien J.; Bru-Mercier, Gilles; Courboulin, Audrey; Quatredeniers, Marceau; Rucker-Martin, Catherine; Antigny, Fabrice; Nakhleh, Morad K.; et al. "NMDA-Type Glutamate Receptor Activation Promotes Vascular Remodeling and Pulmonary Arterial Hypertension". Circulation (2018): https://publons.com/publon/1044276/.
    10.1161/CIRCULATIONAHA.117.029930
  36. Nossent, Esther J.; Antigny, Fabrice; Montani, David; Bogaard, Harm Jan; Ghigna, Maria Rosa; Lambert, Melanie; de Montpreville, Vincent Thomas; et al. "Pulmonary vascular remodeling patterns and expression of general control nonderepressible 2 (GCN2) in pulmonary veno-occlusive disease". The Journal of Heart and Lung Transplantation (2018): https://publons.com/publon/3842945/.
    10.1016/J.HEALUN.2017.09.022
  37. Olschewski A; Veale EL; Nagy BM; Nagaraj C; Kwapiszewska G; Antigny F; Lambert M; et al. "TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications.". The European respiratory journal (2017): http://europepmc.org/abstract/med/29122916.
    10.1183/13993003.00754-2017
  38. Hautefort A; Chesné J; Preussner J; Pullamsetti SS; Tost J; Looso M; Antigny F; et al. "Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension.". Oncotarget (2017): http://europepmc.org/abstract/med/28881789.
    10.18632/oncotarget.18031
  39. Perros F; de Man FS; Bogaard HJ; Antigny F; Simonneau G; Bonnet S; Provencher S; et al. "Use of ß-Blockers in Pulmonary Hypertension.". Circulation. Heart failure (2017): http://europepmc.org/abstract/med/28364092.
    10.1161/circheartfailure.116.003703
  40. Philippe R; Antigny F; Buscaglia P; Norez C; Huguet F; Castelbou C; Trouvé P; et al. "Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.". Cell calcium (2017): http://europepmc.org/abstract/med/28189267.
    10.1016/j.ceca.2017.01.011
  41. Antigny F; Ranchoux B; Nadeau V; Lau E; Bonnet S; Perros F. "Corrigendum to "A Simple Method to Assess In Vivo Proliferation in Lung Vasculature with EdU: The Case of MMC-Induced PVOD in Rat".". Analytical cellular pathology (Amsterdam) (2017): http://europepmc.org/abstract/med/28265532.
    10.1155/2017/4697379
  42. Antigny F; Sabourin J; Saüc S; Bernheim L; Koenig S; Frieden M; Fabrice Antigny; et al. "TRPC1 and TRPC4 channels functionally interact with STIM1L to promote myogenesis and maintain fast repetitive Ca2+ release in human myotubes.". Biochimica et biophysica acta (2017): http://europepmc.org/abstract/med/28185894.
    10.1016/j.bbamcr.2017.02.003
  43. Sankhe, Safietou; Manousakidi, Sevasti; Antigny, Fabrice; Ataam, Jennifer Arthur; Bentebbal, Sana; Ruchon, Yann; Lecerf, Florence; et al. "T-type Ca2+ channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2017): https://publons.com/publon/3842944/.
    10.1016/J.BBAMCR.2017.06.018
  44. Sabourin J; Bartoli F; Antigny F; Gomez AM; Benitah JP; Jessica Sabourin; Fiona Bartoli; et al. "Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.". The Journal of biological chemistry (2016): http://europepmc.org/abstract/med/27129253.
    10.1074/jbc.M115.693911
  45. Fabrice Antigny; Aurélie Hautefort; Jolyane Meloche; Milia Belacel-Ouari; Boris Manoury; Catherine Rucker-Martin; Christine Péchoux; et al. Corresponding author: Fabrice Antigny. "Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension". Circulation (2016): https://publons.com/publon/3842980/.
    10.1161/CIRCULATIONAHA.115.020951
  46. Boucherat O; Chabot S; Antigny F; Perros F; Provencher S; Bonnet S. "Potassium channels in pulmonary arterial hypertension.". The European respiratory journal (2015): http://europepmc.org/abstract/med/26341985.
    10.1183/13993003.00798-2015
  47. Bertrand J; Dannhoffer L; Antigny F; Vachel L; Jayle C; Vandebrouck C; Becq F; et al. "A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.". European journal of pharmacology (2015): http://europepmc.org/abstract/med/26265544.
    10.1016/j.ejphar.2015.08.005
  48. Fabrice A; Benoît R; Valérie N; Lau E; Sébastien B; Frédéric P. "A simple method to assess in vivo proliferation in lung vasculature with EdU: the case of MMC-induced PVOD in rat.". Analytical cellular pathology (Amsterdam) (2015): http://europepmc.org/abstract/med/26345623.
    10.1155/2015/326385
  49. Perros F; Günther S; Ranchoux B; Godinas L; Antigny F; Chaumais MC; Dorfmüller P; et al. "Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models.". Circulation (2015): http://europepmc.org/abstract/med/26130118.
    10.1161/circulationaha.115.014207
  50. Ranchoux B; Antigny F; Rucker-Martin C; Hautefort A; Péchoux C; Bogaard HJ; Dorfmüller P; et al. "Endothelial-to-mesenchymal transition in pulmonary hypertension.". Circulation (2015): http://europepmc.org/abstract/med/25593290.
    10.1161/circulationaha.114.008750
  51. Frédéric Perros; Benoît Ranchoux; Mohamed Izikki; Sana Bentebbal; Chris Happé; Fabrice Antigny; Philippe Jourdon; et al. "Nebivolol for Improving Endothelial Dysfunction, Pulmonary Vascular Remodeling, and Right Heart Function in Pulmonary Hypertension". JACC: Journal of the American College of Cardiology (2015): https://publons.com/publon/3842989/.
    10.1016/J.JACC.2014.11.050
  52. Réginald Philippe; Fabrice Antigny; Paul Buscaglia; Caroline Norez; Frédéric Becq; Maud Frieden; Olivier Mignen; et al. "SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2015): https://publons.com/publon/3842984/.
    10.1016/J.BBAMCR.2015.01.010
  53. Ranchoux, Benoit; Gunether, Sven; Quarck, Rozenn; Chaumais, Marie-Camille; Dorfmueller, Peter; Antigny, Fabrice; Dumas, Sebastien J.; et al. "Chemotherapy-Induced Pulmonary Hypertension Role of Alkylating Agents". The American Journal of Pathology (2015): https://publons.com/publon/2304093/.
    10.1016/J.AJPATH.2014.10.021
  54. Meloche, Jolyane; Le Guen, Marie; Potus, Francois; Vinck, Jerome; Ranchoux, Benoit; Johnson, Ian; Antigny, Fabrice; et al. "miR-223 reverses experimental pulmonary arterial hypertension". AJP: Cell Physiology (2015): https://publons.com/publon/3842983/.
    10.1152/AJPCELL.00149.2015
  55. S. Sauc; M. Bulla; P. Nunes; L. Orci; A. Marchetti; F. Antigny; L. Bernheim; et al. "STIM1L traps and gates Orai1 channels without remodeling the cortical ER". Journal of Cell Science (2015): https://publons.com/publon/3842982/.
    10.1242/JCS.164228
  56. Antigny F; Konig S; Bernheim L; Frieden M; Fabrice Antigny; Stéphane Konig; Laurent Bernheim; Maud Frieden. "Inositol 1,4,5 trisphosphate receptor 1 is a key player of human myoblast differentiation.". Cell calcium (2014): http://europepmc.org/abstract/med/25468730.
    10.1016/j.ceca.2014.10.014
  57. Girerd B; Perros F; Antigny F; Humbert M; Montani D. "KCNK3: new gene target for pulmonary hypertension?". Expert review of respiratory medicine (2014): http://europepmc.org/abstract/med/24742047.
    10.1586/17476348.2014.909731
  58. C Norez; C Vandebrouck; J Bertrand; S Noel; E Durieu; N Oumata; H Galons; et al. "Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism". British Journal of Pharmacology (2014): https://publons.com/publon/3842987/.
    10.1111/BPH.12859
  59. George PM; Oliver E; Dorfmuller P; Dubois OD; Reed DM; Kirkby NS; Mohamed NA; et al. "Evidence for the involvement of type I interferon in pulmonary arterial hypertension.". Circulation research (2013): http://europepmc.org/abstract/med/24334027.
    10.1161/CIRCRESAHA.114.302221
  60. F. Antigny; S. Koenig; L. Bernheim; M. Frieden; Antigny F; Koenig S; Bernheim L; Frieden M. "During post-natal human myogenesis, normal myotube size requires TRPC1- and TRPC4-mediated Ca2+ entry". Journal of Cell Science (2013): https://publons.com/publon/3842985/.
    10.1242/JCS.122911
  61. Sabourin J; Antigny F; Robin E; Frieden M; Raddatz E. "Activation of transient receptor potential canonical 3 (TRPC3)-mediated Ca2+ entry by A1 adenosine receptor in cardiomyocytes disturbs atrioventricular conduction.". The Journal of biological chemistry (2012): http://europepmc.org/abstract/med/22692208.
    10.1074/jbc.M112.378588
  62. Jessica Sabourin; Fabrice Antigny; Elodie Robin; Maud Frieden; Eric Raddatz. "Activation of Transient Receptor Potential Canonical 3 (TRPC3)-mediated Ca 2+ Entry by A 1 Adenosine Receptor in Cardiomyocytes Disturbs Atrioventricular Conduction". Journal of Biological Chemistry (2012): https://publons.com/publon/3842990/.
    10.1074/JBC.M112.378588
  63. Fabrice Antigny; Nathalie Girardin; Maud Frieden. "Transient Receptor Potential Canonical Channels Are Required for in Vitro Endothelial Tube Formation". Journal of Biological Chemistry (2012): https://publons.com/publon/3842991/.
    10.1074/JBC.M111.295733
  64. Antigny F; Girardin N; Frieden M. "Transient receptor potential canonical channels are required for in vitro endothelial tube formation.". The Journal of biological chemistry (2011): http://europepmc.org/abstract/med/22203682.
    10.1074/jbc.M111.295733
  65. Antigny F; Norez C; Becq F; Vandebrouck C. "CFTR and Ca Signaling in Cystic Fibrosis.". Frontiers in Pharmacology (2011): http://europepmc.org/abstract/med/22046162.
    10.3389/fphar.2011.00067
  66. Fabrice Antigny; Hélène Jousset; Stéphane König; Maud Frieden; Antigny F; Jousset H; König S; Frieden M. "Thapsigargin activates Ca2+ entry both by store-dependent, STIM1/Orai1-mediated, and store-independent, TRPC3/PLC/PKC-mediated pathways in human endothelial cells". Cell Calcium (2011): https://publons.com/publon/3842999/.
    10.1016/J.CECA.2010.12.001
  67. Fabrice Antigny; Caroline Norez; Luc Dannhoffer; Johanna Bertrand; Dorothée Raveau; Pierre Corbi; Christophe Jayle; et al. "Transient Receptor Potential Canonical Channel 6 Links Ca 2+ Mishandling to Cystic Fibrosis Transmembrane Conductance Regulator Channel Dysfunction in Cystic Fibrosis". American Journal of Respiratory Cell and Molecular Biology (2011): https://publons.com/publon/3842997/.
    10.1165/RCMB.2009-0347OC
  68. Girardin, Nathalie C.; Antigny, Fabrice; Frieden, Maud; Girardin NC; Antigny F; Frieden M. "Electrophysiological characterization of store-operated and agonist-induced Ca2+ entry pathways in endothelial cells". Pflügers Archiv - European Journal of Physiology (2010): https://publons.com/publon/3842998/.
    10.1007/S00424-010-0825-1
  69. Norez C; Antigny F; Noel S; Vandebrouck C; Becq F; Caroline Norez; Fabrice Antigny; et al. "A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype.". American journal of respiratory cell and molecular biology (2009): http://europepmc.org/abstract/med/19131642.
    10.1165/rcmb.2008-0285oc
  70. Fabrice Antigny; Nathalie Girardin; Dorothée Raveau; Maud Frieden; Frédéric Becq; Clarisse Vandebrouck. "Dysfunction of mitochondria Ca2+ uptake in cystic fibrosis airway epithelial cells". Mitochondrion (2009): https://publons.com/publon/3842996/.
    10.1016/J.MITO.2009.02.003
  71. Antigny F; Norez C; Cantereau A; Becq F; Vandebrouck C. "Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.". Respiratory research (2008): http://europepmc.org/abstract/med/18973672.
    10.1186/1465-9921-9-70
  72. Norez C; Vandebrouck C; Antigny F; Dannhoffer L; Blondel M; Becq F; Norez, Caroline; et al. "Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells.". European journal of pharmacology (2008): http://europepmc.org/abstract/med/18640110.
    10.1016/j.ejphar.2008.06.103
  73. Lenglet, Sebastien; Antigny, Fabrice; Vetterli, Laurene; Dufour, Jean-Francois; Rossier, Michel F.; Lenglet S; Antigny F; et al. "Hint2 Is Expressed in the Mitochondria of H295R Cells and Is Involved in Steroidogenesis". Endocrinology (2008): https://publons.com/publon/3842993/.
    10.1210/EN.2008-0400
  74. Auzanneau C; Norez C; Antigny F; Thoreau V; Jougla C; Cantereau A; Becq F; et al. "Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel.". Biochemical pharmacology (2007): http://europepmc.org/abstract/med/17945192.
    10.1016/j.bcp.2007.09.004
  75. Antigny F; Norez C; Becq F; Vandebrouck C; Fabrice Antigny; Caroline Norez; Frédéric Becq; Clarisse Vandebrouck. "Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.". Cell calcium (2007): http://europepmc.org/abstract/med/17590432.
    10.1016/j.ceca.2007.05.002
  76. Norez C; Antigny F; Becq F; Vandebrouck C; Caroline Norez; Fabrice Antigny; Frédéric Becq; Clarisse Vandebrouck. "Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.". Traffic (Copenhagen, Denmark) (2006): http://europepmc.org/abstract/med/16643279.
    10.1111/j.1600-0854.2006.00409.x
Working paper
  1. David Montani; Fabrice, Antigny; Etienne-Marie Jutant; Chaumais, Marie-Camille; Hélène Le Ribeuz; Julien Grynblat; charles khoury; Humbert, Marc. Corresponding author: David Montani. 2023. "Pulmonary hypertension associated with diazoxide: the SUR1 paradox".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/29 “Store-operated channels in pulmonary hypertension” Seminar at the Madrid school of Medecine
Madrid school of Medecine (Spain)
2023/09/18 Role of Orai1 Ca2+ Channel in the development of pulmonary arterial hypertension
Ion channels Congress (France)
2018/11/06 Revisiting the role of K+ channel in pulmonary hypertension AHA Scientific meeting
AHA (United States)
2017/09/17 Role of KCNK3 channel in the development of pulmonary arterial hypertension Invited conference
Ludwig Boltzmann Gesellschaft, the Medical University of Graz (Austria)
2016/09/03 Role of KCNK3 channel in the development of pulmonary arterial hypertension
European respiratory society (United Kingdom)
2016/05/05 Role of KCNK3 channel in the development of pulmonary arterial hypertension
American thoracic society (United States)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/10/01 - 2026/09/30 Etude des mécanismes physiopathologiques de l'hypertension artérielle pulmonaire et de l'insuffisance ventriculaire droite
Supervisor
Université Paris-Saclay, France
2022/10/01 - 2025/09/30 Rôle des partenaires régulateurs du canal calcique Orai1 dans le développement de l’hypertension artérielle pulmonaire
Supervisor
Université Paris-Saclay, France
2020/10/01 - 2023/10/01 Rôle des canaux Orai et TRPC dans le développement de l'hypertension artérielle pulmonaire
Supervisor
Université Paris-Saclay, France
2018/12/01 - 2021/12/01 Rôle des canaux potassiques KCNK3/TASK-1 et KATP dans la pathogenèse de l’hypertension artérielle pulmonaire
Supervisor
Université Paris-Saclay, France
2016/10/01 - 2019/10/01 Etude de l’implication de la dysfonction de Kcnk3 dans le développement de l’hypertension artérielle pulmonaire
Supervisor
Université Paris-Saclay, France
2013/09/01 - 2017/10/01 Etude des mécanismes inflammatoires, génétiques et épigénétiques impliqués dans la physiopathologie de l'hypertension artérielle pulmonaire
Co-supervisor
Université Paris-Saclay, France

Mentoring / Tutoring

Topic Student name
2021/01/01 - 2021/09/30 Mechanism of RV failure in pulmonary arterial banding rat model Antoine Beauvais
2021/01/01 - 2021/06/30 Role of SOC channel in the development of pulmonary endothelial dysfunction occurring in pulmonary hypertension Loann Laubry
2021/01/01 - 2021/06/30 Role of Orai1 regulatory partners in the development of pulmonary arterial hypertension Anaïs Saint-Martin Willer
2020/01/01 - 2020/06/30 Role of Orai/TRPC channels in the development of pulmonary arterial hypertension Léa Bernard
2020/01/01 - 2020/06/30 Role of KCNK3 channel in the development of pulmonary arterial hypertension Raja Chebbi
2015/01/01 - 2015/06/30 Role of KCNK3 channel in the development of pulmonary arterial hypertension Mélanie Lambert

Other jury / evaluation

Activity description Institution / Organization
2018/06/03 - Current Evaluation of the abstract submitted to AHA scientific meeting American Heart Association Inc, United States
Distinctions

Award

2023 RIPEC3 INSERM
INSERM Délégation Régionale Paris 11, France

Title

2019 Habilitation à diriger les recherches
Université Paris-Saclay, France
2017 Full time assistant professor
INSERM, France
2008 PhD
Université de Poitiers, France