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I obtained my PhD in Biology in 2015, at the University of Coimbra. My research concerned the molecular mechanisms of Machado-Joseph disease (MJD), and was developed at the Centre for Neuroscience and Cell Biology (CNC), at Professor Ana Luisa Carvalho's lab, dedicated to basic neuroscience. Drawing from the expertise I earned in the field of polyglutamine (polyQ) diseases and aiming at contributing to the development of advanced therapies for MJD, in 2016 I joined Professor Luís Almeida's lab (CNC) as a post-doc. In his lab my researched focused on applying gene editing-based silencing and correction to MJD therapy. During that period I specialized in the CRISPR system, having attended a competitive EMBO course on genome engineering at the Max Planck Institute (Dresden, Germany). In 2019, I moved to the University of Algarve (UAlg), where I was hired as a Contracted Researcher at the lab of Professor Clévio Nóbrega. The lab is dedicated to research on MJD, spinocerebellear ataxia type 2 (SCA2) and Cockayne syndrome (CS), and aims at developing advanced therapies for these diseases. I am currently involved in developing and testing new gene therapies for SCA2 and CS. I have published a total of 19 papers in international journals, 13 in the last 5 years. I have co-authored (and fully illustrated) a book, the Handbook of Gene and Cell Therapy, and I am also author of 2 book chapters on gene therapy. My publications have garnered 527 citations and I have a h-index of 12. In 2019 I was awarded a 15.000 USD seed grant project, as Principal Investigator, by USA's National Ataxia Foundation, and in 2022 I received a 10.000€ grant to explore gene therapy-based approaches to CS. I have been the main supervisor of 4 MSc students, I have co-supervised 5 others, and I am currently (co-)supervising 3 PhD students and 4 BSc students. So far, I have participated in 24 juries of academic degrees. At this point in my career, I am focused on establishing myself as a researcher at UAlg, and at acquiring higher degrees of scientific independence. I am bent on bringing together my background on neuroscience, gene therapy and gene editing in order to better understand, and treat, rare disorders.
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Identification

Personal identification

Full name
Carlos Adriano Albuquerque Andrade de Matos

Citation names

  • Matos, Carlos A

Author identifiers

Ciência ID
DC14-C299-222A
ORCID iD
0000-0002-9019-7569

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Physiology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Human Genetics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Japanese Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1)
Education
Degree Classification
2023/12/21
Concluded
 Integrated Master in Pharmaceutical Sciences (Mestrado)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Antibiotherapy of infections caused by multidrug-resistant Gram-positive cocci" (THESIS/DISSERTATION)
 18
2017
Concluded
 EMBO Practical Course on Mouse Genome Engineering (Outros)
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Germany
2015/02/03
Concluded
 PhD in Biology, speciality of Cell Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Regulation of ataxin-3 by phosphorylation: Relevance for Machado-Joseph disease" (THESIS/DISSERTATION)
 Approved with Distinction and Honors, by unanimity
2014
Concluded
 Laboratory Animal Sciences Course - B Category (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Certified
2010
Concluded
 Science Communication (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009
Concluded
 Master's degree in Molecular Cell Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Post-translational modifications of ataxin-3, the protein involved in Machado-Joseph disease: evidences for phosphorylation and sumoylation" (THESIS/DISSERTATION)
 19
2009
Concluded
 Neurodegenerative Disorders (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007
Concluded
 Bachelor's degree in Biology (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Not applicable" (THESIS/DISSERTATION)
 18
Affiliation

Science

Category
Host institution 		Employer
2019/02/26 - 2022/02/25 Contracted Researcher (Research) Universidade do Algarve, Portugal
Universidade do Algarve, Portugal
2015/02/04 - 2019/01/31 Postdoc (Research) CNC.IBILI, Portugal
2013/10/03 - 2015/09/30 Researcher (Research) CNC.IBILI, Portugal
2008/09/01 - 2008/11/30 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2022/03/04 - Current Invited Assistant Professor (University Teacher) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2019 - 2019 Invited Assistant Professor (University Teacher) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Others

Category
Host institution 		Employer
2009 - 2013 PhD Student Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
CNC.IBILI, Portugal
2007 - 2009 MSc Student Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
CNC.IBILI, Portugal
Projects

Grant

Designation Funders
2019 - Current The role of stress granules in Polyglutamine disease: from pathogenesis to molecular therapy
ALG-01-0145-FEDER-29480
Integration into Research Grant Fellow
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2022/05/05 - 2023/05/05 Cockayne syndrome: pioneer exploration of a gene therapy-based approach to the treatment of a neglected disease
Not applicable
Principal investigator
Algarve Biomedical Center Research Institute, Portugal
 Algarve Biomedical Center
Concluded
2022/05/05 - 2023/05/05 Explore the mechanisms behind neurodegenerative rare disorders - is mitosis on the aetiology of these diseases?
Not applicable
Co-Principal Investigator (Co-PI)
Algarve Biomedical Center Research Institute, Portugal
 Algarve Biomedical Center
Concluded
2019/03/01 - 2020/10/01 Silencing the SCA3-causing gene ATXN3 through CRISPR interference
616430
Principal investigator
CNC.IBILI, Portugal
 National Ataxia Foundation
Concluded
2020 - 2020 Development of a new assay do detect SARS-CoV-2 directly from clinical samples
126_596760136
Researcher
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2019 BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Post-doc Fellow
CNC.IBILI, Portugal
 European Regional Development Fund
Concluded
2016 - 2019 Advanced models of polyglutamine disorders (Huntington's disease, SCA3 and SCA7)
JPCOFUND/0005/2015
Post-doc
CNC.IBILI, Portugal
 Horizon 2020
2016 - 2017 SYNSPREAD - Roles and mechanisms of synuclein and ataxin3 spreading in Parkinson and Machado-Joseph diseases
JPND-CD/0001/2013
Post-doc Fellow
CNC.IBILI, Portugal
 Horizon 2020
Concluded
2015 - 2016 Financiamento Incentivo 2014
Incetivo/SAU/LA0001/2014
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 A novel model for Schizophrenia: defects in stargazing-mediated homeostatic plasticity
PTDC/NEU-NMC/0750/2012
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2014 Regulation by phosphorylation of ataxin-3, the mutated protein in Machado Joseph Disease
PTDC/SAU-NMC/110602/2009
Researcher
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/10/01 - 2013/09/30 ANALYSIS OF SYNAPTIC DYSFUNCTION AND ATAXIN-3 PHOSPHORYLATION IN A MOUSE MODEL OF MACHADO-JOSEPH DISEASE
SFRH/BD/47160/2008
 Fundação para a Ciência e a Tecnologia
Concluded
2008 - 2008 Molecular determinants of ataxin-3 aggregation and toxicity in Machado-Joseph's disease
POCI/SAU-MMO/60156/2004
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/07/01 - 2022/06/30 Blocking neurodegeneration by spreading of gene silencers
PTDC/BTM-SAL/29716/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Nóbrega, Clévio; Mendonça, Liliana; Matos, Carlos A.. A Handbook of Gene and Cell Therapy. Switzerland: Springer International Publishing. 2020.
    Published • 10.1007/978-3-030-41333-0
Book chapter
  1. M. Codêsso, José; A. Matos, Carlos; Nóbrega, Clévio. "RNA Interference Applications for Machado-Joseph Disease". In RNA Therapeutics - History, Design, Manufacturing, and Applications. St. Louis, United States: IntechOpen, 2022.
    Published • 10.5772/intechopen.109261
  2. Matos, Carlos A.; Carmona, Vítor; Vijayakumar, Udaya-Geetha; Lopes, Sara; Albuquerque, Patrícia; Conceição, Mariana; Nobre, Rui Jorge; Nóbrega, Clévio; de Almeida, Luís Pereira. "Gene Therapies for Polyglutamine Diseases". In Advances in Experimental Medicine and Biology, 395-438. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-71779-1_20
Conference abstract
  1. Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Sofia M. Calado; Matos, Carlos A. Corresponding author: Matos, Carlos A. "Generation of a CSB-iPSC disease model as a platform to develop gene therapy approaches for Cockayne Syndrome type B". Paper presented in Meeting of the Portuguese Society of Pharmacology (SPF Meeting), Lisbon, 2024.
    Published
  2. Matos, Carlos A; Conceição, Jaime; Nóbrega, Clévio. "Terapia Génica e Celular: História e inovação no ensino das Ciências Biomédicas na Universidade do Algarve". Paper presented in 3.º Congresso Internacional de História da Ciência no Ensino, Faro, 2023.
    Published
  3. Afonso, Inês T.; Lima, Patrícia; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Ataxin-2 pathological features are altered by the aging process". Paper presented in 25th Annual Meeting of the Portuguese Society of Human Genetics, Porto, 2022.
    Published
  4. Sara Lopes; Miguel Lopes; Rui Nobre; Clévio Nóbrega; Matos, Carlos A; Ana Vasconcelos-Ferreira; Neville Sanjana; et al. "Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), Lisbon, 2021.
    Published
  5. Adriana Marcelo; Ana Rosa; Marta Santos; Benedita Ferreira; Rebekah Koppenol; Matos, Carlos A; Clévio Nóbrega. "Autophagy impairment in spinocerebellar ataxia type 2: first evidences and a potential therapeutic strategy". Paper presented in 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), Lisbon, 2021.
    Published
  6. Ricardo Reis; Rebekah Koppenol; Luís Pereira de Almeida; Matos, Carlos A; Clévio Nóbrega. "Silencing ATXN2 expression using CRISPR/Cas9". Paper presented in 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), Lisbon, 2021.
    Published
  7. Conceição, André; Koppenol, Rebekah; Tomé, Sandra; Carmo-Silva, Sara; Matos, Carlos A; Pereira de Almeida, Luis Fernando Morgado; Nóbrega, Clévio David Rodrigues. "A RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Paper presented in 24th Anual Meeting of Portuguese Human Genetics Society. Proceedings published in Medicine, 2021.
    Published • 10.1097/MD.0000000000023585
  8. André Conceição; Raquel Koppenol; Joana Silva; Ricardo Reis; José Codesso; Sandra Tomé; Sara Carmo-Silva; et al. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Paper presented in 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), Lisbon, 2020.
    Published
Conference paper
  1. Afonso, Inês T.; Koppenol, Rebekah; Conceição, André; Paulino, Rodrigo; Mirapalheta, Lourenzo; Matos, Carlos A; Nóbrega, Clévio. "From the molecular hallmarks to motor behavior: characterization of a new transgenic mouse model for spinocerebellar ataxia type 2". 2023.
Conference poster
  1. Lopes, Sara Monteiro; Miguel M. Lopes; Nobre, Rui Jorge; Vasconcelos-Ferreira, Ana; Pereira, Dina; Fernandes, Ana Rita; Barros, Maria Inês; et al. Corresponding author: Pereira de Almeida, Luis. "Targeting the ATXN3 gene with CRISPR-Cas9 for the therapy of Machado-Joseph disease". Paper presented in 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023.
  2. Conceição, André; Koppenol, Rebekah; Inês Afonso; Paulino, Rodrigo; Mirapalheta, Lourenzo; Matos, Carlos; Nóbrega, Clévio David Rodrigues. "A novel SCA2 transgenic mouse model displays disease-associated phenotype.". Paper presented in FENS Regional Meeting 2023 – Algarve, 2023.
  3. Koppenol, Rebekah; Matos, Carlos A; Afonso-Reis, Ricardo; de Almeida, Luis Pereira; Nóbrega, Clévio David Rodrigues. "Tackling spinocerebellar ataxia type 2: targeting the ATXN2 gene with CRISPR-Cas-based silencing strategies.". Paper presented in FENS Regional Meeting 2023 – Algarve, 2023.
  4. Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Matos, Carlos A; Sofia M. Calado. "Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells.". Paper presented in FENS Regional Meeting 2023 – Algarve, 2023.
  5. Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Matos, Carlos A; Sofia M. Calado. "Neuronal cultures differentiated from patient-derived induced pluripotent stem cells as a novel model of Cockayne syndrome B.". Paper presented in European Neuroscience Conference by Doctoral Students (ENCODS) Meeting 2023, 2023.
  6. Afonso, Inês T.; Koppenol, Rebekah; Conceição, André; Vieira R; Paulino, Rodrigo; Mirapelha, L.; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "From the molecular hallmarks to motor behavior: characterization of a novel transgenic mouse model for Spinocerebellar ataxia type 2". Paper presented in ISN-ESN, 2023.
  7. Rafael G. Costa; Afonso, Inês T.; Afonso-Reis, Ricardo; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "The role of a stress granules' component as a modulator of progerin's expression: a prospective approach to slow down accelerated aging in HGPS cells". Paper presented in Ageing Without Borders 2022, 2022.
  8. Perdigão, PRL; Matos, Carlos A; Lopes, Sara M. ; Fernandes, Ana Rita; Miguel M. Lopes; Conceição, A; Faro, R; et al. "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair.". Paper presented in 26th Annual Portuguese Society of Human Genetics Meeting, 2022.
  9. Perdigão, P; Matos, Carlos A; Lopes, Sara; Fernandes, Ana Rita; Lopes, Miguel; Conceição, André; Faro, Rosario; et al. "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9-mediated correction of ATXN3-CAG expansion". Paper presented in ESGCT 29th Annual Congress, European Society of Gene and Cell Therapy, Edinburgh, 2022, 2022.
  10. Koppenol, Rebekah; Conceição, André; Afonso, Inês T.; Afonso-Reis, Ricardo; Costa, Rafael G; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Motor phenotype characterization of a new transgenic mouse model for Spinocerebellar ataxia type 2.". Paper presented in ABC Days - V National Meeting of the Algarve Biomedical Center, 2022.
  11. Marcelo, Adriana. "Autophagy induction mitigates Spinocerebellar ataxia type 2 disease hallmarks.". Paper presented in Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms, 2022.
  12. Conceição, André. "Expression of G3BP1 reduces neuropathological and motor abnormalities in models of spinocerebeçllar ataxia type 3". Paper presented in Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms, 2022.
  13. Koppenol, Rebekah. "Development of CRISPR-Cas-based strategies for spinocerebellar ataxia type 2.". Paper presented in European Society of Gene and Cell Therapy (ESGCT) 29th congress in collaboration with British Society for Gene and Cell Therapy (BSGCT), 2022.
  14. Koppenol, Rebekah; Conceição, André; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Codêsso, José Miguel; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "G3BP1 expression mitigates pathological phenotype in mouse models different polyglutamine diseases". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  15. Afonso-Reis, Ricardo; Koppenol, Rebekah; Conceição, André; Teixeira, Diogo; Marcelo, Adriana; Tomé, Sandra; Carmo-Silva, Sara; et al. "ASSESSING THE ROLE OF DIFFERENT G3BP1 REGIONS IN THE MITIGATION OF THE PATHOLOGICAL PHENOTYPE IN SCA2 AND SCA3 DISEASE MODELS". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  16. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2021.
  17. "Development of a gene based strategy as a potential therapy for Hutchinson Gilford Progeria Syndrome". Paper presented in Annual International (bio)Medical Students (AIMS) Meeting, 2021.
  18. "Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models". Paper presented in IV Jornadas Algarve Biomedical Center, 2021.
  19. "G3BP1 as a therapeutic target for spinocerebellar ataxias: mitigation of pathological traits in different mouse models". Paper presented in IV Jornadas Algarve Biomedical Center, 2021.
  20. "Is mutant ataxin-2 aggregation modulated by aging?". Paper presented in IV Jornadas Algarve Biomedical Center, 2021.
  21. "Assessing the Role of G3bp1 Domains in the Mitigation of the Pathological Phenotype in SCA2 and SCA3 Disease Models". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  22. "Precise and scarless correction of ATXN3-CAG expansion by CRISPR/Cas9 for the generation of patient-derived MJD isogenic iPSC.". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  23. "From molecular mechanisms to therapy: a new lentiviral mouse model for Spinocerebellar ataxia type 2". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  24. "G3BP1 expression mitigates pathological phenotype in mouse models of different polyglutamine diseases". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  25. "Generation of a novel transgenic mouse model of spinocerebellar ataxia type 2 expressing mutant ATXN2 in cerebellar Purkinje cells". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  26. Brito, David V.C.; Afonso, I; Matos, Carlos A; Hilmar Bading; Nóbrega, Clévio David Rodrigues. "Targeting the NMDAR/TRPM4 complex as a novel therapeutic strategy for polyglutamine spinocerebellar ataxia type 2". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  27. "Impact of aging in neuropathological hallmarks associated with the expression of mutant ATAXIN-2". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  28. Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "Striatal neuropathology in spinocerebellar ataxia type 2: a new lentiviral mouse model". Paper presented in FENS 2020 Virtual Forum, 2020.
  29. Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "A lentiviral genetic mouse model for Spinocerebellar ataxia type 2". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020.
  30. "Silencing ATXN2 expression using CRISPR/Cas9". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2020.
  31. "Autophagy impairment in spinocerebellar ataxia type 2: first evidences and a potential therapeutic strategy". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2020.
  32. Sara Lopes; Matos, Carlos A; André Conceição; Frederico Pena; Miguel Lopes; Rui Nobre; Nóbrega, Clévio; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease". Paper presented in 2019 International Machado-Joseph Research Disease Conference, Washington, 2019.
  33. Sara Lopes; Matos, Carlos A; André Conceição; Frederico Pena; Miguel Lopes; Rui Nobre; Nóbrega, Clévio; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph disease.". Paper presented in 3rd International Ataxia Research Conference (IARC), Washington, DC, USA., 2019.
  34. Matos, Carlos A; André Conceição; Sara Lopes; Luis Pereira de Almeida. "CRISPR-CAS9 as a tool for silencing and correcting ATXN3, the gene causing Machado-Joseph disease.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  35. Matos, Carlos A; André Conceição; Frederico Pena; Sara Lopes; Sónia Duarte; Catarina Miranda; Luís Pereira de Almeida. "Transcriptional repression of mutant human ATNX3 using CRISPR interference mitigates the pathological phenotype of an in vivo Machado-Joseph disease model.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  36. Rebekah Koppenol; Adriana Marcelo; Matos, Carlos A; Sara Carmo-Silva; Luis Pereira de Almeida; Clévio Nóbrega. "On the role of stress granules in autophagy.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  37. Matos, Carlos A. "CYP46A1-gene therapy alleviates Machado-Joseph disease". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  38. Matos, Carlos A. "RNA-binding proteins: new molecular targets for polyglutamine diseases?". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  39. Matos, Carlos A. "CRISPR-Cas9-mediated pre-transcriptional silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model". Paper presented in 22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC, USA, 2019.
  40. Matos, Carlos A. "Ibuprofen improves neuropathology and increases neural progenitors proliferation, synaptic function and neurite growth in Machado-Joseph disease.". Paper presented in 2nd International Ataxia Research Conference (IARC), Pisa, Italy, 2017.
  41. Matos, Carlos A. "TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease". Paper presented in 2nd International Ataxia Research Conference (IARC), Pisa, Italy, 2017.
  42. Matos, Carlos A. "CRISPR-Cas9 as a tool for Machado-Joseph disease treatment and animal model generation". Paper presented in EMBO Practical Course on Mouse Genome Engineering. Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany, 2017.
  43. Matos, Carlos A. "Modulation of catalytic activity and polyQ toxicity by phosphorylation in spinocerebellar ataxia type 3". Paper presented in 5th Ataxia Investigators Meeting, Las Vegas, USA, 2014.
  44. Matos, Carlos A. "Post-translational modifications and polyglutamine diseases: the effects of ataxin-3 phosphorylation". Paper presented in Champalimaud Neuroscience Programme Symposium, Lisbon, Portugal, 2013.
  45. Matos, Carlos A. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Paper presented in XIII Meeting of the Portuguese Society for Neuroscience (SPN), Luso, Portugal, 2013.
  46. Matos, Carlos A. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Paper presented in X Center for Neuroscience and Cell Biology (CNC) Annual Meeting, Cantanhede, Portugal, 2012.
  47. Matos, Carlos A. "Regulation by phosphorylation of ataxin-3, the mutated protein in Machado-Joseph disease". Paper presented in 8th Federation of European Neurosciences (FENS) Forum of Neuroscience, Barcelona, Spain, 2012.
  48. Matos, Carlos A. "Regulation by phosphorylation of ataxin-3, the mutated protein in Machado-Joseph disease". Paper presented in Gordon Research Conference on CAG Triplet Disorders, Luca, Italy, 2011.
Journal article
  1. Brito, D. V. C.; Esteves, F.; Rajado, A. T.; Silva, N.; Andrade, R.; Apolónio, J.; Calado, S.; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". NPJ Aging 9 1 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6.
    10.1038/s41514-023-00120-6
  2. Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David; Binnie, Alexandra; Araújo, Inês M.; Nóbrega, Clévio; Bragança, José; Castelo-Branco, Pedro. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging (2023): http://dx.doi.org/10.18632/aging.204668.
    10.18632/aging.204668
  3. Estevam, Bernardo; Matos, Carlos A; Nóbrega, Clévio. "PolyQ Database - an integrated database on polyglutamine diseases". Database 2023 (2023): http://dx.doi.org/10.1093/database/baad060.
    10.1093/database/baad060
  4. Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vania Palma; Araújo, Inês Maria; et al. "Reprogramming iPSCs to study age-related diseases: models, therapeutics, and clinical trials". (2023): http://hdl.handle.net/10400.1/20141.
    10.1016/j.mad.2023.111854
  5. Koppenol, Rebekah; Conceição, André; Afonso, Inês T; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; et al. "The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits". Brain 146 6 (2022): 2346-2363. http://dx.doi.org/10.1093/brain/awac473.
    10.1093/brain/awac473
  6. Marcelo, Adriana; Matos, Carlos A.; Nóbrega, Clévio. "Autophagy is dysregulated in spinocerebellar ataxia type 2". Autophagy Reports 1 1 (2022): 179-182. http://dx.doi.org/10.1080/27694127.2022.2065603.
    10.1080/27694127.2022.2065603
  7. Afonso, Inês T.; Lima, Patrícia; Conceição, André; Matos, Carlos A; Nóbrega, Clévio. "Mutant Ataxin-2 expression in aged animals aggravates neuropathological features associated with Spinocerebellar Ataxia type 2". (2022): http://hdl.handle.net/10400.1/18390.
    10.3390/ijms231911896
  8. Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V. C.; Costa, Rafael G.; Rosa, Ana; Alves-Cruzeiro, João; et al. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death & Disease 12 12 (2021): http://dx.doi.org/10.1038/s41419-021-04404-1.
    10.1038/s41419-021-04404-1
  9. Adriana Marcelo; Rebekah Koppenol; Luís Pereira de Almeida; Carlos A. Matos; Clévio Nóbrega. "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?". Cell Death & Disease 12 6 (2021): https://doi.org/10.1038/s41419-021-03873-8.
    Open access • Published • 10.1038/s41419-021-03873-8
  10. Nóbrega, Clévio; Conceição, André; Costa, Rafael G.; Koppenol, Rebekah; Sequeira, Raquel L.; Nunes, Ricardo; Carmo-Silva, Sara; et al. "The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease". BMC Research Notes 13 1 (2020): http://dx.doi.org/10.1186/s13104-020-05053-x.
    10.1186/s13104-020-05053-x
  11. Nóbrega, Clévio; Mendonça, Liliana; Marcelo, Adriana; Lamazière, Antonin; Tomé, Sandra; Despres, Gaetan; Matos, Carlos A.; et al. "Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia". Acta Neuropathologica 138 5 (2019): 837-858. http://dx.doi.org/10.1007/s00401-019-02019-7.
    10.1007/s00401-019-02019-7
  12. Mendonça, Liliana S; Nóbrega, Clévio; Tavino, Silvia; Brinkhaus, Maximilian; Matos, Carlos; Tomé, Sandra; Moreira, Ricardo; et al. "Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado–Joseph disease models". Human Molecular Genetics 28 22 (2019): 3691-3703. http://dx.doi.org/10.1093/hmg/ddz097.
    10.1093/hmg/ddz097
  13. Nunes, Catarina; Mestre, Isa; Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Nóbrega, Clévio. "MSGP: the first database of the protein components of the mammalian stress granules". Database 2019 (2019): http://dx.doi.org/10.1093/database/baz031.
    10.1093/database/baz031
  14. Matos, Carlos A.; de Almeida, Luís Pereira; Nóbrega, Clévio. "Machado-Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy". Journal of Neurochemistry 148 1 (2018): 8-28. http://dx.doi.org/10.1111/jnc.14541.
    10.1111/jnc.14541
  15. Marcelo, Adriana; Brito, Filipa; Carmo-Silva, Sara; Matos, Carlos A; Alves-Cruzeiro, João; Vasconcelos-Ferreira, Ana; Koppenol, Rebekah; et al. "Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models". Human Molecular Genetics 28 1 (2018): 51-63. http://dx.doi.org/10.1093/hmg/ddy328.
    10.1093/hmg/ddy328
  16. Matos, C.A.; de Almeida, L.P.; Nóbrega, C.. "Proteolytic cleavage of polyglutamine disease-causing proteins: Revisiting the toxic fragment hypothesis". Current Pharmaceutical Design 23 5 (2017): 753-775. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017122161&partnerID=MN8TOARS.
    10.2174/1381612822666161227121912
  17. Matos CA; Nóbrega C; Louros SR; Almeida B; Ferreiro E; Valero J; Pereira de Almeida L; Macedo-Ribeiro S; Carvalho AL. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.". Journal of Cell Biology (2016): http://europepmc.org/abstract/med/26880203.
    10.1083/jcb.201506025
  18. Almeida B; Abreu IA; Matos CA; Fraga JS; Fernandes S; Macedo MG; Gutiérrez-Gallego R; et al. "SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.". Biochimica et Biophysica Acta - Molecular Basis of Disease (2015): http://europepmc.org/abstract/med/26073430.
    10.1016/j.bbadis.2015.06.010
  19. Matos CA; de Macedo-Ribeiro S; Carvalho AL. "Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph disease.". Progress in Neurobiology (2011): http://europepmc.org/abstract/med/21740957.
    10.1016/j.pneurobio.2011.06.007
Online resource
  1. Estevam, Bernardo; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. A Database for Polyglutamine Diseases. 2023. https://polyq.pt.
  2. Clévio Nóbrega; Catarina Nunes; Isa Mestre; Adriana Marcelo; Rebekah Koppenol; Matos, Carlos A. MSGP Database - Mammalian Stress Granules Proteome. 2018. https://msgp.pt.
Thesis / Dissertation
  1. "Antibiotherapy of infections caused by multidrug-resistant Gram-positive cocci". Master, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2023.
  2. Matos, Carlos A. "Regulation of ataxin-3 by phosphorylation: Relevance for Machado-Joseph disease.". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2015.
  3. Matos, Carlos A. "Post-translational modifications of ataxin-3, the protein involved in Machado-Joseph disease: evidences for phosphorylation and sumoylation.". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009.

Artistic / Performance

Theatre play
  1. 2016. Luz-Livro.
  2. 2016. O Ponto Que Nos Une.
  3. 2015. Atos de Laboratório.
  4. 2015. Luz de Perdição.

Other

Dataset
  1. Matos, Carlos A. NeuroMorpho.Org. http://neuromorpho.org/about.jsp.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/16 Gene therapy - promisses and challenges Universidade Sénior de Loulé
Universidade Sénior de Loulé (Loulé, Portugal)
2024 Generation of a CSB-iPSC disease model as a platform to develop gene therapy approaches for Cockayne Syndrome type B LIV Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2023/11/09 Gene Editing: From reality to fiction "Geneticamente falando" seminar cycle
Sociedade Portuguesa de Genética (SPG) (Portugal)
2023/10/31 Gene Editing - Biological principles and technical bases ESN-ISN Neurochemistry School 2023
Algarve Biomedical Center Research Institute (ABCRI) (Faro, Portugal)
2023/09/05 Gene and Cell Therapy: History and innovation in the teaching of Biomedical Sciences at the University of Algarve 3rd International Congress of History of Science in Teaching
Universidade do Algarve (Faro, Portugal)
2023/07/11 Multiple sclerosis Universidade Sénior de Loulé
Universidade Sénior de Loulé (Loulé, Portugal)
2023 Characterization of a new transgenic mouse model for spinocerebellar ataxia type 2 with 129 glutamine repeats: unraveling neuropathologic and motor phenotype. I FloripaNeuro
Universidade Federal de Santa Catarina (Florianópolis, Brazil)
2023 Novel approaches to the treatment of rare neurodegenerative diseases: development and pre-clinical testing of gene therapies. 44th European Pharmaceutical Students' Associations (EPSA) Annual Congress
European Pharmaceutical Students' Associations (EPSA) (Podcetrtek, Slovenia)
2023 Gene Editing - A new hope for untreatable diseases. 44th European Pharmaceutical Students' Associations (EPSA) Annual Congress
European Pharmaceutical Students' Associations (EPSA) (Podcetrtek, Slovenia)
2023 Invited speech at the “From the reconfiguration of the organic: genomic editing” session of the Public Session of the Portuguese National Ethics Council for the Life Sciences Public Session of the Portuguese National Ethics Council for the Life Sciences
Portuguese National Ethics Council for the Life Sciences (Faro, Portugal)
2023 Gene Therapy - promises and challenges Topics in Biology Applied seminar
University of Algarve (Faro, Portugal)
2023 Is it possible to use viruses to treat diseases? Seminar to middle school students
Escola E.B. 2,3 Dr. Garcia Domingues (Silves, Portugal)
2022/03/03 Será possível usar vírus para tratar doenças? (Is it possible to use virus to treat diseases?) Seminar to middle school students
Escola E.B. 2,3 Dr. Garcia Domingues (Silves, Portugal)
2022 Are the neuropathological features associated with mutant Ataxin-2 expression exacerbated by aging? Aging Without Borders
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Faro, Portugal)
2022 Ataxia espinocerebelosa tipo 2: caracterização de um novo modelo transgénico de murganho com fenótipo neuropatológico e motor. (Spinocerebellar ataxia type 2: characterization of a novel transgenic mouse model with a neuropathological and motor phenotype) Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms
Meeting of the Portuguese Society of Movement Disorders (SPDMov) (Luso, Portugal)
2022 Upregulation of autophagy as a therapeutic strategy for spinocerebellar ataxia type 2. XLXII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2022 The stress granule protein G3BP1 reverts pathological defects in two diferent polyglutamine diseases. XLXII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2022 ATXN2 knockdown through CRISPR-Cas-based strategies: a therapeutic approach for spinocerebellar ataxia type 2? XLXII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2022 Hereditary ataxias caused by repeat expansion mutations: The special case of Machado-Joseph disease Expression and Pathology seminar lectured to the students of the MSc degree in Molecular and Microbial Biology
Universidade do Algarve Faculdade de Ciências e Tecnologia (Faro, Portugal)
2022 Gene Therapy - promises and challenges Topics in Applied Biology seminar
University of Algarve (Faro, Portugal)
2022 Is it possible to use viruses to treat diseases? Seminar to middle school students
Escola E.B. 2,3 Dr. Garcia Domingues (Silves, Portugal)
2022 The brain and time XII National Journey of Biomedical Sciences 2022
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas (Faro, Portugal)
2021/10/08 Terapia génica: da promessa à realidade (Gene therapy: from promise to reality) IV Jornadas Algarve Biomedical Center
Algarve Biomedical Center (Moura, Portugal)
2021/05/28 CRISPR-based therapies - from fiction to fact The CRISPR Revolution: a workshop in gene editing, from cells to animal models
University of Algarve (Faro, Portugal)
2021/05/24 Gene Editing - Biological principals and technical bases The CRISPR Revolution: a workshop in gene editing, from cells to animal models
University of Algarve (Faro, Portugal)
2021/05/24 The CRISPR toolbox The CRISPR Revolution: a workshop in gene editing, from cells to animal models
University of Algarve (Faro, Portugal)
2021 RBP-X protein mitigates disease traits in different mice models of polyglutamine diseases XLXI Meeting
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021 The CRISPR system – Biologic bases, technical perspectives and applications Experimental Techniques seminar
University of Algarve (Faro, Portugal)
2021 Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models XLXI Meeting
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021 CRISPR/Cas9-mediated silencing of ATXN2 expression XLXI Meeting
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021 Autophagy dysfunction in spinocerebellar ataxia type 2 models and a potential therapeutic strategy XLXI Meeting
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021 Mutant ataxin-2 pathological features is altered by the aging process 25th Annual Meeting of the Portuguese Society of Human Genetics (SPGH)
Portuguese Society of Human Genetics (SPGH) (Porto, Portugal)
2021 The RNA-binding Protein X Mitigates Common Age-associated Features in Progerin-expressing Cells IV Jornadas Algarve Biomedical Center
Algarve Biomedical Center (Moura, Portugal)
2021 Gene Therapy - promises and challenges Topics in Applied Biology seminar
University of Algarve (Faro, Portugal)
2021 CRISPR-mediated gene silencing in the treatment of Machado-Joseph disease Eukaryotic Molecular Genetics seminar
University of Algarve (Faro, Portugal)
2021 When RNA-binding proteins meet the Hutchinson-Gilford Progeria syndrome: a gene delivery approach to mitigate premature aging. International Health Sciences Conference 2021
(Kaunas, Lithuania)
2020 CRISPR-mediated silencing of mutant ataxin-3 ameliorates motor symptoms of a Machado-Joseph disease model in vivo. XLX Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2020 Stress granules crosstalk with autophagy in a context of polyglutamine diseases. XLX Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2020 RNA-binding proteins as potential therapeutic targets for polyglutamine diseases. XLX Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2020 Gene Therapy – promises and challenges Topics in Applied Biology seminar
University of Algarve (Faro, Portugal)
2020 Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease 24th Annual Meeting
Portuguese Society for Human Genetics (SPGH) (Lisbon, Portugal)
2020 Stress granules dynamics in polyglutamine diseases International Meeting of the Portuguese Society of Genetics
Portuguese Society of Genetics (Faro, Portugal)
2019 CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease 2019 International Machado-Joseph Research Disease Conference
The Israeli Machado - Joseph (MJD) Association (Washington, United States)
2019 CYP46A1-gene therapy improves Machado-Joseph disease in mouse models. 23rd Annual Meeting of the Portuguese Society of Human Genetics (SPGH)
Portuguese Society of Human Genetics (SPGH) (Coimbra, Portugal)
2019 Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease. XVI Meeting of the Portuguese Society for Neuroscience (SPN)
Portuguese Society for Neuroscience (SPN) (Lisbon, Portugal)
2019 CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019 CRISPR as a tool for Machado-Joseph disease therapy. Distinguished Seminars, Center for Biomedical Research – CBMR
Center for Biomedical Research – CBMR, University of Algarve (Faro, Portugal)
2019 CRISPR as a tool for Machado-Joseph disease therapy. Seminar session
University of Algarve (Faro, Portugal)
2019 Gene correction and disease models. Pharmaceutical Biotechnology class
University of Coimbra (Coimbra, Portugal)
2019 Cell cultures in neurodegenerative diseases investigation Animal Cell Culture Technology seminar
University of Algarve (Faro, Portugal)
2019 Ataxin-3 phosphorylation as a neuroprotective mechanism in the context of Machado-Joseph disease Neurobiology seminar
University of Algarve (Faro, Portugal)
2019 Development and characterization of a lentiviral mouse model for spinocerebellar ataxia type 2 3rd Meeting
Algarve Biomedical Center (Albufeira, Portugal)
2018 CRISPR-Cas9-mediated pre- transcriptional silencing of mutant ataxin-3. XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia (SPF) (Lisbon, Portugal)
2018 Tailoring gene editing strategies for the treatment of Machado-Joseph disease. Portuguese Society of Movement Disorders (SPDMov) Congress
Portuguese Society of Movement Disorders (SPDMov) (Curia, Portugal)
2018 Ibuprofen decreases neuroinflammation and improves neuropathology and motor impairments in Machado-Joseph disease. XLVIII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2018 Gene editing in the treatment of neurodegenerative diseases. Meet.Lab Coimbra Symposium
Núcleo de Estudantes de Biologia da Associação Académica da Universidade de Coimbra (NEBAAC) (Coimbra, Portugal)
2018 CRISPR-Cas9 in MJD treatment and disease model generation MIT Portugal Doctoral Programme in Bioengineering Systems class
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2018 Gene editing strategies in gene therapy Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) class
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2018 Genome Editing: nuclease-based approaches Molecular Cell Biology class
University of Coimbra (Coimbra, Portugal)
2018 CYP46A1-gene therapy alleviates spinocerebellar ataxia in mouse models Congress
European Society of Gene and Cell Therapy (ESGCT) (Lausanne, Switzerland)
2017 TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease. 2nd International Ataxia Research Conference (IARC)
FARA, Ataxia UK, fara Australia and Gofar (Pisa, Italy)
2017 Pre-transcriptional silencing of ataxin-3 using a CRISPR-Cas9-derived system. Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2017 Gene editing strategies for Machado-Joseph disease. XLVII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2017 Ibuprofen reduces neuroinflammation and neuropathology in Machado-Joseph disease. XLVII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2017 CRISPR-Cas9 as a tool for Disease Model Generation MIT Portugal Doctoral Programme in Bioengineering Systems class
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2016 Phosphorylation of ataxin-3 decreases neuronal defects in Machado-Joseph disease models. XLVI Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2016 Modulating polyglutamine toxicity through phosphorylation: the example of ataxin-3, the protein involved in Machado-Joseph disease. CNC.IBILI Seminar
CNC.IBILI (Coimbra, Portugal)
2016 Modulating polyglutamine toxicity through phosphorylation: the example of ataxin-3, the protein involved in Machado-Joseph disease Seminar
Center for Neuroscience and Cell Biology
2016 Nuclease-based genome editing technologies Doctoral Programme in Experimental Biology and Biomedicine (PDBEB)
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2016 Gene Editing – Molecular bases, technical perspectives and applications Gene Therapy seminar
University of Algarve (Faro, Portugal)
2014 Protein phosphorylation as a toxicity modulator in Machado-Joseph disease. XVIII Congress of the Portuguese Biochemical Society (SPB)
Portuguese Biochemical Society (SPB) (Coimbra, Portugal)
2014 Protein phosphorylation as a modulator in Machado-Joseph disease. 5th Anniversary of the Department of Life Sciences
Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra (Coimbra, Portugal)
2013 Ataxin-3 phosphorylation: effects on polyglutamine toxicity mechanisms involved in Machado-Joseph disease. XI Center for Neuroscience and Cell Biology (CNC) Annual Meeting
CNC.IBILI (Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Evaluation of the expression of human ERCC6 protein in mice upon AAV-mediated delivery
Supervisor of Carolina Martinheira
 Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Current Utilization of riluzole, a modulator of glutamatergic neurotransmission indicated in the treatment of amyotrophic lateral sclerosis, as a potential therapeutic agent in the context of other neurodegenerative diseases
Supervisor of Raquel Loureiro
 Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/09/01 - Current Disease spreading in spinocerebellar ataxia type 2: from pathogenic mechanisms to targeted therapeutics
Co-supervisor of Rafael Gomes Costa
 Ciências Biomédicas (PhD)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - Current Connecting mutant Ataxin-2 and synaptic disfunction: are stress granules the link?
Co-supervisor of André Filipe Vieira Conceição
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2019 - Current Targeting the ATXN2 gene with the CRISPR-Cas9 system as a therapeutic strategy for spinocerebellar ataxia type 2
Co-supervisor of Rebekah Koppenol
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2023 - 2024 Mechanisms of intercellular dissemination of ataxin-2 mRNA: impact of RNA-binding proteins and extracellular vesicles
Supervisor of Isabelli Mendes Hombri
 Biology (Degree)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2022 - 2023 Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells
Supervisor of Cristiana Raquel Rodrigues Madeira
 Ciências Biomédicas - Mecanismos de Doenças (Master)
Universidade do Algarve, Portugal
2021 - 2022/11/28 PolyQ Database - A polyglutamine disease database
Co-supervisor of Bernardo Alexandre Encarnação Estevam
 Ciências Biomédicas - Mecanismos de Doença (Master)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022 Evaluation of the levels of aneuploidy in fibroblasts from an individual with spinocerebellar ataxia type 3 caused by polyglutamine expansion
Supervisor of Júlia Pereira Gonçalves
 Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022 Assessing the neuropathologic profile and the motor phenotype of a novel spinocerebellar ataxia type 2 mouse model with severe human ATXN2 expression
Supervisor of João Paulo Viegas Amaro
 Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022 Development of ATXN2 gene silencing strategies based on the CRISPR-Cas gene editing system
Supervisor of Erica Goufa Coelho
 Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022 Assessing the motor phenotype and the neuropathologic profile of a novel spinocerebellar ataxia type 2 mouse model with moderate human ATXN2 expression
Supervisor of Andreia Sofia de Sá Barreira Cordeiro
 Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - 2021/11/26 Insights into the spreading of ataxin-2 through extracellular vesicles
Co-supervisor of Rafael Gomes Costa
 Ciências Biomédicas - Mecanismos de Doença (Master)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - 2021 Silencing of the mutant form of the ATXN2 gene as a putative therapeutic strategy for spinocdrebllar ataxia type 2
Supervisor of Catarina Barbosa
 Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - 2021 Assessing CRISPR/Cas9-mediated insertion of an indel mutation in the ATXN2 gene
Supervisor of Raquel Costa
 Ciências Biomédicas (Degree)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2019 - 2020 Silencing ATXN2 through CRISPR-mediated insertion of a premature STOP codon
Supervisor of Ricardo Reis
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2019 - 2020 A comparative study on the function and activity of ZEB transcription factors in glioblastoma.
Co-supervisor of Nuno Ramalho
 Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2019 - 2019 Modelling cholesterol metabolism in the hypothalamus and its impact on white adipose tissue
Co-supervisor of Joana Filipa Rolo
 Ciências Biomédicas (Degree)
Universidade do Algarve, Portugal
2018 - 2019 CRISPR-Cas9 as a tool for gene therapy in Machado-Joseph disease: silencing ATXN3 and CAG expansion correction
Supervisor of André Filipe Vieira da Conceição
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019 Insights into the role of GXXXX on Polyglutamine diseases
Co-supervisor of Diogo Teixeira
 Biologia Molecular e Microbiana (Master)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018 CRISPR-mediated pre-transcriptional silencing of ATXN3, the gene involved in Machado-Joseph disease
Supervisor of Frederico Mendes e Pena
 Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 Development of a cellular model for Amyotrophic Lateral Sclerosis (ALS)
Supervisor of Rebekah Koppenol
 Ciências Biomédicas (Degree)
Universidade do Algarve, Portugal
2012 - 2012 Role of atx-3 aggregation and phosphorylation in the pathogenesis of MJD
Supervisor of Marilisa Vigorita
 Pharmacologic Basis of Therapy (Master)
Università degli Studi del Sannio, Italy

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/10/29 - 2023/11/04 ESN-ISN Neurochemistry School 2023 (2023/10/29 - 2023/11/04)
Other (Co-organisor)
 Algarve Biomedical Center Research Institute, Portugal
2023/05/05 - 2023/05/05 "Advances in Polyglutamine diseases research", a scientific symposium of FENS Regional Meeting 2023 - Algarve. Albufeira, Portugal. (2023/05/05 - 2023/05/05)
Symposium (Co-organisor)
 Algarve Biomedical Center Research Institute, Portugal
2023 - 2023 3rd International Congress of History of Science in Teaching (3.º Congresso Internacional de História da Ciência no Ensino) (2023/09/04 - 2023/09/06)
Congress (Member of the Organising Committee)
 Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2022 - 2023 FENS Regional Meeting 2023 (2022 - 2023)
Meeting (Member of the Organising Committee)
 Universidade do Algarve, Portugal
2022 - 2022 Ageing without borders - Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (2022 - 2022)
Meeting (Member of the Organising Committee)
 Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal

Algarve Biomedical Center Research Institute, Portugal
2022 - 2022 ABC Days - V National Meeting of the Algarve Biomedical Center. Sagres, Portugal. (2022 - 2022)
Meeting (Member of the Organising Committee)
 Algarve Biomedical Center, Portugal
2021 - 2022 Fala-me NEURO (Talk NEURO to me) science communication initiative (2021 - 2022)
Other (Co-organisor)
 Sociedade Portuguesa de Neurociências, Portugal
2021/05/24 - 2021/05/28 The CRISPR Revolution: a workshop on gene editing, from cells to animal models (2021/05/24 - 2021/05/28)
Workshop (Co-organisor)
 Universidade do Algarve, Portugal
2018 - 2018 "Overcoming Challenges in Scientific Careers ", a symposium on career development for PhD students and PhD holders (2018 - 2018)
Symposium (Member of the Organising Committee)
 CNC.IBILI, Portugal
2018 - 2018 “Me in the spotlight: self-presentation for networking and career development”, a workshop on career development for PhD students and PhD holders (2018 - 2018)
Workshop (Member of the Organising Committee)
 CNC.IBILI, Portugal
2018 - 2018 “Finishing the PhD: how to turn anxiety into an actionable plan?”, a workshop on career development for PhD students and PhD holders (2018 - 2018)
Workshop (Member of the Organising Committee)
 CNC.IBILI, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/02/07 - 2024/02/09 LIV Meeting of the Portuguese Society of Pharmacology (SPF)
Meeting
 LIV Meeting of the Portuguese Society of Pharmacology (SPF)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/12/19 - 2023/12/20 Biomedical Sciences PhD Program Annual Journey
Meeting
 Biomedical Sciences PhD Program Annual Journey
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/11/17 - 2023/11/17 5ª Edition of Doctoral Conversations: "Evolution of Humanity and Environmental Adaptations"
Meeting
 5ª Edition of Doctoral Conversations: "Evolution of Humanity and Environmental Adaptations"
Universidade do Algarve, Portugal
2023/05/03 - 2023/05/05 FENS Regional Meeting 2023 - Algarve
Meeting
 FENS Regional Meeting 2023 – Algarve
Algarve Biomedical Center Research Institute, Portugal
2023/02/17 - 2023/02/17 Round table discussion under the subject "From the reconfiguration of the organic: genomic editing"
Round table
 Public Session of the Portuguese National Ethics Council for the Life Sciences
Conselho Nacional de Ética para as Ciências da Vida, Portugal
2023/02/17 - 2023/02/17 Public Session of the Portuguese National Ethics Council for the Life Sciences , as part of the Report on the State of the Application of New Technologies to Human Life 2022 “Dysruptive Health Technologies”. Faro, Portugal.
Conference
 Public Session of the Portuguese National Ethics Council for the Life Sciences , as part of the Report on the State of the Application of New Technologies to Human Life 2022 “Dysruptive Health Technologies”
Conselho Nacional de Ética para as Ciências da Vida, Portugal
2023 - 2023 44th European Pharmaceutical Students' Associations (EPSA) Annual Congress, Podcetrtek, Slovenia
Congress
 44th European Pharmaceutical Students' Associations (EPSA) Annual Congress
2023 - 2023 MEEting 2023, Faro, Portugal.
Meeting
 MEEting 2023
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - 2023 Open Day of the University of Algarve
Other
 Open Day of the University of Algarve
Universidade do Algarve, Portugal
2023 - 2023 3rd International Congress of History of Science in Teaching
Congress
 3rd International Congress of History of Science in Teaching
Universidade do Algarve, Portugal
2022/12/19 - 2022/12/20 Biomedical Sciences PhD Program Annual Journey
Meeting
 Biomedical Sciences PhD Program Annual Journey
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022 Round table discussion on the role of research in the access to a directed therapy
Round table
 National Ataxias Congress
Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2022 - 2022 Meeting of the Portuguese Society of Movement Disorders (SPDMov) - Classical and Atypical Parkinsonisms
Meeting
 Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms
Sociedade Portuguesa das Doenças do Movimento, Portugal
2022 - 2022 Moderation of seminar sessions of the ABC-RI International Forum Spring Edition 2022 – Gene and Cell Therapies for Healthy Ageing
Symposium
 ABC-RI International Forum Spring Edition 2022 – Gene and Cell Therapies for Healthy Ageing
Algarve Biomedical Center Research Institute, Portugal
2022 - 2022 Ageing without borders - Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
Meeting
 Ageing without borders - Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal

Algarve Biomedical Center Research Institute, Portugal
2022 - 2022 ABC Days - V National Meeting of the Algarve Biomedical Center. Sagres, Portugal.
Meeting
 ABC Days - V National Meeting of the Algarve Biomedical Center
Algarve Biomedical Center, Portugal
2022 - 2022 I National Ataxias Congress
Meeting
 I National Ataxias Congress
Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2022 - 2022 MEEting 2022, Faro, Portugal
Meeting
 MEEting 2022
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022 FIC.A (Festival Internacional de Ciência, International Science Festival), Oeiras, Portugal
Exhibition
 FIC.A (Festival Internacional de Ciência, International Science Festival)
2021/12 - 2021/12 XVII Meeting of the Portuguese Society for Neuroscience (SPN)
Meeting
 XVII Meeting of the Portuguese Society for Neuroscience (SPN)
Sociedade Portuguesa de Neurociências, Portugal
2021/12 - 2021/12 Biomedical Sciences PhD Program Annual Journey
Meeting
 Biomedical Sciences PhD Program Annual Journey
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021/10 - 2021/10 IV Jornadas Algarve Biomedical Center
Meeting
 IV Jornadas Algarve Biomedical Center
Algarve Biomedical Center, Portugal
2021/05/24 - 2021/05/28 The CRISPR Revolution: a workshop on gene editing, from cells to animal models.
Workshop
 The CRISPR Revolution: a workshop on gene editing, from cells to animal models
Universidade do Algarve, Portugal
2021/04/26 - 2021/04/27 JCB–JEM 2021 Symposium on Neurodegeneration
Symposium
 JCB–JEM 2021 Symposium on Neurodegeneration
The Rockefeller University Press, United States
2021 - 2021 XLXI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Lisbon, Portugal.
Conference
 XLXI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia, Portugal
2021 - 2021 Ataxias, um mundo - Avanços no desenvolvimento de novas terapias (Ataxias - Advances in the development of novel therapies)
Meeting
Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2020 - 2020 XLX Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Coimbra, Portugal.
Conference
 XLX Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia, Portugal
2019 - 2019 XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal
Conference
 XVI Meeting of the Portuguese Society for Neuroscience (SPN)
Sociedade Portuguesa de Neurociências, Portugal
2019 - 2019 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI). Coimbra, Portugal.
Conference
 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation, Netherlands
2019 - 2019 3as Jornadas Algarve Biomedical Center. Albufeira, Portugal.
Conference
 3as Jornadas Algarve Biomedical Center
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2018 - 2018 XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Lisbon, Portugal.
Congress
 XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF).
Sociedade Portuguesa de Farmacologia, Portugal
2018 - 2018 Workshop "Visual Communication Graphical abstracts". PostDocs@UC, University of Coimbra, Coimbra, Portugal.
Workshop
 Visual Communication Graphical abstracts
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - 2017 XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Coimbra, Portugal.
Conference
 XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia, Portugal
2017 - 2017 EMBO Practical Course on Mouse Genome Engineering. Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany.
Other
 EMBO Practical Course on Mouse Genome Engineering
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Germany
2016 - 2016 10th World Congress on Controversies in Neurology (CONy) – Workshop in Machado-Joseph disease
Workshop
 10th World Congress on Controversies in Neurology (CONy) – Workshop in Machado-Joseph disease
2016 - 2016 XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Porto, Portugal
Conference
 XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia, Portugal
2016 - 2016 1st Brain without Borders International Symposium. Coimbra, Portugal.
Symposium
 1st Brain without Borders International Symposium
CNC.IBILI, Portugal
2015/05/28 - 2015/05/28 Integration of PhD holders in Companies: Challenges and Solutions for the Future (Integração de Doutorados nas Empresas: Desafios e Soluções para o Futuro)
Symposium
 Integração de Doutorados nas Empresas: Desafios e Soluções para o Futuro
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015 - 2015 Ineo start – technology transfer and business plan acceleration program. Instituto Pedro Nunes (IPN), Coimbra, Portugal.
Other
 Ineo start – technology transfer and business plan acceleration program
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2015 - 2015 Workshop "CRISPR Tools in Genetically Tractable Organisms". Fundação Champalimaud, Lisboa, Portugal.
Workshop
 CRISPR Tools in Genetically Tractable Organisms
Fundação Champalimaud, Portugal
2014 - 2014 XVIII Congress of the Portuguese Biochemical Society (SPB). Coimbra, Portugal.
Congress
 XVIII Congress of the Portuguese Biochemical Society (SPB)
Sociedade Portuguesa de Bioquímica, Portugal
2014 - 2014 5th Ataxia Investigators Meeting. Las Vegas, USA.
Conference
 5th Ataxia Investigators Meeting
National Ataxia Foundation, United States
2014 - 2014 Laboratory Animal Sciences Course - B Category. Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Other
 aboratory Animal Sciences Course - B Category
CNC.IBILI, Portugal
2013 - 2013 Champalimaud Neuroscience Programme Symposium. Lisbon, Portugal.
Symposium
 Champalimaud Neuroscience Programme Symposium
Programa Champalimaud de Neurociências, Portugal
2013 - 2013 XIII Meeting of the Portuguese Society for Neuroscience (SPN), Luso, Portugal.
Conference
 XIII Meeting of the Portuguese Society for Neuroscience (SPN)
Sociedade Portuguesa de Neurociências, Portugal
2013 - 2013 XI Center for Neuroscience and Cell Biology (CNC) Annual Meeting, Coimbra, Portugal.
Meeting
 XI Center for Neuroscience and Cell Biology (CNC) Annual Meeting
CNC.IBILI, Portugal
2013 - 2013 Workshop "The nematode C. elegans – a model for biomedical research". Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal.
Workshop
 The nematode C. elegans – a model for biomedical research
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012 - 2012 8th Federation of European Neurosciences (FENS) Forum of Neuroscience, Barcelona, Spain.
Conference
 8th Federation of European Neurosciences (FENS) Forum of Neuroscience
Federation of European Neuroscience Societies, Belgium
2012 - 2012 1st Doctoral Programme in Experimental Biology and Biomedicine (BEB) Symposium – Science dreams, challenges arise, Coimbra, Portugal
Symposium
 1st Doctoral Programme in Experimental Biology and Biomedicine (BEB) Symposium – Science dreams, challenges arise
CNC.IBILI, Portugal
2012 - 2012 X Center for Neuroscience and Cell Biology (CNC) Annual Meeting, Cantanhede, Portugal.
Meeting
 X Center for Neuroscience and Cell Biology (CNC) Annual Meeting
CNC.IBILI, Portugal
2011 - 2011 Gordon Research Conference on CAG Triplet Disorders, Luca, Italy. Gordon Research Conference on CAG Triplet Disorders
Gordon Research Conferences, United States

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/15 Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells
Supervisor
 Cristiana Raquel Rodrigues Madeira (Master)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/12/05 Modelling aging in vitro using stem cells-derived cells
(Thesis) Main arguer
 Pedro Miguel Canada de Sousa (Master)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/07/27 A robust study on the Ataxin-3 fibrillization pathway for the discovery of new inhibitory compounds Francisco Rosário de Figueiredo (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/04/22 Establishing the relevance of Tau isoform imbalance in the onset and progression of Machado Joseph disease
(Thesis) Main arguer
 Beatriz Rocha Ferreira (Master)
Universidade do Minho, Portugal
2022 Intracerebral cerebrovascular calcifications as an etiological and prognosis biomarker in ischemic stroke: an exploratory study
(Thesis) Main arguer
 Adriana Filipa Batista Barros (Other)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 Study of the functional parameters of the autonomous nervous system in migraine patients
(Thesis) Main arguer
 Matilde Oliveira Farias (Other)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 Cervical cancer: what is the utility of p16 and other biomarkers in the diagnosis?
(Thesis) Main arguer
 Sara Guapo de Almeida Boom (Other)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 Animal models of Down's syndrome; applications and limitation in the study of the nervous system
(Thesis) Arguer
 Sofia Isabel Gonçalves Fernandes (Other)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 qPCR validation of genes differentially expressed in embryonic stem cells in response to decreased Cited2 expression
(Thesis) Arguer
 Filipe Vitorino (Other)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 Silencing ATXN2 through CRISPR-mediated insertion of a premature STOP codon
Supervisor
 Ricardo Reis (Master)
Universidade do Algarve, Portugal
2020 Non-codifying RNA molecules in the temporal control of embryonic development
(Thesis) Arguer
 André Filipe Coelho de Jesus (Other)
Universidade do Algarve, Portugal
2020 Synaptic Plasticity: What changes in the Aging Brain?
(Thesis) Arguer
 Inês Alexandre Couto de Almeida (Other)
Universidade do Algarve, Portugal
2020 Utilizing the dominant negative technique in the analysis of molecular and behavioural changes in the study of atypical Rett syndrome in zebra-fish
(Thesis) Arguer
 Pedro Miguel Xabregas Moreno dos Santos (Other)
Universidade do Algarve, Portugal
2020 Development of the microglia and autism
(Thesis) Arguer
 Beatriz Passos Paulo (Other)
Universidade do Algarve, Portugal
2020 Development of a lineage tracing strategy for the evaluation of substantia nigra regeneration in a Acomys cahirinus model of Parkinson’s disease
(Thesis) Arguer
 Giulia Fest Donnici (Other)
Universidade do Algarve, Portugal
2020 Complementary approaches to the treatment of chronic pain: acupuncture and mindfulness
(Thesis) Arguer
 Vera Mascarenhas (Other)
Universidade do Algarve, Portugal
2019 CRISPR-Cas9 as a tool for gene therapy in Machado-Joseph disease: silencing ATXN3 and CAG expansion correction
Supervisor
 André Filipe Vieira Conceição (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 Utilizing bacteriophages as a means to tackle bacterial infections
(Thesis) Arguer
 Diana Sofia Carvalho Varela (Other)
Universidade do Algarve, Portugal
2019 Development of a MCT8 gene knockout model using the CRISPR/Cas9 technology
(Thesis) Arguer
 Vanda Salgueiro Evaristo (Other)
Universidade do Algarve, Portugal
2018 Multiplexed CRISPR activation of neuroprotective genes for Alzheimer´s Disease
(Thesis) Main arguer
 Fábio Duarte (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 CRISPR-mediated pre-transcriptional silencing of ATXN3, the gene involved in Machado-Joseph disease
Supervisor
 Frederico Mendes e Pena (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 Gene therapy for Huntington’s disease: molecular activation of autophagy
(Thesis) Arguer
 Ricardo Nunes (Other)
Universidade do Algarve, Portugal
2018 Identification of neuronal cells dependent on thyroid hormones
(Thesis) Arguer
 Ana Rita Martins Luz (Other)
Universidade do Algarve, Portugal
2018 Molecular activation of the autophagic pathway in Polyglutamine diseases
(Thesis) Arguer
 Raquel Lourenço das Neves Sequeira (Other)
Universidade do Algarve, Portugal

Association member

Society Organization name Role
2024/02/09 - Current Ordem dos Farmacêuticos (Portuguese Order of Pharmacists) Effective member
2022 - Current Ataxia Global Initiative Effective member
2020 - Current Portuguese Society of Pharmacology (SPF) Effective member
2013 - Current Portuguese Society of Neuroscience (SPF) Effective member
2013 - Current Federation of European Neuroscience Societies (FENS) Effective member

Committee member

Activity description
Role 		Institution / Organization
2023 - Current Member of the Course Committee of the PhD Program in Biomedical Sciences
Member
 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - Current Member of the Scientific Council of the Algarve Biomedical Center Research Institute (ABC-RI)
Member
 Algarve Biomedical Center Research Institute, Portugal
2019 - 2021 Member of the Scientific Council of the Centre for Biomedical Research (CBMR)
Member
 Universidade do Algarve, Portugal
2017 - 2019 Elected member of the CNC.IBILI PostDoc representatives committee
Member
 CNC.IBILI, Portugal

Conference scientific committee

Conference name Conference host
2024 - Current XIX Congress of the Portuguese Society of Diagnostic and Therapeutic Neurorradiology Universidade do Algarve

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023 - Current Fundamentals of Bioinformatics Ciências Biomédicas (Licenciatura) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Current Scientific Methods Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Current Anatomophysiology I Ciências Farmacêuticas (Mestrado integrado) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - Current Basic and Clinical Sciences Medicina (Mestrado integrado) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Current Anatomy and Physiology Bioengenharia (Licenciatura) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - Current Applications in Histology Ciências Biomédicas (Licenciatura) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - Current Molecular and Cellular Mechanisms Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve, Portugal
2023 - Current Advances in Gene Therapies Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve, Portugal
2023 - Current Development of New Medicines Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve, Portugal
2023 - Current Anti-Cancer Drug Discovery Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado integrado) Universidade do Algarve, Portugal
2022 - Current Practicals of Molecular Research Ciências Biomédicas (Licenciatura) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021 - Current OncoLab 2 Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado integrado) Universidade do Algarve, Portugal
2020 - Current Neurobiology Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2020 - Current Animal Models in Biomedical Research Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2020 - Current Functional Organic Systems 301 - Nervous System And Special Senses Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2019 - Current Gene and Cell Therapy Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2018 - 2023 Advanced Systems of Gene and Cell Therapy Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve, Portugal
2014 - 2018 Do Gene à Proteína (From Gene to Protein). Theoretical and practical teaching of molecular cell biology techniques to high school students and teachers. Molecular Cell Biology (Outros) Instituto de Educação e Cidadania, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022 - 2022 Member of the evaluation committee of the PhD candidates of the Biomedical Sciences Program at the Biomedical Sciences PhD Program Annual Journey
Evaluator
 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2021 Member of the evaluation committee of the PhD candidates of the Biomedical Sciences Program at the Biomedical Sciences PhD Program Annual Journey
Evaluator
 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal

Mentoring / Tutoring

Topic Student name
2021/07 - Current PhD project: Development of an AAV-mediated allele-specific therapy for Machado-Joseph Disease Ana Carolina Pinheiro da Silva
2022 - 2022 Systemic Hypertension Associated with Chronic Intermittent Hypoxia Miguel António Figueira Domingos
2022 - 2022 Pre- and post-surgery incapacity in Inflammatory Bowel Disease – short- and long-term results evaluated by IBD DISK Juliana Sofia Rodrigues Ferreira
2022 - 2022 Analysis of Cysteine and Homocysteine as biomarkers for Obstructive Sleep Apnea Syndrome and Arterial Hypertension Diogo Alexandre Rosado Leça
2022 - 2022 Optimization of a cryopreservation protocol for future application in the isolation of Urine-Derived Stem Cells (UDSC) from patients with Amyotrophic Lateral Sclerosis Beatriz Galhano Lopes
2020 - 2020 Laboratory Methods - Bioinformatic tools Ana Letícia Fernandes Gomes

Other jury / evaluation

Activity description Institution / Organization
2021/07/14 - Current Jury of Ana Carolina Pinheiro da Silva PhD Thesis project "Development of an AAV-mediated allele-specific therapy for Machado-Joseph Disease" of Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023 - 2023 Poster evaluation, in the context of the "Student-Selected Modules 1" course unit of the Integrated Master in Medicine Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022 Poster evaluation, in the context of the "Student-Selected Modules 1" course unit of the Integrated Master in Medicine Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022 Poster evaluation at the Meeting of the Portuguese Society of Movement Disorders (SPDMov) - Classical and Atypical Parkinsonisms, Luso, Portugal Sociedade Portuguesa das Doenças do Movimento, Portugal
Distinctions

Award

2023 Teaching and Learning Award from the University of Algarve 2021/22
Universidade do Algarve, Portugal

Other distinction

2020 Finalist of the Roche Building Tomorrow Together (Roche-BTT) Program
2009 Award for the best student from the Faculty of Sciences end Technology of the University of Coimbra 2008/09
2009 PhD Fellowship (SFRH/BD/47160/2008).
Fundação para a Ciência e a Tecnologia, Portugal
2007 University of Coimbra's 3% Best Students Award
Universidade de Coimbra, Portugal
2006 Merit Scholarship
Universidade de Coimbra, Portugal
2006 University of Coimbra's 3% Best Students Award
Universidade de Coimbra, Portugal
2005 Merit Scholarship
Universidade de Coimbra, Portugal
2005 University of Coimbra's 3% Best Students Award
Universidade de Coimbra, Portugal
2004 University of Coimbra's 3% Best Students Award
Universidade de Coimbra, Portugal