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Antigny Fabrice. Is Invited Auxiliary Researcher in INSERM U999.
Identificação

Identificação pessoal

Nome completo
Antigny Fabrice

Nomes de citação

  • Fabrice, Antigny

Identificadores de autor

Ciência ID
AA1F-B051-F467
ORCID iD
0000-0002-9515-6571

Telefones

Telefone
  • (+33) 0140942299 (Profissional)

Websites

  • http://www.u999.universite-paris-saclay.fr/en/ (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês (Idioma materno)
Inglês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1)
Formação
Grau Classificação
2005/10/01 - 2008/11/30
Concluído
PhD thesis (Doctorat)
Université de Poitiers, França
"Homéostasie calcique dans les cellules épithéliales mucoviscidosiques (F508del-CFTR)" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2013/09/01 - Atual Investigador principal (carreira) (Investigação) INSERM U999, França
Université Paris-Saclay, França
Projetos

Bolsa

Designação Financiadores
2023/05/01 - 2026/04/30 Orai1 Ca2+ channel: a new therapeutic target in Pulmonary Arterial Hypertension
#POCs(2023)-121503
Investigador responsável
Concluído
2018/10/01 - 2022/06/01 KCNK3 channel A new therapeutic target in Pulmonary Arterial Hypertension – KAPAH
Investigador responsável
Agence nationale de la recherche
Em curso
Produções

Publicações

Artigo em revista
  1. Poisson C; Hlavaty A; Favrolt N; Marie-Camille Chaumais; Grynblat J; Jutant EM; Lechartier B; et al. "Pulmonary Hypertension Associated With Trastuzumab-Emtansine: An Analysis of French PH Registry and WHO Pharmacovigilance Database.". Chest (2024): https://doi.org/10.1016/j.chest.2024.11.006.
    10.1016/j.chest.2024.11.006
  2. Gregoire Ruffenach; Le Ribeuz H; Dutheil M; El Jekmek K; Dumont F; Anaïs Saint-Martin Willer; Humbert M; et al. "Transcriptome analyses reveal common immune system dysregulation in PAH patients and <i>Kcnk3</i>-deficient rats.". Pulmonary circulation (2024): https://europepmc.org/articles/PMC11497494.
    10.1002/pul2.12434
  3. Anaïs Saint-Martin Willer; El Jekmek K; Fabrice Antigny. "Therapeutic Potential of Sodium Houttuyfonate in Pulmonary Hypertension through Orai-Ca<sup>2+</sup> Channels.". American journal of respiratory cell and molecular biology (2024): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376245.
    10.1165/rcmb.2024-0214ed
  4. Saint-Martin Willer, Anaïs; El Jekmek, Kristell; Antigny, Fabrice. "Therapeutic Potential of Sodium Houttuyfonate in Pulmonary Hypertension through Orai-Ca2+ Channels". American Journal of Respiratory Cell and Molecular Biology 71 3 (2024): 262-263. https://doi.org/10.1165/rcmb.2024-0214ed.
    10.1165/rcmb.2024-0214ed
  5. Santos-Gomes, Joana; Mendes-Ferreira, Pedro; Adão, Rui; Maia-Rocha, Carolina; Rego, Beatriz; Poels, Manu; Saint-Martin Willer, Anaïs; et al. "Unraveling the Impact of miR-146a in Pulmonary Arterial Hypertension Pathophysiology and Right Ventricular Function". International Journal of Molecular Sciences 25 15 (2024): 8054. https://doi.org/10.3390/ijms25158054.
    10.3390/ijms25158054
  6. Hélène Le Ribeuz; Anaïs Saint-Martin Willer; Chevalier B; Sancho M; Bastien Masson; MELANIE EYRIES; Vincent Jung; et al. "Role of KCNK3 Dysfunction in Dasatinib-associated Pulmonary Arterial Hypertension and Endothelial Cell Dysfunction.". American journal of respiratory cell and molecular biology (2024): https://doi.org/10.1165/rcmb.2023-0185OC.
    10.1165/rcmb.2023-0185oc
  7. Joana Santos-Gomes; Pedro Mendes-Ferreira; Adão R; Maia-Rocha C; Beatriz Rego; Manu Poels; Anaïs Saint-Martin Willer; et al. "Unraveling the Impact of miR-146a in Pulmonary Arterial Hypertension Pathophysiology and Right Ventricular Function". International Journal of Molecular Sciences (2024): https://www.mdpi.com/1422-0067/25/15/8054.
    10.3390/ijms25158054
  8. Julien GRYNBLAT; Charles Khouri; Hlavaty A; XAVIER JAIS; Laurent Savale; Marie-Camille Chaumais; Mithum Kularatne; et al. "Characteristics and outcomes of patients developing pulmonary hypertension associated with proteasome inhibitors.". The European respiratory journal (2024): https://doi.org/10.1183/13993003.02158-2023.
    10.1183/13993003.02158-2023
  9. Anaïs Saint-Martin Willer; Montani D; Capuano V; Antigny F. "Orai1/STIMs modulators in pulmonary vascular diseases.". Cell calcium (2024): https://doi.org/10.1016/j.ceca.2024.102892.
    10.1016/j.ceca.2024.102892
  10. Anaïs Saint-Martin Willer; Capuano V; David Montani; Fabrice Antigny. "Response to a Letter to the Editor: Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart.". The Journal of physiology (2024): https://doi.org/10.1113/JP286650.
    10.1113/jp286650
  11. Julien GRYNBLAT; Harm Jan Bogaard; Eyries M; Olivier Meyrignac; Laurent Savale; Jaïs X; Ghigna MR; et al. "Pulmonary vascular phenotype identified in patients with GDF2 (BMP9) or BMP10 variants: an international multicentre study.". The European respiratory journal (2024): https://doi.org/10.1183/13993003.01634-2023.
    10.1183/13993003.01634-2023
  12. Péchoux C; Antigny F; Perros F. "A correlated light and electron microscopy approach to study the subcellular localization of phosphorylated vimentin in human lung tissue.". Methods in cell biology (2024): https://doi.org/10.1016/bs.mcb.2024.02.034.
    10.1016/bs.mcb.2024.02.034
  13. Luo R; Gourriérec PL; Antigny F; Bedouet K; Séverine DOMENICHINI; Ana M Gomez; Benitah JP; Jessica Sabourin. "STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated Ca2+ entry and mitochondrial Ca2+ homeostasis in cardiomyocytes.". Cell calcium (2024): https://doi.org/10.1016/j.ceca.2024.102871.
    10.1016/j.ceca.2024.102871
  14. Yegen CH; Lambert M; Beurnier A; Montani D; Humbert M; Planès C; Boncoeur E; Voituron N; Antigny F. "KCNK3 channel is important for the ventilatory response to hypoxia in rats.". Respiratory physiology & neurobiology (2023): https://doi.org/10.1016/j.resp.2023.104164.
    10.1016/j.resp.2023.104164
  15. Anaïs Saint-Martin Willer; Santos-Gomes J; Adão R; Bras-Silva C; Eyries M; Francisco Perez-Vizcaino; Capuano V; Montani D; Fabrice Antigny. "Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart.". The Journal of physiology (2023): https://doi.org/10.1113/JP284936.
    10.1113/jp284936
  16. Bastien Masson; Anaïs Saint-Martin Willer; Dutheil M; Penalva L; Le Ribeuz H; El Jekmek K; Ruchon Y; et al. "Contribution of transient receptor potential canonical channels in human and experimental pulmonary arterial hypertension.". American journal of physiology. Lung cellular and molecular physiology (2023): https://doi.org/10.1152/ajplung.00011.2023.
    10.1152/ajplung.00011.2023
  17. Hélène Le Ribeuz; Bastien Masson; Mary Dutheil; Angèle Boët; Antoine Beauvais; Jessica Sabourin; Vincent Thomas De Montpreville; et al. "Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension". Frontiers in Cardiovascular Medicine 9 (2023): http://dx.doi.org/10.3389/fcvm.2022.1066047.
    10.3389/fcvm.2022.1066047
  18. Spiro KHOURY; Antoine Beauvais; Jenny Colas; Anaïs Saint-Martin Willer; Frédéric Perros; Marc Humbert; clarisse Vandebrouck; et al. "Lipidomic Profile Analysis of Lung Tissues Revealed Lipointoxication in Pulmonary Veno-Occlusive Disease". Biomolecules (2022): https://www.mdpi.com/2218-273X/12/12/1878.
    10.3390/biom12121878
  19. Bastien Masson; Hélène Le Ribeuz; Jessica Sabourin; Loann Laubry; Emily Woodhouse; Richard Foster; Yann; et al. "Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension". Circulation Research 131 9 (2022): http://dx.doi.org/10.1161/circresaha.122.321041.
    10.1161/circresaha.122.321041
  20. Jessica Sabourin; Antoine Beauvais; Rui Luo; David Montani; Jean-Pierre Benitah; Bastien Masson; Fabrice Antigny. "The SOCE Machinery: An Unbalanced Knowledge between Left and Right Ventricular Pathophysiology". Cells (2022): https://www.mdpi.com/2073-4409/11/20/3282.
    10.3390/cells11203282
  21. Antigny F. "Role of Ion Channels in the Development of Pulmonary Arterial Hypertension.". Biomolecules (2022): https://europepmc.org/articles/PMC9599897.
    10.3390/biom12101373
  22. Benoît Chevalier; Nesrine Baatallah; Matthieu Najm; Solène Castanier; Vincent Jung; Iwona Pranke; Anita Golec; et al. "Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/16/8937.
    10.3390/ijms23168937
  23. Joana Gomes; Hélène Le Ribeuz; Bras-Silva C; Fabrice Antigny; Adão R. "Role of Ion Channel Remodeling in Endothelial Dysfunction Induced by Pulmonary Arterial Hypertension". Biomolecules (2022): https://www.mdpi.com/2218-273X/12/4/484.
    10.3390/biom12040484
  24. Le Ribeuz, Hélène; Masson, Bastien; Capuano, Véronique; Dutheil, Mary; Gooroochurn, Hans; Boët, Angèle; Ghigna, Maria-Rosa; et al. Autor correspondente: Antigny, Fabrice. "SUR1 as a New Therapeutic Target for Pulmonary Arterial Hypertension". American Journal of Respiratory Cell and Molecular Biology (2022): http://dx.doi.org/10.1165/rcmb.2021-0180oc.
    10.1165/rcmb.2021-0180oc
  25. Cheron, Céline; McBride, Susan Ainslie; Antigny, Fabrice; Girerd, Barbara; Chouchana, Margot; Chaumais, Marie-Camille; Jaïs, Xavier; et al. "Sex and gender in pulmonary arterial hypertension". European Respiratory Review 30 162 (2021): 200330. http://dx.doi.org/10.1183/16000617.0330-2020.
    10.1183/16000617.0330-2020
  26. Bastien Masson; David Montani; Marc Humbert; Véronique Capuano; Fabrice Antigny. Autor correspondente: Fabrice Antigny. "Role of Store-Operated Ca2+ Entry in the Pulmonary Vascular Remodeling Occurring in Pulmonary Arterial Hypertension". Biomolecules (2021): https://www.mdpi.com/2218-273X/11/12/1781.
    10.3390/biom11121781
  27. Antigny, Fabrice; Le Ribeuz, Hélène; Humbert, Marc; Montani, David. Autor correspondente: Antigny, Fabrice. "Comment on: Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype". European Respiratory Journal 58 2 (2021): 2101365. http://dx.doi.org/10.1183/13993003.01365-2021.
    10.1183/13993003.01365-2021
  28. Thaïs Hautbergue; Fabrice Antigny; Angèle Boët; François Haddad; Bastien Masson; Melanie Lambert; Amélie Delaporte; et al. "Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure". Cells (2021): https://www.mdpi.com/2073-4409/10/6/1559.
    10.3390/cells10061559
  29. Le Ribeuz, Hélène; To, Lucie; Ghigna, Maria-Rosa; Martin, Clémence; Nagaraj, Chandran; Dreano, Elise; Rucker-Martin, Catherine; et al. "Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension". European Respiratory Journal 58 5 (2021): 2000653. http://dx.doi.org/10.1183/13993003.00653-2020.
    10.1183/13993003.00653-2020
  30. Le Ribeuz, Hélène; Montani, David; Antigny, Fabrice. Autor correspondente: Antigny, Fabrice. "The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model". Frontiers in Physiology 12 (2021): http://dx.doi.org/10.3389/fphys.2021.668267.
    10.3389/fphys.2021.668267
  31. Burgos, Miguel; Philippe, Reginald; Antigny, Fabrice; Buscaglia, Paul; Masson, Emmanuelle; Mukherjee, Sreya; Dubar, Pauline; et al. "The p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis". Journal of Cell Science 134 3 (2021): http://dx.doi.org/10.1242/jcs.244012.
    10.1242/jcs.244012
  32. Lambert, Mélanie; Mendes-Ferreira, Pedro; Ghigna, Maria-Rosa; LeRibeuz, Hélène; Adão, Rui; Boet, Angèle; Capuano, Véronique; et al. Autor correspondente: Antigny, Fabrice. "Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload". Cardiovascular Research 117 12 (2021): 2474-2488. http://dx.doi.org/10.1093/cvr/cvab016.
    10.1093/cvr/cvab016
  33. Hélène Le Ribeuz; Florent Dumont; Guillaume Ruellou; Mélanie Lambert; Thierry Balliau; Marceau Quatredeniers; Barbara Girerd; et al. Autor correspondente: Fabrice Antigny. "Proteomic Analysis of KCNK3 Loss of Expression Identified Dysregulated Pathways in Pulmonary Vascular Cells". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/19/7400.
    10.3390/ijms21197400
  34. Hélène Le Ribeuz; Véronique Capuano; Barbara Girerd; Marc Humbert; David Montani; Fabrice Antigny. "Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension". Biomolecules (2020): https://www.mdpi.com/2218-273X/10/9/1261.
    10.3390/biom10091261
  35. Le Ribeuz H; Courboulin A; Ghigna MR; Lambert M; Hautefort A; Humbert M; David Montani; et al. "In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression.". Respiratory research (2020): https://europepmc.org/articles/PMC7364627.
    10.1186/s12931-020-01444-7
  36. Fabrice, Antigny. "Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease.". American journal of respiratory cell and molecular biology (2020): https://doi.org/10.1165/rcmb.2019-0015OC.
    10.1165/rcmb.2019-0015oc
  37. Fabrice, Antigny. Autor correspondente: Fabrice, Antigny. "Excitation-contraction coupling and relaxation alteration in right ventricular remodelling caused by pulmonary arterial hypertension.". Archives of cardiovascular diseases (2020): https://doi.org/10.1016/j.acvd.2019.10.009.
    10.1016/j.acvd.2019.10.009
  38. Fabrice, Antigny. "Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload.". Circulation (2020): https://europepmc.org/articles/PMC6970549.
    10.1161/CIRCULATIONAHA.118.038891
  39. Fabrice, Antigny. "Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes.". Cells (2019): https://europepmc.org/articles/PMC7017140.
    10.3390/cells9010047
  40. Fabrice, Antigny. Autor correspondente: Fabrice, Antigny. "Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension.". Circulation research (2019): https://doi.org/10.1161/CIRCRESAHA.119.314793.
    10.1161/circresaha.119.314793
  41. Fabrice, Antigny. Autor correspondente: Fabrice, Antigny. "Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective.". Fundamental & clinical pharmacology (2019): https://doi.org/10.1111/fcp.12493.
    10.1111/fcp.12493
  42. Fabrice, Antigny. Autor correspondente: Fabrice, Antigny. "Pulmonary arterial hypertension in patient treated for multiple sclerosis with 4-aminopyridine.". Fundamental & clinical pharmacology (2019): https://doi.org/10.1111/fcp.12489.
    10.1111/fcp.12489
  43. Fabrice, Antigny. "The BET Bromodomain Inhibitor I-BET-151 Induces Structural and Functional Alterations of the Heart Mitochondria in Healthy Male Mice and Rats.". International journal of molecular sciences (2019): https://europepmc.org/articles/PMC6480532.
    10.3390/ijms20071527
  44. Quatredeniers M; Nakhleh MK; Dumas SJ; Courboulin A; Vinhas MC; Antigny F; Phan C; et al. "Functional interaction between PDGF and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension.". American journal of physiology. Lung cellular and molecular physiology (2018): http://europepmc.org/abstract/med/30543306.
    10.1152/ajplung.00537.2017
  45. Lambert M; Capuano V; Olschewski A; Sabourin J; Nagaraj C; Girerd B; Weatherald J; Humbert M; Antigny F. Autor correspondente: Antigny F. "Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?". International journal of molecular sciences (2018): http://europepmc.org/abstract/med/30322215.
    10.3390/ijms19103162
  46. Hautefort A; Mendes-Ferreira P; Sabourin J; Manaud G; Bertero T; Rücker-Martin C; Riou M; et al. "Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension.". Circulation (2018): http://europepmc.org/abstract/med/30586714.
    10.1161/circulationaha.118.033744
  47. Lambert, Melanie; Boet, Angele; Rucker-Martin, Catherine; Mendes-Ferreira, Pedro; Capuano, Veronique; Hatem, Stephane; Adao, Rui; et al. Autor correspondente: Antigny, Fabrice. "Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension.". Cardiovascular research (2018): http://europepmc.org/abstract/med/29360952.
    10.1093/cvr/cvy016
  48. Sabourin, Jessica; Boët, Angèle; Lambert, Mélanie; Lambert, Melanie; Gomez, Ana-Maria; Benitah, Jean-Pierre; Perros, Frederic; Humbert, Marc; Antigny, Fabrice. Autor correspondente: Antigny, Fabrice. "Ca2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.". Journal of molecular and cellular cardiology (2018): http://europepmc.org/abstract/med/29634917.
    10.1016/j.yjmcc.2018.04.003
  49. Dumas, Sebastien J.; Bru-Mercier, Gilles; Courboulin, Audrey; Quatredeniers, Marceau; Rucker-Martin, Catherine; Antigny, Fabrice; Nakhleh, Morad K.; et al. "NMDA-Type Glutamate Receptor Activation Promotes Vascular Remodeling and Pulmonary Arterial Hypertension". Circulation (2018): https://publons.com/publon/1044276/.
    10.1161/CIRCULATIONAHA.117.029930
  50. Nossent, Esther J.; Antigny, Fabrice; Montani, David; Bogaard, Harm Jan; Ghigna, Maria Rosa; Lambert, Melanie; de Montpreville, Vincent Thomas; et al. "Pulmonary vascular remodeling patterns and expression of general control nonderepressible 2 (GCN2) in pulmonary veno-occlusive disease". The Journal of Heart and Lung Transplantation (2018): https://publons.com/publon/3842945/.
    10.1016/J.HEALUN.2017.09.022
  51. Olschewski A; Veale EL; Nagy BM; Nagaraj C; Kwapiszewska G; Antigny F; Lambert M; et al. "TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications.". The European respiratory journal (2017): http://europepmc.org/abstract/med/29122916.
    10.1183/13993003.00754-2017
  52. Hautefort A; Chesné J; Preussner J; Pullamsetti SS; Tost J; Looso M; Antigny F; et al. "Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension.". Oncotarget (2017): http://europepmc.org/abstract/med/28881789.
    10.18632/oncotarget.18031
  53. Perros F; de Man FS; Bogaard HJ; Antigny F; Simonneau G; Bonnet S; Provencher S; et al. "Use of ß-Blockers in Pulmonary Hypertension.". Circulation. Heart failure (2017): http://europepmc.org/abstract/med/28364092.
    10.1161/circheartfailure.116.003703
  54. Philippe R; Antigny F; Buscaglia P; Norez C; Huguet F; Castelbou C; Trouvé P; et al. "Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.". Cell calcium (2017): http://europepmc.org/abstract/med/28189267.
    10.1016/j.ceca.2017.01.011
  55. Antigny F; Ranchoux B; Nadeau V; Lau E; Bonnet S; Perros F. "Corrigendum to "A Simple Method to Assess In Vivo Proliferation in Lung Vasculature with EdU: The Case of MMC-Induced PVOD in Rat".". Analytical cellular pathology (Amsterdam) (2017): http://europepmc.org/abstract/med/28265532.
    10.1155/2017/4697379
  56. Antigny F; Sabourin J; Saüc S; Bernheim L; Koenig S; Frieden M; Fabrice Antigny; et al. "TRPC1 and TRPC4 channels functionally interact with STIM1L to promote myogenesis and maintain fast repetitive Ca2+ release in human myotubes.". Biochimica et biophysica acta (2017): http://europepmc.org/abstract/med/28185894.
    10.1016/j.bbamcr.2017.02.003
  57. Sankhe, Safietou; Manousakidi, Sevasti; Antigny, Fabrice; Ataam, Jennifer Arthur; Bentebbal, Sana; Ruchon, Yann; Lecerf, Florence; et al. "T-type Ca2+ channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2017): https://publons.com/publon/3842944/.
    10.1016/J.BBAMCR.2017.06.018
  58. Sabourin J; Bartoli F; Antigny F; Gomez AM; Benitah JP; Jessica Sabourin; Fiona Bartoli; et al. "Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.". The Journal of biological chemistry (2016): http://europepmc.org/abstract/med/27129253.
    10.1074/jbc.M115.693911
  59. Fabrice Antigny; Aurélie Hautefort; Jolyane Meloche; Milia Belacel-Ouari; Boris Manoury; Catherine Rucker-Martin; Christine Péchoux; et al. Autor correspondente: Fabrice Antigny. "Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension". Circulation (2016): https://publons.com/publon/3842980/.
    10.1161/CIRCULATIONAHA.115.020951
  60. Boucherat O; Chabot S; Antigny F; Perros F; Provencher S; Bonnet S. "Potassium channels in pulmonary arterial hypertension.". The European respiratory journal (2015): http://europepmc.org/abstract/med/26341985.
    10.1183/13993003.00798-2015
  61. Bertrand J; Dannhoffer L; Antigny F; Vachel L; Jayle C; Vandebrouck C; Becq F; et al. "A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.". European journal of pharmacology (2015): http://europepmc.org/abstract/med/26265544.
    10.1016/j.ejphar.2015.08.005
  62. Fabrice A; Benoît R; Valérie N; Lau E; Sébastien B; Frédéric P. "A simple method to assess in vivo proliferation in lung vasculature with EdU: the case of MMC-induced PVOD in rat.". Analytical cellular pathology (Amsterdam) (2015): http://europepmc.org/abstract/med/26345623.
    10.1155/2015/326385
  63. Perros F; Günther S; Ranchoux B; Godinas L; Antigny F; Chaumais MC; Dorfmüller P; et al. "Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Models.". Circulation (2015): http://europepmc.org/abstract/med/26130118.
    10.1161/circulationaha.115.014207
  64. Ranchoux B; Antigny F; Rucker-Martin C; Hautefort A; Péchoux C; Bogaard HJ; Dorfmüller P; et al. "Endothelial-to-mesenchymal transition in pulmonary hypertension.". Circulation (2015): http://europepmc.org/abstract/med/25593290.
    10.1161/circulationaha.114.008750
  65. Frédéric Perros; Benoît Ranchoux; Mohamed Izikki; Sana Bentebbal; Chris Happé; Fabrice Antigny; Philippe Jourdon; et al. "Nebivolol for Improving Endothelial Dysfunction, Pulmonary Vascular Remodeling, and Right Heart Function in Pulmonary Hypertension". JACC: Journal of the American College of Cardiology (2015): https://publons.com/publon/3842989/.
    10.1016/J.JACC.2014.11.050
  66. Réginald Philippe; Fabrice Antigny; Paul Buscaglia; Caroline Norez; Frédéric Becq; Maud Frieden; Olivier Mignen; et al. "SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2015): https://publons.com/publon/3842984/.
    10.1016/J.BBAMCR.2015.01.010
  67. Ranchoux, Benoit; Gunether, Sven; Quarck, Rozenn; Chaumais, Marie-Camille; Dorfmueller, Peter; Antigny, Fabrice; Dumas, Sebastien J.; et al. "Chemotherapy-Induced Pulmonary Hypertension Role of Alkylating Agents". The American Journal of Pathology (2015): https://publons.com/publon/2304093/.
    10.1016/J.AJPATH.2014.10.021
  68. Meloche, Jolyane; Le Guen, Marie; Potus, Francois; Vinck, Jerome; Ranchoux, Benoit; Johnson, Ian; Antigny, Fabrice; et al. "miR-223 reverses experimental pulmonary arterial hypertension". AJP: Cell Physiology (2015): https://publons.com/publon/3842983/.
    10.1152/AJPCELL.00149.2015
  69. S. Sauc; M. Bulla; P. Nunes; L. Orci; A. Marchetti; F. Antigny; L. Bernheim; et al. "STIM1L traps and gates Orai1 channels without remodeling the cortical ER". Journal of Cell Science (2015): https://publons.com/publon/3842982/.
    10.1242/JCS.164228
  70. Antigny F; Konig S; Bernheim L; Frieden M; Fabrice Antigny; Stéphane Konig; Laurent Bernheim; Maud Frieden. "Inositol 1,4,5 trisphosphate receptor 1 is a key player of human myoblast differentiation.". Cell calcium (2014): http://europepmc.org/abstract/med/25468730.
    10.1016/j.ceca.2014.10.014
  71. Girerd B; Perros F; Antigny F; Humbert M; Montani D. "KCNK3: new gene target for pulmonary hypertension?". Expert review of respiratory medicine (2014): http://europepmc.org/abstract/med/24742047.
    10.1586/17476348.2014.909731
  72. C Norez; C Vandebrouck; J Bertrand; S Noel; E Durieu; N Oumata; H Galons; et al. "Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism". British Journal of Pharmacology (2014): https://publons.com/publon/3842987/.
    10.1111/BPH.12859
  73. George PM; Oliver E; Dorfmuller P; Dubois OD; Reed DM; Kirkby NS; Mohamed NA; et al. "Evidence for the involvement of type I interferon in pulmonary arterial hypertension.". Circulation research (2013): http://europepmc.org/abstract/med/24334027.
    10.1161/CIRCRESAHA.114.302221
  74. F. Antigny; S. Koenig; L. Bernheim; M. Frieden; Antigny F; Koenig S; Bernheim L; Frieden M. "During post-natal human myogenesis, normal myotube size requires TRPC1- and TRPC4-mediated Ca2+ entry". Journal of Cell Science (2013): https://publons.com/publon/3842985/.
    10.1242/JCS.122911
  75. Sabourin J; Antigny F; Robin E; Frieden M; Raddatz E. "Activation of transient receptor potential canonical 3 (TRPC3)-mediated Ca2+ entry by A1 adenosine receptor in cardiomyocytes disturbs atrioventricular conduction.". The Journal of biological chemistry (2012): http://europepmc.org/abstract/med/22692208.
    10.1074/jbc.M112.378588
  76. Jessica Sabourin; Fabrice Antigny; Elodie Robin; Maud Frieden; Eric Raddatz. "Activation of Transient Receptor Potential Canonical 3 (TRPC3)-mediated Ca 2+ Entry by A 1 Adenosine Receptor in Cardiomyocytes Disturbs Atrioventricular Conduction". Journal of Biological Chemistry (2012): https://publons.com/publon/3842990/.
    10.1074/JBC.M112.378588
  77. Fabrice Antigny; Nathalie Girardin; Maud Frieden. "Transient Receptor Potential Canonical Channels Are Required for in Vitro Endothelial Tube Formation". Journal of Biological Chemistry (2012): https://publons.com/publon/3842991/.
    10.1074/JBC.M111.295733
  78. Antigny F; Girardin N; Frieden M. "Transient receptor potential canonical channels are required for in vitro endothelial tube formation.". The Journal of biological chemistry (2011): http://europepmc.org/abstract/med/22203682.
    10.1074/jbc.M111.295733
  79. Antigny F; Norez C; Becq F; Vandebrouck C. "CFTR and Ca Signaling in Cystic Fibrosis.". Frontiers in Pharmacology (2011): http://europepmc.org/abstract/med/22046162.
    10.3389/fphar.2011.00067
  80. Fabrice Antigny; Hélène Jousset; Stéphane König; Maud Frieden; Antigny F; Jousset H; König S; Frieden M. "Thapsigargin activates Ca2+ entry both by store-dependent, STIM1/Orai1-mediated, and store-independent, TRPC3/PLC/PKC-mediated pathways in human endothelial cells". Cell Calcium (2011): https://publons.com/publon/3842999/.
    10.1016/J.CECA.2010.12.001
  81. Fabrice Antigny; Caroline Norez; Luc Dannhoffer; Johanna Bertrand; Dorothée Raveau; Pierre Corbi; Christophe Jayle; et al. "Transient Receptor Potential Canonical Channel 6 Links Ca 2+ Mishandling to Cystic Fibrosis Transmembrane Conductance Regulator Channel Dysfunction in Cystic Fibrosis". American Journal of Respiratory Cell and Molecular Biology (2011): https://publons.com/publon/3842997/.
    10.1165/RCMB.2009-0347OC
  82. Girardin, Nathalie C.; Antigny, Fabrice; Frieden, Maud; Girardin NC; Antigny F; Frieden M. "Electrophysiological characterization of store-operated and agonist-induced Ca2+ entry pathways in endothelial cells". Pflügers Archiv - European Journal of Physiology (2010): https://publons.com/publon/3842998/.
    10.1007/S00424-010-0825-1
  83. Norez C; Antigny F; Noel S; Vandebrouck C; Becq F; Caroline Norez; Fabrice Antigny; et al. "A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype.". American journal of respiratory cell and molecular biology (2009): http://europepmc.org/abstract/med/19131642.
    10.1165/rcmb.2008-0285oc
  84. Fabrice Antigny; Nathalie Girardin; Dorothée Raveau; Maud Frieden; Frédéric Becq; Clarisse Vandebrouck. "Dysfunction of mitochondria Ca2+ uptake in cystic fibrosis airway epithelial cells". Mitochondrion (2009): https://publons.com/publon/3842996/.
    10.1016/J.MITO.2009.02.003
  85. Antigny F; Norez C; Cantereau A; Becq F; Vandebrouck C. "Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.". Respiratory research (2008): http://europepmc.org/abstract/med/18973672.
    10.1186/1465-9921-9-70
  86. Norez C; Vandebrouck C; Antigny F; Dannhoffer L; Blondel M; Becq F; Norez, Caroline; et al. "Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells.". European journal of pharmacology (2008): http://europepmc.org/abstract/med/18640110.
    10.1016/j.ejphar.2008.06.103
  87. Lenglet, Sebastien; Antigny, Fabrice; Vetterli, Laurene; Dufour, Jean-Francois; Rossier, Michel F.; Lenglet S; Antigny F; et al. "Hint2 Is Expressed in the Mitochondria of H295R Cells and Is Involved in Steroidogenesis". Endocrinology (2008): https://publons.com/publon/3842993/.
    10.1210/EN.2008-0400
  88. Auzanneau C; Norez C; Antigny F; Thoreau V; Jougla C; Cantereau A; Becq F; et al. "Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel.". Biochemical pharmacology (2007): http://europepmc.org/abstract/med/17945192.
    10.1016/j.bcp.2007.09.004
  89. Antigny F; Norez C; Becq F; Vandebrouck C; Fabrice Antigny; Caroline Norez; Frédéric Becq; Clarisse Vandebrouck. "Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.". Cell calcium (2007): http://europepmc.org/abstract/med/17590432.
    10.1016/j.ceca.2007.05.002
  90. Norez C; Antigny F; Becq F; Vandebrouck C; Caroline Norez; Fabrice Antigny; Frédéric Becq; Clarisse Vandebrouck. "Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.". Traffic (Copenhagen, Denmark) (2006): http://europepmc.org/abstract/med/16643279.
    10.1111/j.1600-0854.2006.00409.x
Documento de trabalho
  1. David Montani; Fabrice, Antigny; Etienne-Marie Jutant; Chaumais, Marie-Camille; Hélène Le Ribeuz; Julien Grynblat; charles khoury; Humbert, Marc. Autor correspondente: David Montani. 2023. "Pulmonary hypertension associated with diazoxide: the SUR1 paradox".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/06/12 Animal model of right ventricular failure (RVF) 38th Meeting of the European Section of International Society for Heart Research (ISHR-ES)"
European Section of International Society for Heart Research
2024/02/29 “Store-operated channels in pulmonary hypertension” Seminar at the Madrid school of Medecine
Madrid school of Medecine (Espanha)
2023/09/18 Role of Orai1 Ca2+ Channel in the development of pulmonary arterial hypertension
Ion channels Congress (França)
2018/11/06 Revisiting the role of K+ channel in pulmonary hypertension AHA Scientific meeting
AHA (Estados Unidos)
2017/09/17 Role of KCNK3 channel in the development of pulmonary arterial hypertension Invited conference
Ludwig Boltzmann Gesellschaft, the Medical University of Graz (Áustria)
2016/09/03 Role of KCNK3 channel in the development of pulmonary arterial hypertension
European respiratory society (Reino Unido)
2016/05/05 Role of KCNK3 channel in the development of pulmonary arterial hypertension
American thoracic society (Estados Unidos)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2023/10/01 - 2026/09/30 Etude des mécanismes physiopathologiques de l'hypertension artérielle pulmonaire et de l'insuffisance ventriculaire droite
Orientador
Université Paris-Saclay, França
2022/10/01 - 2025/09/30 Rôle des partenaires régulateurs du canal calcique Orai1 dans le développement de l’hypertension artérielle pulmonaire
Orientador
Université Paris-Saclay, França
2020/10/01 - 2023/10/01 Rôle des canaux Orai et TRPC dans le développement de l'hypertension artérielle pulmonaire
Orientador
Université Paris-Saclay, França
2018/12/01 - 2021/12/01 Rôle des canaux potassiques KCNK3/TASK-1 et KATP dans la pathogenèse de l’hypertension artérielle pulmonaire
Orientador
Université Paris-Saclay, França
2016/10/01 - 2019/10/01 Etude de l’implication de la dysfonction de Kcnk3 dans le développement de l’hypertension artérielle pulmonaire
Orientador
Université Paris-Saclay, França
2013/09/01 - 2017/10/01 Etude des mécanismes inflammatoires, génétiques et épigénétiques impliqués dans la physiopathologie de l'hypertension artérielle pulmonaire
Coorientador
Université Paris-Saclay, França

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2018/06/03 - Atual Evaluation of the abstract submitted to AHA scientific meeting American Heart Association Inc, Estados Unidos

Tutoria

Tópico Nome do aluno
2021/01/01 - 2021/09/30 Mechanism of RV failure in pulmonary arterial banding rat model Antoine Beauvais
2021/01/01 - 2021/06/30 Role of SOC channel in the development of pulmonary endothelial dysfunction occurring in pulmonary hypertension Loann Laubry
2021/01/01 - 2021/06/30 Role of Orai1 regulatory partners in the development of pulmonary arterial hypertension Anaïs Saint-Martin Willer
2020/01/01 - 2020/06/30 Role of Orai/TRPC channels in the development of pulmonary arterial hypertension Léa Bernard
2020/01/01 - 2020/06/30 Role of KCNK3 channel in the development of pulmonary arterial hypertension Raja Chebbi
2015/01/01 - 2015/06/30 Role of KCNK3 channel in the development of pulmonary arterial hypertension Mélanie Lambert
Distinções

Prémio

2023 RIPEC3 INSERM
INSERM Délégation Régionale Paris 11, França

Título

2024 Full Professor
INSERM, França
2019 Habilitation à diriger les recherches
Université Paris-Saclay, França
2017 Full time assistant professor
INSERM, França
2008 PhD
Université de Poitiers, França