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Caio H. Franco completed a Ph.D. in Sciences (Major in Microbiology and Immunology) from the Federal University of São Paulo in 2018. He has published 26 articles in peer-reviewed journals, accumulating more than 560 citations to date (accumulated impact factor 185.7, h-factor: 15, Scopus - 2024). The main research developed by C. Franco is in Cell Biology, Microbiology and Parasitology. His main activities are focused on the design and establishment of numerous high-content microscopy assays, performing large-scale screenings with libraries of small molecules/natural products, and phenotypic and genetic characterization of drug-resistant parasites (Trypanosoma cruzi, Plasmodium falciparum). He has also established a screening assay to identify compounds that disrupt/inhibit biofilm formation by Gram-positive bacteria. Recently, C. Franco has investigated factors relevant to S. aureus infection of mammalian cells, through genome-wide microscopy-based screenings; moreover, he has dedicated himself to characterizing the intracellular lifestyle of antibiotic-resistant bacterial strains. He was also the Principal Investigator of an Exploratory Research Project entitled "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains", funded by FCT; the project was developed at the RNA & Infection laboratory (PI: Ana Eulalio - Center for Neurosciences and Cell Biology - University of Coimbra). Since 2023 C. Franco has been working as an Assistant Doctoral Researcher at the Collaborative Laboratory AccelBio, where he is engaged in translational, product-centred drug discovery projects with a focus on high-throughput/high-content assays development, management of compound libraries and performing chemical/genetic screening in relevant human disease models.
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Identificação

Identificação pessoal

Nome completo
Caio Haddad Franco

Nomes de citação

  • Franco, Caio
  • Franco, C. H.

Identificadores de autor

Ciência ID
E117-7526-DDBF
ORCID iD
0000-0003-2467-9401

Moradas

  • UC Biotech - Biocant Park , 3060-197, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A1)
Formação
Grau Classificação
2014/02 - 2018/03
Concluído
 Doutorado em Ciências (Doutoramento)
Especialização em Microbiology and Immunology
Universidade Federal de São Paulo, Brasil
"Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening" (TESE/DISSERTAÇÃO)
2007/08 - 2013/08
Concluído
 Biotechnology Engineer (Bachelor)
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brasil
"Evaluation of germination, vegetative development and genotoxicity of lettuce from irradiated seeds" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/01 - Atual Assistente de Investigação (carreira) (Investigação) Co-Lab AccelBio, Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
(...)
2019/05 - 2022/12 Investigador (Investigação) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/05 - 2019/03 Pós-doutorado (Investigação) Fundação de Apoio a Universidade de São Paulo, Brasil
Universidade de São Paulo, Brasil
2012/08 - 2013/06 Estagiário de Investigação (Investigação) Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil
Universidade de São Paulo Centro de Energia Nuclear na Agricultura, Brasil
2011/08 - 2012/07 Estagiário de Investigação (Investigação) Institut Pasteur Korea, Coreia do Sul
Institut Pasteur Korea, Coreia do Sul

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2014/02 - 2018/03 PhD fellow Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil
Centro Nacional de Pesquisa em Energia e Materiais, Brasil
(...)
2010/01 - 2011/12 Scientific Trainee Fellow Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brasil
2010/08 - 2011/07 Junior Enterprise Organization Biotec Júnior, Brasil
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brasil
Projetos

Bolsa

Designação Financiadores
2022 - 2023 Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains
EXPL/BIA-MIC/1251/2021
Investigador responsável
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2019 - 2022 Large-scale identification and functional characterization of host microRNAs regulating infection by clinically relevant Staphylococcus aureus strains
POCI-01-0145-FEDER-029999
Bolseiro de Pós-Doutoramento
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018 - 2019 Development of an in vitro antibiofilm screening assay against strains of S. aureus and S. epidermidis
FUSP3236
Bolseiro de Pós-Doutoramento
Universidade de São Paulo Instituto de Ciencias Biomédicas, Brasil

Eurofarma Laboratórios, Brasil
Fundação de Apoio a Universidade de São Paulo
Concluído
2017 - 2019 Identification of starting points for drug discovery and target identification against major neglected diseases
MMV2016
Bolseiro de Doutoramento
Laboratório Nacional de Biociências, Brasil

Centro Nacional de Pesquisa em Energia e Materiais, Brasil

Universidade de São Paulo, Brasil
Medicines for Malaria Venture
Concluído
2014 - 2018 Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening
141635/2014-2
Bolseiro de Doutoramento
Conselho Nacional de Desenvolvimento Científico e Tecnológico
2014 - 2017 NMTrypl - New Drugs for Trypanosomatidic Infections
603240
Bolseiro de Doutoramento
Laboratório Nacional de Biociências, Brasil

Centro Nacional de Pesquisa em Energia e Materiais, Brasil
European Commission Seventh Framework Programme for Research and Technological Development Regions of Knowledge
Concluído
2010 - 2013 Determination of generic doses of ionizing radiation for quarantine treatment
800405
Bolseiro de Iniciação Científica
Universidade de São Paulo Centro de Energia Nuclear na Agricultura, Brasil
Concluído
Produções

Publicações

Artigo em revista
  1. Alcântara, Laura; Franco, Caio; Moretti, Nilmar; Pilger, Denise. "Editorial: Drug discovery for emerging and neglected tropical diseases: advances, challenges and perspectives". Frontiers in Drug Discovery 3 1346042 (2023): http://dx.doi.org/10.3389/fddsv.2023.1346042.
    Acesso aberto • Publicado • 10.3389/fddsv.2023.1346042
  2. Pandey, Ramendra P.; Nascimento, Marilda Savoia; Franco, C. H.; Bortoluci, Karina; Silva, Marcelo Nunes; Zingales, Bianca; Gibaldi, Daniel; et al. "Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi In Vitro and In Vivo". Antimicrobial Agents and Chemotherapy (2022):
    Publicado • 10.1128/aac.00284-22
  3. Pereira, Catarina G.; Moraes, Carolina Borsoi; Franco, Caio H.; Feltrin, Clarissa; Grougnet, Raphaël; Barbosa, Euzébio Guimarães; Panciera, Michele; et al. "In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.)". Plants 10 11 (2021): 2235.
    Publicado • 10.3390/plants10112235
  4. Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Le, Hai; Giardini, Miriam A.; Pascoalino, Bruno S.; et al. "Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity". International Journal for Parasitology: Drugs and Drug Resistance 13 (2020): 107-120.
    Acesso aberto • Publicado • 10.1016/j.ijpddr.2020.06.001
  5. Conrado, Gabrielly Galdino; Grazzia, Nathalia; de Oliveira, Adriana da Silva S.; Franco, Caio Haddad; Moraes, Carolina Borsoi; Gadelha, Fernanda Ramos; Miguel, Danilo Ciccone; Garcia, Vera Lucia. "Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity". Planta Medica 86 11 (2020): 782-789.
    Publicado • 10.1055/a-1179-1003
  6. Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; et al. "Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes". International Journal of Molecular Sciences 21 10 (2020): 3659.
    Acesso aberto • Publicado • 10.3390/ijms21103659
  7. Bonatto, Vinicius; Batista, Pedro Henrique Jatai; Cianni, Lorenzo; De Vita, Daniela; Silva, Daniel G.; Cedron, Rodrigo; Tezuka, Daiane Y.; et al. "On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors". RSC Medicinal Chemistry 11 11 (2020): 1275-1284.
    Publicado • 10.1039/d0md00097c
  8. Gomes, Juliana C.; Cianni, Lorenzo; Ribeiro, Jean; dos Reis Rocho, Fernanda; da Costa Martins Silva, Samelyn; Batista, Pedro Henrique Jatai; Moraes, Carolina Borsoi; et al. "Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement". Bioorganic & Medicinal Chemistry 27 22 (2019): 115083.
    Publicado • 10.1016/j.bmc.2019.115083
  9. Caio Haddad Franco; Laura Maria Alcântara; Eric Chatelain; Lucio Freitas-Junior; Carolina Borsoi Moraes. "Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection". Tropical Medicine and Infectious Disease 4 2 (2019): 82-82.
    Acesso aberto • Publicado • 10.3390/tropicalmed4020082
  10. Cleber C. Melo-Filho; Rodolpho C. Braga; Eugene N. Muratov; Caio Haddad Franco; Carolina B. Moraes; Lucio H. Freitas-Junior; Carolina Horta Andrade. "Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening". European Journal of Medicinal Chemistry 163 (2019): 649-659.
    Publicado • 10.1016/j.ejmech.2018.11.062
  11. Borsari, Chiara; Dolores Jimenez-Anton, Maria; Eick, Julia; Bifeld, Eugenia; Jose Torrado, Juan; Isabel Olias-Molero, Ana; Jesus Corral, Maria; et al. "Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics". European Journal of Medicinal Chemistry (2019):
    Publicado • 10.1016/J.EJMECH.2019.111676
  12. Linciano, Pasquale; Pozzi, Cecilia; dello Iacono, Lucia; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; et al. "Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections". Journal of Medicinal Chemistry (2019):
    Publicado • 10.1021/ACS.JMEDCHEM.8B02021
  13. Rodrigues e Silva Tiago; Vaz dos Santos Neto Eugenio; Lucia Tasca Goiz Ruiz Ana; Ann Foglio Mary; Haddad Franco Caio; Borsoi Moraes Carolina; Maia de Oliveira Valéria. "Antimicrobial, antiparasitic and antiproliferative effects of the extract of Bacillus safensis SG-32 isolated from a Brazilian oil reservoir". African Journal of Microbiology Research 12 37 (2018): 897-907.
    Publicado • 10.5897/ajmr2018.8940
  14. Karim Bouchmella; Felipe Davi Campanaro; Gabriela Borba Mondo; Murilo Izidoro Santos; Caio Haddad Franco; Carolina Borsoi Moraes; Christine Biolley; Ahmad Mehdi; Mateus Borba Cardoso. "Tetracycline@silver ions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration". Nanomedicine 13 14 (2018):
    Publicado • 10.2217/nnm-2018-0027
  15. Fabricio Castro Machado; Caio Haddad Franco; Jose Vitorino dos Santos Neto; Karina Luiza Dias-Teixeira; Carolina Borsoi Moraes; Ulisses Gazos Lopes; Bertal Huseyin Aktas; Sergio Schenkman. "Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation". Scientific Reports 8 1 (2018):
    Acesso aberto • Publicado • 10.1038/s41598-018-23259-9
  16. Tiago R. Silva; Alysson W. F. Duarte; Michel R. Z. Passarini; Ana Lucia T. G. Ruiz; Caio Haddad Franco; Carolina Borsoi Moraes; Itamar Soares de Melo; et al. "Bacteria from Antarctic environments: diversity and detection of antimicrobial, antiproliferative, and antiparasitic activities". Polar Biology 41 7 (2018): 1505-1519.
    Publicado • 10.1007/s00300-018-2300-y
  17. Palace-Berl, F.; Pasqualoto, K.F.M.; Zingales, B.; Moraes, C.B.; Bury, M.; Franco, C.H.; da Silva Neto, A.L.; et al. "Investigating the structure-activity relationships of N’-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds". European Journal of Medicinal Chemistry 144 (2018): 29-40.
    Publicado • 10.1016/j.ejmech.2017.12.011
  18. Linciano, P.; Moraes, C.B.; Alcantara, L.M.; Franco, C.H.; Pascoalino, B.; Freitas-Junior, L.H.; Macedo, S.; et al. "Aryl thiosemicarbazones for the treatment of trypanosomatidic infections". European Journal of Medicinal Chemistry 146 (2018): 423-434.
    Publicado • 10.1016/j.ejmech.2018.01.043
  19. Daniel G. Silva; Jean F.R. Ribeiro; Daniela De Vita; Lorenzo Cianni; Caio Haddad Franco; Lucio H. Freitas-Junior; Carolina Borsoi Moraes; et al. "A comparative study of warheads for design of cysteine protease inhibitors". Bioorganic & Medicinal Chemistry Letters 27 22 (2017): 5031-5035.
    Publicado • 10.1016/j.bmcl.2017.10.002
  20. Chiara Borsari; Nuno Santarem; Juan Torrado; Ana Isabel Olías; María Jesús Corral; Catarina Baptista; Sheraz Gul; et al. "Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds". European Journal of Medicinal Chemistry 126 (2017): 1129-1135.
    Publicado • 10.1016/j.ejmech.2016.12.017
  21. Balfour, M.N.; Franco, C.H.; Moraes, C.B.; Freitas-Junior, L.H.; Stefani, H.A.. "Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols". European Journal of Medicinal Chemistry 128 (2017): 202-212.
    Publicado • 10.1016/j.ejmech.2017.01.040
  22. Carolina B. Moraes; Caio H. Franco. "Novel drug discovery for Chagas disease". Expert Opinion on Drug Discovery 11 5 (2016): 447-455.
    Publicado • 10.1517/17460441.2016.1160883
  23. Damien Bosc; Elisabeth Mouray; Sandrine Cojean; Caio Haddad Franco; Philippe M. Loiseau; Lucio H. Freitas-Junior; Carolina Borsoi Moraes; Philippe Grellier; Joëlle Dubois. "Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors". European Journal of Medicinal Chemistry 109 (2016): 173-186.
    Publicado • 10.1016/j.ejmech.2015.12.045
  24. Silva, F.T.; Franco, C.H.; Favaro, D.C.; Freitas-Junior, L.H.; Moraes, C.B.; Ferreira, E.I.. "Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues". European Journal of Medicinal Chemistry 121 (2016): 553-560.
    Publicado • 10.1016/j.ejmech.2016.04.065
  25. Caio Haddad Franco; Valter H.M. dos Santos; Luciana P. Silva; Valter Arthur; Regildo M.G. Silva. "Mutagenic potential of lettuce grown from irradiated seeds". Scientia Horticulturae 182 (2015): 27-30.
    Publicado • 10.1016/j.scienta.2014.11.011
  26. Moraes, C.B.; Giardini, M.A.; Kim, H.; Franco, C.H.; Araujo-Junior, A.M.; Schenkman, S.; Chatelain, E.; Freitas-Junior, L.H.. "Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: Implications for Chagas disease drug discovery and development". Scientific Reports 4 (2014): 1-11.
    Publicado • 10.1038/srep04703
  27. Laura M. Alcantara; Junwon Kim; Carolina B. Moraes; Caio H. Franco; Kathrin D. Franzoi; Sukjun Lee; Lucio H. Freitas-Junior; Lawrence S. Ayong. "Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites". Experimental Parasitology 134 2 (2013): 235-243.
    Publicado • 10.1016/j.exppara.2013.03.022
Capítulo de livro
  1. Ariely Barbosa Leite; Ana Caroline Nascimento Castro; Franco, C. H.; Leila Maria dos Santos Moura; Laura M. Alcantara; Elton J. R. Vasconcelos; Rubens Lima do Monte Neto; Nilmar Silvio Moretti. "Fármacos usados nos tratamentos das protozooses e das ectoparasitoses". In Livro-Texto De Farmacologia - Casos Clínicos E Atividades Didáticas, editado por Girardi, Adriana Castello Costa; Cruz, Fábio Cardoso; Pereira, Gustavo José da Silva; Santos, Paulo Caleb Junior de Lima, 1-25. São Paulo, Brasil: Atheneu, 2020.
    Publicado
Poster em conferência
  1. Franco, Caio; Costa, Susana; Mano, Miguel; Eulalio, Ana. "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains". Trabalho apresentado em RNA Biology in Host-Pathogens Interactions, 2024.
  2. Costa, Susana; Franco, Caio; Mano, Miguel; Eulalio, Ana. "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains". Trabalho apresentado em EMBO | EMBL Symposium: The non-coding genome, 2023.
  3. Franco, C. H.; Costa, Susana; Mano, Miguel; Eulalio, Ana. "Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains". Trabalho apresentado em XI ptRNA Meeting - RNA in Disease, 2023.
  4. Alcântara, Laura; Franco, Caio; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Trabalho apresentado em XI ptRNA Meeting - RNA in Disease, 2023.
  5. Alcântara, Laura; Franco, C. H.; Lopes, Inês Rodrigues; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Trabalho apresentado em Cold Spring Harbor Laboratory Conference Microbial Pathogenesis & Host Response, 2021.
  6. Franco, C. H.; Alcântara, Laura; Inês Lopes; Mano, Miguel; Eulalio, Ana. "Functional high-throughput screening identifies microRNAs that regulate infection by Staphylococcus aureus". Trabalho apresentado em EMBO | EMBL Symposium: New Approaches and Concepts in Microbiology, 2021.
  7. Franco, C. H.; Bruna Wenyi Chuang Jou; Lucio Freitas-Junior; Carolina Borsoi Moraes. "Development of a phenotypic assay and studies of target deconvolution for Staphylococcus aureus and Staphylococcus epidermidis biofilm formation". Trabalho apresentado em II Postdoctoral Symposium from University of São Paulo, 2018.
  8. Penteado, A. B.; Franco, C. H.; Moraes, C. B.; Diaz, I. E. C.; Singh, A. K. ; Fischer, D. C. H.. "Alkaloid Profile And High Content Screening Trypanocidal Actvity Assay In Annona Species". Trabalho apresentado em VIII Simpósio Ibero-americano de Plantas Medicinais e III Simpósio Ibero-americano de Investigação em Câncer, 2016.
  9. Castro, N. S. V.; Franco, C. H.; Moraes, C. B.; Diaz, I. E. C.; Fischer, D. C. H.. "Volatile Oil From Apiaceae Chemical Composition And High Content Screening Trypanocidal Activity Assay". Trabalho apresentado em VIII Simpósio Ibero-americano de Plantas Medicinais e III Simpósio Ibero-americano de Investigação em Câncer, 2016.
  10. Franco, C. H.; Naves, L. S.; Freitas-Junior, L.H.; Moraes, C. B.. "Trypanosoma cruzi high content screening assay: Experimental Standardization and Triage Validation". Trabalho apresentado em XXXI Annual Meeting of the Brazilian Society of Protozoology, 2015.
  11. Franco, J. G.; Franco, C. H.; Franco, S. S. H.; Arthur, P. B.; Arthur, V.. "Microwave Radiation Effects on the Different Stages of Sitophilus oryzae (Linné, 1763) (Coleopter, Curculionidae) Evolutive Cycle in Rice, Focusing its Control". Trabalho apresentado em International Nuclear Atlantic Conference - INAC 2013, 2013.
  12. Franco, C. H.; Arthur, V.; Franco, S. S. H.; Franco, J. G.; Arthur, P. B.. "Gamma Radiation On The Quality Of Green Bean Minimally Processed". Trabalho apresentado em 21 Simpósio Internacional de Iniciação Científica e Tecnológica da USP, 2013.
  13. Franco, C. H.; Valter Arthur; Regildo M.G. Silva; José Gilmar Franco; Suely Salumita Haddad Franco. "Evaluation Of Germination, Vegetative Development And Genotoxicity Of Lettuce From Irradiated Seeds". Trabalho apresentado em International Nuclear Atlantic Conference, 2013.
  14. Franco, C. H.; Regildo M.G. Silva; Valter Arthur. "Avaliação do desenvolvimento de mudas de alface (Lactuca sativa L.) provenientes de sementes irradiadas.". Trabalho apresentado em X Encontro de Engenharia Biotecnológica e Biociências, 2010.
  15. Franco, C. H.; da Silva. R. M. G.; Arthur, V.; Franco, S. S. H.; Franco, J. G.. "Evaluation of germination and development of Lactuca sativa (Asteracea) from irradiated seeds". Trabalho apresentado em XXII Congresso de Iniciação Científica da Unesp, 2010.
Resumo em conferência
  1. Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Giardini, Miriam A.; Pascoalino, Bruno S.; Freitas-Junior, Lucio H.; et al. "Phenotypic and Genetic Characterization of Trypanosoma cruzi Resistant to Ravuconazole". Trabalho apresentado em XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, Caxambu, 2018.
    Publicado
  2. Alcântara, Laura M.; Ferreira, Talita C. ; Franco, Caio H.; Schenkman, Sergio; Freitas-Junior, Lucio H.; Moraes, Carolina B.. "Screening of the Pathogen Box Library for Discovery of Broad-Spectrum Anti-Trypanosomatidic Agents". Trabalho apresentado em XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease, Caxambu, 2018.
    Publicado
Tese / Dissertação
  1. Franco, C. H.. "Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening". Doutoramento, Universidade Federal de São Paulo, 2018.
  2. Franco, C. H.. "Evaluation of germination, vegetative development and genotoxicity of lettuce from irradiated seeds". Licenciatura, Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, 2012.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/06/06 Presented the work: Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains RNA Biology in Host-Pathogens Interactions
EpiViral (Porto, Portugal)
2022 Lecturer at PhD Program Course: Image Analysis - Cell profiler PDBEB course: High-Throughput Screening for Target and Drug Discovery
University of Coimbra (Cantanhede, Portugal)
2018 Presented the work: Phenotypic and Genetic Characterization of Trypanosoma cruzi resistant to ravuconazole XXXIV Annual Meeting of the Brazilian Society of Protozoology / XLV Annual Meeting on Basic Research in Chagas Disease
Brazilian Society of Protozoology (Caxambu, Brasil)
2017 Presented the work: High content screening of pharmacologically active compounds against Trypanosoma cruzi: impact of different host cell lineages for hit selection XXXIII Annual Meeting of the Brazilian Society of Protozoology / XLIV Annual Meeting on Basic Research in Chagas Disease
Brazilian Society of Protozoology (Caxambu, Brasil)
2015 Presented the seminar: High Content Screening in Trypanosomes International Course on Bioimaging by Automated Microscopy
Instituto Oswaldo Cruz (Rio de Janeiro, Brasil)
2015 Invited Speaker at a Mini-Course: " Studying Neglected Diseases" at Open Congress for Biology Students Open Congress for Biology Students (C.A.E.B)
Universidade Estadual de Campinas/ CAEB (Campinas, Brasil)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2021 - 2021 Volunteer Organizer and Speed Dating Presenter of the 2021 edition of European Researchers´s Night - Coimbra (2021/09/24 - 2021/09/24)
Exposição (Outra)
 Universidade de Coimbra, Portugal
2018 - 2018 Member of the organizing committee of this 2-days international event: Tools and Platforms for phenotypic Drug Discovery (150 attendees) (2018 - 2018)
Conferência (Membro da Comissão Organizadora)
 Universidade de São Paulo, Brasil

Drugs for Neglected Diseases initiative, Suiça
2015 - 2015 Member of the organizing committee of this 2-weeks event: Sao Paulo School of Advanced Science on Neglected Diseases Drug Discovery – focus on Kinetoplastids (80 participants) (2015 - 2015)
Outro (Membro da Comissão Organizadora)
 Laboratório Nacional de Biociências, Brasil

Fundação de Amparo à Pesquisa do Estado de São Paulo, Brasil
2015 - 2015 Member of the organizing committee of the meeting Building International Consortia on parasitic diseases: the NMTrypl experience (100 participants) (2015 - 2015)
Encontro (Membro da Comissão Organizadora)
 Laboratório Nacional de Biociências, Brasil
2011 - 2011 Coordinated the winter course Bioinformatic Applied to Omics (2011 - 2011)
Oficina (workshop) (Presidente da Comissão Organizadora)
 Biotec Júnior, Brasil

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2024/09/27 - Atual Coordinator of the exhibition "Superbugs: the invisible threat" during the 2024 edition of European Researchers´ Night - Coimbra
Exposição
 European Researchers´ Night
Universidade de Coimbra, Portugal
2024/07/03 - 2024/07/05 Attended the Encontro Ciência 2024 - Science and Technology Summit in Portugal
Conferência
 Encontro Ciência 2024
Fundação para a Ciência e a Tecnologia, Portugal
2024/02/06 - 2024/02/07 Attended the event Antimicrobial Chemotherapy Conference 2024
Conferência
 Antimicrobial Chemotherapy Conference 2024
Global Antibiotic Research and Development Partnership, Suiça

British Society for Antimicrobial Chemotherapy, Reino Unido
2023/11/20 - 2023/11/22 Attended the 2023 EU-OPENSCREEN Autumn Training School
Outro
 2023 Autumn Training School
EU-OPENSCREEN, Alemanha
2023/09/29 - 2023/09/29 Coordinator of the exhibition "Superbugs: the invisible threat" during the 2023 edition of European Researchers´ Night - Coimbra
Exposição
 European Researchers´ Night
Universidade de Coimbra, Portugal
2022/11/14 - 2022/11/18 Attended the 2022 EU-OPENSCREEN Autumn Training School
Outro
 2022 Autumn Training School
EU-OPENSCREEN, Alemanha
2022/11 - 2022/11 Attended the workshop "Impulsione o potencial de publicação da sua investigação"
Oficina (workshop)
 Impulsione o potencial de publicação da sua investigação
Fundação para a Ciência e a Tecnologia, Portugal

Biblioteca do Conhecimento Online, Portugal

The Elsevier Foundation, Países Baixos
2022/09/30 - 2022/09/30 Coordinator of the exhibition "Superbugs: the invisible threat" during the 2022 edition of European Researchers´ Night - Coimbra
Exposição
 European Researchers´ Night
Universidade de Coimbra, Portugal
2022/02/21 - 2022/02/25 Attended (virtually) Advanced Course : High-Throughput Screening for Target and Drug Discovery - 2022
Oficina (workshop)
 PDBEB course: High-Throughput Screening for Target and Drug Discovery
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/06/28 - 2021/06/28 Attended (virtually) the seminar: Automating functional cell-based bioassays: assay reproducibility and performance for potency testing programmes
Seminário
 Automating functional cell-based bioassays: assay reproducibility and performance for potency testing programmes
Drug Target Review, Reino Unido
2021/04/27 - 2021/04/27 Attended (virtually) the conference Emerging Infectious Diseases and related environmental, clinical and translational challenges
Conferência
 Emerging Infectious Diseases and related environmental, clinical and translational challenges
Portuguese European Union Presidency , Portugal

European Molecular Biology Laboratory, Alemanha
2021/03/23 - 2021/03/23 Attended (virtually) the seminar: High content screening reveals the phenotypic landscape of intestinal organoid regeneration
Seminário
Drug Target Review, Reino Unido
2021/02/01 - 2021/02/05 Attended (virtually) Advanced Course : High-Throughput Screening for Target and Drug Discovery - 2021
Oficina (workshop)
 High Throughput Screening For Target And Drug Discovery
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/01/25 - 2021/01/27 Attended (virtually) to SLAS 2021 - Science Ignite - Digital Conference and Exhibition
Conferência
 SLAS - 2021
Society for Laboratory Automation and Screening, Estados Unidos
2019/02/04 - 2019/02/04 Attended the workshop "How to get Published"
Oficina (workshop)
 Researcher Academy On Campus: How to get Published
Elsevier BV, Países Baixos

Universidade de Coimbra, Portugal
2018/10/31 - 2018/10/31 Attended the international workshop on contemporary concepts on bacterial resistance Contemporary Concepts on Bacterial Resistance
Unión Iberoamericana de Universidades , Espanha
2018/06/06 - 2018/06/06 Attended the international symposium on drug discovery and development held by pharmaceutic companies and research institutes.
Simpósio
 Drug Discovery in Academia: learning from success and failure
Instituto Butantan, Brasil
2017/06/21 - 2017/06/23 Attended a Scientific Meeting: Searching for active compounds against neglected diseases
Encontro
 III Scientific Meeting - Searching for active compounds against neglected diseases: from traditional knowledge to structural synthesis
Universidade de São Paulo, Brasil
2016/06/06 - 2016/06/10 Attended seminars on new approaches to drug discovery against tropical diseases
Seminário
 New Approaches To Drug Discovery Against Tropical Diseases
Universidade Estadual de Campinas, Brasil
2015/06/16 - 2015/06/23 Attended Seminars on Drug Discovery against Neglected Diseases
Seminário
 Current Drug Discovery for Neglected Diseases
Centro Nacional de Pesquisa em Energia e Materiais, Brasil
2014/03/31 - 2014/04/04 Participated on the first Brazilian Meeting of High Content Screening
Encontro
 1st Brazilian Meeting on High Content Screening
Fundação Hemocentro de Ribeirão Preto, Brasil
2014/01/06 - 2014/01/17 Attended the Theoretical and Practical Course on Transmission Electron Microscopy
Outro
 V Theoretical-Practical Course on Electron Microscopy
Laboratório Nacional de Nanotecnologia, Brasil
2011/08/01 - 2012/01/31 Attended the course HOST-PATHOGENS INTERACTIONS at the Centers for Neglected Diseases Drug Discovery
Oficina (workshop)
 Institut Pasteur Korea Seminars
Institut Pasteur Korea, Coreia do Sul
2011/08/01 - 2012/01/31 Attended the course INTRODUCTION TO DRUG DISCOVERY at the Centers for Neglected Diseases Drug Discovery
Oficina (workshop)
 Institut Pasteur Korea Seminars
Institut Pasteur Korea, Coreia do Sul
2011/11/24 - 2011/11/28 Attended a Hands-on workshop in Plant Breeding approaches
Oficina (workshop)
 II Workshop in Genetics and Plant Breeding
Universidade de São Paulo Escola Superior de Agricultura Luiz de Queiroz, Brasil
2011/05/14 - 2011/05/15 Attended the Basic Design Course: learning basic aspects of Illustrator, Phtotoshop and After Effects
Outro
 Biotec Jr. Basic Design Course
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Assis, Brasil
2011/04/29 - 2011/05/01 Attended Seminars on Planning and Managing a Junior Enterprise
Encontro
 XV Meeting of Junior Enterprises from Unesp
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Franca, Brasil
2010/07/12 - 2010/07/16 Attended the Hands-on workshop in Plant Breeding approaches
Oficina (workshop)
 I Workshop in Genetics and Plant Breeding
Universidade de São Paulo Escola Superior de Agricultura Luiz de Queiroz, Brasil
2010/06/17 - 2010/06/19 Attended the Workshop on Medicinal Plants
Oficina (workshop)
 IX Workshop on Medicinal Plants
Universidade Estadual Paulista Júlio de Mesquita Filho - Câmpus de Botucatu, Brasil
2009/07/20 - 2009/07/24 Attended the workshop Genetic manipulation - General approaches and tools
Oficina (workshop)
 V Winter Course in Genetics
Universidade Estadual de Londrina, Brasil

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/12/06 Master thesis arguer: Identifying New Molecular Modulators of Direct Cardiac Conversion
Arguente
 Inês da Costa Loureiro (Mestrado)
Universidade de Aveiro, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2023 - Atual Pathogens (2076-0817) MDPI
2022/09 - 2024/01/01 Frontiers in Drug Discovery (2674-0338) Frontiers

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022/11/10 - Atual Lecturer at MSc Program: discipline Methodologies in Cellular and Molecular Biology Hands-on: image segmentation and automated image analysis (Mestrado) Universidade de Coimbra, Portugal

Membro de associação

Nome da associação Tipo de participação
2010 - 2011 Secretariat coordinator for the Biotechnology Engineer Students Council Secretariat Coordinator

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019 - 2019 Undergraduation Scientific Training Symposium - Poster Session evaluation
Membro
 Universidade de São Paulo, Brasil

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2023 - Atual Antibiotics (2079-6382) MDPI
2022 - Atual Molecules (1420-3049) MDPI
2024/03 - 2024/04 Vaccines (2076-393X) MDPI
2023/03 - 2023/04 Pathogens (2076-0817) MDPI
2022/10 - 2022/11 Journal of Clinical Medicine (2077-0383) MDPI
2022/04/15 - 2022/04/21 Journal of Pharmaceutical Research International (2456-9119) Asia Pacific Publishers
2021/08/01 - 2021/08/31 Asian Hematology Research Journal OA Academic Press
2021/07/01 - 2021/08/31 Gene Reports (24520144) Elsevier

Tutoria

Tópico Nome do aluno
2024 - Atual Co-supervision of a PhD student from Universidade de Lisboa (Faculty of Medicine) David Ferreira
2021/11 - 2022/01 Co-supervised the Applied Biology project of an undergraduate scientific trainee from University of Coimbra (Major em Biology) Francisca Costa
2018/07 - 2019/03 Co-supervised an undergraduate scientific trainee from University of São Paulo School of Pharmacy. Bruna Wenyi Chuang Jou
2015/10 - 2016/01 Supervised an undergraduate scientific trainee from Universidade Paulista. Camila Ferreira
2014/10 - 2015/07 Supervised an undergraduate scientific trainee from Universidade Estadual de Campinas. Luisa Santos Naves
Distinções

Prémio

2022 MDPI John M Goldsmid Award for Best Research Article 2019-2020 (Drug Discovery for Chagas Disease: Impact of Different Host Cells Lines on Assay Performance and hit Compound Selection)
MDPI , Suiça
2018 Postdoctoral fellowship
Eurofarma Laboratórios, Brasil

Fundação de Apoio a Universidade de São Paulo, Brasil
2014 PhD fellowship
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil
2011 Annual Photography Contest
Câmara Municipal de Assis, Brasil
2010 Undergraduate scientific training scholarship
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil

Outra distinção

2018 PhD Thesis Defense: Approved with distinction
Universidade Federal de São Paulo, Brasil