???global.info.a_carregar???
I obtained my PhD in Biology in 2015, at the University of Coimbra. My research concerned the molecular mechanisms of Machado-Joseph disease (MJD), and was developed at the Centre for Neuroscience and Cell Biology (CNC), at Professor Ana Luisa Carvalho's lab, dedicated to basic neuroscience. Drawing from the expertise I earned in the field of polyglutamine (polyQ) diseases and aiming at contributing to the development of advanced therapies for MJD, in 2016 I joined Professor Luís Almeida's lab (CNC) as a post-doc. In his lab my researched focused on applying gene editing-based silencing and correction to MJD therapy. During that period I specialized in the CRISPR system, having attended a competitive EMBO course on genome engineering at the Max Planck Institute (Dresden, Germany). In 2019, I moved to the University of Algarve (UAlg), where I was hired as a Contracted Researcher at the lab of Professor Clévio Nóbrega. The lab is dedicated to research on MJD, spinocerebellear ataxia type 2 (SCA2) and Cockayne syndrome (CS), and aims at developing advanced therapies for these diseases. I am currently involved in developing and testing new gene therapies for SCA2 and CS. I have published a total of 19 papers in international journals, 13 in the last 5 years. I have co-authored (and fully illustrated) a book, the Handbook of Gene and Cell Therapy, and I am also author of 2 book chapters on gene therapy. My publications have garnered 527 citations and I have a h-index of 12. In 2019 I was awarded a 15.000 USD seed grant project, as Principal Investigator, by USA's National Ataxia Foundation, and in 2022 I received a 10.000€ grant to explore gene therapy-based approaches to CS. I have been the main supervisor of 4 MSc students, I have co-supervised 5 others, and I am currently (co-)supervising 3 PhD students and 4 BSc students. So far, I have participated in 24 juries of academic degrees. At this point in my career, I am focused on establishing myself as a researcher at UAlg, and at acquiring higher degrees of scientific independence. I am bent on bringing together my background on neuroscience, gene therapy and gene editing in order to better understand, and treat, rare disorders.
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Carlos Adriano Albuquerque Andrade de Matos

Nomes de citação

  • Matos, Carlos A

Identificadores de autor

Ciência ID
DC14-C299-222A
ORCID iD
0000-0002-9019-7569

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Japonês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Francês Utilizador elementar (A1)
Formação
Grau Classificação
2023/12/21
Concluído
 Integrated Master in Pharmaceutical Sciences (Mestrado)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Antibiotherapy of infections caused by multidrug-resistant Gram-positive cocci" (TESE/DISSERTAÇÃO)
 18
2017
Concluído
 EMBO Practical Course on Mouse Genome Engineering (Outros)
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
2015/02/03
Concluído
 PhD in Biology, speciality of Cell Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Regulation of ataxin-3 by phosphorylation: Relevance for Machado-Joseph disease" (TESE/DISSERTAÇÃO)
 Approved with Distinction and Honors, by unanimity
2014
Concluído
 Laboratory Animal Sciences Course - B Category (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Certified
2010
Concluído
 Science Communication (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009
Concluído
 Master's degree in Molecular Cell Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Post-translational modifications of ataxin-3, the protein involved in Machado-Joseph disease: evidences for phosphorylation and sumoylation" (TESE/DISSERTAÇÃO)
 19
2009
Concluído
 Neurodegenerative Disorders (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007
Concluído
 Bachelor's degree in Biology (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Not applicable" (TESE/DISSERTAÇÃO)
 18
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02/26 - 2022/02/25 Investigador Contratado (Investigação) Universidade do Algarve, Portugal
Universidade do Algarve, Portugal
2015/02/04 - 2019/01/31 Pós-doutorado (Investigação) CNC.IBILI, Portugal
2013/10/03 - 2015/09/30 Investigador (Investigação) CNC.IBILI, Portugal
2008/09/01 - 2008/11/30 Investigador (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/03/04 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2019 - 2019 Professor Auxiliar Convidado (Docente Universitário) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2009 - 2013 PhD Student Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
CNC.IBILI, Portugal
2007 - 2009 MSc Student Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
CNC.IBILI, Portugal
Projetos

Bolsa

Designação Financiadores
2019 - Atual The role of stress granules in Polyglutamine disease: from pathogenesis to molecular therapy
ALG-01-0145-FEDER-29480
Bolseiro de Integração na Investigação
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2022/05/05 - 2023/05/05 Cockayne syndrome: pioneer exploration of a gene therapy-based approach to the treatment of a neglected disease
Not applicable
Investigador responsável
Algarve Biomedical Center Research Institute, Portugal
 Algarve Biomedical Center
Concluído
2022/05/05 - 2023/05/05 Explore the mechanisms behind neurodegenerative rare disorders - is mitosis on the aetiology of these diseases?
Not applicable
Co-Investigador Responsável (Co-IR)
Algarve Biomedical Center Research Institute, Portugal
 Algarve Biomedical Center
Concluído
2019/03/01 - 2020/10/01 Silencing the SCA3-causing gene ATXN3 through CRISPR interference
616430
Investigador responsável
CNC.IBILI, Portugal
 National Ataxia Foundation
Concluído
2020 - 2020 Development of a new assay do detect SARS-CoV-2 directly from clinical samples
126_596760136
Investigador
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2017 - 2019 BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Bolseiro de Pós-Doutoramento
CNC.IBILI, Portugal
 European Regional Development Fund
Concluído
2016 - 2019 Advanced models of polyglutamine disorders (Huntington's disease, SCA3 and SCA7)
JPCOFUND/0005/2015
Investigador Pós-doutorado
CNC.IBILI, Portugal
 Horizon 2020
2016 - 2017 SYNSPREAD - Roles and mechanisms of synuclein and ataxin3 spreading in Parkinson and Machado-Joseph diseases
JPND-CD/0001/2013
Bolseiro de Pós-Doutoramento
CNC.IBILI, Portugal
 Horizon 2020
Concluído
2015 - 2016 Financiamento Incentivo 2014
Incetivo/SAU/LA0001/2014
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2013 - 2015 A novel model for Schizophrenia: defects in stargazing-mediated homeostatic plasticity
PTDC/NEU-NMC/0750/2012
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
Concluído
2011 - 2014 Regulation by phosphorylation of ataxin-3, the mutated protein in Machado Joseph Disease
PTDC/SAU-NMC/110602/2009
Investigador
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009/10/01 - 2013/09/30 ANALYSIS OF SYNAPTIC DYSFUNCTION AND ATAXIN-3 PHOSPHORYLATION IN A MOUSE MODEL OF MACHADO-JOSEPH DISEASE
SFRH/BD/47160/2008
 Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2008 Molecular determinants of ataxin-3 aggregation and toxicity in Machado-Joseph's disease
POCI/SAU-MMO/60156/2004
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2018/07/01 - 2022/06/30 Blocking neurodegeneration by spreading of gene silencers
PTDC/BTM-SAL/29716/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Afonso, Inês T.; Koppenol, Rebekah; Conceição, André; Paulino, Rodrigo; Mirapalheta, Lourenzo; Matos, Carlos A; Nóbrega, Clévio. "From the molecular hallmarks to motor behavior: characterization of a new transgenic mouse model for spinocerebellar ataxia type 2". 2023.
Artigo em revista
  1. Rafael G. Costa; André Conceição; Carlos A. Matos; Clévio Nóbrega. "The polyglutamine protein ATXN2: from its molecular functions to its involvement in disease". Cell Death & Disease (2024): https://doi.org/10.1038/s41419-024-06812-5.
    10.1038/s41419-024-06812-5
  2. Brito, D. V. C.; Esteves, F.; Rajado, A. T.; Silva, N.; Andrade, R.; Apolónio, J.; Calado, S.; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". NPJ Aging 9 1 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6.
    10.1038/s41514-023-00120-6
  3. Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David; Binnie, Alexandra; Araújo, Inês M.; Nóbrega, Clévio; Bragança, José; Castelo-Branco, Pedro. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging (2023): http://dx.doi.org/10.18632/aging.204668.
    10.18632/aging.204668
  4. Estevam, Bernardo; Matos, Carlos A; Nóbrega, Clévio. "PolyQ Database - an integrated database on polyglutamine diseases". Database 2023 (2023): http://dx.doi.org/10.1093/database/baad060.
    10.1093/database/baad060
  5. Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vania Palma; Araújo, Inês Maria; et al. "Reprogramming iPSCs to study age-related diseases: models, therapeutics, and clinical trials". (2023): http://hdl.handle.net/10400.1/20141.
    10.1016/j.mad.2023.111854
  6. Koppenol, Rebekah; Conceição, André; Afonso, Inês T; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; et al. "The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits". Brain 146 6 (2022): 2346-2363. http://dx.doi.org/10.1093/brain/awac473.
    10.1093/brain/awac473
  7. Marcelo, Adriana; Matos, Carlos A.; Nóbrega, Clévio. "Autophagy is dysregulated in spinocerebellar ataxia type 2". Autophagy Reports 1 1 (2022): 179-182. http://dx.doi.org/10.1080/27694127.2022.2065603.
    10.1080/27694127.2022.2065603
  8. Afonso, Inês T.; Lima, Patrícia; Conceição, André; Matos, Carlos A; Nóbrega, Clévio. "Mutant Ataxin-2 expression in aged animals aggravates neuropathological features associated with Spinocerebellar Ataxia type 2". (2022): http://hdl.handle.net/10400.1/18390.
    10.3390/ijms231911896
  9. Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V. C.; Costa, Rafael G.; Rosa, Ana; Alves-Cruzeiro, João; et al. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death & Disease 12 12 (2021): http://dx.doi.org/10.1038/s41419-021-04404-1.
    10.1038/s41419-021-04404-1
  10. Adriana Marcelo; Rebekah Koppenol; Luís Pereira de Almeida; Carlos A. Matos; Clévio Nóbrega. "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?". Cell Death & Disease 12 6 (2021): https://doi.org/10.1038/s41419-021-03873-8.
    Acesso aberto • Publicado • 10.1038/s41419-021-03873-8
  11. Nóbrega, Clévio; Conceição, André; Costa, Rafael G.; Koppenol, Rebekah; Sequeira, Raquel L.; Nunes, Ricardo; Carmo-Silva, Sara; et al. "The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease". BMC Research Notes 13 1 (2020): http://dx.doi.org/10.1186/s13104-020-05053-x.
    10.1186/s13104-020-05053-x
  12. Nóbrega, Clévio; Mendonça, Liliana; Marcelo, Adriana; Lamazière, Antonin; Tomé, Sandra; Despres, Gaetan; Matos, Carlos A.; et al. "Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia". Acta Neuropathologica 138 5 (2019): 837-858. http://dx.doi.org/10.1007/s00401-019-02019-7.
    10.1007/s00401-019-02019-7
  13. Mendonça, Liliana S; Nóbrega, Clévio; Tavino, Silvia; Brinkhaus, Maximilian; Matos, Carlos; Tomé, Sandra; Moreira, Ricardo; et al. "Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado–Joseph disease models". Human Molecular Genetics 28 22 (2019): 3691-3703. http://dx.doi.org/10.1093/hmg/ddz097.
    10.1093/hmg/ddz097
  14. Nunes, Catarina; Mestre, Isa; Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Nóbrega, Clévio. "MSGP: the first database of the protein components of the mammalian stress granules". Database 2019 (2019): http://dx.doi.org/10.1093/database/baz031.
    10.1093/database/baz031
  15. Matos, Carlos A.; de Almeida, Luís Pereira; Nóbrega, Clévio. "Machado-Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy". Journal of Neurochemistry 148 1 (2018): 8-28. http://dx.doi.org/10.1111/jnc.14541.
    10.1111/jnc.14541
  16. Marcelo, Adriana; Brito, Filipa; Carmo-Silva, Sara; Matos, Carlos A; Alves-Cruzeiro, João; Vasconcelos-Ferreira, Ana; Koppenol, Rebekah; et al. "Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models". Human Molecular Genetics 28 1 (2018): 51-63. http://dx.doi.org/10.1093/hmg/ddy328.
    10.1093/hmg/ddy328
  17. Matos, C.A.; de Almeida, L.P.; Nóbrega, C.. "Proteolytic cleavage of polyglutamine disease-causing proteins: Revisiting the toxic fragment hypothesis". Current Pharmaceutical Design 23 5 (2017): 753-775. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017122161&partnerID=MN8TOARS.
    10.2174/1381612822666161227121912
  18. Matos CA; Nóbrega C; Louros SR; Almeida B; Ferreiro E; Valero J; Pereira de Almeida L; Macedo-Ribeiro S; Carvalho AL. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.". Journal of Cell Biology (2016): http://europepmc.org/abstract/med/26880203.
    10.1083/jcb.201506025
  19. Almeida B; Abreu IA; Matos CA; Fraga JS; Fernandes S; Macedo MG; Gutiérrez-Gallego R; et al. "SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.". Biochimica et Biophysica Acta - Molecular Basis of Disease (2015): http://europepmc.org/abstract/med/26073430.
    10.1016/j.bbadis.2015.06.010
  20. Matos CA; de Macedo-Ribeiro S; Carvalho AL. "Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph disease.". Progress in Neurobiology (2011): http://europepmc.org/abstract/med/21740957.
    10.1016/j.pneurobio.2011.06.007
Capítulo de livro
  1. M. Codêsso, José; A. Matos, Carlos; Nóbrega, Clévio. "RNA Interference Applications for Machado-Joseph Disease". In RNA Therapeutics - History, Design, Manufacturing, and Applications. St. Louis, Estados Unidos: IntechOpen, 2022.
    Publicado • 10.5772/intechopen.109261
  2. Matos, Carlos A.; Carmona, Vítor; Vijayakumar, Udaya-Geetha; Lopes, Sara; Albuquerque, Patrícia; Conceição, Mariana; Nobre, Rui Jorge; Nóbrega, Clévio; de Almeida, Luís Pereira. "Gene Therapies for Polyglutamine Diseases". In Advances in Experimental Medicine and Biology, 395-438. Springer International Publishing, 2018.
    Publicado • 10.1007/978-3-319-71779-1_20
Livro
  1. Nóbrega, Clévio; Mendonça, Liliana; Matos, Carlos A.. A Handbook of Gene and Cell Therapy. Suiça: Springer International Publishing. 2020.
    Publicado • 10.1007/978-3-030-41333-0
Poster em conferência
  1. Lopes, Sara Monteiro; Miguel M. Lopes; Nobre, Rui Jorge; Vasconcelos-Ferreira, Ana; Pereira, Dina; Fernandes, Ana Rita; Barros, Maria Inês; et al. Autor correspondente: Pereira de Almeida, Luis. "Targeting the ATXN3 gene with CRISPR-Cas9 for the therapy of Machado-Joseph disease". Trabalho apresentado em 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023.
  2. Conceição, André; Koppenol, Rebekah; Inês Afonso; Paulino, Rodrigo; Mirapalheta, Lourenzo; Matos, Carlos; Nóbrega, Clévio David Rodrigues. "A novel SCA2 transgenic mouse model displays disease-associated phenotype.". Trabalho apresentado em FENS Regional Meeting 2023 – Algarve, 2023.
  3. Koppenol, Rebekah; Matos, Carlos A; Afonso-Reis, Ricardo; de Almeida, Luis Pereira; Nóbrega, Clévio David Rodrigues. "Tackling spinocerebellar ataxia type 2: targeting the ATXN2 gene with CRISPR-Cas-based silencing strategies.". Trabalho apresentado em FENS Regional Meeting 2023 – Algarve, 2023.
  4. Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Matos, Carlos A; Sofia M. Calado. "Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells.". Trabalho apresentado em FENS Regional Meeting 2023 – Algarve, 2023.
  5. Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Matos, Carlos A; Sofia M. Calado. "Neuronal cultures differentiated from patient-derived induced pluripotent stem cells as a novel model of Cockayne syndrome B.". Trabalho apresentado em European Neuroscience Conference by Doctoral Students (ENCODS) Meeting 2023, 2023.
  6. Afonso, Inês T.; Koppenol, Rebekah; Conceição, André; Vieira R; Paulino, Rodrigo; Mirapelha, L.; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Autor correspondente: Nóbrega, Clévio David Rodrigues. "From the molecular hallmarks to motor behavior: characterization of a novel transgenic mouse model for Spinocerebellar ataxia type 2". Trabalho apresentado em ISN-ESN, 2023.
  7. Rafael G. Costa; Afonso, Inês T.; Afonso-Reis, Ricardo; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Autor correspondente: Nóbrega, Clévio David Rodrigues. "The role of a stress granules' component as a modulator of progerin's expression: a prospective approach to slow down accelerated aging in HGPS cells". Trabalho apresentado em Ageing Without Borders 2022, 2022.
  8. Perdigão, PRL; Matos, Carlos A; Lopes, Sara M. ; Fernandes, Ana Rita; Miguel M. Lopes; Conceição, A; Faro, R; et al. "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair.". Trabalho apresentado em 26th Annual Portuguese Society of Human Genetics Meeting, 2022.
  9. Perdigão, P; Matos, Carlos A; Lopes, Sara; Fernandes, Ana Rita; Lopes, Miguel; Conceição, André; Faro, Rosario; et al. "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9-mediated correction of ATXN3-CAG expansion". Trabalho apresentado em ESGCT 29th Annual Congress, European Society of Gene and Cell Therapy, Edinburgh, 2022, 2022.
  10. Koppenol, Rebekah; Conceição, André; Afonso, Inês T.; Afonso-Reis, Ricardo; Costa, Rafael G; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Motor phenotype characterization of a new transgenic mouse model for Spinocerebellar ataxia type 2.". Trabalho apresentado em ABC Days - V National Meeting of the Algarve Biomedical Center, 2022.
  11. Marcelo, Adriana. "Autophagy induction mitigates Spinocerebellar ataxia type 2 disease hallmarks.". Trabalho apresentado em Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms, 2022.
  12. Conceição, André. "Expression of G3BP1 reduces neuropathological and motor abnormalities in models of spinocerebeçllar ataxia type 3". Trabalho apresentado em Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms, 2022.
  13. Koppenol, Rebekah. "Development of CRISPR-Cas-based strategies for spinocerebellar ataxia type 2.". Trabalho apresentado em European Society of Gene and Cell Therapy (ESGCT) 29th congress in collaboration with British Society for Gene and Cell Therapy (BSGCT), 2022.
  14. Koppenol, Rebekah; Conceição, André; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Codêsso, José Miguel; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "G3BP1 expression mitigates pathological phenotype in mouse models different polyglutamine diseases". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  15. Afonso-Reis, Ricardo; Koppenol, Rebekah; Conceição, André; Teixeira, Diogo; Marcelo, Adriana; Tomé, Sandra; Carmo-Silva, Sara; et al. "ASSESSING THE ROLE OF DIFFERENT G3BP1 REGIONS IN THE MITIGATION OF THE PATHOLOGICAL PHENOTYPE IN SCA2 AND SCA3 DISEASE MODELS". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  16. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2021.
  17. "Development of a gene based strategy as a potential therapy for Hutchinson Gilford Progeria Syndrome". Trabalho apresentado em Annual International (bio)Medical Students (AIMS) Meeting, 2021.
  18. "Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models". Trabalho apresentado em IV Jornadas Algarve Biomedical Center, 2021.
  19. "G3BP1 as a therapeutic target for spinocerebellar ataxias: mitigation of pathological traits in different mouse models". Trabalho apresentado em IV Jornadas Algarve Biomedical Center, 2021.
  20. "Is mutant ataxin-2 aggregation modulated by aging?". Trabalho apresentado em IV Jornadas Algarve Biomedical Center, 2021.
  21. "Assessing the Role of G3bp1 Domains in the Mitigation of the Pathological Phenotype in SCA2 and SCA3 Disease Models". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  22. "Precise and scarless correction of ATXN3-CAG expansion by CRISPR/Cas9 for the generation of patient-derived MJD isogenic iPSC.". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  23. "From molecular mechanisms to therapy: a new lentiviral mouse model for Spinocerebellar ataxia type 2". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  24. "G3BP1 expression mitigates pathological phenotype in mouse models of different polyglutamine diseases". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  25. "Generation of a novel transgenic mouse model of spinocerebellar ataxia type 2 expressing mutant ATXN2 in cerebellar Purkinje cells". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  26. Brito, David V.C.; Afonso, I; Matos, Carlos A; Hilmar Bading; Nóbrega, Clévio David Rodrigues. "Targeting the NMDAR/TRPM4 complex as a novel therapeutic strategy for polyglutamine spinocerebellar ataxia type 2". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  27. "Impact of aging in neuropathological hallmarks associated with the expression of mutant ATAXIN-2". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021.
  28. Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "Striatal neuropathology in spinocerebellar ataxia type 2: a new lentiviral mouse model". Trabalho apresentado em FENS 2020 Virtual Forum, 2020.
  29. Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "A lentiviral genetic mouse model for Spinocerebellar ataxia type 2". Trabalho apresentado em International Meeting of the Portuguese Society of Genetics, 2020.
  30. "Silencing ATXN2 expression using CRISPR/Cas9". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2020.
  31. "Autophagy impairment in spinocerebellar ataxia type 2: first evidences and a potential therapeutic strategy". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2020.
  32. Sara Lopes; Matos, Carlos A; André Conceição; Frederico Pena; Miguel Lopes; Rui Nobre; Nóbrega, Clévio; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease". Trabalho apresentado em 2019 International Machado-Joseph Research Disease Conference, Washington, 2019.
  33. Sara Lopes; Matos, Carlos A; André Conceição; Frederico Pena; Miguel Lopes; Rui Nobre; Nóbrega, Clévio; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph disease.". Trabalho apresentado em 3rd International Ataxia Research Conference (IARC), Washington, DC, USA., 2019.
  34. Matos, Carlos A; André Conceição; Sara Lopes; Luis Pereira de Almeida. "CRISPR-CAS9 as a tool for silencing and correcting ATXN3, the gene causing Machado-Joseph disease.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  35. Matos, Carlos A; André Conceição; Frederico Pena; Sara Lopes; Sónia Duarte; Catarina Miranda; Luís Pereira de Almeida. "Transcriptional repression of mutant human ATNX3 using CRISPR interference mitigates the pathological phenotype of an in vivo Machado-Joseph disease model.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  36. Rebekah Koppenol; Adriana Marcelo; Matos, Carlos A; Sara Carmo-Silva; Luis Pereira de Almeida; Clévio Nóbrega. "On the role of stress granules in autophagy.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  37. Matos, Carlos A. "CYP46A1-gene therapy alleviates Machado-Joseph disease". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  38. Matos, Carlos A. "RNA-binding proteins: new molecular targets for polyglutamine diseases?". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019.
  39. Matos, Carlos A. "CRISPR-Cas9-mediated pre-transcriptional silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model". Trabalho apresentado em 22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC, USA, 2019.
  40. Matos, Carlos A. "Ibuprofen improves neuropathology and increases neural progenitors proliferation, synaptic function and neurite growth in Machado-Joseph disease.". Trabalho apresentado em 2nd International Ataxia Research Conference (IARC), Pisa, Italy, 2017.
  41. Matos, Carlos A. "TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease". Trabalho apresentado em 2nd International Ataxia Research Conference (IARC), Pisa, Italy, 2017.
  42. Matos, Carlos A. "CRISPR-Cas9 as a tool for Machado-Joseph disease treatment and animal model generation". Trabalho apresentado em EMBO Practical Course on Mouse Genome Engineering. Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany, 2017.
  43. Matos, Carlos A. "Modulation of catalytic activity and polyQ toxicity by phosphorylation in spinocerebellar ataxia type 3". Trabalho apresentado em 5th Ataxia Investigators Meeting, Las Vegas, USA, 2014.
  44. Matos, Carlos A. "Post-translational modifications and polyglutamine diseases: the effects of ataxin-3 phosphorylation". Trabalho apresentado em Champalimaud Neuroscience Programme Symposium, Lisbon, Portugal, 2013.
  45. Matos, Carlos A. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Trabalho apresentado em XIII Meeting of the Portuguese Society for Neuroscience (SPN), Luso, Portugal, 2013.
  46. Matos, Carlos A. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Trabalho apresentado em X Center for Neuroscience and Cell Biology (CNC) Annual Meeting, Cantanhede, Portugal, 2012.
  47. Matos, Carlos A. "Regulation by phosphorylation of ataxin-3, the mutated protein in Machado-Joseph disease". Trabalho apresentado em 8th Federation of European Neurosciences (FENS) Forum of Neuroscience, Barcelona, Spain, 2012.
  48. Matos, Carlos A. "Regulation by phosphorylation of ataxin-3, the mutated protein in Machado-Joseph disease". Trabalho apresentado em Gordon Research Conference on CAG Triplet Disorders, Luca, Italy, 2011.
Recurso online
  1. Estevam, Bernardo; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. A Database for Polyglutamine Diseases. 2023. https://polyq.pt.
  2. Clévio Nóbrega; Catarina Nunes; Isa Mestre; Adriana Marcelo; Rebekah Koppenol; Matos, Carlos A. MSGP Database - Mammalian Stress Granules Proteome. 2018. https://msgp.pt.
Resumo em conferência
  1. Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Sofia M. Calado; Matos, Carlos A. Autor correspondente: Matos, Carlos A. "Generation of a CSB-iPSC disease model as a platform to develop gene therapy approaches for Cockayne Syndrome type B". Trabalho apresentado em Meeting of the Portuguese Society of Pharmacology (SPF Meeting), Lisbon, 2024.
    Publicado
  2. Matos, Carlos A; Conceição, Jaime; Nóbrega, Clévio. "Terapia Génica e Celular: História e inovação no ensino das Ciências Biomédicas na Universidade do Algarve". Trabalho apresentado em 3.º Congresso Internacional de História da Ciência no Ensino, Faro, 2023.
    Publicado
  3. Afonso, Inês T.; Lima, Patrícia; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Ataxin-2 pathological features are altered by the aging process". Trabalho apresentado em 25th Annual Meeting of the Portuguese Society of Human Genetics, Porto, 2022.
    Publicado
  4. Sara Lopes; Miguel Lopes; Rui Nobre; Clévio Nóbrega; Matos, Carlos A; Ana Vasconcelos-Ferreira; Neville Sanjana; et al. "Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), Lisbon, 2021.
    Publicado
  5. Adriana Marcelo; Ana Rosa; Marta Santos; Benedita Ferreira; Rebekah Koppenol; Matos, Carlos A; Clévio Nóbrega. "Autophagy impairment in spinocerebellar ataxia type 2: first evidences and a potential therapeutic strategy". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), Lisbon, 2021.
    Publicado
  6. Ricardo Reis; Rebekah Koppenol; Luís Pereira de Almeida; Matos, Carlos A; Clévio Nóbrega. "Silencing ATXN2 expression using CRISPR/Cas9". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), Lisbon, 2021.
    Publicado
  7. Conceição, André; Koppenol, Rebekah; Tomé, Sandra; Carmo-Silva, Sara; Matos, Carlos A; Pereira de Almeida, Luis Fernando Morgado; Nóbrega, Clévio David Rodrigues. "A RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Trabalho apresentado em 24th Anual Meeting of Portuguese Human Genetics Society. Proceedings published in Medicine, 2021.
    Publicado • 10.1097/MD.0000000000023585
  8. André Conceição; Raquel Koppenol; Joana Silva; Ricardo Reis; José Codesso; Sandra Tomé; Sara Carmo-Silva; et al. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Trabalho apresentado em 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), Lisbon, 2020.
    Publicado
Tese / Dissertação
  1. "Antibiotherapy of infections caused by multidrug-resistant Gram-positive cocci". Mestrado, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2023.
  2. Matos, Carlos A. "Regulation of ataxin-3 by phosphorylation: Relevance for Machado-Joseph disease.". Doutoramento, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2015.
  3. Matos, Carlos A. "Post-translational modifications of ataxin-3, the protein involved in Machado-Joseph disease: evidences for phosphorylation and sumoylation.". Mestrado, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009.

Artística / Interpretação

Obra teatral
  1. 2016. Luz-Livro.
  2. 2016. O Ponto Que Nos Une.
  3. 2015. Atos de Laboratório.
  4. 2015. Luz de Perdição.

Outros

Conjunto de dados
  1. Matos, Carlos A. NeuroMorpho.Org. http://neuromorpho.org/about.jsp.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/01/16 Gene therapy - promisses and challenges Universidade Sénior de Loulé
Universidade Sénior de Loulé (Loulé, Portugal)
2024 Generation of a CSB-iPSC disease model as a platform to develop gene therapy approaches for Cockayne Syndrome type B LIV Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2023/11/09 Gene Editing: From reality to fiction "Geneticamente falando" seminar cycle
Sociedade Portuguesa de Genética (SPG) (Portugal)
2023/10/31 Gene Editing - Biological principles and technical bases ESN-ISN Neurochemistry School 2023
Algarve Biomedical Center Research Institute (ABCRI) (Faro, Portugal)
2023/09/05 Gene and Cell Therapy: History and innovation in the teaching of Biomedical Sciences at the University of Algarve 3rd International Congress of History of Science in Teaching
Universidade do Algarve (Faro, Portugal)
2023/07/11 Multiple sclerosis Universidade Sénior de Loulé
Universidade Sénior de Loulé (Loulé, Portugal)
2023 Characterization of a new transgenic mouse model for spinocerebellar ataxia type 2 with 129 glutamine repeats: unraveling neuropathologic and motor phenotype. I FloripaNeuro
Universidade Federal de Santa Catarina (Florianópolis, Brasil)
2023 Novel approaches to the treatment of rare neurodegenerative diseases: development and pre-clinical testing of gene therapies. 44th European Pharmaceutical Students' Associations (EPSA) Annual Congress
European Pharmaceutical Students' Associations (EPSA) (Podcetrtek, Eslovénia)
2023 Gene Editing - A new hope for untreatable diseases. 44th European Pharmaceutical Students' Associations (EPSA) Annual Congress
European Pharmaceutical Students' Associations (EPSA) (Podcetrtek, Eslovénia)
2023 Invited speech at the “From the reconfiguration of the organic: genomic editing” session of the Public Session of the Portuguese National Ethics Council for the Life Sciences Public Session of the Portuguese National Ethics Council for the Life Sciences
Portuguese National Ethics Council for the Life Sciences (Faro, Portugal)
2023 Gene Therapy - promises and challenges Topics in Biology Applied seminar
University of Algarve (Faro, Portugal)
2023 Is it possible to use viruses to treat diseases? Seminar to middle school students
Escola E.B. 2,3 Dr. Garcia Domingues (Silves, Portugal)
2022/03/03 Será possível usar vírus para tratar doenças? (Is it possible to use virus to treat diseases?) Seminar to middle school students
Escola E.B. 2,3 Dr. Garcia Domingues (Silves, Portugal)
2022 Are the neuropathological features associated with mutant Ataxin-2 expression exacerbated by aging? Aging Without Borders
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Faro, Portugal)
2022 Ataxia espinocerebelosa tipo 2: caracterização de um novo modelo transgénico de murganho com fenótipo neuropatológico e motor. (Spinocerebellar ataxia type 2: characterization of a novel transgenic mouse model with a neuropathological and motor phenotype) Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms
Meeting of the Portuguese Society of Movement Disorders (SPDMov) (Luso, Portugal)
2022 Upregulation of autophagy as a therapeutic strategy for spinocerebellar ataxia type 2. XLXII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2022 The stress granule protein G3BP1 reverts pathological defects in two diferent polyglutamine diseases. XLXII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2022 ATXN2 knockdown through CRISPR-Cas-based strategies: a therapeutic approach for spinocerebellar ataxia type 2? XLXII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2022 Hereditary ataxias caused by repeat expansion mutations: The special case of Machado-Joseph disease Expression and Pathology seminar lectured to the students of the MSc degree in Molecular and Microbial Biology
Universidade do Algarve Faculdade de Ciências e Tecnologia (Faro, Portugal)
2022 Gene Therapy - promises and challenges Topics in Applied Biology seminar
University of Algarve (Faro, Portugal)
2022 Is it possible to use viruses to treat diseases? Seminar to middle school students
Escola E.B. 2,3 Dr. Garcia Domingues (Silves, Portugal)
2022 The brain and time XII National Journey of Biomedical Sciences 2022
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas (Faro, Portugal)
2021/10/08 Terapia génica: da promessa à realidade (Gene therapy: from promise to reality) IV Jornadas Algarve Biomedical Center
Algarve Biomedical Center (Moura, Portugal)
2021/05/28 CRISPR-based therapies - from fiction to fact The CRISPR Revolution: a workshop in gene editing, from cells to animal models
University of Algarve (Faro, Portugal)
2021/05/24 Gene Editing - Biological principals and technical bases The CRISPR Revolution: a workshop in gene editing, from cells to animal models
University of Algarve (Faro, Portugal)
2021/05/24 The CRISPR toolbox The CRISPR Revolution: a workshop in gene editing, from cells to animal models
University of Algarve (Faro, Portugal)
2021 RBP-X protein mitigates disease traits in different mice models of polyglutamine diseases XLXI Meeting
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021 The CRISPR system – Biologic bases, technical perspectives and applications Experimental Techniques seminar
University of Algarve (Faro, Portugal)
2021 Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models XLXI Meeting
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021 CRISPR/Cas9-mediated silencing of ATXN2 expression XLXI Meeting
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021 Autophagy dysfunction in spinocerebellar ataxia type 2 models and a potential therapeutic strategy XLXI Meeting
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021 Mutant ataxin-2 pathological features is altered by the aging process 25th Annual Meeting of the Portuguese Society of Human Genetics (SPGH)
Portuguese Society of Human Genetics (SPGH) (Porto, Portugal)
2021 The RNA-binding Protein X Mitigates Common Age-associated Features in Progerin-expressing Cells IV Jornadas Algarve Biomedical Center
Algarve Biomedical Center (Moura, Portugal)
2021 Gene Therapy - promises and challenges Topics in Applied Biology seminar
University of Algarve (Faro, Portugal)
2021 CRISPR-mediated gene silencing in the treatment of Machado-Joseph disease Eukaryotic Molecular Genetics seminar
University of Algarve (Faro, Portugal)
2021 When RNA-binding proteins meet the Hutchinson-Gilford Progeria syndrome: a gene delivery approach to mitigate premature aging. International Health Sciences Conference 2021
(Kaunas, Lituânia)
2020 CRISPR-mediated silencing of mutant ataxin-3 ameliorates motor symptoms of a Machado-Joseph disease model in vivo. XLX Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2020 Stress granules crosstalk with autophagy in a context of polyglutamine diseases. XLX Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2020 RNA-binding proteins as potential therapeutic targets for polyglutamine diseases. XLX Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2020 Gene Therapy – promises and challenges Topics in Applied Biology seminar
University of Algarve (Faro, Portugal)
2020 Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease 24th Annual Meeting
Portuguese Society for Human Genetics (SPGH) (Lisbon, Portugal)
2020 Stress granules dynamics in polyglutamine diseases International Meeting of the Portuguese Society of Genetics
Portuguese Society of Genetics (Faro, Portugal)
2019 CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease 2019 International Machado-Joseph Research Disease Conference
The Israeli Machado - Joseph (MJD) Association (Washington, Estados Unidos)
2019 CYP46A1-gene therapy improves Machado-Joseph disease in mouse models. 23rd Annual Meeting of the Portuguese Society of Human Genetics (SPGH)
Portuguese Society of Human Genetics (SPGH) (Coimbra, Portugal)
2019 Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease. XVI Meeting of the Portuguese Society for Neuroscience (SPN)
Portuguese Society for Neuroscience (SPN) (Lisbon, Portugal)
2019 CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019 CRISPR as a tool for Machado-Joseph disease therapy. Distinguished Seminars, Center for Biomedical Research – CBMR
Center for Biomedical Research – CBMR, University of Algarve (Faro, Portugal)
2019 CRISPR as a tool for Machado-Joseph disease therapy. Seminar session
University of Algarve (Faro, Portugal)
2019 Gene correction and disease models. Pharmaceutical Biotechnology class
University of Coimbra (Coimbra, Portugal)
2019 Cell cultures in neurodegenerative diseases investigation Animal Cell Culture Technology seminar
University of Algarve (Faro, Portugal)
2019 Ataxin-3 phosphorylation as a neuroprotective mechanism in the context of Machado-Joseph disease Neurobiology seminar
University of Algarve (Faro, Portugal)
2019 Development and characterization of a lentiviral mouse model for spinocerebellar ataxia type 2 3rd Meeting
Algarve Biomedical Center (Albufeira, Portugal)
2018 CRISPR-Cas9-mediated pre- transcriptional silencing of mutant ataxin-3. XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia (SPF) (Lisbon, Portugal)
2018 Tailoring gene editing strategies for the treatment of Machado-Joseph disease. Portuguese Society of Movement Disorders (SPDMov) Congress
Portuguese Society of Movement Disorders (SPDMov) (Curia, Portugal)
2018 Ibuprofen decreases neuroinflammation and improves neuropathology and motor impairments in Machado-Joseph disease. XLVIII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2018 Gene editing in the treatment of neurodegenerative diseases. Meet.Lab Coimbra Symposium
Núcleo de Estudantes de Biologia da Associação Académica da Universidade de Coimbra (NEBAAC) (Coimbra, Portugal)
2018 CRISPR-Cas9 in MJD treatment and disease model generation MIT Portugal Doctoral Programme in Bioengineering Systems class
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2018 Gene editing strategies in gene therapy Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) class
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2018 Genome Editing: nuclease-based approaches Molecular Cell Biology class
University of Coimbra (Coimbra, Portugal)
2018 CYP46A1-gene therapy alleviates spinocerebellar ataxia in mouse models Congress
European Society of Gene and Cell Therapy (ESGCT) (Lausanne, Suiça)
2017 TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease. 2nd International Ataxia Research Conference (IARC)
FARA, Ataxia UK, fara Australia and Gofar (Pisa, Itália)
2017 Pre-transcriptional silencing of ataxin-3 using a CRISPR-Cas9-derived system. Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2017 Gene editing strategies for Machado-Joseph disease. XLVII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2017 Ibuprofen reduces neuroinflammation and neuropathology in Machado-Joseph disease. XLVII Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2017 CRISPR-Cas9 as a tool for Disease Model Generation MIT Portugal Doctoral Programme in Bioengineering Systems class
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2016 Phosphorylation of ataxin-3 decreases neuronal defects in Machado-Joseph disease models. XLVI Meeting of the Portuguese Society of Pharmacology (SPF)
Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2016 Modulating polyglutamine toxicity through phosphorylation: the example of ataxin-3, the protein involved in Machado-Joseph disease. CNC.IBILI Seminar
CNC.IBILI (Coimbra, Portugal)
2016 Modulating polyglutamine toxicity through phosphorylation: the example of ataxin-3, the protein involved in Machado-Joseph disease Seminar
Center for Neuroscience and Cell Biology
2016 Nuclease-based genome editing technologies Doctoral Programme in Experimental Biology and Biomedicine (PDBEB)
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2016 Gene Editing – Molecular bases, technical perspectives and applications Gene Therapy seminar
University of Algarve (Faro, Portugal)
2014 Protein phosphorylation as a toxicity modulator in Machado-Joseph disease. XVIII Congress of the Portuguese Biochemical Society (SPB)
Portuguese Biochemical Society (SPB) (Coimbra, Portugal)
2014 Protein phosphorylation as a modulator in Machado-Joseph disease. 5th Anniversary of the Department of Life Sciences
Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra (Coimbra, Portugal)
2013 Ataxin-3 phosphorylation: effects on polyglutamine toxicity mechanisms involved in Machado-Joseph disease. XI Center for Neuroscience and Cell Biology (CNC) Annual Meeting
CNC.IBILI (Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023 - Atual Evaluation of the expression of human ERCC6 protein in mice upon AAV-mediated delivery
Orientador de Carolina Martinheira
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Atual Utilization of riluzole, a modulator of glutamatergic neurotransmission indicated in the treatment of amyotrophic lateral sclerosis, as a potential therapeutic agent in the context of other neurodegenerative diseases
Orientador de Raquel Loureiro
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/09/01 - Atual Disease spreading in spinocerebellar ataxia type 2: from pathogenic mechanisms to targeted therapeutics
Coorientador de Rafael Gomes Costa
 Ciências Biomédicas (Doutoramento)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - Atual Connecting mutant Ataxin-2 and synaptic disfunction: are stress granules the link?
Coorientador de André Filipe Vieira Conceição
 Ciências Biomédicas (Doutoramento)
Universidade do Algarve, Portugal
2019 - Atual Targeting the ATXN2 gene with the CRISPR-Cas9 system as a therapeutic strategy for spinocerebellar ataxia type 2
Coorientador de Rebekah Koppenol
 Ciências Biomédicas (Doutoramento)
Universidade do Algarve, Portugal
2023 - 2024 Mechanisms of intercellular dissemination of ataxin-2 mRNA: impact of RNA-binding proteins and extracellular vesicles
Orientador de Isabelli Mendes Hombri
 Biology (Licenciatura/Bacharelato)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2022 - 2023 Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells
Orientador de Cristiana Raquel Rodrigues Madeira
 Ciências Biomédicas - Mecanismos de Doenças (Mestrado)
Universidade do Algarve, Portugal
2021 - 2022/11/28 PolyQ Database - A polyglutamine disease database
Coorientador de Bernardo Alexandre Encarnação Estevam
 Ciências Biomédicas - Mecanismos de Doença (Mestrado)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022 Evaluation of the levels of aneuploidy in fibroblasts from an individual with spinocerebellar ataxia type 3 caused by polyglutamine expansion
Orientador de Júlia Pereira Gonçalves
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022 Assessing the neuropathologic profile and the motor phenotype of a novel spinocerebellar ataxia type 2 mouse model with severe human ATXN2 expression
Orientador de João Paulo Viegas Amaro
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022 Development of ATXN2 gene silencing strategies based on the CRISPR-Cas gene editing system
Orientador de Erica Goufa Coelho
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022 Assessing the motor phenotype and the neuropathologic profile of a novel spinocerebellar ataxia type 2 mouse model with moderate human ATXN2 expression
Orientador de Andreia Sofia de Sá Barreira Cordeiro
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - 2021/11/26 Insights into the spreading of ataxin-2 through extracellular vesicles
Coorientador de Rafael Gomes Costa
 Ciências Biomédicas - Mecanismos de Doença (Mestrado)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - 2021 Silencing of the mutant form of the ATXN2 gene as a putative therapeutic strategy for spinocdrebllar ataxia type 2
Orientador de Catarina Barbosa
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - 2021 Assessing CRISPR/Cas9-mediated insertion of an indel mutation in the ATXN2 gene
Orientador de Raquel Costa
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2019 - 2020 Silencing ATXN2 through CRISPR-mediated insertion of a premature STOP codon
Orientador de Ricardo Reis
 Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2019 - 2020 A comparative study on the function and activity of ZEB transcription factors in glioblastoma.
Coorientador de Nuno Ramalho
 Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2019 - 2019 Modelling cholesterol metabolism in the hypothalamus and its impact on white adipose tissue
Coorientador de Joana Filipa Rolo
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve, Portugal
2018 - 2019 CRISPR-Cas9 as a tool for gene therapy in Machado-Joseph disease: silencing ATXN3 and CAG expansion correction
Orientador de André Filipe Vieira da Conceição
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019 Insights into the role of GXXXX on Polyglutamine diseases
Coorientador de Diogo Teixeira
 Biologia Molecular e Microbiana (Mestrado)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018 CRISPR-mediated pre-transcriptional silencing of ATXN3, the gene involved in Machado-Joseph disease
Orientador de Frederico Mendes e Pena
 Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 Development of a cellular model for Amyotrophic Lateral Sclerosis (ALS)
Orientador de Rebekah Koppenol
 Ciências Biomédicas (Licenciatura/Bacharelato)
Universidade do Algarve, Portugal
2012 - 2012 Role of atx-3 aggregation and phosphorylation in the pathogenesis of MJD
Orientador de Marilisa Vigorita
 Pharmacologic Basis of Therapy (Mestrado)
Università degli Studi del Sannio, Itália

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/10/29 - 2023/11/04 ESN-ISN Neurochemistry School 2023 (2023/10/29 - 2023/11/04)
Outro (Coorganizador)
 Algarve Biomedical Center Research Institute, Portugal
2023/05/05 - 2023/05/05 "Advances in Polyglutamine diseases research", a scientific symposium of FENS Regional Meeting 2023 - Algarve. Albufeira, Portugal. (2023/05/05 - 2023/05/05)
Simpósio (Coorganizador)
 Algarve Biomedical Center Research Institute, Portugal
2023 - 2023 3rd International Congress of History of Science in Teaching (3.º Congresso Internacional de História da Ciência no Ensino) (2023/09/04 - 2023/09/06)
Congresso (Membro da Comissão Organizadora)
 Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2022 - 2023 FENS Regional Meeting 2023 (2022 - 2023)
Encontro (Membro da Comissão Organizadora)
 Universidade do Algarve, Portugal
2022 - 2022 Ageing without borders - Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (2022 - 2022)
Encontro (Membro da Comissão Organizadora)
 Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal

Algarve Biomedical Center Research Institute, Portugal
2022 - 2022 ABC Days - V National Meeting of the Algarve Biomedical Center. Sagres, Portugal. (2022 - 2022)
Encontro (Membro da Comissão Organizadora)
 Algarve Biomedical Center, Portugal
2021 - 2022 Fala-me NEURO (Talk NEURO to me) science communication initiative (2021 - 2022)
Outro (Coorganizador)
 Sociedade Portuguesa de Neurociências, Portugal
2021/05/24 - 2021/05/28 The CRISPR Revolution: a workshop on gene editing, from cells to animal models (2021/05/24 - 2021/05/28)
Oficina (workshop) (Coorganizador)
 Universidade do Algarve, Portugal
2018 - 2018 "Overcoming Challenges in Scientific Careers ", a symposium on career development for PhD students and PhD holders (2018 - 2018)
Simpósio (Membro da Comissão Organizadora)
 CNC.IBILI, Portugal
2018 - 2018 “Me in the spotlight: self-presentation for networking and career development”, a workshop on career development for PhD students and PhD holders (2018 - 2018)
Oficina (workshop) (Membro da Comissão Organizadora)
 CNC.IBILI, Portugal
2018 - 2018 “Finishing the PhD: how to turn anxiety into an actionable plan?”, a workshop on career development for PhD students and PhD holders (2018 - 2018)
Oficina (workshop) (Membro da Comissão Organizadora)
 CNC.IBILI, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2024/02/07 - 2024/02/09 LIV Meeting of the Portuguese Society of Pharmacology (SPF)
Encontro
 LIV Meeting of the Portuguese Society of Pharmacology (SPF)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/12/19 - 2023/12/20 Biomedical Sciences PhD Program Annual Journey
Encontro
 Biomedical Sciences PhD Program Annual Journey
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/11/17 - 2023/11/17 5ª Edition of Doctoral Conversations: "Evolution of Humanity and Environmental Adaptations"
Encontro
 5ª Edition of Doctoral Conversations: "Evolution of Humanity and Environmental Adaptations"
Universidade do Algarve, Portugal
2023/05/03 - 2023/05/05 FENS Regional Meeting 2023 - Algarve
Encontro
 FENS Regional Meeting 2023 – Algarve
Algarve Biomedical Center Research Institute, Portugal
2023/02/17 - 2023/02/17 Round table discussion under the subject "From the reconfiguration of the organic: genomic editing"
Mesa-redonda
 Public Session of the Portuguese National Ethics Council for the Life Sciences
Conselho Nacional de Ética para as Ciências da Vida, Portugal
2023/02/17 - 2023/02/17 Public Session of the Portuguese National Ethics Council for the Life Sciences , as part of the Report on the State of the Application of New Technologies to Human Life 2022 “Dysruptive Health Technologies”. Faro, Portugal.
Conferência
 Public Session of the Portuguese National Ethics Council for the Life Sciences , as part of the Report on the State of the Application of New Technologies to Human Life 2022 “Dysruptive Health Technologies”
Conselho Nacional de Ética para as Ciências da Vida, Portugal
2023 - 2023 44th European Pharmaceutical Students' Associations (EPSA) Annual Congress, Podcetrtek, Slovenia
Congresso
 44th European Pharmaceutical Students' Associations (EPSA) Annual Congress
2023 - 2023 MEEting 2023, Faro, Portugal.
Encontro
 MEEting 2023
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - 2023 Open Day of the University of Algarve
Outro
 Open Day of the University of Algarve
Universidade do Algarve, Portugal
2023 - 2023 3rd International Congress of History of Science in Teaching
Congresso
 3rd International Congress of History of Science in Teaching
Universidade do Algarve, Portugal
2022/12/19 - 2022/12/20 Biomedical Sciences PhD Program Annual Journey
Encontro
 Biomedical Sciences PhD Program Annual Journey
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022 Round table discussion on the role of research in the access to a directed therapy
Mesa-redonda
 National Ataxias Congress
Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2022 - 2022 Meeting of the Portuguese Society of Movement Disorders (SPDMov) - Classical and Atypical Parkinsonisms
Encontro
 Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms
Sociedade Portuguesa das Doenças do Movimento, Portugal
2022 - 2022 Moderation of seminar sessions of the ABC-RI International Forum Spring Edition 2022 – Gene and Cell Therapies for Healthy Ageing
Simpósio
 ABC-RI International Forum Spring Edition 2022 – Gene and Cell Therapies for Healthy Ageing
Algarve Biomedical Center Research Institute, Portugal
2022 - 2022 Ageing without borders - Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
Encontro
 Ageing without borders - Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal

Algarve Biomedical Center Research Institute, Portugal
2022 - 2022 ABC Days - V National Meeting of the Algarve Biomedical Center. Sagres, Portugal.
Encontro
 ABC Days - V National Meeting of the Algarve Biomedical Center
Algarve Biomedical Center, Portugal
2022 - 2022 I National Ataxias Congress
Encontro
 I National Ataxias Congress
Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2022 - 2022 MEEting 2022, Faro, Portugal
Encontro
 MEEting 2022
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022 FIC.A (Festival Internacional de Ciência, International Science Festival), Oeiras, Portugal
Exposição
 FIC.A (Festival Internacional de Ciência, International Science Festival)
2021/12 - 2021/12 XVII Meeting of the Portuguese Society for Neuroscience (SPN)
Encontro
 XVII Meeting of the Portuguese Society for Neuroscience (SPN)
Sociedade Portuguesa de Neurociências, Portugal
2021/12 - 2021/12 Biomedical Sciences PhD Program Annual Journey
Encontro
 Biomedical Sciences PhD Program Annual Journey
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021/10 - 2021/10 IV Jornadas Algarve Biomedical Center
Encontro
 IV Jornadas Algarve Biomedical Center
Algarve Biomedical Center, Portugal
2021/05/24 - 2021/05/28 The CRISPR Revolution: a workshop on gene editing, from cells to animal models.
Oficina (workshop)
 The CRISPR Revolution: a workshop on gene editing, from cells to animal models
Universidade do Algarve, Portugal
2021/04/26 - 2021/04/27 JCB–JEM 2021 Symposium on Neurodegeneration
Simpósio
 JCB–JEM 2021 Symposium on Neurodegeneration
The Rockefeller University Press, Estados Unidos
2021 - 2021 XLXI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Lisbon, Portugal.
Conferência
 XLXI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia, Portugal
2021 - 2021 Ataxias, um mundo - Avanços no desenvolvimento de novas terapias (Ataxias - Advances in the development of novel therapies)
Encontro
Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2020 - 2020 XLX Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Coimbra, Portugal.
Conferência
 XLX Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia, Portugal
2019 - 2019 XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal
Conferência
 XVI Meeting of the Portuguese Society for Neuroscience (SPN)
Sociedade Portuguesa de Neurociências, Portugal
2019 - 2019 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI). Coimbra, Portugal.
Conferência
 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation, Países Baixos
2019 - 2019 3as Jornadas Algarve Biomedical Center. Albufeira, Portugal.
Conferência
 3as Jornadas Algarve Biomedical Center
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2018 - 2018 XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Lisbon, Portugal.
Congresso
 XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF).
Sociedade Portuguesa de Farmacologia, Portugal
2018 - 2018 Workshop "Visual Communication Graphical abstracts". PostDocs@UC, University of Coimbra, Coimbra, Portugal.
Oficina (workshop)
 Visual Communication Graphical abstracts
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - 2017 XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Coimbra, Portugal.
Conferência
 XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia, Portugal
2017 - 2017 EMBO Practical Course on Mouse Genome Engineering. Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany.
Outro
 EMBO Practical Course on Mouse Genome Engineering
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
2016 - 2016 10th World Congress on Controversies in Neurology (CONy) – Workshop in Machado-Joseph disease
Oficina (workshop)
 10th World Congress on Controversies in Neurology (CONy) – Workshop in Machado-Joseph disease
2016 - 2016 XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Porto, Portugal
Conferência
 XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF)
Sociedade Portuguesa de Farmacologia, Portugal
2016 - 2016 1st Brain without Borders International Symposium. Coimbra, Portugal.
Simpósio
 1st Brain without Borders International Symposium
CNC.IBILI, Portugal
2015/05/28 - 2015/05/28 Integration of PhD holders in Companies: Challenges and Solutions for the Future (Integração de Doutorados nas Empresas: Desafios e Soluções para o Futuro)
Simpósio
 Integração de Doutorados nas Empresas: Desafios e Soluções para o Futuro
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015 - 2015 Ineo start – technology transfer and business plan acceleration program. Instituto Pedro Nunes (IPN), Coimbra, Portugal.
Outro
 Ineo start – technology transfer and business plan acceleration program
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2015 - 2015 Workshop "CRISPR Tools in Genetically Tractable Organisms". Fundação Champalimaud, Lisboa, Portugal.
Oficina (workshop)
 CRISPR Tools in Genetically Tractable Organisms
Fundação Champalimaud, Portugal
2014 - 2014 XVIII Congress of the Portuguese Biochemical Society (SPB). Coimbra, Portugal.
Congresso
 XVIII Congress of the Portuguese Biochemical Society (SPB)
Sociedade Portuguesa de Bioquímica, Portugal
2014 - 2014 5th Ataxia Investigators Meeting. Las Vegas, USA.
Conferência
 5th Ataxia Investigators Meeting
National Ataxia Foundation, Estados Unidos
2014 - 2014 Laboratory Animal Sciences Course - B Category. Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Outro
 aboratory Animal Sciences Course - B Category
CNC.IBILI, Portugal
2013 - 2013 Champalimaud Neuroscience Programme Symposium. Lisbon, Portugal.
Simpósio
 Champalimaud Neuroscience Programme Symposium
Programa Champalimaud de Neurociências, Portugal
2013 - 2013 XIII Meeting of the Portuguese Society for Neuroscience (SPN), Luso, Portugal.
Conferência
 XIII Meeting of the Portuguese Society for Neuroscience (SPN)
Sociedade Portuguesa de Neurociências, Portugal
2013 - 2013 XI Center for Neuroscience and Cell Biology (CNC) Annual Meeting, Coimbra, Portugal.
Encontro
 XI Center for Neuroscience and Cell Biology (CNC) Annual Meeting
CNC.IBILI, Portugal
2013 - 2013 Workshop "The nematode C. elegans – a model for biomedical research". Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal.
Oficina (workshop)
 The nematode C. elegans – a model for biomedical research
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012 - 2012 8th Federation of European Neurosciences (FENS) Forum of Neuroscience, Barcelona, Spain.
Conferência
 8th Federation of European Neurosciences (FENS) Forum of Neuroscience
Federation of European Neuroscience Societies, Bélgica
2012 - 2012 1st Doctoral Programme in Experimental Biology and Biomedicine (BEB) Symposium – Science dreams, challenges arise, Coimbra, Portugal
Simpósio
 1st Doctoral Programme in Experimental Biology and Biomedicine (BEB) Symposium – Science dreams, challenges arise
CNC.IBILI, Portugal
2012 - 2012 X Center for Neuroscience and Cell Biology (CNC) Annual Meeting, Cantanhede, Portugal.
Encontro
 X Center for Neuroscience and Cell Biology (CNC) Annual Meeting
CNC.IBILI, Portugal
2011 - 2011 Gordon Research Conference on CAG Triplet Disorders, Luca, Italy. Gordon Research Conference on CAG Triplet Disorders
Gordon Research Conferences, Estados Unidos

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/12/15 Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells
Orientador
 Cristiana Raquel Rodrigues Madeira (Mestrado)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/12/05 Modelling aging in vitro using stem cells-derived cells
Arguente principal
 Pedro Miguel Canada de Sousa (Mestrado)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/07/27 A robust study on the Ataxin-3 fibrillization pathway for the discovery of new inhibitory compounds Francisco Rosário de Figueiredo (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/04/22 Establishing the relevance of Tau isoform imbalance in the onset and progression of Machado Joseph disease
Arguente principal
 Beatriz Rocha Ferreira (Mestrado)
Universidade do Minho, Portugal
2022 Intracerebral cerebrovascular calcifications as an etiological and prognosis biomarker in ischemic stroke: an exploratory study
Arguente principal
 Adriana Filipa Batista Barros (Outro)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 Study of the functional parameters of the autonomous nervous system in migraine patients
Arguente principal
 Matilde Oliveira Farias (Outro)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 Cervical cancer: what is the utility of p16 and other biomarkers in the diagnosis?
Arguente principal
 Sara Guapo de Almeida Boom (Outro)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 Animal models of Down's syndrome; applications and limitation in the study of the nervous system
Arguente
 Sofia Isabel Gonçalves Fernandes (Outro)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 qPCR validation of genes differentially expressed in embryonic stem cells in response to decreased Cited2 expression
Arguente
 Filipe Vitorino (Outro)
Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 Silencing ATXN2 through CRISPR-mediated insertion of a premature STOP codon
Orientador
 Ricardo Reis (Mestrado)
Universidade do Algarve, Portugal
2020 Non-codifying RNA molecules in the temporal control of embryonic development
Arguente
 André Filipe Coelho de Jesus (Outro)
Universidade do Algarve, Portugal
2020 Synaptic Plasticity: What changes in the Aging Brain?
Arguente
 Inês Alexandre Couto de Almeida (Outro)
Universidade do Algarve, Portugal
2020 Utilizing the dominant negative technique in the analysis of molecular and behavioural changes in the study of atypical Rett syndrome in zebra-fish
Arguente
 Pedro Miguel Xabregas Moreno dos Santos (Outro)
Universidade do Algarve, Portugal
2020 Development of the microglia and autism
Arguente
 Beatriz Passos Paulo (Outro)
Universidade do Algarve, Portugal
2020 Development of a lineage tracing strategy for the evaluation of substantia nigra regeneration in a Acomys cahirinus model of Parkinson’s disease
Arguente
 Giulia Fest Donnici (Outro)
Universidade do Algarve, Portugal
2020 Complementary approaches to the treatment of chronic pain: acupuncture and mindfulness
Arguente
 Vera Mascarenhas (Outro)
Universidade do Algarve, Portugal
2019 CRISPR-Cas9 as a tool for gene therapy in Machado-Joseph disease: silencing ATXN3 and CAG expansion correction
Orientador
 André Filipe Vieira Conceição (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 Utilizing bacteriophages as a means to tackle bacterial infections
Arguente
 Diana Sofia Carvalho Varela (Outro)
Universidade do Algarve, Portugal
2019 Development of a MCT8 gene knockout model using the CRISPR/Cas9 technology
Arguente
 Vanda Salgueiro Evaristo (Outro)
Universidade do Algarve, Portugal
2018 Multiplexed CRISPR activation of neuroprotective genes for Alzheimer´s Disease
Arguente principal
 Fábio Duarte (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 CRISPR-mediated pre-transcriptional silencing of ATXN3, the gene involved in Machado-Joseph disease
Orientador
 Frederico Mendes e Pena (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 Gene therapy for Huntington’s disease: molecular activation of autophagy
Arguente
 Ricardo Nunes (Outro)
Universidade do Algarve, Portugal
2018 Identification of neuronal cells dependent on thyroid hormones
Arguente
 Ana Rita Martins Luz (Outro)
Universidade do Algarve, Portugal
2018 Molecular activation of the autophagic pathway in Polyglutamine diseases
Arguente
 Raquel Lourenço das Neves Sequeira (Outro)
Universidade do Algarve, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2024 - Atual XIX Congress of the Portuguese Society of Diagnostic and Therapeutic Neurorradiology Universidade do Algarve

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2022 - 2022 Member of the evaluation committee of the PhD candidates of the Biomedical Sciences Program at the Biomedical Sciences PhD Program Annual Journey
Avaliador
 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2021 Member of the evaluation committee of the PhD candidates of the Biomedical Sciences Program at the Biomedical Sciences PhD Program Annual Journey
Avaliador
 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023 - Atual Fundamentals of Bioinformatics Ciências Biomédicas (Licenciatura) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Atual Scientific Methods Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Atual Anatomophysiology I Ciências Farmacêuticas (Mestrado integrado) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - Atual Basic and Clinical Sciences Medicina (Mestrado integrado) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Atual Anatomy and Physiology Bioengenharia (Licenciatura) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - Atual Applications in Histology Ciências Biomédicas (Licenciatura) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - Atual Molecular and Cellular Mechanisms Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve, Portugal
2023 - Atual Advances in Gene Therapies Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve, Portugal
2023 - Atual Development of New Medicines Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve, Portugal
2023 - Atual Anti-Cancer Drug Discovery Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado integrado) Universidade do Algarve, Portugal
2022 - Atual Practicals of Molecular Research Ciências Biomédicas (Licenciatura) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2021 - Atual OncoLab 2 Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado integrado) Universidade do Algarve, Portugal
2020 - Atual Neurobiology Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2020 - Atual Animal Models in Biomedical Research Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2020 - Atual Functional Organic Systems 301 - Nervous System And Special Senses Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2019 - Atual Gene and Cell Therapy Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2018 - 2023 Advanced Systems of Gene and Cell Therapy Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado) Universidade do Algarve, Portugal
2014 - 2018 Do Gene à Proteína (From Gene to Protein). Theoretical and practical teaching of molecular cell biology techniques to high school students and teachers. Molecular Cell Biology (Outros) Instituto de Educação e Cidadania, Portugal

Membro de associação

Nome da associação Tipo de participação
2024/02/09 - Atual Ordem dos Farmacêuticos (Portuguese Order of Pharmacists) Effective member
2022 - Atual Ataxia Global Initiative Effective member
2020 - Atual Portuguese Society of Pharmacology (SPF) Effective member
2013 - Atual Portuguese Society of Neuroscience (SPF) Effective member
2013 - Atual Federation of European Neuroscience Societies (FENS) Effective member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023 - Atual Member of the Course Committee of the PhD Program in Biomedical Sciences
Membro
 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - Atual Member of the Scientific Council of the Algarve Biomedical Center Research Institute (ABC-RI)
Membro
 Algarve Biomedical Center Research Institute, Portugal
2019 - 2021 Member of the Scientific Council of the Centre for Biomedical Research (CBMR)
Membro
 Universidade do Algarve, Portugal
2017 - 2019 Elected member of the CNC.IBILI PostDoc representatives committee
Membro
 CNC.IBILI, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2021/07/14 - Atual Jury of Ana Carolina Pinheiro da Silva PhD Thesis project "Development of an AAV-mediated allele-specific therapy for Machado-Joseph Disease" of Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023 - 2023 Poster evaluation, in the context of the "Student-Selected Modules 1" course unit of the Integrated Master in Medicine Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022 Poster evaluation, in the context of the "Student-Selected Modules 1" course unit of the Integrated Master in Medicine Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022 Poster evaluation at the Meeting of the Portuguese Society of Movement Disorders (SPDMov) - Classical and Atypical Parkinsonisms, Luso, Portugal Sociedade Portuguesa das Doenças do Movimento, Portugal

Tutoria

Tópico Nome do aluno
2021/07 - Atual PhD project: Development of an AAV-mediated allele-specific therapy for Machado-Joseph Disease Ana Carolina Pinheiro da Silva
2022 - 2022 Systemic Hypertension Associated with Chronic Intermittent Hypoxia Miguel António Figueira Domingos
2022 - 2022 Pre- and post-surgery incapacity in Inflammatory Bowel Disease – short- and long-term results evaluated by IBD DISK Juliana Sofia Rodrigues Ferreira
2022 - 2022 Analysis of Cysteine and Homocysteine as biomarkers for Obstructive Sleep Apnea Syndrome and Arterial Hypertension Diogo Alexandre Rosado Leça
2022 - 2022 Optimization of a cryopreservation protocol for future application in the isolation of Urine-Derived Stem Cells (UDSC) from patients with Amyotrophic Lateral Sclerosis Beatriz Galhano Lopes
2020 - 2020 Laboratory Methods - Bioinformatic tools Ana Letícia Fernandes Gomes
Distinções

Prémio

2023 Teaching and Learning Award from the University of Algarve 2021/22
Universidade do Algarve, Portugal

Outra distinção

2020 Finalist of the Roche Building Tomorrow Together (Roche-BTT) Program
2009 Award for the best student from the Faculty of Sciences end Technology of the University of Coimbra 2008/09
2009 PhD Fellowship (SFRH/BD/47160/2008).
Fundação para a Ciência e a Tecnologia, Portugal
2007 University of Coimbra's 3% Best Students Award
Universidade de Coimbra, Portugal
2006 Merit Scholarship
Universidade de Coimbra, Portugal
2006 University of Coimbra's 3% Best Students Award
Universidade de Coimbra, Portugal
2005 Merit Scholarship
Universidade de Coimbra, Portugal
2005 University of Coimbra's 3% Best Students Award
Universidade de Coimbra, Portugal
2004 University of Coimbra's 3% Best Students Award
Universidade de Coimbra, Portugal