???global.info.a_carregar???
Luís Cruz (LC) has a PhD in Chemistry (FCUP, 2010) studying polyphenols chemistry of plant-based foods. LC realized an internship in the Group of F. Pina (UNL, PT), where he developed skills in spectroscopy characterization of polyphenolic-based dyes, which were crucial to unveil molecular-level mechanisms for their optical properties during his PostDoc (2011-2016). In 2017, LC got a Research Contract (NORTE-01-0145-FEDER-000011) to explore novel approaches for dye color stabilization through supramolecular interactions. From 2018-2023, LC was an Assistant Researcher (DL57/2016/CP1334/CT0008) for developing stimuli-responsive polyphenol-based materials for applications in food, cosmetics, and biomedical. In 2023, LC was awarded Principal Researcher in the Scientific Employment Stimulus Individual Call (2023.07923.CEECIND) with the project “An innovative integrated platform to increase food safety and food waste reduction”. LC published 61 papers, 3 reviews, 3 book chapters, over 1500 citations (h-index 23). LC was Invited Assistant Professor at FCUP (2018-2022), teaching food chemistry, nutrition, and organic chemistry laboratory, and since 2016, is an Invited Adjunct Professor at the Polytechnic Institute of Porto, teaching applied organic chemistry and biological chemistry topics. LC has been demonstrating research independence by extending his collaborations with high-cited researchers: E. Megia (SP); R. Blackburn (UK); E. Salas (Mexico); K. Yoshida (JP), O. Dangles (FR). LC internationalization was strengthened with J. Simal-Gandara (SP) under the IACOBUS mobility program (2022) where he developed skills in greener and cleaner extraction technologies. Most of the investigation had been performed with his well-established national (32%) and international (22%) network, as proved by the papers published with 112 Co-Authors. LC demonstrated leadership and management skills in 2 funded competitive projects as PI (FoodSmarTag and Anthophilic, 240k€), and by participating in more than 10 national projects as team member (880k€), where he was the task leader for providing and characterization of polyphenolic-based materials. Concerning European calls, LC participated in an International Cooperative Research Network (2M€, 0377_IBERPHENOL_6_E, 2017-2020), and currently is membership of 2 WGs of a COST action (ACRYRED-CA21149, 2022-2026). In total, LC has concluded the supervision of 1 post-doc researcher, 3 PhD and 2 MSc students, 4 research fellows, and 8 undergraduate students. He had mentored 2 foreign PhD students (IT, Mexico) during their research internships in his lab. LC is currently supervising 1 PhD student, 1 MSc student, and 1 graduation student. Currently, LC is Invited Adjunct Professor in ESS-IPP where LC gave 4 invited keynote lectures in '13th, 14th National Joint Meetings of Organic and 6th, 7th Medicinal Chemistry (Lisbon-2022 and Aveiro-2020)', 'XXVIII Portuguese Chemical Society National Conference' and 'XI Young Investigators Workshop (Vienna-2019)'. LC was internationally recognized by EuChemS as the Best Portuguese Organic Chemist under 40 years old (2019). LC won 2 travel grants given by 'Groupe of Polyphenols' and 1 poster prize in an international conference. LC was the principal arguer of academic degrees of 1 PhD (Spain), 1 PhD (FCT-UNL, PT), 1 MSc (FCT-UNL, PT), and several graduated students. LC has experience as Guest Editor of Special Journals (Processes, IJMS) and has an intense reviewer activity in many SCI journals; organizing team member of XXVI National Meeting of Portuguese Chemical Society (2019), XXIV Luso-Galego Chemistry Meeting (2018) and 7th International Workshop of Anthocyanin (2013).
Read full resume ↓
Identification

Personal identification

Full name
Luis Cruz

Citation names

  • Cruz, Luis

Author identifiers

Ciência ID
C412-965B-E40A
ORCID iD
0000-0003-2226-0404

Email addresses

  • luis.cruz@fc.up.pt (Professional)

Telephones

Fax
  • 220402658 (Professional)
Telephone
  • 220402558 (Professional)

Addresses

  • Faculty of Sciences, University of Porto. Rua do Campo Alegre, 687, 4169-007, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
French Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2007/01/01 - 2010/11/25
Concluded
 Chemistry (Doutoramento)
Major in Organic Chemistry of Natural Products
Universidade do Porto Faculdade de Ciências, Portugal
"Study of reactions between catechins and anthocyanins. Synthesis of new compounds." (THESIS/DISSERTATION)
 Approved by unanimity
2004/10/01 - 2006/11/21
Concluded
 Chemistry (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Synthesis of 8-vinyl-catechin" (THESIS/DISSERTATION)
 Very Good
2000/09/01 - 2004/07/23
Concluded
 Chemistry (Scientific path) (Licenciatura)
Major in Food Chemistry
Universidade do Porto Faculdade de Ciências, Portugal
"Polyphenolic characterization of grapes and wines from Vinho Verde Region with biological properties related with cardiovascular diseases prevention" (THESIS/DISSERTATION)
 15 values
Affiliation

Science

Category
Host institution 		Employer
2017/01/01 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/09/01 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Ciências, Portugal
2017/09/15 - Current Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Others

Category
Host institution 		Employer
2011/04/01 - 2016/12/31 Post-Doctoral Fellow. Research on 'Novel functionalized anthocyanidin derivatives towards improved applicability' Universidade do Porto Faculdade de Ciências, Portugal
2007/01/01 - 2010/11/25 PhD Chemistry Student Universidade do Porto Faculdade de Ciências, Portugal
2007/10/01 - 2008/02/29 Invited Assistant of organic chemistry laboratory classes in the chemistry graduation (1st semester, 2nd year). Universidade do Porto Faculdade de Ciências, Portugal
2004/10/01 - 2006/10/31 Chemistry Master Student Universidade do Porto Faculdade de Ciências, Portugal
Projects

Contract

Designation Funders
2024/06/01 - Current An innovative integrated platform to increase food safety and food waste reduction
2023.07923.CEECIND
Principal investigator
Fundação para a Ciência e a Tecnologia
2017/05 - Current IBERPHENOL – Research cooperative within the scope of polyphenols and its industrial applications
0377_IBERPHENOL_6_E
 European Fund for Regional Development – INTERREG Spain-Portugal
2022/10/18 - 2026/10/17 Reducing acrylamide exposure of consumers by a cereals supply-chain approach targeting asparagine (ACRYRED)
CA21149
Membership of two Working Groups of COST action
Ongoing
2018/10/20 - 2022/04/19 FoodSmarTag-Novel Anthocyanin-Based Smart Sensors for Food Packaging
PTDC/OCE-ETA/31250/2017
Principal investigator
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/06 - 2021/05 WINPUT - Wine-INspired synthesis of blUe pyranoflavyliums for topical Photodynamic Therapy
PTDC/QUI-OUT/29013/2017
 Fundação para a Ciência e Tecnologia
2019/01/01 - 2019/12/31 Development of novel ANC-lipophilic bioactives for technological applications
REQUIMTE
Principal investigator
Rede de Química e Tecnologia Laboratório Associado para a Química Verde
Concluded
2016/02 - 2019/01 ANTHO4SKIN – New anthocyanin derivatives for technological applications in the cosmetic industry
PTDC/AGR-TEC/3078/2014
 Fundação para a Ciência e a Tecnologia
2016/01 - 2018/12 FoodNanoSense: Bio-sensing research on food astringency and bitterness of natural phenolics
PTDC/AGR-TEC/6547/2014
 Fundação para a Ciência e a Tecnologia
2015/09 - 2018/08 SOLFLAV: Dye Sensitized Solar Cells based on ionic liquids and synthetic flavylium compounds
PTDC/QEQ-QFI/1971/2014
 Fundação para a Ciência e a Tecnologia
2011/01 - 2015/01 BIOPAD – Bio-inspired synthesis of new classes of anthocyanin derivatives from wines
PTDC/QUI-QUI/117996/2010
 Fundação para Ciência e a Tecnologia
2007/01/01 - 2009/12/31 Reactions between catechins and anthocyanins. Synthesis of new pigments.
PTDC/AGR-ALI/67681/2006
PhD Student Fellow
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e Tecnologia
Outputs

Publications

Book chapter
  1. Cruz, Luis; Victor Freitas; Nuno Mateus. "Polyphenolic characterization of grapes and wines from Vinho Verde Region with biological properties related with cardiovascular diseases prevention.". In Instituto de Bebidas e Saúde (IBeSa), 2ª Jornada Bebidas e Saúde, Faculdade de Farmácia da Universidade do Porto, 1 de Fevereiro de 2005, 182-259. Porto, Portugal: MEDIADIGITAL, 2005.
    Published
Conference abstract
  1. Cruz, Luis; Guimaraes, Marta; Mateus, Nuno; Victor Armando Pereira de Freitas. "Chemical Acylation vs. Enzymatic Esterification of Malvidin-3-Glucoside-Rich Wine Extract with Oleic Acid". Paper presented in 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry, Porto, 2016.
    Published • 10.3390/ph9010015
Conference paper
  1. Pereira, Antia G.; Cruz, Luis; Cassani, Lucia; Chamorro, Franklin; Lourenço-Lopes, Catarina; Freitas, Victor; Otero, Paz; et al. "Comparative Study of Microwave-Assisted Extraction and Ultrasound-Assisted Extraction Techniques (MAE vs. UAE) for the Optimized Production of Enriched Extracts in Phenolic Compounds of Camellia japonica var Eugenia de Montijo". Paper presented in The 2nd International Electronic Conference on Processes, 2023.
    Published • 10.3390/ecp2023-14615
  2. Ana Faria; Diogo Pestana ; Cruz, Luis; Victor De Freitas, ; Isabel Azevedo; Conceição Calhau; Nuno Mateus,. "Flavan-3-ols Transport Across Blood-Brain Barrier". Paper presented in The FASEB journal, 2009.
    Published • 10.1096/fasebj.23.1_supplement.717.8
Conference poster
  1. Ana Sofia Pires; Nuno Basílio; Mateus, Nuno; Victor Armando Pereira de Freitas; Cruz, Luis. "Cyclodextrin-flavylium dye host-guest systems for encapsulation of biogenic amines in spoiled food products". Paper presented in XXVII Encontro Luso-Galego de Química, 2023.
  2. Mariana Cunha; Victor Armando Pereira de Freitas; João M. M. Rodrigues; Cruz, Luis. "Chitosan-flavylium conjugates towards construction of pH-responsive multilayer membranes for food spoilage detection". Paper presented in XXVIII Encontro Nacional da Sociedade Portuguesa de Química, 2023.
  3. Ana Sofia Pires; Vania Gomes; Victor Armando Pereira de Freitas; Basilio, Nuno; Cruz, Luis. "NEW HOST-GUEST SYSTEMS BASED ON MACROCYCLIC-PYRANOFLAVYLIUM COMPLEXES FOR BIOGENIC AMINES SENSING". Paper presented in XXXI International Conference on Polyphenols, 2023.
  4. Mariana Cunha; Victor Armando Pereira de Freitas; Cruz, Luis. "Chitosan-flavylium conjugates towards construction of pH-responsive membranes for food spoilage detection". Paper presented in Investigação Jovem da Universidade do Porto, 2023.
  5. Vania Gomes; Roberto Bermudez; Mateus, Nuno; Jose Manuel Lorenzo; Victor Armando Pereira de Freitas; Cruz, Luis. "iLabel: Intelligent colorimetric labels for fish freshness monitoring in real-time". Paper presented in Dare2Change-Innovation-Driven Agrifood Business, 2023.
  6. Cruz, Luis; Nuno Filipe da Cruz Baptista Mateus; Victor Armando Pereira de Freitas. "Development of chromatographic tools to identify and characterized anthocyanin-fatty acid adducts". Paper presented in 12º Encontro Nacional Cromatografia, 2022.
  7. Ana Sofia Pires; Basilio, Nuno; Vania Gomes; Nuno Filipe da Cruz Baptista Mateus; Victor Armando Pereira de Freitas; Cruz, Luis. "Host-guest system based on sulfonatocalixarene and pyranoflavylium dye for biogenic amine sensing during food spoilage". Paper presented in XVI Encontro Quimica dos Alimentos, 2022.
  8. Ana Sofia Pires; Vania Gomes; Neves, Dina; Mateus, Nuno; Victor de Freitas,; Cruz, Luis. "Development of novel colorimetric pyranoflavylium-biopolymer hybrid conjugates". Paper presented in XXI EUROFOODCHEM, 2021.
  9. Gomes, Vânia; Ana Sofia Pires; Mateus, Nuno; Victor de Freitas; Cruz, Luis. "Pyranoflavylium salt incorporated in cellulose acetate films with glycerol as colorimetric pH-sensors for food packaging applications". Paper presented in XXVII Encontro Nacional da Sociedade Portuguesa de Química, 2021.
  10. Neves, Dina; Mateus, Nuno; Freitas, Victor; Cruz, Luis. "White crowberry (Corema album spp.): a phytochemical and pharmacological overview". Paper presented in IV International Summer School on Natural Products (Virtual Edition), Faculty of Pharmacy of University of Naples Federico II, Italy, 2021.
  11. Cruz, Luis; Vânia Gomes; Marta Guimarães; Nuno Filipe da Cruz Baptista Mateus; Victor Armando Pereira de Freitas. "Equilibria network of pyranoanthocyanin-type pigments in solution and their chromatic features". Paper presented in International Symposium on Dyes & Pigments, 2019.
  12. Cruz, Luis; A. Pinto; V. Gomes,; P. Araújo; J. Oliveira; H. Cruz,; G. Calogero; et al. "Dye-Sensitized Solar Cells based on Pyranoanthocyanin derivatives". Paper presented in XXVI Encontro Nacional da Sociedade Portuguesa de Química, 2019.
  13. Ana Lucia Pinto; Cruz, Luis; Vânia Gomes; Joana Oliveira; Paula Araújo; Victor de Freitas; Fernando Pina; J. Carlos Lima. ""From red wine to energy: Pyranoanthocyanins as light-harvesters in Dye-Sensitized Solar Cells"". Paper presented in 6th Portuguese Young Chemists Meeting, Setúbal., 2018.
  14. Vânia Gomes; Nuno Mateus; Victor Freitas; Luis Cruz. "Novel Symmetrical Pyrano-Styryl-Flavylium Dye". Paper presented in 12º Encontro Nacional de Quimica Orgânica e 5º Encontro de Quimica Terapêutica, Coimbra, 2018.
    10.5753/cbie.sbie.2016.510
  15. Ignacio Garcia-Estévez, ; Cruz, Joana; Marques, Alda; Victor Freitas, ; Susana Soares,. "“First evidences of interaction of between pyranoanthocyanins and salivary proline rich-proteins”". Paper presented in In Vino Analytica Scientia, Salamanca, Spain, 17-20 July 2017., 2017.
  16. Ana Évora, ; Iva Fernandes, ; Cruz, Luis; Marta Guimarães, ; Victor de Freitas, ; Nuno Mateus,. "“Extracts and new derivatives of anthocyanins as potential cosmetic ingredients – a skin-barrier model optimization using ECIS”.". Paper presented in XXV Encontro Nacional da SPQ, 16-19 Julho 2017., 2017.
  17. Joana L. C. Sousa, ; Nuno Mateus, ; Victor de Freitas, ; Cruz, Luis. "“Synthesis and structural characterization of novel pyrano-deoxyanthocyanin dyes”". Paper presented in XXII Encontro Luso-Galego de Química, Bragança, 9-11 November 2016., 2016.
  18. Iva Fernandes, ; Ana Évora,; Marta Guimarães,; Luís Cruz,; Victor de Freitas,; Nuno Mateus. "New anthocyanin derivatives for technological applications in the cosmetic industry". Paper presented in XXII Encontro Luso-Galego de Química, Bragança, 9-11 November 2016., 2016.
  19. Marta Guimarães,; Luís Cruz,; Victor de Freitas,; Nuno Mateus. "“Lipophilicity parameters and antioxidant features of malvidin-3-glucoside-fatty acid derivatives”,". Paper presented in XIII Encontro Quimica dos Alimentos, Porto, 14-16 September 2016., 2016.
  20. Nuno Basílio, ; Luís Cruz,; Victor Freitas, ; Fernando Pina. "Two interconnected flavylium networks of chemical reactions operated by pH and supramolecular inputs". Paper presented in MRP, Multi-Responsive Photochromes, Nantes, France, 25 a 28 de Abril de 2016, 2016.
  21. Cruz, Luis; Marta Guimarães,; Victor de Freitas,; Nuno Mateus. "Chemical acylation vs enzymatic esterification of malvidin-3-glucoside-rich wine extract with oleic acid". Paper presented in 11º Encontro Nacional de Quimica Orgânica e Quimica Terapêutica, 1-3 December 2015., 2015.
  22. Cruz, Luis; Nuno Basílio, ; Nuno Mateus, ; Victor Freitas, ; Fernando Pina. "Study of isomerization of a synthetic flavylium: 6-, 8-bromo-4’,5,7-trihydroxyflavylium". Paper presented in 19th European Symposium on Organic Chemistry, Lisbon, Portugal, 12 a 16 de Julho de 2015., 2015.
  23. Natércia Teixeira, ; Cruz, Luis; Natércia Brás, ; Nuno Mateus, ; Maria João Ramos, ; Victor de Freitas,. "Structural features of copigmentation of oenin with different polyphenol copigments". Paper presented in 7th International Workshop on Anthocyanins, Porto, Portugal, 9-11 de Setembro de 2013., 2013.
  24. Cruz, Luis; Iva Fernandes,; Nuno Mateus, ; Victor de Freitas,. "Anthocyanin metabolites: chemical standards for biological studies". Paper presented in 7th International Workshop on Anthocyanins, Porto, Portugal, 9-11 de Setembro de 2013., 2013.
  25. Cruz, Luis; Nuno Mateus,; Victor de Freitas,. "Chemical synthesis of a bioavailable anthocyanin metabolite: cyanidin-4’-O-methyl-3-glucoside". Paper presented in 10º Encontro Nacional de Química Orgânica, Lisboa, Portugal, 4-6 de Setembro de 2013., 2013.
  26. Luís Cruz,; Nuno Mateus; Victor de Freitas,. "New insights on malvidin-3-glucoside-catechin dimeric compound". Paper presented in XXVIth International Conference on Polyphenols, Florença, Itália, 22-26 de Julho de 2012., 2012.
  27. Cruz, Luis; Victor de Freitas,. "Physico-Chemical Properties of Pyranoanthocyanin-type Pigments". Paper presented in 6th International Workshop on Anthocyanins, Charlotte/Concord, Estados Unidos, 11-14 de Setembro de 2011, 2011.
  28. Cruz, Luis; Vesselin Petrov, ; Nuno Mateus, ; Fernando Pina, ; Victor de Freitas, ; Natércia Teixeira,; Victor de Freitas,; Fernando Pina,. "Contribution of different types of pyranoanthocyanins to the red wine color". Paper presented in In Vino Analytica Scientica, Graz, Áustria, 21-23 de Julho de 2011., 2011.
  29. Cruz, Luis; Natércia F. Brás, ; Natércia Teixeira, ; Nuno Mateus, ; Maria João Ramos, ; Olivier Dangles ; Victor Freitas,. "Vinylcatechin dimers have much greater affinity for anthocyanins oenin and malvin than dimeric procyanidin B3". Paper presented in XXVth International Conference on Polyphenols, Montpellier, França, 24-27 de Agosto de 2010., 2010.
  30. Joana Azevedo, ; Joana Oliveira, ; Luís Cruz,; Natércia Teixeira, ; Victor de Freitas,; Nuno Mateus,. "Antioxidant properties of red wine anthocyanin-derived pigments". Paper presented in XXVth International Conference on Polyphenols, Montpellier, França, 24-27 de Agosto de 2010., 2010.
  31. Frederico Nave, ; Luís Cruz,; Nuno Mateus,; Olivier Dangles,; Victor de Freitas,. "Flavanolic substitution of anthocyanins: effects on copigmentation". Paper presented in XXVth International Conference on Polyphenols, Montpellier, França, 24-27 de Agosto de 2010., 2010.
  32. Joana Oliveira, ; Joana Azevedo, ; Artur M. S. Silva, ; Natércia Teixeira, ; Luís Cruz,; Nuno Mateus,; Victor de Freitas,. "A new family of anthocyanin-derived pigments presenting a turquoise blue colour in Port wine". Paper presented in XXVth International Conference on Polyphenols, Montpellier, França, 24-27 de Agosto de 2010., 2010.
  33. Luís Cruz,; Natércia Teixeira,; Artur M. S. Silva,; Enrique Borges,. "Synthesis of pyranoanthocyanin-catechin pigments". Paper presented in International Workshop on Anthocyanins, Chikusa Nagoya, Japão, 15-18 de Setembro de 2009., 2009.
  34. Joana Oliveira, ; Natércia Teixeira,; Victor de Freitas,; Nuno Mateus. "Different chemical pathways leading to the formation of portisins in red wines". Paper presented in In Vino Analytica Scientica, Angers, França, 2-4 de Julho de 2009., 2009.
  35. Luís Cruz,; Natércia Teixeira, ; Artur M. S. Silva,; Nuno Mateus, ; Enrique Borges,; Victor de Freitas,. "Formation of new compounds from the reaction between malvidin-3-glucoside and 8-vinylcatechin". Paper presented in In Vino Analytica Scientica, Angers, França, 2-4 de Julho de 2009., 2009.
  36. Cruz, Luis; Natércia F. Brás,; Natércia Teixeira,; Nuno Mateus,; Maria João Ramos,; José Borges, ; Victor de Freitas,. "Two diasteroisomers of vinylcatechin dimers obtained from an unsual acid catalyzed dimerization". Paper presented in 8º Encontro Nacional de Química Orgânica, Aveiro, Portugal, 1-3 de Julho de 2009., 2009.
  37. N. F. Brás, ; Luis Cruz,; P. A. Fernandes, ; N. Mateus,; V. de Freitas, ; M. J. Ramos,. "Computational studies on vinylcatechin dimers conformations". Paper presented in 9º Encontro Nacional de Química-Física, Aveiro, Portugal, 15-16 de Junho de 2009., 2009.
  38. Ana Faria, ; Diogo Pestana, ; Luís Cruz,; Pierre-Olivier Courad, ; Ignacio Romero, ; Victor de Freitas, ; Isabel Azevedo, ; Nuno Mateus; Conceição Calhau. "Transporte de 3-flavanóis num modelo de barreira hemo-encefálica". Paper presented in 9º Encontro de Química dos Alimentos: Qualidade e sustentabilidade, Angra do Heroísmo, Portugal, 29 de Abril a 2 de Maio de 2009., 2009.
  39. Luís Cruz,; Natércia Teixeira, ; Artur Silva, ; Nuno Mateus,; Enrique Borges,; Victor Freitas,. "O papel da vinilcatequina na formação de novos pigmentos durante o envelhecimento do vinho tinto". Paper presented in 9º Encontro de Química dos Alimentos: Qualidade e sustentabilidade, Angra do Heroísmo, Portugal, 29 de Abril a 2 de Maio de 2009., 2009.
  40. Ana Faria, ; Diogo Pestana, ; Luís Cruz,; Isabel Azevedo,; Nuno Mateus,; Conceição Calhau,. "Flavan-3-ols transport across blodd-brain barrier". Paper presented in Experimental Biology 2009, New Orleans, Louisiana, E.U.A., 18-22 de Abril de 2009., 2009.
  41. Natércia Teixeira, ; Cruz, Luis; Nuno Mateus, ; Victor Freitas,. "Synthesis of pyranoanthocyanin-catechins through reaction between 8-vinylcatechin and different anthocyanins". Paper presented in XXIVth International Conference on Polyphenols, Salamanca, Espanha, 8-11 de Julho de 2008, 2008.
  42. Cruz, Luis; Natércia Teixeira,; Nuno Mateus,; Jose Borges, ; Jose Borges, Victor Freitas,. "Synthesis, structural characterization and chromatic features of two pyranoanthocyanin-(+)-catechin pigments". Paper presented in XXIVth International Conference on Polyphenols, Salamanca, Espanha, 8-11 de Julho de 2008., 2008.
  43. Cruz, Luis; Natércia Teixeira, ; Artur Silva, ; Nuno Mateus, ; Enrique Borges,; Victor Freitas,. "The crucial role of 8-vinylcatechin in synthesis of anthocyanin-derived pigments". Paper presented in Second International Symposium on Macromolecules and Secondary Metabolites of Grapevine and Wines, Montpellier, França, 4-6 de Junho de 2008., 2008.
  44. Cruz, Luis; Jose Borges, Victor Freitas, ; Nuno Mateus, ; Victor Freitas,. "Synthesis of 8-vinyl-catechin". Paper presented in 15th European Symposium on Organic Chemistry, Dublin, Irlanda, 8 a 13 de Julho de 2007., 2007.
  45. Cruz, Luis; Cláudia ROCHA, ; Nuno MATEUS ; Victor DE FREITAS. "Analysis of anthocyanins, tannins, quercetins and resveratrol in grapes and wines from the Vinho Verde and Douro Regions". Paper presented in 7º Encontro de Química dos Alimentos – Alimentos: Tradição e Inovação, Saúde e Segurança”, Viseu, Portugal, 13 a 16 de Abril de 2005., 2005.
  46. Cruz, Luis. "Design of 2-cyclopentenone derivatives with enhanced NF-kB: DNA Binding Inhibitory Properties". Paper presented in Quitel2004 - XXXCongresso de Químicos Teóricos de Expressão Latina, 2004.
Journal article
  1. Joana Azevedo; Joana Oliveira; Luís Cruz; Nuno Mateus; Victor de Freitas. "Identification and structural characterization of a novel (+)-catechin-caffeic acid adduct present in wines". Food Chemistry (2024): https://doi.org/10.1016/j.foodchem.2024.138480.
    10.1016/j.foodchem.2024.138480
  2. Cunha, Mariana; Freitas, Victor; Rodrigues, João M. M.; Mano, Joao F.; Borges, João; Cruz, Luis. "Acidochromic free-standing multilayered chitosan-pyranoflavylium_alginate membranes towards food smart packaging applications". ACS Applied Polymer Materials (2024):
    Submitted
  3. Hiléia K. S. de Souza; Marta Guimarães; Mateus, Nuno; Victor Armando Pereira de Freitas; Cruz, Luis. "Chitosan-polyvinyl alcohol-based biofilms using ternary deep eutectic solvents towards innovative color-stabilizing systems for anthocyanins". Food Chemistry (2024):
    Submitted
  4. Pires, Ana Sofia; Droguett Muñoz, Kevin; de Freitas, Victor; Basílio, Nuno; Cruz, Luís. "Host–Guest Chemosensor Ensembles based on Water-Soluble Sulfonated Calix[n]arenes and a Pyranoflavylium Dye for the Optical Detection of Biogenic Amines". Journal of Agricultural and Food Chemistry 72 7 (2024): 3719-3729. http://dx.doi.org/10.1021/acs.jafc.3c08695.
    Published • 10.1021/acs.jafc.3c08695
  5. Sara C. Silva-Reis; Xavier C. Correia; Hugo F. Costa-Almeida; Beatriz L. Pires-Lima; Daiane Maronde; Vera M. Costa; Xerardo García-Mera; et al. "Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors". ACS Medicinal Chemistry Letters (2023): https://doi.org/10.1021/acsmedchemlett.3c00264.
    10.1021/acsmedchemlett.3c00264
  6. Vânia Gomes; Nuno Mateus; Victor de Freitas; Joana Oliveira; Luís Cruz. "Pyranoanthocyanins and other pyranoflavylium dyes: From chemistry towards novel applications". Dyes and Pigments (2023): https://doi.org/10.1016/j.dyepig.2023.111683.
    10.1016/j.dyepig.2023.111683
  7. Vânia Gomes; Roberto Bermudez; Nuno Mateus; Alexandra Guedes; Jose Manuel Lorenzo; Victor de Freitas; Luís Cruz. "FoodSmarTag: An innovative dynamic labeling system based on pyranoflavylium-based colorimetric films for real-time monitoring of food freshness". Food Hydrocolloids (2023): https://doi.org/10.1016/j.foodhyd.2023.108914.
    10.1016/j.foodhyd.2023.108914
  8. Antía González Pereira; Luis Cruz; Lucia Cassani; Franklin Noel Chamorro Rivo; Catarina Lourenço-Lopes; Victor Freitas; Paz Otero; et al. "Comparative Study of Microwave-Assisted Extraction and Ultrasound-Assisted Extraction Techniques (MAE vs. UAE) for the Optimized Production of Enriched Extracts in Phenolic Compounds of Camellia japonica var Eugenia de Montijo". Engineering Proceedings (2023): https://www.mdpi.com/2673-4591/37/1/124.
    10.3390/ECP2023-14615
  9. Dina Neves; Paula B. Andrade; Romeu A. Videira; Victor de Freitas; Luís Cruz. "Berry anthocyanin-based films in smart food packaging: A mini-review". Food Hydrocolloids 133 (2022): 107885-107885. https://doi.org/10.1016/j.foodhyd.2022.107885.
    10.1016/j.foodhyd.2022.107885
  10. Marta Monteiro; Ivo E. Sampaio-Dias; Nuno Mateus; Victor de Freitas; Luís Cruz. "Application of carbodiimide coupling chemistry towards a new generation of lipophilic pyranoanthocyanin derivatives". Food Chemistry 393 (2022): 133429. https://doi.org/10.1016/j.foodchem.2022.133429.
    Published
  11. Ana Sofia Pires; Vânia Gomes; Dina Neves; Nuno Mateus; Victor de Freitas; Luís Cruz. "Colorimetric pH-Responsive Biomaterials Based on Pyranoflavylium-Biopolymer Hybrid Conjugates". ACS Applied Polymer Materials (2022): https://doi.org/10.1021/acsapm.2c00514.
    10.1021/acsapm.2c00514
  12. Cruz, Luís; Mateus, Nuno; de Freitas, Victor. "pH-regulated interaction modes between cyanidin-3-glucoside and phenylboronic acid-modified alginate". Carbohydrate Polymers 280 (2022): 119029. http://dx.doi.org/10.1016/j.carbpol.2021.119029.
    10.1016/j.carbpol.2021.119029
  13. Luis Cruz; Nuno Basílio; Nuno Mateus; Victor de Freitas; Fernando Pina. "Natural and Synthetic Flavylium-Based Dyes: The Chemistry Behind the Color". Chemical Reviews (2022): https://doi.org/10.1021/acs.chemrev.1c00399.
    10.1021/acs.chemrev.1c00399
  14. Vânia Gomes; Ana Sofia Pires; Nuno Mateus; Victor de Freitas; Luís Cruz. "Pyranoflavylium-cellulose acetate films and the glycerol effect towards the development of pH-freshness smart label for food packaging". Food Hydrocolloids (2022): https://doi.org/10.1016/j.foodhyd.2022.107501.
    10.1016/j.foodhyd.2022.107501
  15. Monteiro, M.; Sampaio-Dias, I.E.; Mateus, N.; de Freitas, V.; Cruz, L.. "Preparation of 10-(hexylcarbamoyl)pyranomalvidin-3-glucoside from 10-carboxypyranomalvidin-3-glucoside using carbodiimide chemistry". Food Chemistry 393 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85131801284&partnerID=MN8TOARS.
    10.1016/j.foodchem.2022.133429
  16. Cruz, L.; Parcero-Bouzas, S.; Fernandez-Megia, E.; Mateus, N.; Freitas, V.. "Corrigendum to “pH-regulated interaction modes between cyanidin-3-glucoside and phenylboronic acid-modified alginate” [Carbohydr. Polym. 280 (2022) 119029] (Carbohydrate Polymers (2022) 280, (S0144861721014168), (10.1016/j.carbpol.2021.119029))". Carbohydrate Polymers 287 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85127322287&partnerID=MN8TOARS.
    10.1016/j.carbpol.2022.119423
  17. Nuno Basílio; A. Jorge Parola; Diogo Sousa; Vesselin Petrov; Luis Cruz; Victor de Freitas; Fernando Pina. "Achieving Complexity at the Bottom: Molecular Metamorphosis Generated by Anthocyanins and Related Compounds". ACS Omega (2021): https://doi.org/10.1021/acsomega.1c04456.
    10.1021/acsomega.1c04456
  18. Johan Mendoza; Luis Cruz; Victor de Freitas; Fernando Pina; Nuno Basílio. "Anthocyanin Color Stabilization by Host-Guest Complexation with p-Sulfonatocalix[n]arenes". Molecules (2021): https://doi.org/10.3390/molecules26175389.
    10.3390/molecules26175389
  19. Vânia Gomes; Ana Sofia Pires; Iva Fernandes; Nuno Mateus; Victor de Freitas; Luís Cruz. "Synthesis of novel pyrano-3,7-deoxyanthocyanin derivatives and study of their thermodynamic, photophysical and cytotoxicity properties". Journal of Photochemistry and Photobiology A: Chemistry 415 (2021): 113313-113313. https://doi.org/10.1016%2Fj.jphotochem.2021.113313.
    10.1016/j.jphotochem.2021.113313
  20. A.S. Marquez-Rodriguez; M. Guimarães; N. Mateus; V. de Freitas; M.L. Ballinas-Casarrubias; M.E. Fuentes-Montero; E. Salas; L. Cruz. "Disaccharide anthocyanin delphinidin 3-O-sambubioside from Hibiscus sabdariffa L.: Candida antarctica lipase B-catalyzed fatty acid acylation and study of its color properties". Food Chemistry 344 (2021): 128603-128603. https://doi.org/10.1016/j.foodchem.2020.128603.
    Published • 10.1016/j.foodchem.2020.128603
  21. Vânia Gomes; Nuno Mateus; Victor de Freitas; Luís Cruz. "A pH-responsive fluorescent sensor based on a new pyranoxanthylium salt". Photochemical & Photobiological Sciences (2021): https://doi.org/10.1007/s43630-021-00033-x.
    10.1007/s43630-021-00033-x
  22. Cruz, Luís; Correa, Juan; Mateus, Nuno; de Freitas, Victor; Tawara, Maun H.; Fernandez-Megia, Eduardo. "Dendrimers as Color-Stabilizers of Pyranoanthocyanins: The Dye Concentration Governs the Host–Guest Interaction Mechanisms". ACS Applied Polymer Materials (2021): http://dx.doi.org/10.1021/acsapm.0c01321.
    Published • 10.1021/acsapm.0c01321
  23. Hélder Oliveira; Patrícia Correia; Lucinda J. Bessa; Marta Guimarães; Paula Gameiro; Victor de Freitas; Nuno Mateus; Luís Cruz; Iva Fernandes. "Cyanidin-3-Glucoside Lipophilic Conjugates for Topical Application: Tuning the Antimicrobial Activities with Fatty Acid Chain Length". Processes 9 (2021): 340. https://doi.org/10.3390/pr9020340.
    Published • 10.3390/pr9020340
  24. Hiléia K. S. Souza; Nuno Mateus; Victor de Freitas; Maria Pilar Gonçalves; Luís Cruz. "Chemical/Color Stability and Rheological Properties of Cyanidin-3-Glucoside in Deep Eutectic Solvents as a Gateway to Design Task-Specific Bioactive Compounds". ACS Sustainable Chemistry & Engineering 8 43 (2020): 16184-16196. https://doi.org/10.1021/acssuschemeng.0c04839.
    Published • 10.1021/acssuschemeng.0c04839
  25. Cruz, Luis. "Dye-sensitized solar cells based on dimethylamino-p-bridge-pyranoanthocyanin dyes". Solar Energy 206 (2020): 188-199. http://dx.doi.org/10.1016/j.solener.2020.05.101.
    Published • 10.1016/j.solener.2020.05.101
  26. Marta Guimarães; Nuno Mateus; Victor de Freitas; Luis C. Branco; Luís Cruz. "Microwave-Assisted Synthesis and Ionic Liquids: Green and Sustainable Alternatives toward Enzymatic Lipophilization of Anthocyanin Monoglucosides". Journal of Agricultural and Food Chemistry 68 (2020): 7387-7392. https://doi.org/10.1021/acs.jafc.0c02599.
    Published • 10.1021/acs.jafc.0c02599
  27. Cruz, Luis. "Color stabilization of cyanidin-3-glucoside-based dyes by encapsulation with biocompatible PEGylated phospholipid micelles". Dyes and Pigments 181 (2020): 108592. http://dx.doi.org/10.1016/j.dyepig.2020.108592.
    Published • 10.1016/j.dyepig.2020.108592
  28. Fernanda Fernandez-Aulis; Andrea Torres; Ernesto Sanchez-Mendoza; Luis Cruz; Arturo Navarro-Ocana. "New acylated cyanidin glycosides extracted from underutilized potential sources: Enzymatic synthesis, antioxidant activity and thermostability". Food Chemistry 309 (2020): 125796-125796. https://doi.org/10.1016/j.foodchem.2019.125796.
    10.1016/j.foodchem.2019.125796
  29. Vânia Gomes; Marta Guimarães; Gabriela Gonçalves; Victor de Freitas; Luís Cruz. "Bioinspired Synthesis and Physical-Chemical Properties of a New 10-Methylpyrano-4'-hydroxyflavylium Chloride Salt". Synlett 31 04 (2020): 334-338. https://doi.org/10.1055/s-0039-1690744.
    Published • 10.1055/s-0039-1690744
  30. Fuliang Han; Helder Oliveira; Natércia Brás; Iva Fernandes; Luis Cruz; Victor de Freitas,; Victor de Freitas; Nuno Mateus. "In vitro gastrointestinal absorption of red wine anthocyanins - Impact of structural complexity and phase II metabolization". Food Chemistry 317 (2020): 126398. http://dx.doi.org/10.1016/j.foodchem.2020.126398.
    Published • 10.1016/j.foodchem.2020.126398
  31. Luís Cruz; Nuno Basílio; Johan Mendoza; Nuno Mateus; Victor de Freitas; Maun H. Tawara; Juan Correa; Eduardo Fernandez-Megia. "Impact of a Water-Soluble Gallic Acid-Based Dendrimer on the Color-Stabilizing Mechanisms of Anthocyanins". Chemistry – A European Journal 25 (2019): 11696-11706. https://doi.org/10.1002/chem.201901912.
    Published • 10.1002/chem.201901912
  32. Marta Guimarães; Maria Pérez-Gregorio; Nuno Mateus; Victor de Freitas; Cláudia F. Galinha; João G. Crespo; Carla A.M. Portugal; Luís Cruz; Cruz, Luis. "An efficient method for anthocyanins lipophilization based on enzyme retention in membrane systems". Food Chemistry 300 (2019): 125167-125167. https://doi.org/10.1016/j.foodchem.2019.125167.
    Published • 10.1016/j.foodchem.2019.125167
  33. Ana Lucia Pinto; Cruz, Luis; Vânia Gomes; Victor de Freitas; Giuseppe Calogero; Hugo Cruz; A. Jorge Parola; et al. "Catechol versus carbonyl linkage impact on DSSC performance of synthetic pyranoflavylium salts". Dyes and Pigments 170 (2019): 107577-107577. https://doi.org/10.1016/j.dyepig.2019.107577.
    Published • 10.1016/j.dyepig.2019.107577
  34. Vânia Gomes; Nuno Mateus; Victor de Freitas; Cruz, Luis. "Synthesis and chemical equilibria of a new 10-methylpyrano-2-styrylbenzopyrylium pigment in aqueous solution and its modulation by different micellar systems.". Dyes and Pigments 167 (2019): 60-67.
    Published • 10.1016/j.dyepig.2019.04.004
  35. Luís Cruz; Meryem Benohoud; Christopher M. Rayner; Nuno Mateus; Victor de Freitas; Richard S. Blackburn. "Selective enzymatic lipophilization of anthocyanin glucosides from blackcurrant ( Ribes nigrum L.) skin extract and characterization of esterified anthocyanins". Food Chemistry 266 (2018): 415-419. https://doi.org/10.1016/j.foodchem.2018.06.024.
    10.1016/j.foodchem.2018.06.024
  36. Marta Guimarães; Nuno Mateus; Victor de Freitas; Luís Cruz. "Improvement of the Color Stability of Cyanidin-3-glucoside by Fatty Acid Enzymatic Acylation". Journal of Agricultural and Food Chemistry 66 (2018): 10003-10010. https://doi.org/10.1021/acs.jafc.8b03536.
    10.1021/acs.jafc.8b03536
  37. Vânia Gomes; Nuno Mateus; Victor de Freitas; Luís Cruz. "Synthesis and Structural Characterization of a Novel Symmetrical 2,10-Bis-Styryl-1-Benzopyrylium Dye". Synlett 29 (2018): 1390-1394. https://doi.org/10.1055/s-0036-1591978.
    Published • 10.1055/s-0036-1591978
  38. Cruz, Luis. "Extending the stability of red and blue colors of malvidin-3-glucoside-lipophilic derivatives in the presence of SDS micelles". Dyes and Pigments (2018):
    doi.org/10.1016/j.dyepig.2018.01.007
  39. Cruz, L.; Guirnaraes, M.; Araujo, P.; Evora, A.; de Freitas, V.; Mateus, N.. "Malvidin 3-Glucoside-Fatty Acid Conjugates: From Hydrophilic toward Novel Lipophilic Derivatives". Journal of Agricultural and Food Chemistry 65 31 (2017): 6513-6518. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000407540600019&KeyUID=WOS:000407540600019.
    10.1021/acs.jafc.6b05461
  40. Garcia-Estevez, I.; Cruz, L.; Oliveira, J.; Mateus, N.; de Freitas, V.; Soares, S.. "First evidences of interaction between pyranoanthocyanins and salivary proline-rich proteins". Food Chemistry 228 (2017): 574-581. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000398751700073&KeyUID=WOS:000398751700073.
    10.1016/j.foodchem.2017.02.030
  41. Sousa, J. L. C.; Gomes, V.; Mateus, N.; Pina, F.; de Freitas, V.; Cruz, L.. "Synthesis and equilibrium multistate of new pyrano-3-deoxyanthocyanin-type pigments in aqueous solutions". Tetrahedron 73 41 (2017): 6021-6030. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412957800006&KeyUID=WOS:000412957800006.
    10.1016/j.tet.2017.08.051
  42. Fernandes, I.; Marques, C.; Evora, A.; Cruz, L.; de Freitas, V.; Calhau, C.; Faria, A.; Mateus, N.. "Pharmacokinetics of table and Port red wine anthocyanins: a crossover trial in healthy men". Food & Function 8 5 (2017): 2030-2037. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000402046800031&KeyUID=WOS:000402046800031.
    10.1039/c7fo00329c
  43. Cruz, L.; Fernandes, I.; Evora, A.; De Freitas, V.; Mateus, N.. "Synthesis of the Main Red Wine Anthocyanin Metabolite: Malvidin-3-O-beta-Glucuronide". Synlett 28 5 (2017): 593-596. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000402748900011&KeyUID=WOS:000402748900011.
    10.1055/s-0036-1588673
  44. Cruz, L.; Sousa, J. L. C.; Marinho, A.; Mateus, N.; de Freitas, V.. "Synthesis and structural characterization of novel pyranoluteolinidin dyes". Tetrahedron Letters 58 2 (2017): 159-162. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392038900011&KeyUID=WOS:000392038900011.
    10.1016/j.tetlet.2016.11.123
  45. Basilio, N.; Lima, J. C.; Cruz, L.; de Freitas, V.; Pina, F.; Ando, H.; Kimura, Y.; Oyama, K. I.; Yoshida, K.. "Unveiling the 6,8-Rearrangement in 8-Phenyl-5,7-dihydroxyflavylium and 8-Methyl-5,7-dihydroxyflavylium through Host-Guest Complexation". European Journal of Organic Chemistry 37 (2017): 5617-5626. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412595500017&KeyUID=WOS:000412595500017.
    10.1002/ejoc.201701009
  46. Basilio, Nuno; Cruz, Luis; de Freitas, Victor; Pina, Fernando. "A Multistate Molecular Switch Based on the 6,8-Rearrangement in Bromo-apigeninidin Operated with pH and Host-Guest Inputs.". The journal of physical chemistry. B 120 29 (2016): 7053-61. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:27378215&KeyUID=MEDLINE:27378215.
    10.1021/acs.jpcb.6b03694
  47. Cruz, Luis; Fernandes, Iva; Guimaraes, Marta; de Freitas, Victor; Mateus, Nuno. "Enzymatic synthesis, structural characterization and antioxidant capacity assessment of a new lipophilic malvidin-3-glucoside-oleic acid conjugate". Food & Function 7 6 (2016): 2754-2762. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000378238100030&KeyUID=WOS:000378238100030.
    10.1039/c6fo00466k
  48. Cruz, L. M.; Basilio, N. M.; de Freitas, V. A.; Lima, J. C.; Pina, F. J.. "Extending the Study of the 6,8 Rearrangement in Flavylium Compounds to Higher pH Values: Interconversion between 6-Bromo and 8-Bromo-apigeninidin". Chemistryopen 5 3 (2016): 236-246. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000379681700011&KeyUID=WOS:000379681700011.
    10.1002/open.201500210
  49. Sousa, Andre; Araujo, Paula; Azevedo, Joana; Cruz, Luis; Fernandes, Iva; Mateus, Nuno; de Freitas, Victor. "Antioxidant and antiproliferative properties of 3-deoxyanthocyanidins". Food chemistry 192 (2016): 142-8. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:26304331&KeyUID=MEDLINE:26304331.
    10.1016/j.foodchem.2015.06.108
  50. Cruz, Luis; Fernandes, Virginia C.; Araujo, Paula; Mateus, Nuno; de Freitas, Victor. "Synthesis, characterisation and antioxidant features of procyanidin B4 and malvidin-3-glucoside stearic acid derivatives". Food Chemistry 174 (2015): 480-486. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000348088000066&KeyUID=WOS:000348088000066.
    10.1016/j.foodchem.2014.11.062
  51. Cruz, Luis; Basilio, Nuno; Mateus, Nuno; Pina, Fernando; de Freitas, Victor. "Characterization of Kinetic and Thermodynamic Parameters of Cyanidin-3-glucoside Methyl and Glucuronyl Metabolite Conjugates". Journal of Physical Chemistry B 119 5 (2015): 2010-2018. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349137000024&KeyUID=WOS:000349137000024.
    10.1021/jp511537e
  52. Azevedo, Joana; Oliveira, Joana; Cruz, Luis; Teixeira, Natercia; Bras, Natercia F.; De Freitas, Victor; Mateus, Nuno. "Antioxidant Features of Red Wine Pyranoanthocyanins: Experimental and Theoretical Approaches". Journal of Agricultural and Food Chemistry 62 29 (2014): 7002-7009. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339471800015&KeyUID=WOS:000339471800015.
    10.1021/jf404735j
  53. Sousa, Andre; Araujo, Paula; Cruz, Luis; Bras, Natercia F.; Mateus, Nuno; De Freitas, Victor. "Evidence for Copigmentation Interactions between Deoxyanthocyanidin Derivatives (Oaklins) and Common Copigments in Wine Model Solutions". Journal of Agricultural and Food Chemistry 62 29 (2014): 6995-7001. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339471800014&KeyUID=WOS:000339471800014.
    10.1021/jf404640m
  54. Cruz, L.; Mateus, N.; De Freitas, V.. "Erratum: First chemical synthesis report of an anthocyanin metabolite with in vivo occurrence: Cyanidin-4'-O-methyl-3-glucoside (Tetrahedron Letters (2013) 54 (2865-2869))". Tetrahedron Letters 55 18 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899522124&partnerID=MN8TOARS.
    10.1016/j.tetlet.2014.03.079
  55. Teixeira, Natércia; Cruz, Luís; Brás, Natércia F.; Mateus, Nuno; Ramos, Maria João; de Freitas, Victor. "Structural Features of Copigmentation of Oenin with Different Polyphenol Copigments". Journal of Agricultural and Food Chemistry 61 28 (2013): 6942-6948. http://dx.doi.org/10.1021/jf401174b.
    10.1021/jf401174b
  56. Cruz, Luis; Mateus, Nuno; de Freitas, Victor. "First chemical synthesis report of an anthocyanin metabolite with in vivo occurrence: cyanidin-4 '-O-methyl-3-glucoside". Tetrahedron Letters 54 22 (2013): 2865-2869.
    10.1016/j.tetlet.2013.03.100
  57. Nave, Frederico; Bras, Natercia F.; Cruz, Luis; Teixeira, Natercia; Mateus, Nuno; Ramos, Maria J.; Di Meo, Florent; et al. "Influence of a Flavan-3-ol Substituent on the Affinity of Anthocyanins (Pigments) toward Vinylcatechin Dimers and Proanthocyanidins (Copigments)". Journal of Physical Chemistry B 116 48 (2012): 14089-14099.
    10.1021/jp307782y
  58. Cruz, L.; Mateus, N.; De Freitas, V.. "Identification by mass spectrometry of new compounds arising from the reactions involving malvidin-3-glucoside-(O)-catechin, catechin and malvidin-3-glucoside". Rapid Communications in Mass Spectrometry 26 18 (2012): 2123-2130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864874343&partnerID=MN8TOARS.
    10.1002/rcm.6330
  59. Bras, Natercia F.; Cruz, Luis; Fernandes, Pedro A.; De Freitas, Victor; Ramos, Maria Joao. "Conformational Study of Two Diasteroisomers of Vinylcatechin Dimers in a Methanol Solution". International Journal of Quantum Chemistry 111 7-8 (2011): 1498-1510.
    10.1002/qua.22631
  60. Oliveira, Joana; Azevedo, Joana; Silva, Artur M. S.; Teixeira, Natercia; Cruz, Luis; Mateus, Nuno; de Freitas, Victor. "Pyranoanthocyanin Dimers: A New Family of Turquoise Blue Anthocyanin-Derived Pigments Found in Port Wine". Journal of Agricultural and Food Chemistry 58 8 (2010): 5154-5159.
    10.1021/jf9044414
  61. Cruz, Luis; Petrov, Vesselin; Teixeira, Natercia; Mateus, Nuno; Pina, Fernando; de Freitas, Victor. "Establishment of the Chemical Equilibria of Different Types of Pyranoanthocyanins in Aqueous Solutions: Evidence for the Formation of Aggregation in Pyranomalvidin-3-O-coumaroylglucoside-(+)-catechin". Journal of Physical Chemistry B 114 41 (2010): 13232-13240.
    10.1021/jp1045673
  62. Cruz, Luis; Bras, Natercia F.; Teixeira, Natercia; Mateus, Nuno; Ramos, Maria Joao; Dangles, Olivier; De Freitas, Victor. "Vinylcatechin Dimers Are Much Better Copigments for Anthocyanins than Catechin Dimer Procyanidin B3". Journal of Agricultural and Food Chemistry 58 5 (2010): 3159-3166.
    10.1021/jf9037419
  63. Fernandes, Ana; Fernandes, Iva; Cruz, Luis; Mateus, Nuno; Cabral, Miguel; de Freitas, Victor. "Antioxidant and Biological Properties of Bioactive Phenolic Compounds from Quercus suber L". Journal of Agricultural and Food Chemistry 57 23 (2009): 11154-11160.
    10.1021/jf902093m
  64. Cruz, Luis; Bras, Natercia F.; Teixeira, Natercia; Fernandes, Ana; Mateus, Nuno; Ramos, Maria Joao; Rodriguez-Borges, Jose; de Freitas, Victor. "Synthesis and Structural Characterization of Two Diasteroisomers of Vinylcatechin Dimers". Journal of Agricultural and Food Chemistry 57 21 (2009): 10341-10348.
    10.1021/jf901608n
  65. Cruz, Luis; Borges, Enrique; Silva, Artur M. S.; Mateus, Nuno; de Freitas, Victor. "Synthesis of a New (+)-Catechin-Derived Compound: 8-Vinylcatechin". Letters in Organic Chemistry 5 7 (2008): 530-536.
    10.2174/157017808785982211
  66. Cruz, Luis; Teixeira, Natercia; Silva, Artur M. S.; Mateus, Nuno; Borges, Jose; de Freitas, Victor. "Role of Vinylcatechin in the Formation of Pyranomalvidin-3-glucoside-(+)-Catechin". Journal of Agricultural and Food Chemistry 56 22 (2008): 10980-10987.
    10.1021/jf8021496
  67. Fernandes, P. A.; Cruz, A. I. S.; Maia, A. R. R.; Almeida, A. A. S.; da Silva, A. M. N.; Silva, B. F. B.; Ribeiro, C. M. S.; et al. "Design of 2-cyclopentenone derivatives with enhanced NF-kappa B: DNA binding inhibitory properties". Journal of Molecular Structure-Theochem 685 1-3 (2004): 73-82.
    10.1016/j.theochem.2004.06.027

Intellectual property

Provisional application for patent
  1. 2019. "NPAT353'2019 - Lipophilization of flavylium salts, biological properties and technological applications".
    Disclosed
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/22 Layer-by-Layer supramolecular assembly of alginate/pyranoflavylium-modified chitosan acidochromic biomembranes 15º Encontro Nacional Química Orgânica e 8º Encontro Nacional Quimica Terapêutica
2023/07/26 Building chemical strategies to expand flavylium-based dyes applications XXVIII Encontro Nacional da Sociedade Portuguesa de Química
2023/07/25 Host-guest complexes based on p-sulfonatocalix[n]arenes and a pyranoflavylium-type dye for dynamic capture of biogenic amines XXVIII Encontro Nacional da Sociedade Portuguesa de Química
2022/11/16 Flavylium-based host-guest systems for biogenic amine sensing during food spoilage XXVI Encontro Galego-Portugués de Química
2022/10/23 COLORIMETRIC LABELS BASED ON PYRANOFLAVYLIUM-CELLULOSE ACETATE FILMS FOR FOOD INTELLIGENT PACKAGING XVI Encontro Quimica dos Alimentos
2022/09/05 Host-guest sensing system based on sulfonatocalixarene and pyranoflavylium dye for biogenic amine sensing during food spoilage 12th Ibero-American Congress on Sensors
2022/09/05 COLORIMETRIC PYRANOFLAVYLIUM-CONTAINING FILMS FOR FOOD SPOILAGE MONITORING 12th Ibero-American Congress on Sensors
2022/01 Colorimetric cellulose-pyranoflavylium hybrid films for food spoilage smart sensing (invited) 14º Encontro Nacional Quimica Organica e 7º Encontro Nacional Quimica Terapêutica
Portuguese Chemical Society (Lisboa, Portugal)
2021/09 Pyranoflavylium salt as a colorimetric pH-sensor in cellulose acetate films for food packaging applications. Effect of the presence of glycerol as a plasticizer. XV Food Chemistry Meeting
Chemical Portuguese Society
2021/07 Dendrimer-based Polymers as New Hosts for Color Tuning of Anthocyanin-type Guests XXVII National Meeting of Chemical Portuguese Society
Chemical Portuguese Society
2021/07 Dendrimers as Color-Stabilizers of Anthocyanin-type Dyes: How the Structure and Concentration of the Dye Modulates the Interaction Mechanisms XXXth International Conference on Polyphenols
Polyphenols Group
2020/01 Synthesis, photophysical properties and applications of pyrano-3-deoxyanthocyanin dyes (invited) 13º Encontro Nacional de Quimica Orgânica e 5º Encontro de Quimica Terapêutica
Sociedade Portuguesa de Quimica
2019/12 New approaches to color stabilization of anthocyanin-type pigments (invited) 3rd International Caparica Christmas Conference on Translational Chemistry
PROTEOMASS scientific society
2019/11 New method for anthocyanin lipophilization based on enzyme retention membrane systems XXV Encontro Galego-Português de Química
Colegio de Quimicos de Galicia
2019/09 Impact of a water-soluble gallic acid-based dendrimer on the color-stabilizing mechanisms of anthocyanins 10th International Workshop of Anthocyanins and Betalains
(Trento, Italy)
2019/07 Flavylium-based systems towards technological applications (invited) XI Young Investigators Workshop
Division Organic Chemistry, EuChemS
2018/11/21 Effect of enzymatic acylation on the chromatic properties of novel anthocyanin monoglucoside derivatives XXIV Encontro Galego-Português de Química
(Porto, Portugal)
2018/11/21 Pyrano-Styryl-Flavyliuns - new bioinspired pigments and their color modulation by micellar systems XXIV Encontro Galego-Português de Química
(Porto, Portugal)
2018/09/12 New Synthetic Pyranoflavylium salts: a bio-inspired approach for light-harvesting in Dye-Sensitized Solar Cells Advanced Energy Materials
(Surrey, United Kingdom)
2018/07/16 EXTENDING THE BLUE COLOR STABILIZATION OF ANTHOCYANIN DERIVATIVES XXIXth International Conference on Polyphenols
(Madison, United States)
2018/03/07 Multifunctional anthocyanin-based compounds for tecnhological applications, 7th Worshop in mass spectrometry and carbohydrates (invited) 7th Worshop in mass spectrometry and carbohydrates
Universidade de Aveiro (Aveiro, Portugal)
2017/12/04 Thermostability studies of oil-soluble cyanidin-3-glucoside dyes 10º Encontro Nacional de Cromatografia
(Bragança, Portugal)
2017/11/15 Lipophilization of anthocyanins from food wastes as a tool to produce valuable oil-soluble ingredients XXIII Encontro Galego-Português de Química
(Ferrol, Spain)
2017/07/16 Synthesis and physical-chemical characterization of novel anthocyanin-lipophilic bioactives XXV Encontro Nacional da SPQ
(Lisboa, Portugal)
2016/07/11 Malvidin-3-glucoside-fatty acid conjugates: from hydrophilic towards novel lipophilic derivatives XVIIIth International Conference on Polyphenols
(Vienna, Austria)
2013/06/12 Anthocyanin metabolites: chemical standards for biological studies XXIII Encontro Nacional da SPQ
(Aveiro, Portugal)
2010/08/23 8-vinylcatechin dimerization lead to the formation of two diasteroisomers of vinylcatechin dimers XXVth International Conference on Polyphenols
(Montpellier, France)
2008/12 Flavan-3-ols transport across blodd-brain barrier XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica e VIII Reunião de Toxicologia
(Lisboa, Portugal)
2005/02/01 Caracterização dos principais compostos polifenólicos de castas da Região dos Vinhos Verdes com propriedades biológicas relacionadas com a prevenção das doenças cardiovasculares IbeSa, Instituto de Bebidas e Saúde,
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/09/01 - Current Development of new colorimetric and fluorescent systems based on pyranoanthocyanins for selective recognition of food metabolites resulting from food spoilage
Supervisor of Ana Sofia Pires
 Sustainable Chemistry Doctoral Programme (FCT grant 2021.08670.BD) (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2020/09/01 - Current Development of anthocyanin-based biofilms for smart release of bioactive compounds in a food perspective
Supervisor of Dina Neves
 Sustainable Chemistry Doctoral Programme (FCT grant 2020.06523.BD) (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2019/02/01 - Current Synthesis and study of the chromatic features of anthocyanin derivatives with potential application as pH sensors for food packaging
Supervisor of Vânia Gomes
 PhD Student in Chemistry (FCT grant SFRH/BD/136556/2018)
Universidade do Porto Faculdade de Ciências, Portugal
2022/09/01 - 2023/11/16 Chitosan-flavylium conjugates towards construction of pH-responsive membranes for food spoilage detection
Supervisor of Mariana Cunha
 Chemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2022/02/01 - 2022/07/31 Smart antioxidant systems based on boronic acid-modified flavylium pigments
Supervisor of Beatriz Senra
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2022/02/01 - 2022/07/01 Sensor films based on boronic acid-modified pyranoanthocyanins for detection of spoilage markers of milk
Supervisor
 Chemistry (Scientific initiation)
Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2019/05 - 2021/11 She his working in the frame of FoodSmarTag project in development of active and smart coatings and films based on anthocyanins for food packaging applications.
Supervisor
 Post-Doc (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2021/02/01 - 2021/07/31 Chemical functionalization of natural anthocyanin derivatives for new technological applications
Supervisor of Marta Monteiro
 Chemistry (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2021/01/02 - 2021/07/14 Synthesis of novel fluorescent sensors based in bis-flavylium compounds modified with boronic acids for biological applications
Supervisor of Rui Rachão
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/09/01 - 2020/12/11 pH-responsive films based on pyranoflavylium dyes for food inteligent packaging
Supervisor of Ana Sofia Soares
 Master in Chemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2019/07/15 - 2020/01/15 Characterization and enzymatic transformation of pigments from Hibiscus sabdariffa L.
Supervisor of Ana Selene Márquez
Universidade do Porto Faculdade de Ciências, Portugal
2018/12/15 - 2019/08/14 Novel Anthocyanin-Based Smart Sensors for Food Packaging
Supervisor of Marta Guimarães
 MSc Researcher of FoodSmarTag project (PTDC/OCE-ETA/31250/2017) (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2017/02/01 - 2019/01/31 Synthesis of bioinspired pyranoflavylium compounds for application in dye sensitized solar cells
Supervisor of Vânia Gomes
 MSc Researcher of SOLFLAV project (PTDC/QEQ-QFI/1971/2014) (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2016/10/01 - 2018/11/21 Synthesis, characterization and study of chromatic features of new anthocyanin lipophilic derivatives
Supervisor of Marta Filipa Guimarães
 Mestrado em Ciência e Tecnologia Alimentar (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2016 - 2017 Synthesis, isolation and characterization of novel flavylium photosensitizers for application in solar cells
Supervisor of Andreia Marinho
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2016 - 2017 Development of lipophilic anthocyanin derivatives for application in dermatological products
Supervisor of Pedro Nascimento
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2016/09/01 - 2016/12/31 Synthesis of bioinspired pyranoflavylium compounds for application in dye sensitized solar cells
Supervisor of Joana Sousa
 Pos-Doc Researcher of Project SOLFLAV (PTDC/QEQ-QFI/1971/2014) (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2015 - 2016 Structural modifications of natural anthocyanins for technological applications
Supervisor of Marta Guimarães
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2011 - 2015 Deoxyanthocyanidins and derivatives: physical-chemical and antioxidant properties in aqueous solutions
Co-supervisor of André Sousa
 Chemistry (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2013 - 2014 Chemical synthesis of relevant anthocyanin metabolites for application in biological studies
Supervisor of Filipa Lima
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2008/01/01 - 2010/12/31 Study of reactions between catechins and anthocyanins. Synthesis of new pigments.
Supervisor of Natércia Teixeira
 MSc Researcher of FCT project PTDC/AGR-ALI/67681/2006 (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2009 - 2010 Synthesis of anthocyanin-derived and vinylcatechin dyes with potential applications for food industry
Supervisor of Suzete Almeida
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2009 - 2010 Bioactive compounds for drug design
Supervisor of Cátia Guedes e Juliana Perazzo
 Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018 - Current XXIV Luso-Galego Chemistry Meeting (2018)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2013 - Current 7th international workshop of anthocyanins (2013)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/10/16 BIOINSPIRED ELECTROCHEMICAL PLATFORM FOR DETECTION OF INFLAMMATION-RELATED BIOMARKERS
(Thesis) Arguer
 Beatriz Oliveira Moreira (Master)
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2023/08/01 OPTIMIZATION OF ANTHOCYANINS RECOVERY FROM BLACK RICE BRAN USING EMERGING TECHNOLOGIES AND ENZYMATIC ACYLATION
Thesis Member
 Eduardo Leonarski (Other)
Universidade Federal de Santa Catarina, Brazil
2022/11/25 Functional Materials for Intelligent Food Packaging
(Thesis) Main arguer
 Bárbara Dias (Master)
Universidade Nova de Lisboa, Portugal
2021/02/05 Exploring and improving the color stability of natural anthocyanins and synthetic derivatives and their application as pH/light-sensitive systems
(Thesis) Arguer
 Johan Mendoza Chacón (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/12/13 Thermal Azide-Alkyne Cycloaddition (TAAC) as Efficient Clicked Chemistry Tool for the Functionalization of Dendrimers and Polymers
(Thesis) Arguer
 Ma'un Hasan Haroon Tawara (PhD)
Universidade de Santiago de Compostela, Spain

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/02/01 - Current Química dos Alimentos e Nutrição Química (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal
2020/02/10 - Current Química Orgânica Aplicada Farmácia (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/02/10 - Current Química Biológica II Biotecnologia Medicinal (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2019/09/15 - 2020/02/10 Laboratório de Química Orgânica Licenciatura Universidade do Porto Faculdade de Ciências, Portugal
2017/09 - 2018/09 Práticas Laboratoriais Integradas Farmácia Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Mentoring / Tutoring

Topic Student name
2023/09/01 - Current ActInPads - Development of antioxidant, anti-inflammatory, and pH-responsive starch/pyranoflavylium-based materials Sumeja Ferreira
2022/09/01 - 2023/07/11 ActInPads-Development of sustainable antioxidant, anti-inflammatory, and pH-responsive starch/pyranoflavylium-based wound Marta Monteiro
2021/10 - 2021/11 Synthesis of silver nanowires and fabrication of substrates for Surface Enhanced Raman Spectroscopy for detection of biomolecules Dr Chiara Amicucci (Italian PhD student)
2020/07 - 2020/12 Characterization and enzymatic transformation of pigments from Hibiscus sabdariffa L. Dr Selene Marquez (Mexican PhD student)

Scientific expedition

Activity description Institution / Organization
2022/07/01 - 2022/07/31 International Internship under the frame of IACOBUS programme in Analytical and Food Chemistry Department of University of Vigo, Spain.
Distinctions

Award

2018 Senior Grant for attending the XXIXth International Conference on Polyphenols, Madison, USA, 16-20 July 2018.
2017 Best Poster entitled “First evidences of interaction of between pyranoanthocyanins and salivary proline rich-proteins” presented in Vino Analytica Scientia Conference, Salamanca, Spain, 17-20 July 2017.
2010 Junior Grant for attending the XXVth International Conference on Polyphenols, Montpellier, France, 24-27 August 2010.
2004 Prémio de incentivo à pesquisa e investigação atribuído por Instituto de Bebidas e Saúde (IBeSa)

Other distinction

2019 XI Young Investigator Workshop 2019, Division of Organic Chemistry of EuChemS (representing Portugal nominated by Portuguese Chemical Society)