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Isabel Calejo graduated with a degree in Bioengineering from the Catholic University of Porto in 2012. She began her research career at the Lab of Pharmacology and Neurobiology (ICBAS-UP) as a trainee, contributing to hands-on teaching for MSc students. In 2015, she completed her MSc in Forensic Sciences - Toxicology at FMUP, focusing on metabolomic profiling via GC-MS to differentiate urine samples from diseased (prostate cancer) and healthy individuals, leading to her first publication as a first author. In 2016, Isabel was awarded a PhD scholarship for the Tissue Engineering, Stem Cells and Regenerative Medicine at the University of Minho, 3B's Research Group. Her thesis, defended in May 2021, explored the engineering of tendon-to-bone interface through gradient scaffolds, culminating in 5 original articles, 2 reviews, and 2 book chapters. Concurrently, she enhanced her networking and leadership skills through an international mentoring program with the Director of Bioinformatics at BenevolentAI, England. Nonetheless, her work was recognized abroad by receiving a travel grant for attending an international conference. Before completing her PhD, Isabel started a postdoc at the University of Twente (Netherlands), focusing on microfluidic chips for real-time biomarker monitoring in collaboration with ERASMUS MC, resulting in a co-authored publication (10.1016/j.bios.2023.115510). Also, in 2021, she joined the i3S Bioengineered 3D Microenvironments Group (Porto) as a postdoctoral fellow, investigating endothelial plasticity to enhance therapeutic angiogenesis for ischemic cardiac tissues, where she developed her skills on microtissues fabrication and hydrogels synthesis. Later, in 2023, she joined the "Cello" project (FMUP, Porto), working on label-free methodologies for biomarkers detection. Isabel has excelled in competitive grant writing, securing over €20,000 in funding. Notable awards include a Kick-Starter grant for fabricating 3D biotextiles for skeletal muscle regeneration (2022) and the EORS Grant Tank competition for her "MuSculpt - Magnetic sculpting of vascularized skeletal muscle tissue" project (2023). As an expert reviewer for European Commission (H2020 Europe), Isabel provides critical evaluations for high-impact projects. Additionally, she has authored/co-authored >20 scientific communications, 16 articles ( 14 articles, 2 reviews and 2 book chapters). She also serves as a reviewer for top journals (Bioac. Mat., MDPI, ACS Biomaterials) and served as Guest Editor for Bioengineering (MDPI) and Co-Editor at Frontiers. Over the years, with a commitment to mentoring and supervision, Isabel has supervised MSc and PhD students and also participated in academic examinations, being the principal jury in two MSCs defenses: "Development of fibrous structures based on nanocellulose wetspun microfibers for tendon and ligament repair, healing an regeneration” and "Polymeric-based devices such as medical adhesives – from biomaterials to biological characterization tests". Overall, her expertise spans from biomaterials, microfabrication, cell biology, bioinformatics (Python, machine learning), to intellectual property management, underscored by advanced training in research project management and life sciences entrepreneurship.
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Identificação

Identificação pessoal

Nome completo
Isabel Calejo

Nomes de citação

  • Calejo, Isabel
  • Calejo, I.

Identificadores de autor

Ciência ID
1A1F-B26C-15CC
ORCID iD
0000-0002-6015-0655
Researcher Id
S-3103-2016

Endereços de correio eletrónico

  • icalejo@med.up.pt (Profissional)

Websites

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Engenharia dos Materiais
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2023/05
Concluído
 Molecular Bioinformatics - Hands-on Course Online, 9th Edition (Pós-Graduação)
Especialização em Bioinformatics
Universidade do Porto Faculdade de Medicina, Portugal
 17
2023/03 - 2023/03
Concluído
 INTRODUCTION TO PYTHON AND MACHINE LEARNING FOR THE BIOSCIENCES, 5TH EDITION (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/11 - 2022/11
Concluído
 LIFE SCIENCE INTELECTUAL PROPERTY: MANAGEMENT AND EXPLOITATION (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/09 - 2022/09
Concluído
 EIT HEALTH RIS ACADEMY - Empowering women's entrepreneurship in health (Outros)
Universidad de Navarra IESE Business School, Espanha
2022/01
Concluído
 RESEARCH PROJECT MANAGEMENT (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2021
Concluído
 Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais (Doutoramento)
Universidade do Minho - 3Bs Research Group, Portugal
"Engineering the tendon-to-bone tissue interface mimicking its microenvironment: from stem cells to gradient scaffolds." (TESE/DISSERTAÇÃO)
2019/11 - 2020/11
Concluído
 Programa internacional de mentorias em Biomedicina – Desenvolvimento de Soft Skills (Outros)
Especialização em Soft skills
International Mentoring Foundation for the Advancement of Higher Education, Espanha
2016/07
Concluído
 Curso de Laboratório em Ciências Animais (equivalente à categoria C FELASA) (Outros)
Centro de investigação médica, Faculdade de Medicina, Universidade do Porto (CIM-FMUP), Portugal
2015
Concluído
 Ciências Forenses (Mestrado)
Especialização em Toxicologia Forense
Universidade do Porto Faculdade de Medicina, Portugal
"Development of a GC-MS method for determination of volatile carbonyl compounds in biological matrices: aplication to clinical and post-mortem samples" (TESE/DISSERTAÇÃO)
2012/10/03
Concluído
 Bioengenharia (Licenciatura)
Especialização em Engenharia Biomédica
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
""Testes acelerados para adesividade de adesivos médicos"¿ " (TESE/DISSERTAÇÃO)
 -
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024 - Atual Investigador Contratado (Investigação) International Iberian Nanotechnology Laboratory, Portugal
International Iberian Nanotechnology Laboratory, Portugal
2023/09 - 2024 Investigador Contratado (Investigação) Universidade do Porto Faculdade de Medicina, Portugal
Centro de investigação médica, Faculdade de Medicina, Universidade do Porto (CIM-FMUP), Portugal
2021/09/01 - 2023 Pós-doutorado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/04/01 - 2021/09/01 Pós-doutorado (Investigação) Universiteit Twente, Países Baixos
Universiteit Twente Technical Medical Centre, Países Baixos
(...)
2016/09 - 2021/05/07 Investigador (Investigação) Universidade do Minho - 3Bs Research Group, Portugal
Universidade do Minho, Portugal
2016/01 - 2016/07 Estagiário de Investigação (Investigação) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
(...)
2012/03 - 2014/04 Estagiário de Investigação (Investigação) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
(...)

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/01 - 2023 Editor Convidado - Special Issue "Next Generation Bioengineered Strategies for Musculoskeletal Regeneration MDPI AG, Suiça
2019/11 - 2020/09 Representante dos alunos de doutoramento da unidade I3Bs i3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Portugal
i3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Portugal
2012 - 2012 Estágio Curricular BASTOS VIEGAS, S.A., Portugal
BASTOS VIEGAS, S.A., Portugal
Projetos

Bolsa

Designação Financiadores
2016/09 - 2020/10 Mimicking tendon-to-bone interface: from stern cells to phasic scaffolds
Provided by PTCRIS: PD/BD/128088/2016
 Fundação para a Ciência e a Tecnologia
2012/03 - 2014/04 P2 Purinoceptors in human osteogenesis and bone disease
SFRH/BD/68584/2010
Research Trainee
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2023/09 - Atual MuSculpt - Magnetic sculpting of vascularized skeletal muscle tissue
MuSculpt
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Orthoregeneration Network Foundation (ON)
Em curso
2023/05 - Atual MyoTextile - Living cell-based 3D biotextiles for skeletal muscle tissue regeneration
Myotextile
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Orthoregeneration Network Foundation (ON)
Em curso
2021/01/01 - 2025/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
10.54499/LA/P/0050/2020
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/03/29 - 2024/03/28 Harnessing endothelial plasticity for therapeutic vascularization of ischemic tissues: a bioengineering approach
PTDC/BTM-ORG/5154/2020
Bolseiro de Pós-Doutoramento
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021/04/01 - 2021/09/01 Towards osteoarthritis fingerprinting combining imaging biomarkers and multi-organ-on-chip technology for improved in vitro models
OA-BioDetectChips
Investigador Pós-doutorado
Universiteit Twente - Developmental Bioengineering Group, Países Baixos

Erasmus MC Biomedical Imaging Group Rotterdam, Países Baixos
Samenwerkende Gezondheidsfondsen (SGF)
Em curso
2016/09/01 - 2020/10/31 Mimicking tendon-to-bone interface: from stem cells to phasic scaffolds
PD/BD/128088/2016
Bolseiro de Doutoramento
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
154717UID
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2013 - 2014 Pathophysiological role of purines (ATP and adenosine) in the human bladder hyperactivity
PTDC/SAU-OSM/104369/2008
Research Trainee
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia, I.P. & COMPETE 2020
Concluído
Produções

Publicações

Artigo em conferência
  1. Calejo, I.; Almeida, Raquel Carvalho Ferreira Costa; Reis, R. L.; Gomes, Manuela E.. "Oxygen conditioning effect on an in vitro co-culture model of tendon-to-bone interface". 2019.
    Aceite para publicação
  2. Calejo, Isabel; Costa-Almeida, Raquel; Reis, Rui L.; Manuela E. Gomes. "Topological and compositional gradients to generate 3D textured living microfibres resembling tendon-to-bone interface". Trabalho apresentado em 27th Annual Meeting of the European Orthopaedic Research Society (EORS), Maastricht, 2019.
    Publicado
  3. Almeida, Raquel Carvalho Ferreira Costa; Calejo, I.; Domingues, Rui Miguel Andrade; Reis, R. L.; Gomes, Maria Manuela Estima. "Platelet lysate cell-laden hydrogel-coated suture threads for tendon repair". Trabalho apresentado em EORS - European Orthopedic Research Society (EORS) 2018 - 26th Annual Meeting, 2018.
    Publicado • 10.1302/1358-992X.2018.16.124
  4. Calejo, I.; Almeida, Raquel Carvalho Ferreira Costa; Reis, R. L.; Gomes, Manuela E.. "Optimization and establishment of a co-culture model to study cellular interactions in tendon-to-bone interface". Trabalho apresentado em EORS - 25th Meeting, 2017.
    Publicado • 10.1302/1358-992X.2018.3.070
  5. I. Silva; A. F. Costa; S. Moreira; F. Ferreirinha; M. Teresa Magalhães-Cardoso; Calejo, Isabel; M. Silva-Ramos; P. Correia-de-Sá. "Beta3-adrenoceptors inhibit cholinergic neurotransmission in the bladder indirectly via ADO release and A1 receptor activation". Trabalho apresentado em ISN-ENS 2017 meeting, 2017.
    Publicado
  6. "Organotypic-like tendon explant co-culture systems to study the crosstalk between native tendon cells and adipose stem cells". Trabalho apresentado em European Orthopaedic Research Society (EORS) 25th Annual Meeting,, 2017.
    Aceite para publicação
  7. Calejo, I.; Moreira, N.; Araújo, A.M.; Carvalho, M.; Moreira-Barbosa, C.; Jerónimo, C.; Henrique, R.; Bastos, M.L.; Guedes de Pinho, P.. "Development of an analytical method with PFBHA derivatization followed by headspace SPME-GC/MS for the determination of urinary volatile carbonyl metabolites in patients with prostate cancer". 2015.
    Publicado • 10.1016/j.toxlet.2015.08.686
  8. Calejo, Isabel; José Bernardo Almeida Garrett de Noronha Matos. "Adult bone marrow stromal cells expressing ecto-NTPDase3 may be a novel therapeutic target for defective osteogenesis and bone mineralization". 2014.
    Publicado • 10.1007/s11302-014-9430-7
  9. "Abstracts from Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, held in Bonn, Germany, from July 23–27, 2014.". 2014.
Artigo em revista
  1. Orge, I.D.; Nogueira Pinto, H.; Silva, M.A.; Bidarra, S.J.; Ferreira, S.A.; Calejo, I.; Masereeuw, R.; Mihaila, S.M.; Barrias, C.C.. "Vascular units as advanced living materials for bottom-up engineering of perfusable 3D microvascular networks". Bioactive Materials 38 (2024): 499-511. http://dx.doi.org/10.1016/j.bioactmat.2024.05.021.
    Publicado • 10.1016/j.bioactmat.2024.05.021
  2. Sofia M. Costa; Leandro M. O. Lourenço; Ricardo C. Calhelha; Isabel Calejo; Cristina C. Barrias; Raul Fangueiro; Diana P. Ferreira. "Localized cancer photodynamic therapy approach based on core–shell electrospun nanofibers". Materials Advances (2024): https://doi.org/10.1039/D4MA00647J.
    10.1039/D4MA00647J
  3. Nuno Araújo-Gomes; Giorgia Zambito; Castro Johnbosco; Isabel Calejo; Jeroen Leijten; Clemens Löwik; Marcel Karperien; Laura Mezzanotte; Liliana Moreira Teixeira. "Bioluminescence imaging on-chip platforms for non-invasive high-content bioimaging". Biosensors and Bioelectronics (2023): https://doi.org/10.1016/j.bios.2023.115510.
    10.1016/j.bios.2023.115510
  4. Calejo, Isabel; Labrador-Rached, Claudia J.; Gomez-Florit, Manuel; Docheva, Denitsa; Reis, Rui L.; Domingues, Rui M. A.; Gomes, Manuela E.. "Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathology". Advanced Healthcare Materials 11 15 (2022): http://dx.doi.org/10.1002/adhm.202102863.
    10.1002/adhm.202102863
  5. Ana L. Graça; Rui M. A. Domingues; Isabel Calejo; Manuel Gómez-Florit; Manuela E. Gomes. "Therapeutic Effects of Platelet-Derived Extracellular Vesicles in a Bioengineered Tendon Disease Model". International Journal of Molecular Sciences 23 6 (2022): 2948-2948. https://doi.org/10.3390/ijms23062948.
    10.3390/ijms23062948
  6. Calejo, Isabel; Reis, Rui L.; Domingues, Rui M. A.; Gomes, Manuela E.. "Texturing Hierarchical Tissues by Gradient Assembling of Microengineered Platelet-Lysates Activated Fibers". Advanced Healthcare Materials (2021): 2102076. http://dx.doi.org/10.1002/adhm.202102076.
    Publicado • 10.1002/adhm.202102076
  7. Calejo, Isabel; Costa-Almeida, Raquel; Reis, Rui L.; Gomes, Manuela E.. "In vitro temporal HIF-mediated deposition of osteochondrogenic matrix governed by hypoxia and osteogenic factors synergy". Journal of Cellular Physiology 236 5 (2020): 3991-4007. http://dx.doi.org/10.1002/jcp.30138.
    Publicado • 10.1002/jcp.30138
  8. Calejo, Isabel; Costa-Almeida, Raquel; Reis, Rui L.; Gomes, Manuela E.. "A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering". Trends in Biotechnology 38 1 (2020): 83-98. http://dx.doi.org/10.1016/j.tibtech.2019.06.003.
    Publicado • 10.1016/j.tibtech.2019.06.003
  9. Calejo, Isabel; Costa-Almeida, Raquel; Reis, Rui L.; Gomes, Manuela E.. "Enthesis Tissue Engineering: Biological Requirements Meet at the Interface". Tissue Engineering Part B: Reviews 25 4 (2019): 330-356. http://dx.doi.org/10.1089/ten.teb.2018.0383.
    Publicado • 10.1089/ten.teb.2018.0383
  10. Costa-Almeida, Raquel; Calejo, Isabel; Gomes, Manuela E.. "Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies". International Journal of Molecular Sciences 20 12 (2019): 3002. http://dx.doi.org/10.3390/ijms20123002.
    Publicado • 10.3390/ijms20123002
  11. Calejo, Isabel; Costa-Almeida, Raquel; Reis, Rui L.; Gomes, Manuela E.. "A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon-to-Bone Interface Gradient Scaffolds". Advanced Healthcare Materials 8 15 (2019): 1900200. http://dx.doi.org/10.1002/adhm.201900200.
    Publicado • 10.1002/adhm.201900200
  12. Costa-Almeida, Raquel; Calejo, Isabel; Altieri, Roberta; Domingues, Rui M A; Giordano, Emanuele; Reis, Rui L; Gomes, Manuela E. "Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair". Biomedical Materials 14 3 (2019): 034104. http://dx.doi.org/10.1088/1748-605x/ab0de6.
    Publicado • 10.1088/1748-605x/ab0de6
  13. Calejo, I.; Costa-Almeida, Raquel; Gonçalves, Ana Isabel; Berdecka, Dominika; Reis, Rui Luis; Gomes, Manuela Estima. "Bi-directional modulation of cellular interactions in an in vitro co-culture model of tendon-to-bone interface". Cell Proliferation 51 6 (2018): e12493. http://dx.doi.org/10.1111/cpr.12493.
    Publicado • 10.1111/cpr.12493
  14. Costa-Almeida, Raquel; Calejo, Isabel; Reis, Rui L.; Gomes, Manuela E.. "Crosstalk between adipose stem cells and tendon cells reveals a temporal regulation of tenogenesis by matrix deposition and remodeling". Journal of Cellular Physiology 233 7 (2018): 5383-5395. http://dx.doi.org/10.1002/jcp.26363.
    10.1002/jcp.26363
  15. Silva, Isabel; Costa, Ana Filipa; Moreira, Sílvia; Ferreirinha, Fátima; Magalhães-Cardoso, Maria Teresa; Calejo, Isabel; Silva-Ramos, Miguel; Correia-de-Sá, Paulo. "Inhibition of cholinergic neurotransmission by ß3-adrenoceptors depends on adenosine release and A1-receptor activation in human and rat urinary bladders". American Journal of Physiology-Renal Physiology 313 2 (2017): F388-F403. http://dx.doi.org/10.1152/ajprenal.00392.2016.
    Publicado • 10.1152/ajprenal.00392.2016
  16. Silva, I.; Costa, A. F.; Moreira, S.; Ferreirinha, F.; Magalhaes-Cardoso, M. T.; Calejo, I.; Silva-Ramos, M.; Correia-de-Sa, P.. "Downmodulation of cholinergic neurotransmission by beta 3-adrenoceptor agonists depends on adenosine release and cyclic AMP activation of the exchange protein Epac in the human and rat urinary bladder". The FEBS Journal (2017): https://publons.com/publon/19988441/.
  17. Calejo, Isabel; Moreira, Nathalie; Araújo, Ana Margarida; Carvalho, Márcia; Bastos, Maria de Lourdes; de Pinho, Paula Guedes. "Optimisation and validation of a HS-SPME-GC-IT/MS method for analysis of carbonyl volatile compounds as biomarkers in human urine: Application in a pilot study to discriminate individuals with smoking habits". Talanta 148 (2016): 486-493. http://dx.doi.org/10.1016/j.talanta.2015.09.070.
    Publicado • 10.1016/j.talanta.2015.09.070
Capítulo de livro
  1. Isabel Calejo; Marcel Alexander Heinrich; Giorgia Zambito; Laura Mezzanotte; Jai Prakash; Liliana Moreira Teixeira. "Advancing Tumor Microenvironment Research by Combining Organs-on-Chips and Biosensors". 2022.
    10.1007/978-3-031-04039-9_7
  2. Calejo, Isabel; Costa-Almeida, Raquel; Gomes, Manuela E.. "Cellular Complexity at the Interface: Challenges in Enthesis Tissue Engineering". In Cell Biology and Translational Medicine, Volume 5, 71-90. Springer International Publishing, 2019.
    Publicado • 10.1007/5584_2018_307
Poster em conferência
  1. Graça, Ana L.; Domingues, R.M.A.; Calejo, I.; Gomez-Florit, M.; Gomes, M.E.. "Platelet-derived Extracellular Vesicles Show Therapeutic Effects on a 3D Tendon Disease Model 32nd Annual Conference of the European Society for Biomaterials.". Trabalho apresentado em 32nd Annual Conference of the European Society for Biomaterials, 2022.
  2. "Platelet-derived Extracellular Vesicles Show Therapeutic Effects on a 3D Tendon Disease Model". Trabalho apresentado em Third Achilles Workshop “Gene & Cell Therapy and clinical applications”, 2021.
  3. Calejo, Isabel; Costa-Almeida, Raquel; Reis, R. L.; Manuela E. Gomes. "Textured microfibers with topological and compositional gradients resembling tendon- to-bone interface". Trabalho apresentado em 1st Discoveries Forum on Regenerative and Precision Medicine, 2019.
  4. "Multi-compartment multifunctional composite living fibers for tendon tissue engineering and regeneration". Trabalho apresentado em TERMIS European Chapter Meeting 2019, 2019.
  5. "Engineering continuous textured composite microfibers for tendon-to-bone mimicry". Trabalho apresentado em TERMIS European Chapter Meeting 2019, 2019.
  6. Calejo, Isabel; Costa-Almeida, Raquel; Reis, R. L.; Manuela E. Gomes. "Hypoxia conditioning effect on an in vitro tendon-to-bone interface co-culture model". Trabalho apresentado em Gene2Skin/CHEM2NATURE Final Conference, 2018.
  7. Calejo, Isabel; Costa-Almeida, Raquel; Ana Isabel Gonçalves; Dominika Berdecka; Reis, Rui L.; Manuela E. Gomes. "Unraveling the crosstalk between pre-osteoblasts and tendon cells in tendon-to-bone regeneration". Trabalho apresentado em 5th TERMIS World Congress, 2018.
  8. Calejo, Isabel; Costa-Almeida, Raquel; Reis, Rui L.; Manuela E. Gomes. "Wet-spinning technique for the production of PCL/Gel and PCL/Gel/nHA continuous fibers for tendon-to-bone insertion regeneration". Trabalho apresentado em Chem2Nature/Gene2skin – Summer School, 2018.
  9. R. Costa-Almeida; Calejo, Isabel; R. Altieri; R.M.A. Domingues; E. Giordano; R.L. Reis; M.E. Gomes. "Suture threads coated with cell-laden platelet lysate hydrogel for tendon applications". Trabalho apresentado em CHEM2NATURE Final Conference, 2018.
  10. "PLATELET LYSATE HYDROGEL-COATED SUTURE THREADS FOR TENDON TISSUE ENGINEERED APPROACHES". Trabalho apresentado em Summer School Chem2Nature, 2018.
  11. Calejo, Isabel; Costa-Almeida, Raquel; Reis, Rui L.; Manuela E. Gomes. "Bi-directional crosstalk between tendon cells and pre-osteoblasts: a co-culture approach for tendon-to-bone interfacial tissue engineering". Trabalho apresentado em TERMSTEM/FORECAST 2017 - 1o Workshop of FoReCaST -The Tumour Microenvironment, 2017.
  12. Calejo, Isabel; Costa-Almeida, Raquel; Reis, Rui L.; Manuela E. Gomes. "Co-culture model to study the role of cellular interactions in enthesis". Trabalho apresentado em CHEM2NATURE Second school, 2017.
  13. I. Silva; A. F. Costa; S. Moreira; F. Ferreirinha; M. Teresa Magalhães-Cardoso; Calejo, Isabel; M. Silva-Ramos; P. Correia-de-Sá. "Downmodulation of cholinergic neurotransmission by ß3-adrenoceptor agonists depends on adenosine release and cyclic AMP activation of the exchange protein Epac in the human and rat urinary bladder". Trabalho apresentado em 42nd Federation of European Biochemical Societies Congress - From Molecules to Cells and Back, 2017.
  14. "Adipose stem cells and native tendon cells as partners in orchestrating tendon regeneration: in vitro co-culture approaches". Trabalho apresentado em FORECAST - 1st Workshop, 2017.
  15. Calejo, Isabel; Ana Margarida Araújo;; Nathalie Moreira; Jerónimo, Carmen; Rui Henrique; Bastos, Maria de Lourdes; Márcia Carvalho; Guedes de Pinho, Paula. "A GC-MS methodology for the determination of potential urinary volatile carbonyl as biomarkers of prostate cancer". Trabalho apresentado em I Encontro Anual do Departamento de Ciências Biológicas da Faculdade de Farmácia da Universidade do Porto, 2016.
  16. Calejo, Isabel; Moreira, Nathalie; Ana Margarida Araújo; Carvalho, Márcia; Bastos, Maria de Lourdes; Guedes de Pinho, Paula. "Development and optimisation of a GC methodology with PFBHA derivatization for the determination of volatile carbonyl metabolites in urine of smokers and non-smokers". Trabalho apresentado em I Encontro Anual do Departamento de Ciências Biológicas da Faculdade de Farmácia da Universidade do Porto, 2016.
  17. Calejo, Isabel; Nathalie Moreira; Ana Margarida Araujo; Marcia Carvalho; C. Moreira-Barbosa; Carmem jerónimo; Rui Henrique; M. Lourdes Bastos; Guedes de Pinho, P.. "Development of an analytical method with PFBHA derivatization followed by headspace SPME GC/MS for the determination of urinary volatile carbonyl metabolites in patients with prostate cancer". Trabalho apresentado em 51st Congress of the European Societies of Toxicology (EUROTOX), 2015.
Resumo em conferência
  1. Domingues, Rui M. A.; Calejo, Isabel; Claudia J. Labrador-Rached,; Gomez-Florit, Manuel; Denitsa Docheva; Reis, L. Rui; Manuela E. Gomes. "In vitro modelling of tendon physiology and pathology with 3D microengineered living fibers.". Trabalho apresentado em ESB 2021, 2021.
  2. Noronha-Matos, JB; Calejo, Isabel; Maria Teresa Magalhães-Cardoso; Isabel Silva; MA Costa; Fatima Ferreirinha; R Freitas; et al. "NTPDase3 enzyme inhibition or gene silencing rescues the osteogenic potential of post-menopausal mesenchymal stein cells (MSCs) derived from hone marrow". Trabalho apresentado em PURINERGIC SIGNALLING, 2018.
    Publicado
  3. Silva, Isabel; Costa, AF; Moreira, Sílvia; Ferreirinha, F; Magalhães-Cardoso, MT; Calejo, I; Silva-Ramos, Miguel; et al. "Downmodulation of cholinergic neurotransmission by ß3-adrenoceptor agonists depends on adenosine release and cyclic AMP activation of the exchange protein EPAC in the human rat urinary bladder.". Trabalho apresentado em 42nd FEBS CONGRESS ¿ FROM MOLECULES TO CELLS AND BACK. JERUSALEM, ISRAEL, 2017.
    Publicado
  4. Silva, Isabel; Costa, AF; Ferreirinha, F; Magalhães-Cardoso, MT; Calejo, Isabel; Silva-Ramos, Miguel; Correia-de-Sá, P; et al. "Adenosine release and A1 receptors activation mediate the inhibitory effect of ß3-adrenoceptors in the human and rat urinary bladder.". Trabalho apresentado em XIX NATIONAL CONGRESS OF BIOCHEMISTRY. GUIMARÃES, PORTUGAL, 2016.
    Publicado
  5. Calejo, Isabel; Nathalie Moreira; Araújo, Ana Margarida; Carvalho, M; C. Moreira-Barbosa; Carmen Jerónimo; Rui Henrique; Bastos, ML; Guedes de Pinho, Paula. "Development of an analytical method by HS-SPME-GC/MS for volatile carbonyl biomarkers discovery in urines from patients with prostate cancer". Trabalho apresentado em JUP 2015 - 8º Encontro de Jovens Investigadores da U.PORTO, 2015.
Tese / Dissertação
  1. Calejo, Isabel. "Engineering the tendon-to-bone tissue interface mimicking its microenvironment: from stem cells to gradient scaffolds". Doutoramento, Universidade do Minho - 3Bs Research Group, 2021. https://repositorium.sdum.uminho.pt/handle/1822/75229.
  2. Helena Isabel Pinto Cardoso Teixeira Calejo. "Development of a GC-MS method for determination of volatile carbonyl compounds in biological matrices: aplication to clinical and post-mortem samples". Mestrado, 2015. https://repositorio-aberto.up.pt/handle/10216/88980.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/09/06 In vitro modelling of tendon physiology and pathology with 3D microengineered living fibers ESB 2021
(Porto, Portugal)
2019 Textured microfibers with topological and compositional gradients resembling tendon-to-bone interface 1st Discoveries Forum on Regenerative and Precision Medicine
(Porto, Portugal)
2019 Topological and compositional gradients to generate 3D textured living microfibers resembling tendon-to-bone interface European Orthopaedic Research Society (EORS) - 27th Annual Meeting
(Maastricht, Países Baixos)
2019 Hypoxia mediated response in an in vitro co-culture model of tendon-to-bone interface 1st Achilles Conference – Molecular and biological mechanisms of tendon homeostasis and repair
(Porto, Portugal)
2019 Oxygen conditioning effect on an in vitro co-culture model of tendon-to-bone interface TERMIS European Chapter Meeting 2019
(Rhodes, Grécia)
2018 Platelet lysate cell-laden hydrogel-coated suture threads for tendon repair European Orthopaedic Research Society (EORS) 26th Annual Meeting
(Galway, Irlanda)
2017 Optimization and establishment of a co-culture model to study cellular interactions in tendon-to-bone interface European Orthopaedic Research Society (EORS) 25th Annual Meeting,
(Munich, Alemanha)
2016 GC/MS analysis of carbonyl volatile compounds as human urinary biomarkers: Discrimination between smoking and non-smoking individuals Sociedade Portuguesa Farmacologia
2015 Development of an analytical method by HS-SPME-GC/MS for volatile carbonyl biomarkers discovery in urines from patients with prostate cancer IJUP 2015 - 8º Encontro de Jovens Investigadores da U.PORTO
(Porto, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/10/04 - 2019/10/05 Participated in sessions organization and discussion after oral presentations of key speakers of 2nd Achilles Conference - Tendon biophysical environment¿ (2019/10/04 - 2019/10/05)
Conferência (Coorganizador)
 Universidade do Minho - 3Bs Research Group, Portugal
2019/07/08 - 2019/07/10 Participated in sessions organization and discussion after oral presentations of key speakers at 1st Achilles Conference - Molecular and biological mechanisms of tendon homeostasis and repair¿ (2019/07/08 - 2019/07/10)
Conferência (Coorganizador)
 Universidade do Minho - 3Bs Research Group, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2020/06 - Atual Training seminar on Quality System ISO 9001:2015 Quality Management System on ISO 9001:2015
Universidade do Minho - 3Bs Research Group, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023 Polymeric-based devices such as medical adhesives – from biomaterials to biological characterization tests
Arguente principal
 Mariana Pereira Conceição (Mestrado)
Universidade Católica Portuguesa Centro Regional do Porto, Portugal
2022 Development of fibrous structures based on nanocellulose wetspun microfibers for tendon and ligament repair, healing and regeneration
Arguente principal
 Joana Filipa Magalhães da Rocha (Mestrado)
Universidade do Minho, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2022 - Atual Bioactive Materials Elsevier
2021 - Atual Bioengineering (2306-5354) MDPI
2020 - Atual ACS Biomaterials Science & Engineering ACS Publications
2020 - Atual Tissue Engineering Part A (1937-3341) Mary Ann Liebert

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2021 - Atual Kick-start grant
Avaliador
 Orthoregeneration Network Foundation (ON), Suiça Orthoregeneration Network Foundation (ON)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2016 - 2016 Technical assistance of practical lessons: "Renal excretion of Aspirin metabolites" and "Effect of a loop diuretic in the rabbit: Furosemide" Human Medicine, Veterinary and Biochemistry (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Expedição científica

Descrição da atividade Instituição / Organização
2022/01 - Atual Special Issue "Next Generation Bioengineered Strategies for Musculoskeletal Regeneration". MDPI AG, Suiça

Membro de associação

Nome da associação Tipo de participação
2017 - Atual European Orthopaedic Research Society (EORS) Membership
Distinções

Prémio

2023 ON/EORS Kick Grant Tank Competition
2022 ON/ORS Kick-Starter Grants 2022/23
Orthoregeneration Network Foundation (ON), Suiça
2019 ON/EORS Travel Grant
Orthoregeneration Network Foundation (ON), Suiça
2019 StartUP Voucher

Outra distinção

2016 PhD scholarship
Fundação para a Ciência e a Tecnologia, Portugal