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Nuno L. Alves is a group leader at Instituto de Investigação e Inovação em Saúde (i3S) in Porto. He graduated in Biology from the University of Porto in 2000 and completed his a Ph.D. in Immunology at the University of Amsterdam in 2007 with the support of a GABBA/FCT PhD fellowship. Next, he obtained a long-term EMBO fellowship to develop his post-doctoral research at the Institut Pasteur in Paris. In 2010, he returned to Portugal under the Ciência2008 program and started his independent research team at Instituto de Biologia Molecular e Celular (IBMC) in Porto. In 2014, he established his research group at Instituto de Investigação e Inovação em Saúde(i3S), which is the largest research center in Portugal. He was a recipient of an ECR Starting Grant and holded the position of Principal Investigator, first under the umbrella of the FCT investigator program and then under the Scientific Employment Stimulus program. Since 2023, he is part of the i3S research staff with an open-ended contract as PI. Throughout his career as Immunologist, he has been interested in the mechanisms underlying the homeostasis of T cells, which represent a chief arm of the immune system. During his PhD and Post-Doctoral periods, he studied the role of the cytokines Interleukin 7 (IL-7) and IL-15 in the function of T cells. The studies in his laboratory are focused on the differentiation of thymic epithelial cells (TECs), which play a prominent role in T-cell development and in the establishment of immunological tolerance. He has published 44 articles in high ranked journals, supervised 6 PhD thesis and 7 MSc dissertation thesis. He has received several awards and/or honors and participates and/or participated as Principal investigator in several national and international grants. These 20 years of experience in a highly competitive academic environment have provided him with consolidated experience in all aspects of research and development, the design, and the coordination of multiple projects. He has also extensive experience in securing international and nationally competitive funding, grant writing and management, supervision and mentorship of researchers, and scientific and public, outreach communication activities with the media. Besides his activities as a researcher, he has been responsible for teaching Immunology to under graduated (Uni Algarve) and post-graduated (Uni. Porto) and he has participated as examiner in several Master and Ph.D. thesis in Portugal and abroad. Moreover, he regularly acts as reviewer for several important Immunology-related scientific journals and International Funding Agencies. Between 2018-2021, he was the Vice-President of the Portuguese Society of Immunology (SPI) and he is currently the Vice-Coordinator of the Infection, Immunity and Regeneration research program at i3S, which holds 36 research groups at i3S .
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Identification

Personal identification

Full name
Nuno Miguel de Oliveira Lages Alves

Citation names

  • Alves, Nuno L.

Author identifiers

Ciência ID
DB1E-1B17-0B90
ORCID iD
0000-0002-1567-8389

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Dutch Beginner (A1) Beginner (A1)
Education
Degree Classification
2010 - 2010/09/14
Concluded
 Course in Laboratory Animal Science, FELASA Category C (accreditation No 020/08) (Outros)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2010 - 2010
Concluded
 Accreditation Investigator-Coordinator at Direcção-Geral de Veterinária (Outros)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2007
Concluded
 Immunology - Medicine (Doutoramento)
Universiteit van Amsterdam, Netherlands
"How To Keep T Cells Alive and Kicking" (THESIS/DISSERTATION)
 Cum Laude
1995
Concluded
 Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Not applicable" (THESIS/DISSERTATION)
 Final Mark 17/20 (85%)
Affiliation

Science

Category
Host institution 		Employer
2013 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2009 - 2013 Contracted Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2007/02/28 - 2009/07/31 Postdoc (Research) Institut Pasteur, France
2001/10/01 - 2007/02/01 Research Trainee (Research) Academisch Medisch Centrum Faculteit Geneeskunde, Netherlands

Teaching in Higher Education

Category
Host institution 		Employer
2012 - Current Invited Assistant Professor (University Teacher) Universidade do Algarve, Portugal
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Positions / Appointments

Category
Host institution 		Employer
2018 - 2020 Vice-President Sociedade Portuguesa de Imunologia, Portugal
2015 - 2018 Member of the direction Sociedade Portuguesa de Imunologia, Portugal

Others

Category
Host institution 		Employer
2018 - Current Vice-Coordinator Research Program Infection, Immunity and Regeneration Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2011 - 2014 Co-representative of the researchers at Executive Council of IBMC Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projects

Grant

Designation Funders
2023/12/31 - 2027/12/31 The molecular regulation of T cell development in the thymus: Implications for Infectious Diseases
LCF/PR/HR23/52430019
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação 'la Caixa'
Ongoing
2020 - 2027 An Immunological Hub of Excellence in Porto tailored to fulfil the ERA Priorities
H2020-WIDESPREAD-2018-2020-6
Coordinator
Horizon 2020
2023/12/31 - 2026/12/31 Deciphering the impact of Leukaemia on Immunological Fitness beyond disease
HR23-00608
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação 'la Caixa'
Ongoing
2022/03/01 - 2025/02/28 Molecular Control of Foxn1 Expression in Thymic Epithelial Cells: Advances in Thymus Regenerative Therapies
PTDC/MED-IMU/0888/2021
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2022/03 - 2025/02 Molecular Control of Foxn1 Expression in Thymic Epithelial Cells: Advances in Thymus Regenerative Therapies
PTDC/MED-IMU/0888/2021
 Fundação para a Ciência e Tecnologia
2021/04 - 2024/03 Molecular principles underlying T cell development and tolerance induction in the thymus: Defining the role of RNA binding proteins in thymic epithelial cell lineage specification and function in vivo
PTDC/MED-IMU/1416/2020
Principal investigator
Fundação para a Ciência e a Tecnologia
2022/03 - 2023/06 Genetic Reprogramming of Thymic Epithelial Cells: A new manufacturable platform to study the molecular mechanisms underlying thymic function
EXPL/MED-IMU/1537/2021
Principal investigator
Fundação para a Ciência e a Tecnologia
2020 - 2022 SPINY: Identifying and Modulating the Mechanisms Responsible for Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord
not applicable
Participant: Co-Principal Investigator
Santa Casa da Misericórdia de Lisboa
2018 - 2021 Thymus Regeneration: Development of a high-content discovery program to identify new bioactive compounds and molecular determinants that induce Foxn1 expression in thymic epithelial cells
POCI-01-0145-FEDER-029129
PTDC/MED-IMU/29129/2017
Principal investigator
Fundação para a Ciência e a Tecnologia
2015/07 - 2020 Molecular control of self-renewal and lineage specification in thymic epithelial cell progenitors in vivo.
637843
Principal investigator
ERC Starting Grant - Horizon 2020
2016 - 2019 Bioengineered Therapies for Tissue Regeneration and Infectious Diseases.
NORTE-01-0145-FEDER-000008.
Principal investigator
FEDER funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI)
2015 - 2018 The yin and yang of somatic mutations in cancer immunosurveillance
PTDC/BIM-MEC/2834/2014
Participant: Co-Principal Investigator
Fundação para a Ciência e a Tecnologia
2011/04 - 2014 The function of the thymus in pathophysiological conditions: A systematic approach to study the expression of interleukin 7 during stress-induced thymic injury
PTDC/SAU-IMU/117057/2010
Principal investigator
Fundação para a Ciência e Tecnologia
2010 - 2013 Unveiling the thymic interleukin 7 niche in vivo - A framework to study the cellular and molecular control of a master regulator of T lymphopoiesis
PTDC/SAU-IMU/110116/2009
Principal investigator
Fundação para a Ciência e Tecnologia
Outputs

Publications

Book chapter
  1. Matsumoto, Minoru; Rodrigues, Pedro M.; Sousa, Laura; Tsuneyama, Koichi; Matsumoto, Mitsuru; Alves, Nuno L.. "The Ins and Outs of Thymic Epithelial Cell Differentiation and Function". In Thymus Transcriptome and Cell Biology, 35-65. Springer International Publishing, 2019.
    10.1007/978-3-030-12040-5_3
  2. Arosa, Fernando A.; Fonseca, Ana M.; Santos, Susana G.; Alves, Nuno L.. "The Impact of Environmental Signals on the Growth and Survival of Human T Cells". In Biophysical Aspects of Transmembrane Signaling, 1-32. Springer-Verlag, 2005.
    Published • 10.1007/3-540-26511-2_1
Journal article
  1. Silva, Catarina S.; Pinto, Rute D.; Pires, Ricardo A.; Correia-Neves, Margarida; Reis, Rui L.; Alves, Nuno L.; Martins, Albino; Neves, Nuno M.. "The Influence of Feeder Cell-Derived Extracellular Matrix Density on Thymic Epithelial Cell Culture". ACS Biomaterials Science & Engineering 9 5 (2023): 2514-2523. http://dx.doi.org/10.1021/acsbiomaterials.3c00148.
    10.1021/acsbiomaterials.3c00148
  2. Alves, Inês; Santos-Pereira, Beatriz; de la Cruz, Noelia; Campar, Ana; Pinto, Vanda; Rodrigues, Pedro M.; Araújo, Marco; et al. "Host-derived mannose glycans trigger a pathogenic ¿d T cell/IL-17a axis in autoimmunity". Science Translational Medicine 15 687 (2023): http://dx.doi.org/10.1126/scitranslmed.abo1930.
    10.1126/scitranslmed.abo1930
  3. Sousa, Laura G.; Rodrigues, Pedro M.; Alves, Nuno L.. "T-cell selection in the thymus: New routes toward the identification of the self-peptide ligandome presented by thymic epithelial cells". European Journal of Immunology 53 3 (2023): http://dx.doi.org/10.1002/eji.202250202.
    10.1002/eji.202250202
  4. Gonçalves, Rute; Couto, Joana; Ferreirinha, Pedro; Costa, José Maria; Silvério, Diogo; Silva, Marta L.; Fernandes, Ana Isabel; et al. "SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice". iScience 26 2 (2023): 105972. http://dx.doi.org/10.1016/j.isci.2023.105972.
    10.1016/j.isci.2023.105972
  5. Ferreirinha, Pedro; Pinheiro, Ruben; Landry, Jonathan J. M.; Alves, Nuno L.. "Identification of fibroblast progenitors in the developing thymus". Development (2022): http://dx.doi.org/10.1242/dev.200513.
    10.1242/dev.200513
  6. Rodrigues, Pedro M.; Sousa, Laura G.; Perrod, Chiara; Maceiras, Ana R.; Ferreirinha, Pedro; Pombinho, Rita; Romera-Cárdenas, Gema; et al. Corresponding author: Alves, Nuno L.. "LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development". Autophagy (2022): http://dx.doi.org/10.1080/15548627.2022.2074105.
    Published • 10.1080/15548627.2022.2074105
  7. Nuno L. Alves; Pedro Ferreirinha. "The quest for the “HOIL-1” grail of T-cell development". Cell Death & Differentiation (2021): https://doi.org/10.1038/s41418-021-00856-2.
    10.1038/s41418-021-00856-2
  8. "The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation". Frontiers Immunology (2021): https://www.frontiersin.org/articles/10.3389/fimmu.2021.668528/full.
    Published
  9. Alves, Nuno L.. "Fibronectin-Functionalized Fibrous Meshes as a Substrate to Support Cultures of Thymic Epithelial Cells.". Biomacromolecules (2020): https://doi.org/10.1021/acs.biomac.0c00933.
    10.1021/acs.biomac.0c00933
  10. Alves, Nuno L.. "A novel method to identify Post-Aire stages of medullary thymic epithelial cell differentiation.". European journal of immunology (2020): https://doi.org/10.1002/eji.202048764.
    10.1002/eji.202048764
  11. Alves, Nuno L.. "The Portuguese Society for Immunology (SPI): history and mission.". European journal of immunology (2020): https://doi.org/10.1002/eji.202070075.
    10.1002/eji.202070075
  12. Alves, Nuno L.. "Medullary thymic epithelial cells: Deciphering the functional diversity beyond promiscuous gene expression". Immunology Letters (2019): http://dx.doi.org/10.1016/j.imlet.2019.01.012.
    10.1016/j.imlet.2019.01.012
  13. Ghezzo, Marinella N; Fernandes, Mónica T; Pacheco-Leyva, Ivette; Rodrigues, Pedro M; Machado, Rui S; Araújo, Marta A S; Kalathur, Ravi K; et al. "FoxN1-dependent thymic epithelial cells promote T-cell leukemia development". Carcinogenesis 39 12 (2018): 1463-1476. http://dx.doi.org/10.1093/carcin/bgy127.
    10.1093/carcin/bgy127
  14. Ghezzo, Marinella N; Fernandes, Mónica T; Pacheco-Leyva, Ivette; Rodrigues, Pedro M; Machado, Rui S; Araújo, Marta A S; Kalathur, Ravi K; et al. "FoxN1-dependent thymic epithelial cells promote T-cell leukemia development". Carcinogenesis 39 12 (2018): 1463-1476. http://dx.doi.org/10.1093/carcin/bgy127.
    10.1093/carcin/bgy127
  15. Pedro M. Rodrigues; Ana R. Ribeiro; Nicolas Serafini; Catarina Meireles; James P. Di Santo; Nuno L. Alves. "Intrathymic Deletion of IL-7 Reveals a Contribution of the Bone Marrow to Thymic Rebound Induced by Androgen Blockade". The Journal of Immunology (2018): ji1701112-ji1701112. https://doi.org/10.4049/jimmunol.1701112.
    10.4049/jimmunol.1701112
  16. Rodrigues, Pedro M.; Peterson, Pärt; Alves, Nuno L.. "Setting Up the Perimeter of Tolerance: Insights into mTEC Physiology". Trends in Immunology 39 1 (2018): 2-5. http://dx.doi.org/10.1016/j.it.2017.11.001.
    10.1016/j.it.2017.11.001
  17. Catarina Meireles; Ana R. Ribeiro; Rute D. Pinto; Catarina Leitão; Pedro M. Rodrigues; Nuno L. Alves. "Thymic crosstalk restrains the pool of cortical thymic epithelial cells with progenitor properties". European Journal of Immunology 47 6 (2017): 958-969. https://doi.org/10.1002/eji.201746922.
    10.1002/eji.201746922
  18. Resende, M.; Cardoso, M.S.; Ribeiro, A.R.; Flórido, M.; Borges, M.; Gil Castro, A.; Alves, N.L.; Cooper, A.M.; Appelberg, R.. "Innate IFN-¿-Producing cells developing in the absence of IL-2 receptor common ¿-chain". Journal of Immunology 199 4 (2017): 1429-1439. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027298608&partnerID=MN8TOARS.
    10.4049/jimmunol.1601701
  19. Rodrigues, P.M.; Ribeiro, A.R.; Perrod, C.; Landry, J.J.M.; Araújo, L.; Pereira-Castro, I.; Benes, V.; et al. "Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice". Blood 130 4 (2017): 478-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026293874&partnerID=MN8TOARS.
    10.1182/blood-2016-12-758961
  20. Alves, N.L.; Ribeiro, A.R.. "Thymus medulla under construction: Time and space oddities". European Journal of Immunology 46 4 (2016): 829-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962197424&partnerID=MN8TOARS.
    10.1002/eji.201646329
  21. Remmerswaal, E.B.M.; Klarenbeek, P.L.; Alves, N.L.; Doorenspleet, M.E.; van Schaik, B.D.C.; Esveldt, R.E.E.; Idu, M.M.; et al. "Clonal evolution of CD8+ T cell responses against latent viruses: Relationship among phenotype, localization, and function". Journal of Virology 89 1 (2015): 568-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919433921&partnerID=MN8TOARS.
    10.1128/JVI.02003-14
  22. Fernandes, M.T.; Ghezzo, M.N.; Silveira, A.B.; Kalathur, R.K.; Póvoa, V.; Ribeiro, A.R.; Brandalise, S.R.; et al. "Lymphotoxin-ß receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype". British Journal of Haematology 171 5 (2015): 736-751. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955381960&partnerID=MN8TOARS.
    10.1111/bjh.13760
  23. Ribeiro, A.R.; Meireles, C.; Rodrigues, P.M.; Alves, N.L.. "Intermediate expression of CCRL1 reveals novel subpopulations of medullary thymic epithelial cells that emerge in the postnatal thymus". European Journal of Immunology 44 10 (2014): 2918-2924. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925298291&partnerID=MN8TOARS.
    10.1002/eji.201444585
  24. Alves, N.L.; Takahama, Y.; Ohigashi, I.; Ribeiro, A.R.; Baik, S.; Anderson, G.; Jenkinson, W.E.. "Serial progression of cortical and medullary thymic epithelial microenvironments". European Journal of Immunology 44 1 (2014): 16-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892472653&partnerID=MN8TOARS.
    10.1002/eji.201344110
  25. Ribeiro, A.R.; Rodrigues, P.M.; Meireles, C.; Di Santo, J.P.; Alves, N.L.. "Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo". Journal of Immunology 191 3 (2013): 1200-1209. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880685834&partnerID=MN8TOARS.
    10.4049/jimmunol.1203042
  26. Huntington, N.D.; Alves, N.L.; Legrand, N.; Lim, A.; Strick-Marchand, H.; Plet, A.; Weijer, K.; et al. "Autonomous and extrinsic regulation of thymopoiesis inhuman immune system (HIS) mice". European Journal of Immunology 41 10 (2011): 2883-2893. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053139523&partnerID=MN8TOARS.
    10.1002/eji.201141586
  27. Wensveen, F.M.; Alves, N.L.; Derks, I.A.M.; Reedquist, K.A.; Eldering, E.. "Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1". Apoptosis 16 7 (2011): 708-721. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051546884&partnerID=MN8TOARS.
    10.1007/s10495-011-0599-8
  28. Huntington, N.D.; Alves, N.L.; Legrand, N.; Lim, A.; Strick-Marchand, H.; Mention, J.-J.; Pletf, A.; et al. "IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo". Proceedings of the National Academy of Sciences of the United States of America 108 15 (2011): 6217-6222. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955010744&partnerID=MN8TOARS.
    10.1073/pnas.1019167108
  29. Alves, N.L.; Huntington, N.D.; Mention, J.-J.; Richard-Le Goff, O.; Di Santo, J.P.. "Cutting edge: A thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo". Journal of Immunology 184 11 (2010): 5949-5953. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953449167&partnerID=MN8TOARS.
    10.4049/jimmunol.1000601
  30. Lalanne, A.I.; Moraga, I.; Hao, Y.; Pereira, J.P.; Alves, N.L.; Huntington, N.D.; Freitas, A.A.; Cumano, A.; Vieira, P.. "CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism". Journal of Immunology 184 10 (2010): 5678-5685. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954714801&partnerID=MN8TOARS.
    10.4049/jimmunol.0903854
  31. Huntington, N.D.; Labi, V.; Cumano, A.; Vieira, P.; Strasser, A.; Villunger, A.; Di Santo, J.P.; Alves, N.L.. "Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7". International Immunology 21 6 (2009): 715-725. http://www.scopus.com/inward/record.url?eid=2-s2.0-66249096306&partnerID=MN8TOARS.
    10.1093/intimm/dxp043
  32. Alves, N.L.; Goff, O.R.-L.; Huntington, N.D.; Sousa, A.P.; Ribeiro, V.S.G.; Bordack, A.; Vives, F.L.; et al. "Characterization of the thymic IL-7 niche in vivo". Proceedings of the National Academy of Sciences of the United States of America 106 5 (2009): 1512-1517. http://www.scopus.com/inward/record.url?eid=2-s2.0-60849114415&partnerID=MN8TOARS.
    10.1073/pnas.0809559106
  33. Huntington, N.D.; Legrand, N.; Alves, N.L.; Jaron, B.; Weijer, K.; Plet, A.; Corcuff, E.; et al. "IL-15 trans-presentation promotes human NK cell development and differentiation in vivo". Journal of Experimental Medicine 206 1 (2009): 25-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-60549117539&partnerID=MN8TOARS.
    10.1084/jem.20082013
  34. Alves, N.L.; Huntington, N.D.; Rodewald, H.-R.; Di Santo, J.P.. "Thymic epithelial cells: the multi-tasking framework of the T cell "cradle"". Trends in Immunology 30 10 (2009): 468-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349556314&partnerID=MN8TOARS.
    10.1016/j.it.2009.07.010
  35. Alves, N.L.; Van Leeuwen, E.M.M.; Derks, I.A.M.; Van Lier, R.A.W.. "Differential regulation of human IL-7 receptor a expression by IL-7 and TCR signaling". Journal of Immunology 180 8 (2008): 5201-5210. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449109453&partnerID=MN8TOARS.
  36. Hallaert, D.Y.H.; Spijker, R.; Jak, M.; Derks, I.A.M.; Alves, N.L.; Wensveen, F.M.; de Boer, J.P.; et al. "Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection". Cell Death and Differentiation 14 11 (2007): 1958-1967. http://www.scopus.com/inward/record.url?eid=2-s2.0-35549012854&partnerID=MN8TOARS.
    10.1038/sj.cdd.4402211
  37. Alves, N.L.; Arosa, F.A.; van Lier, R.A.W.. "Common ¿ chain cytokines: Dissidence in the details". Immunology Letters 108 2 (2007): 113-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846650265&partnerID=MN8TOARS.
    10.1016/j.imlet.2006.11.006
  38. Alves, N.L.; van Lier, R.A.W.; Eldering, E.. "Withdrawal symptoms on display: Bcl-2 members under investigation". Trends in Immunology 28 1 (2007): 26-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845636846&partnerID=MN8TOARS.
    10.1016/j.it.2006.11.003
  39. Alves, N.L.; Van Leeuwen, E.M.M.; Remmerswaal, E.B.M.; Vrisekoop, N.; Tesselaar, K.; Roosnek, E.; Ten Berge, I.J.M.; Van Lier, R.A.W.. "A new subset of human naive CD8+ T cells defined by low expression of IL-7Ra". Journal of Immunology 179 1 (2007): 221-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250834965&partnerID=MN8TOARS.
  40. Alves, N.L.; Derks, I.A.M.; Berk, E.; Spijker, R.; van Lier, R.A.W.; Eldering, E.. "The Noxa/Mcl-1 Axis Regulates Susceptibility to Apoptosis under Glucose Limitation in Dividing T Cells". Immunity 24 6 (2006): 703-716. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745006592&partnerID=MN8TOARS.
    10.1016/j.immuni.2006.03.018
  41. Alves, N.L.; Arosa, F.A.; Van Lier, R.A.W.. "IL-21 sustains CD28 expression on IL-15-activated human naive CD8+T cells". Journal of Immunology 175 2 (2005): 755-762. http://www.scopus.com/inward/record.url?eid=2-s2.0-23244444668&partnerID=MN8TOARS.
    10.4049/jimmunol.175.2.755
  42. Gimeno, R.; Weijer, K.; Voordouw, A.; Uittenbogaart, C.H.; Legrand, N.; Alves, N.L.; Wijnands, E.; Blom, B.; Spits, H.. "Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- ¿c -/- mice: Functional inactivation of p53 in developing T cells". Blood 104 13 (2004): 3886-3893. http://www.scopus.com/inward/record.url?eid=2-s2.0-10244237695&partnerID=MN8TOARS.
    10.1182/blood-2004-02-0656
  43. Alves, N.L.; Hooibrink, B.; Arosa, F.A.; Van Lier, R.A.W.. "IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro". Blood 102 7 (2003): 2541-2546. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141705313&partnerID=MN8TOARS.
    10.1182/blood-2003-01-0183

Other

Other output
  1. FoxN1-dependent thymic epithelial cells promote T-cell leukemia development. 2018. Marinella N. Ghezzo; Mónica T. Fernandes; Rui S. Machado; Ivette Pacheco-Leyva; Marta A.S. Araújo; Ravi K. Kalathur; Matthias E. Futschik; Nuno L. Alves; Nuno R. dos Santos. https://doi.org/10.1101/247015.
    10.1101/247015
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/04/11 Molecular Control of Thymic Epithelial Cell Differentiation and Function Invited speaker at 31ST ANNUAL HENRY KUNKEL SOCIETY MEETING
THE ROCKEFELLER UNIVERSITY NEW YORK, NY, USA (New York, United States)
2023/03/23 The transcription factor Foxo3 controls the homeostasis and functional heterogeneity of medullary thymic epithelial cells ThymOz 2023
Global Thymus Network (Australia)
2021 The choreography of T cell development by thymic epithelial cells Seminar series Department of Immunology
Ana Cumano (Paris, France)
2021 The choreography of T cell development by thymic epithelial cells Portuguese Society of Immunology
2019/09 Thymic Epithelial Cell differentiation and Function: The foundation of Immunity and Tolerance Induction CEDOC seminar
(Lisboa, Portugal)
2019/05 Thymic Epithelial Cell differentiation and Function: The foundation of Immunity and Tolerance Induction ThymE: T cell and thymus biology
(Rehovot, Israel)
2018/09/22 Thymic Epithelial Cell differentiation and Function: The foundation of Immunity and Tolerance Induction 9th Meeting on Signal Transduction
(Lisboa)
2018/09/18 Choreographing Immunity and Tolerance Induction in the Thymus Lund University Immunology Seminar
Prof. William Agace (Lund, Sweden)
2018/05/16 Choreographing Immunity and Tolerance Induction in the Thymus 11th International Congress on Autoimmunity
(Lisbon, Portugal)
2018/03/21 Intrathymic deletion of IL-7 reveals a contribution of the bone marrow to thymic rebound induced by androgen blockade. ThymOZ: An International Conference on Thymus and T-cell Biology
(Queenslad , Australia)
2018/02/14 Choreographing Immunity and Tolerance Induction in the Thymus iBiMED Winter 2018 Seminar Series
Prof. Manuel Santos (Aveiro, Portugal)
2017/11/21 Choreographing Immunity and Tolerance Induction in the Thymus 3rd Meeting on Thymus Transcriptome and Cell Biology
Prof. Geraldo Passos (São Paulo , Brazil)
2017/10/05 Choreographing Immunity and Tolerance Induction in the Thymus Universidade Complutense
Prof. Agustin Zapatta (Madrid , Spain)
2017/05/27 Choreographing Immunity and Tolerance Induction in the Thymus XV Congress of the Iberian Cytometry Society (SIC)
(Lisbon, Portugal)
2016/11/17 The Quest for the Thymus, Thymic Epithelial Cell differentiation and Function: The foundation of Immunity and Tolerance Induction 2nd Meeting on Thymus Transcriptome and Cell Biology
Prof. Geraldo Passos (Rio de Janeiro, Brazil)
2016/06/06 Thymic epithelial cells require p53 to support their role in T-cell development and tolerance induction.   2016 ThymUS International Conference
(Maui, United States)
2016/04/04 The Quest for the Thymus, Thymic Epithelial Cell differentiation and Function: The foundation of Immunity and Tolerance Induction Cell Functional And Phenotypical Analysis Course,
(Braga, Portugal)
2015/06/26 The Quest for the Thymus, Thymic Epithelial Cell differentiation and Function: The foundation of Immunity and Tolerance Induction CNC seminar series
Dr. Filipe Pereira (Coimbra, Portugal)
2015/06/23 The Quest for the Thymus, Thymic Epithelial Cell differentiation and Function: The foundation of Immunity and Tolerance Induction Sanquin Seminars Series
Prof. Rene van Lier (Amsterdam , Netherlands)
2015/02/02 The Quest for the Thymus, Thymic Epithelial Cell differentiation and Function: The foundation of Immunity and Tolerance Induction IMM Monday Lecture
(Lisbon, Portugal)
2015/01/12 The Quest for the Thymus, Molecular and Cellular Mechanisms required to understand the development and function of Thymic Epithelial Cells University Children's Hospital of Basel seminar series
Prof. George Hollander (Basel, Switzerland)
2013 Molecular control of thymus biology 4th International Symposium Immunomedicine, Harvard Medical School, Portugal Program
(Coimbra, Portugal)
2012 Molecular control of thymus biology MRC Centre for Immune Regulation – John Squire Seminars, School of Immunity and Infection
(Birmingham, United Kingdom)
2011 Molecular control of thymus biology symposium Modelos Animales e Investigación Traslacional en Biomedicina
(Santiago, Spain)
2009 Molecular control of thymus biology XXXV meeting of the Portuguese Society of Immunology
(Portugal)
2008 Molecular control of thymus biology Friday Noon seminars
(Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/03/01 - 2024/06/21 Delineating the molecular control of medullary thymic epithelial cell differentiation and function. (Delivered and to be defended before July 2024)
Supervisor of Camila Ribeiro
 Doutoramento (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - 2024/05/03 Identification of the genetic program underlying the control of Foxn1 expression during thymic epithelial cell lineage specification in vivo
Supervisor of Laura Sousa
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2023/05/25 The establishment of the stromal microenvironment in the thymus and its implications for T-cell development
Supervisor of Ruben Pinheiro
 PhD thesis (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 - 2022/02 Post-doc fellowship: ERC – Starting Grant 2014 ref 637843
Supervisor of Pedro Rodrigues
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2022 Post-doc fellowship: ERC – Starting Grant 2014 ref 637843
Supervisor of Pedro Ferreirinha
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015 - 2022 Research Fellow
Supervisor of Leonor Araújo
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2020/10 - 2021/12 Molecular Insights into the Role of FoxN1 in Thymic Epithelial Cell Development and Function: Generation of a platform for T-cell development through FoxN1-induced cell reprogramming
Supervisor of Nuno André Roque David
Master Thesis (Master)
Universidade de Coimbra, Portugal
2017 - 2018 Unravelling the functional consequences of TEC specific deletion of p53 in T cell homeostasis
Supervisor of Laura Sousa
Master (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade de Aveiro, Portugal
2017 - 2018 Defining novel stages in medullary thymic epithelial cells: Implications for Tolerane Induciton
Supervisor of Maria Camila Trindade Ribeiro
Master (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015 - 2018 FCT Post-doctoral fellowship (SFRH/BPD/101420/2014)
Supervisor of Rute Pinto
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015 - 2018 Post-doc fellowship: ERC – Starting Grant 2014 ref 637843
Supervisor of Chiara Perrod
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - 2018 Refining thymic epithelial cell differentiation: from progenitor cell isolation to the identification of discrete mature lineages
Supervisor of Helena Catarina Meireles
 PhD (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013 - 2018 How to Keep the Thymus in Shape: New Molecular Insights on Thymic Epithelial Cell homeostasis and function
Supervisor of Pedro Miguel Mendes Rodrigues
 PhD (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2017 Post-doc fellowship: Fundación Alfonso Martín Escudero
Supervisor of Gema Romera
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015 - 2016 The impact of CD8+ T cell selection in medullary thymic epithelial microenvironment
Supervisor of Laura Sousa
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012 - 2016 Unveilling thymic epithelial cell ontogeny : a road map to study the microenvironment for T-cell generation and tolerance
Supervisor of Ana Rosalina Ribeiro
 PhD (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013 - 2014 The importance of the dynamics of CD8 T-cell selection for the establishment of thymic cortical and medullary epithelial microenvironments
Supervisor of Helena Xavier Ferreira
Master (Master)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2012 - 2013 Research Fellow
Supervisor of Catarina Meireles
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2011 - 2012 Dissecting the Thymic Microenvironment : an approach to unveil the impact of defective T cell development in the maintenance of cortical thymic epithelium
Supervisor of Pedro Mendes Rodrigues
 Master (Master)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2010 - 2011 Uncovering the Thymic IL-7 niche in vivo: The impact of Thymic Epithelial Cell-Thymocyte crosstalk on the control of IL-7 expression
Supervisor of Ana Rosalina Ribeiro
 Master (Master)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06/01 - 2024/05/31 Chairman of the International Meeting | ThymE 24. T cell & thymus biology. (2024/05/27 - 2024/05/31)
Congress (President of the Organising Committee)
 Thymus Global Network, United States
2023/04/17 - 2024/04/19 Co-organizer of the 49th annual meeting of the Portuguese Society for Immunology (2024/04/17 - 2024/04/19)
Conference (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal
2018/06/19 - 2019/05/24 Co-organizer EMBO WorkShop, “ThymE: T cell and thymus biology”, Rehovot, Israel (2019/05/19 - 2019/05/24)
Conference (Co-organisor)
 Weizmann Institute of Science, Israel
2016 - 2018 Organizer of the Immunology Day (2016 - 2018)
Meeting (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2017 Chairmam of the XLIII annual meeting of the Portuguese Society of Immunology, “Breaking the barriers of immunotherapy and vaccination: realities and challenges” (2017 - 2017)
Meeting (Other)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013 - 2013 Organizer SPI/IBMC workshop “Thymus@Porto2” (2013 - 2013)
Workshop (President of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 - 2012 Chairman of the XXXVIII annual meeting of the Portuguese Society of Immunology, “From Immune Disorders to Immunotherapies” (2012 - 2012)
Meeting (Other)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2011 Co-organizer SPI workshop “Thymus@Porto” (2011 - 2011)
Workshop (Co-organisor)
 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Association member

Society Organization name Role
2009 - Current Portuguese Society of Immunology (SPI)
2011 - 2013 European Society of Microbiology and Infection

Committee member

Activity description
Role 		Institution / Organization
2021 - Current Associated Editor : European Journal of Immunology
Member
2012 - Current Representative of the Advisory Board of the IBMC animal facility
Advisor / Consultant
 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2020 - 2020 PhD thesis Advisory Board. Samuel Gonçalves, Escola de Ciências da Saúde, Univ. Minho, 2020
Advisor / Consultant
 Universidade do Minho, Portugal
2016 - 2016 PhD thesis Advisory Board. Marinella Ghezzo, Programa de Doutoramento em Ciências Biomédicas e Medicina da Universidade do Algarve 2012-2016.
Advisor / Consultant
 Universidade do Algarve, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018 - Current Invited Professor in the Ph.D. program MCBiology, University of Porto. Teaching Immunology to 1st year PhD students. Immunology (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012 - Current Invited Assistant Professor at the Department of Biomedical Science. Teaching Human Immunology to 3rd year Biomedical Science undergraduate students. Imunologia Humana (Licenciatura) Universidade do Algarve, Portugal
2018 - 2019 Invited Professor at the Advanced Immunology Course, Université Paris descartes, Paris diderot et sorbonne Université Immunology (Master) Université de Paris, France
2018 - 2019 Invited Professor in the Ph.D. program in Biomedicine, University of Aveiro. - Teaching Immunology to 1st year PhD students. Imunologia (Doutoramento) Universidade de Aveiro, Portugal
2007 - 2018 Invited Professor in the Ph.D. program GABBA, University of Porto. Teaching Immunology to 1st year PhD students. Immunology (Doutoramento) Universidade do Porto, Portugal
2015 - 2017 Invited Professor, Master in Molecular Therapies, CESPU, Instituto Superior de Ciências da Saúde Norte. Teaching immunology to 1st year master students. Immunology (Mestrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2010 - 2011 Invited Professor, Master in Molecular Therapies, CESPU, Instituto Superior de Ciências da Saúde Norte. Teaching immunology to 1st year master students. Immunology (Mestrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2010 - 2010 Invited Professor, Master in Bioengineer, ICBAS, Porto. Teaching Immunology to 1st year Master students. Immunology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2019 - Current Peer-reviewing for the Scientific Journal Nature Immunology
2019 - Current Peer-reviewing for the Scientific Journal Nature Communications
2018 - Current Peer-reviewing for the Scientific Journal Scientific Reports
2016 - Current Peer-reviewing for the Scientific Journal Journal of Experimental Medicine
2012 - Current Peer-reviewing for the Scientific Journal, Jornal of Immunology
2011 - Current Peer-reviewing for the Scientific Journal European Journal of Immunology
2010 - Current Peer-reviewing for the Scientific Journal Human Immunology
2010 - Current Peer-reviewing for the Scientific Journal Molecular and Cell Biology
2010 - Current Peer-reviewing for the Scientific Journal British Journal of Pharmacology
2009 - Current Peer-reviewing for the Scientific Journal Apoptosis
2009 - Current Peer-reviewing for the Scientific Journal Molecular Cell Research
2008 - Current Peer-reviewing for the Scientific Journal International Immunology
2007 - Current Peer-reviewing for the Scientific Journal Blood
2017 - 2017 Grant peer-reviewing for the Great Ormond Street Hospital Children's Charity UK
2016 - 2016 Grant peer-reviewing for the Arthritis Research UK
2015 - 2015 Grant peer-reviewing for the Welcome Trust
2015 - 2015 Grant peer-reviewing for the Biotechnology and Biological Sciences Research Council Biotechnology and Biological Sciences Research Council, United Kingdom
2013 - 2015 Peer-reviewing for the Scientific Journal Plos One
2014 - 2014 Grant peer-reviewing for the Deutsche Forschungsgemeinschaft
Evaluator
 Deutsche Forschungsgemeinschaft, Germany
2008 - 2011 Peer-reviewing for the Scientific Journal Immunology Letters

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/06/26 JN Newspaper Report participation JN
2021/05/27 Participation in Diário de Notícias Newspaper Report Diário de Notícias
2018/05/05 This report covers the attribution of the Crioestaminal award
2017 This article covers our discoveries on Thymus Biology Jornal de Noticias - National newspaper
2017 This article covers our discoveries on Thymus biology. Diário de Noticias - National Newspaper
2013 Outreach activity describing the discoveries of our laboratory on thymus biology. "Publico" Portuguese National Newspaper

Interview (tv / radio show)

Program Topic
2022/02/18 - Current CNN Portugal News COVID-19 and Vaccines
2022/02/16 - Current CNN Portugal News COVID-19 and Vaccines
2022/02/08 - Current CNN Portugal News COVID-19 and Vaccines
2022/01/14 - Current RTP News COVID-19 and Vaccines
2022/01/04 - Current CNN Portugal News COVID-19 and Vaccines
2021/12/22 - Current Observador Radio Station News COVID-19 and Vaccines
2021/12/16 - Current CNN Portugal News COVID-19 and Vaccines
2021/11/30 - Current Antena 1 Radio Station News COVID-19 and Vaccines
2021/11/29 - Current CNN Portugal News COVID-19 and Vaccines
2021/11/26 - Current RTP3 News COVID-19 and Vaccines
2021/08/27 - Current RTP News COVID-19 and Vaccines and Group Immunity
2021/07/12 - Current Observador Radio Station Program E=mc2 COVID-19 and Vaccines
2021/05/20 - Current Observador Radio Station Program E=mc2 COVID-19 and Vaccines
2018/10/11 - 2018/10/12 90 segundos de ciencia Autoimmunity
2017/12/17 - 2017/12/18 Mentes que Brilham - Porto Canal Autoimmunity

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current European Journal of Immunology Wiley Online Library
2019 - Current Frontiers in Immunology (1664-3224) Frontiers Media SA

Other jury / evaluation

Activity description Institution / Organization
2019 - 2019 PhD Thesis Examiner. Vânia Cardoso, Faculdade de Medicina, Univ. Lisboa, January 2019 Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2018 PhD Thesis Examiner. Kerstin Wendland, Lund University, September 2018. Lunds Universitet, Sweden
2018 - 2018 PhD Thesis Examiner. Marie Pouzolles, Univiversité Montpellier, September 2018 Institut de Génétique Moléculaire Montpellier, France
2018 - 2018 Master Thesis Examiner. Mariana Esteves Ávila, Instituto Superior Técnico, November 2018. Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 PhD Thesis Examiner. Ricardo Miragaia, Univ. Minho, September 2017. Universidade do Minho, Portugal
2017 - 2017 PhD Thesis Examiner. Olaya Lamas Gonzalez, Universidade Santiago de Compostela, February 17 2017 Complejo Hospitalario Universitario de Santiago de Compostela, Spain
2017 - 2017 PhD Thesis Examiner. Bethania Cassani, Faculdade de Medicina, Univ. Lisboa, March 2017. Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2016 PhD Thesis Examiner. Marco Barsanti, Monash University, Australia, November 2016. Monash University, Australia
2016 - 2016 PhD Thesis Examiner. Ana Rita Gomes, ICBAS, Uni. Porto, January 2016 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2015 PhD Thesis Examiner. Francisca Almeida, Faculdade de Medicina, Univ. Lisboa, July 2015. Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2014 Master Thesis Examiner. Ana de Oliveira Rodrigues Amorim, Faculdade de Ciências, Univ. Porto, 2014 Universidade do Porto Faculdade de Ciências, Portugal
2013 - 2013 Master Thesis Examiner. Inês Baldaia, Faculdade de Ciências, Univ. Porto, November 2013. Universidade do Porto Faculdade de Ciências, Portugal
2012 - 2012 PhD Thesis Examiner. Ricardo Sousa Paiva, Univ. Nova Lisboa ITQB, October 2012. Universidade Nova de Lisboa, Portugal
2012 - 2012 PhD Thesis Examiner Ana de Barros, Faculdade de Medicina, Univ. Lisboa, February 2012. Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - 2012 Master Thesis Examiner. José Pedro Alves Quintanilha, ICBAS/Faculdade de Engenharia, 2012 Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2011 Master Thesis Examiner. Bruno Rodrigues, Escola de Ciências da Saúde, Univ. Minho, July 2011. Universidade do Minho, Portugal
Distinctions

Award

2018 10th Edition Crioestaminal Prize

Other distinction

2018 Individual Call to Scientific Employment Stimulus 2018
Fundação para a Ciência e a Tecnologia, Portugal
2014 Investigator FCT Development Award
2014 ERC Starting Grant
European Commission, Belgium
2009 Post-Doctoral FCT fellowship (Reference: SFRH/BPD/45932/2008) - Contest for individual post-doctoral fellowships 2008 - classification 4,925 (scale 0-5). 1st place on the Scientific Domain: Health Sciences.
Fundação para a Ciência e a Tecnologia, Portugal
2009 Research Grant Ciência 2008 FCT-Portugal
Fundação para a Ciência e a Tecnologia, Portugal
2007 First Prize AMC thesis award
2007 Cum laude distinction on the PhD thesis.
Universiteit van Amsterdam, Netherlands
2007 Post-Doctoral Long-Term fellowship (Reference: ALTF 630-2006).
2000 GABBA PhD fellowship. FCT- Portugal - SFR/B/2740/2000.