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Matthew Holt is the ERA Chair Holder for Neural Cell Biology (NCBio) and vice director of the Neurobiology and Neurologic Disorders integrative program at i3S, University of Porto. He is also head of the NCBio academic-industrial hub for northern Portugal. Dr. Holt holds a Ph.D. in neuroscience from the MRC Laboratory of Molecular Biology (2002); a post-doc from the Max Planck Institute for Biophysical Chemistry (2011) and established his own research group at KU Leuven in 2012. In 2022, Dr. Holt was appointed NCBio ERA Chair Holder at i3S. He has 20 years of scientific experience, particularly in the field of biochemistry (transcriptomics and proteomics) and cell biology. His work has been published in 59 peer-reviewed papers (H index = 35, >8500 citations; Google Scholar), often in high impact factor journals, including Cell, Nature Neuroscience and Nature Immunology. He has written 2 book chapters. His research aims to understand how astrocytes contribute to synapse formation and function. Work from Dr. Holt’s lab (amongst others) has been instrumental in establishing astrocytes as a highly molecularly heterogeneous cell type with implications for local circuit function, which he is currently following up using a range of technologies from advanced proteomics through to electrophysiology. Dr. Holt has attracted > €5M in 18 projects as Principal Investigator and > €11M in 15 projects as co-PI. He supervised/has supervised 10 Ph.D. candidates; 11 M.Sc. students; 7 B.Sc. students and has been an opponent in 31 Ph.D. thesis committees. He has given 50 invited talks at international conferences and has been awarded several prizes, including the prestigious ERC Consolidator Grant (2011) and the ERC Proof-of-Concept (PoC) Grant (2015). Dr. Holt has established an international reputation reflected by his election to the editorial board of the journal Glia, which is the main specialist journal in his field. In addition, he is a regular reviewer for high-impact, prestigious journals including (but not limited to): Cell, Nature, Nature Neuroscience, EMBO Journal, EMBO Molecular Medicine. His expertise is also sought as a regular reviewer for grant agencies including the ERC, and as an evaluator of scientific departments/institutes (such as Collège de France). Dr. Holt is co-founder of Aila Biotech, a spin-off company based on the considerable success of AAV-delivered IL2 in ameliorating traumatic brain injury (TBI), stroke and multiple sclerosis, which was published in Nature Immunology (Yshii et al, 2022). As a founder member, Dr. Holt has a place on the board of directors and acts as a science advisor. He also serves as scientific advisor to Verge Genomics, Janssen Pharma, Sirion Biotech and is inventor of 3 patents.
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Identificação

Identificação pessoal

Nome completo
Matthew Guy Holt

Nomes de citação

  • Holt, Matthew
  • Matthew G. Holt

Identificadores de autor

Ciência ID
3816-811A-DB66
ORCID iD
0000-0002-8958-4027
Researcher Id
AAJ-1813-2020
Scopus Author Id
35775275100

Telefones

Telefone
  • 226074900 (Profissional)

Moradas

  • Instituto de Biologia Molecular e Celular e Instituto de Investigação e Inovação em Saúde (i3S). Rua Alfredo Allen 208, 4200-135, Porto, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês (Idioma materno)
Formação
Grau Classificação
1998 - 2002
Concluído
 Neuroscience (Doctor of Philosophy)
MRC Laboratory of Molecular Biology, Reino Unido
1994 - 1998
Concluído
 Biochemistry (Bachelor)
University of Liverpool, Reino Unido
 1st Class Honors
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022 - Atual Investigador Coordenador (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012 - 2022 Investigador principal (carreira) (Investigação) VIB KU Leuven Center for Brain & Disease Research, Bélgica
2003 - 2011 Pós-doutorado (Investigação) Max-Planck-Institut für Multidisziplinäre Naturwissenschaften, Alemanha
2002 - 2003 Pós-doutorado (Investigação) MRC Laboratory of Molecular Biology, Reino Unido

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2024 - Atual Leitor (Docente Universitário) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto, Portugal
2023 - Atual Leitor (Docente Universitário) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto, Portugal
2023 - 2023 Leitor (Docente Universitário) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Minho, Portugal
2012 - 2022 Professor Auxiliar (Docente Universitário) Associatie KU Leuven, Bélgica

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/01/01 - Atual Vice-Chair for Neurobiology and Neurologic Disorders Program at the i3S Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/02/01 - Atual Head NCBio Academic-Industrial Hub for Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Projetos

Bolsa

Designação Financiadores
2021/01 - 2026/12 Unlocking excellence in research and innovation in neurobiology and neurological disorders at IBMC/i3S
951923
Investigador responsável
European Commission
2022 - 2025 Astrocyte dysfunctions in Phelan-McDermid syndrome: from mechanisms towards new therapeutic strategies
EURON_NDD-003 / SHANKAstro
Co-Investigador Responsável (Co-IR)
European Commission
2022 - 2025 Investigating the role of astrocytes and noradrenaline as critical regulators of neuronal circuit excitability
G0C7922N
Co-Investigador Responsável (Co-IR)
Fonds Wetenschappelijk Onderzoek Vlaanderen
2021 - 2024 Investigating the contribution of astrocytes to experience-dependent cortical plasticity
G080821N
Co-Investigador Responsável (Co-IR)
Fonds Wetenschappelijk Onderzoek Vlaanderen
2021 - 2024 Cell subtype-specific neuron-glia contributions to cortical plasticity
C14/20/071
Co-Investigador Responsável (Co-IR)
Associatie KU Leuven
2021 - 2024 Cell subtype-specific neuron-glia contributions to cortical plasticity
C14/20/071
 Katholieke Universiteit Leuven
2020 - 2024 Integration of complementary, high throughput single-cell 'omics with spatial resolution
I005920N
Co-Investigador Responsável (Co-IR)
Fonds Wetenschappelijk Onderzoek Vlaanderen
2022 - 2022 Confronting dementia in the front line: the role of astrocytes
2020/0020
Investigador responsável
Stichting Alzheimer Onderzoek
2018 - 2022 Mass cytometry by time-of-flight: next-generation flow cytometry for multiplexed single cell analysis
I007418N
Co-Investigador Responsável (Co-IR)
Fonds Wetenschappelijk Onderzoek Vlaanderen
2018 - 2022 Single-cell 'omics in high throughput and at spatial resolution
I001818N
 Fonds Wetenschappelijk Onderzoek Vlaanderen
2020/01 - 2021/12 Treating cognitive decline by targeting energy production in the central nervous system
CELSA/19/036
Investigador responsável
Katholieke Universiteit Leuven
2020 - 2021 Decoding the mechanisms of neuronal wiring: the clustered protocadherin system
Internal Funding
Investigador responsável
Vlaams Instituut voor Biotechnologie
2020 - 2021 Validation of traumatic brain injury targets with large-scale spatial transcriptomics
Internal Funding
Investigador responsável
Vlaams Instituut voor Biotechnologie
2019/01 - 2020/12 Study of the Disease Modifying Properties of an Optimized Vectored Immunoprophylaxis Approach for Alzheimer's
2018/29
Investigador responsável
Stichting Alzheimer Onderzoek
2019 - 2020 Astrocyte driven recovery of neuronal loss in Alzheimer's disease brain
20180024
Investigador responsável
Stichting Alzheimer Onderzoek
2016 - 2020 Development of a technology platform for next-generation cytometry
ZW15_03
Co-Investigador Responsável (Co-IR)
Fonds Wetenschappelijk Onderzoek Vlaanderen
2016 - 2020 A platform comprising complementary fluidics pipelines for high-throughput single-cell processing, sequencing and data analysis
STK2015-143
Co-Investigador Responsável (Co-IR)
Fondation contre le Cancer
2016 - 2020 Live tissue imaging platform with enhanced confocal detection and full non-linear excitation possibilities
AKUL/15/37 - G0H1916N
Co-Investigador Responsável (Co-IR)
Fonds Wetenschappelijk Onderzoek Vlaanderen
2018 - 2019 Tailored AAV delivery systems that boost production of anti-BACE1 nanobodies for effective treatment of Alzheimer’s disease
#20170030
Investigador responsável
Stichting Alzheimer Onderzoek
2017 - 2019 Hi-Fi: Synapses in action: from high-throughput fluorescence imaging assays of synaptic plasticity to drug discovery
HBC.2019.2926
Co-Investigador Responsável (Co-IR)
Vlaanderen Agentschap Innoveren & Ondernemen
2015/01 - 2018/12 Single cell heterogeneity of hippocampal astrocytes: investigating molecular diversity and its correlation to functional specialization
G066715N
Investigador responsável
Fonds Wetenschappelijk Onderzoek Vlaanderen
2016/12 - 2018/05 Alzheimer’s disease and AAV9: Use of a virus-based delivery system for vectored immunoprophylaxis in dementia.
713755
Investigador responsável
European Research Council
2017 - 2018 Role/s of CYFIP1 in brain development and implications in neurodevelopmental disorders
G088415N
Investigador responsável
Fonds Wetenschappelijk Onderzoek Vlaanderen
2014 - 2018 Microfluidics for single-cell 'omics
G0F1914N
Co-Investigador Responsável (Co-IR)
Fonds Wetenschappelijk Onderzoek Vlaanderen
2016/01 - 2017/12 Spatial transcriptomic analysis of amyloid-induced astrogliosis in early Alzheimer’s disease
S#16025
Investigador responsável
Stichting voor Alzheimer Onderzoek
2015/01 - 2016/12 New roles for old actors: immune molecule function in astrocytes
1527315N
Investigador responsável
Fonds Wetenschappelijk Onderzoek Vlaanderen
2012/01 - 2016/12 Molecular Studies of Astrocyte Function in Health and Disease
281961
Investigador responsável
European Research Council
2016 - 2016 Use of an AAV9 based system for vectored immunoprophylaxis (VIP) targeting SOD1 in motor neuron disease.
SOD-VIP
1513616N
Investigador responsável
Fondation Thierry Latran

Fonds Wetenschappelijk Onderzoek Vlaanderen
2016 - 2016 Validation of single cell transcriptomic data using multiplexed in situ hybridization
Internal Funding
Investigador responsável
Vlaams Instituut voor Biotechnologie
2015 - 2016 Delivery of recombinant AAV9 encoding an antibody against BACE1 to treat Alzheimer's disease
P#14006
Investigador responsável
Stichting Alzheimer Onderzoek
2014 - 2015 Dual-color implantable mini-fluorescence microscope for imaging brain function in behaving rodents
Internal Funding
Investigador responsável
Vlaams Instituut voor Biotechnologie
2014/01 - 2014/01 Plastic circuits: in vivo imaging of astrocyte-neuron interactions in the mouse brain
1523014N
 Fonds Wetenschappelijk Onderzoek Vlaanderen
Produções

Publicações

Artigo em conferência
  1. Castorph, S.; Arleth, L.; Sztucki, M.; Vainio, U.; Ghosh, S.K.; Holt, M.; Jahn, R.; Salditt, T.. "Synaptic vesicles studied by SAXS: Derivation and validation of a model form factor". 2010.
    10.1088/1742-6596/247/1/012015
Artigo em revista
  1. Jérôme Wahis; Cansu Akkaya; Andre M. Kirunda; Aline Mak; Karen Zeise; Jens Verhaert; Hayk Gasparyan; Sargis Hovhannisyan; Matthew G. Holt. "The astrocyte a1A-adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex". Glia (2024): https://doi.org/10.1002/glia.24591.
    10.1002/glia.24591
  2. Araks Martirosyan; Rizwan Ansari; Francisco Pestana; Katja Hebestreit; Hayk Gasparyan; Razmik Aleksanyan; Silvia Hnatova; et al. "Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution". Molecular Neurodegeneration (2024): http://dx.doi.org/10.1186/s13024-023-00699-0.
    10.1186/s13024-023-00699-0
  3. Maria João Pereira; Rajagopal Ayana; Matthew G. Holt; Lutgarde Arckens. "Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease". Frontiers in Cell and Developmental Biology (2023): http://dx.doi.org/10.3389/fcell.2023.1193130.
    10.3389/fcell.2023.1193130
  4. João Filipe Viana; João Luís Machado; Daniela Sofia Abreu; Alexandra Veiga; Sara Barsanti; Gabriela Tavares; Manuella Martins; et al. "Astrocyte structural heterogeneity in the mouse hippocampus". Glia (2023): http://dx.doi.org/10.1002/glia.24362.
    10.1002/glia.24362
  5. Pierre Lemaitre; Samar HK Tareen; Emanuela Pasciuto; Loriana Mascali; Araks Martirosyan; Zsuzsanna Callaerts-Vegh; Suresh Poovathingal; et al. "Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain". EMBO Molecular Medicine (2023): https://doi.org/10.15252/emmm.202216805.
    10.15252/emmm.202216805
  6. Juan P Bolaños; Matthew G. Holt. "Astrocyte heterogeneity and interactions with local neural circuits". Essays in Biochemistry (2023): https://doi.org/10.1042/EBC20220136.
    10.1042/EBC20220136
  7. Matthew Holt; Disha Shah; Willy Gsell; Jérôme Wahis; Emma S. Luckett; Tarik Jamoulle; Ben Vermaercke; et al. "Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease". Cell Reports 40 8 (2022): 111280-111280. http://dx.doi.org/10.1016/j.celrep.2022.111280.
    10.1016/j.celrep.2022.111280
  8. Karl Frontzek; Marco Bardelli; Assunta Senatore; Anna Henzi; Regina R. Reimann; Seden Bedir; Marika Marino; et al. "A conformational switch controlling the toxicity of the prion protein". Nature Structural and Molecular Biology 29 8 (2022): 831-840. http://dx.doi.org/10.1038/s41594-022-00814-7.
    10.1038/s41594-022-00814-7
  9. Matthew Holt; Lidia Yshii; Emanuela Pasciuto; Pascal Bielefeld; Loriana Mascali; Pierre Lemaitre; Marika Marino; et al. "Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation". Nature Immunology 23 6 (2022): 878-891. http://dx.doi.org/10.1038/s41590-022-01208-z.
    10.1038/s41590-022-01208-z
  10. Matthew Holt; Ahmed Abdelfattah; Srinivasa Rao Allu; Robert E. Campbell; Xiaojun Cheng; Tomáš Cižmár; Irene Costantini; et al. "Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report". Neurophotonics 9 S1 (2022): http://dx.doi.org/10.1117/1.nph.9.s1.013001.
    10.1117/1.nph.9.s1.013001
  11. Matthew Holt; Marika Marino; Matthew G. Holt. "AAV Vector-Mediated Antibody Delivery (A-MAD) in the Central Nervous System". Frontiers in Neurology 13 (2022): http://dx.doi.org/10.3389/fneur.2022.870799.
    10.3389/fneur.2022.870799
  12. Marika Marino; Lujia Zhou; Melvin Y Rincon; Zsuzsanna Callaerts-Vegh; Jens Verhaert; Jérôme Wahis; Eline Creemers; et al. "AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model". EMBO Molecular Medicine 14 4 (2022): http://dx.doi.org/10.15252/emmm.201809824.
    10.15252/emmm.201809824
  13. Shinmyo Y; Saito K; Hamabe-Horiike T; Kameya N; Ando A; Kawasaki K; Duong TAD; et al. "Localized astrogenesis regulates gyrification of the cerebral cortex.". Science advances (2022): http://europepmc.org/abstract/med/35275722.
    10.1126/sciadv.abi5209
  14. Gong JY; Holt MG; Hoet PHM; Ghosh M. "Neurotoxicity of four frequently used nanoparticles: a systematic review to reveal the missing data.". Archives of toxicology (2022): http://europepmc.org/abstract/med/35278105.
    10.1007/s00204-022-03233-1
  15. Matthew Holt; Jérôme Wahis; Maroussia Hennes; Lutgarde Arckens; Matthew G Holt. "Star power: the emerging role of astrocytes as neuronal partners during cortical plasticity". Current Opinion in Neurobiology 67 (2021): 174-182. http://dx.doi.org/10.1016/j.conb.2020.12.001.
    10.1016/j.conb.2020.12.001
  16. Escartin C; Galea E; Lakatos A; O'Callaghan JP; Petzold GC; Serrano-Pozo A; Steinhäuser C; et al. "Reactive astrocyte nomenclature, definitions, and future directions.". Nature neuroscience (2021): http://europepmc.org/abstract/med/33589835.
    10.1038/s41593-020-00783-4
  17. Wahis J; Holt MG. "Astrocytes, Noradrenaline, a1-Adrenoreceptors, and Neuromodulation: Evidence and Unanswered Questions.". Frontiers in cellular neuroscience (2021): http://europepmc.org/abstract/med/33716677.
    10.3389/fncel.2021.645691
  18. Eykens C; Rossaert E; Duqué S; Rué L; Bento-Abreu A; Hersmus N; Lenaerts A; et al. "AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS.". Molecular therapy. Methods & clinical development (2021): http://europepmc.org/abstract/med/33614825.
    10.1016/j.omtm.2021.01.006
  19. Serneels L; T'Syen D; Perez-Benito L; Theys T; Holt MG; De Strooper B. "Modeling the ß-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease.". Molecular neurodegeneration (2020): http://europepmc.org/abstract/med/33076948.
    10.1186/s13024-020-00399-z
  20. Holt, Matthew. "Astrocytes shape the plastic response of adult cortical neurons to vision loss.". Glia (2020): https://doi.org/10.1002/glia.23830.
    10.1002/glia.23830
  21. Holt, Matthew. "Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.". Nature neuroscience (2020): https://doi.org/10.1038/s41593-020-0602-1.
    10.1038/s41593-020-0602-1
  22. Francisco Pestana; Gabriela Edwards-Faret; T. Grant Belgard; Araks Martirosyan; Matthew G. Holt. "No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience". Brain Sciences 10 3 (2020): 168-168. https://doi.org/10.3390/brainsci10030168.
    10.3390/brainsci10030168
  23. Holt, Matthew. "Identification of region-specific astrocyte subtypes at single cell resolution.". Nature communications (2020): https://europepmc.org/articles/PMC7058027.
    10.1038/s41467-019-14198-8
  24. Holt, Matthew. "Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex.". Current biology : CB (2019): https://doi.org/10.1016/j.cub.2019.07.078.
    10.1016/j.cub.2019.07.078
  25. Holt, Matthew. "Production, Purification, and Quality Control for Adeno-associated Virus-based Vectors.". Journal of visualized experiments : JoVE (2019): https://doi.org/10.3791/58960.
    10.3791/58960
  26. Holt, Matthew. "Widespread transduction of astrocytes and neurons in the mouse central nervous system after systemic delivery of a self-complementary AAV-PHP.B vector.". Gene therapy (2018): https://doi.org/10.1038/s41434-018-0005-z.
    10.1038/s41434-018-0005-z
  27. Holt M. "Satnav for cells: Destination membrane fusion.". Cell calcium (2017): http://europepmc.org/abstract/med/29129204.
    10.1016/j.ceca.2017.10.001
  28. Zhou L; McInnes J; Wierda K; Holt M; Herrmann AG; Jackson RJ; Wang YC; et al. "Tau association with synaptic vesicles causes presynaptic dysfunction.". Nature communications (2017): http://europepmc.org/abstract/med/28492240.
    10.1038/ncomms15295
  29. Batiuk MY; de Vin F; Duqué SI; Li C; Saito T; Saido T; Fiers M; Belgard TG; Holt MG. "An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody.". The Journal of biological chemistry (2017): http://europepmc.org/abstract/med/28373281.
    10.1074/jbc.M116.765313
  30. Koch M; Nicolas M; Zschaetzsch M; de Geest N; Claeys A; Yan J; Morgan MJ; et al. "A Fat-Facets-Dscam1-JNK Pathway Enhances Axonal Growth in Development and after Injury.". Frontiers in cellular neuroscience (2017): http://europepmc.org/abstract/med/29472843.
    10.3389/fncel.2017.00416
  31. Segura I; Lange C; Knevels E; Moskalyuk A; Pulizzi R; Eelen G; Chaze T; et al. "The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.". Cell reports (2016): http://europepmc.org/abstract/med/26972007.
    10.1016/j.celrep.2016.02.047
  32. Muhammad K; Reddy-Alla S; Driller JH; Schreiner D; Rey U; Böhme MA; Hollmann C; et al. "Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.". Nature communications (2015): http://europepmc.org/abstract/med/26471740.
    10.1038/ncomms9362
  33. Kremer A; Lippens S; Bartunkova S; Asselbergh B; Blanpain C; Fendrych M; Goossens A; et al. "Developing 3D SEM in a broad biological context.". Journal of microscopy (2015): http://europepmc.org/abstract/med/25623622.
    10.1111/jmi.12211
  34. Depner H; Lützkendorf J; Babkir HA; Sigrist SJ; Holt MG. "Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS.". Nature protocols (2014): http://europepmc.org/abstract/med/25393777.
    10.1038/nprot.2014.192
  35. Andlauer TF; Scholz-Kornehl S; Tian R; Kirchner M; Babikir HA; Depner H; Loll B; et al. "Drep-2 is a novel synaptic protein important for learning and memory.". eLife (2014): http://europepmc.org/abstract/med/25392983.
    10.7554/eLife.03895
  36. Tudor C; te Riet J; Eich C; Harkes R; Smisdom N; Bouhuijzen Wenger J; Ameloot M; et al. "Syntenin-1 and ezrin proteins link activated leukocyte cell adhesion molecule to the actin cytoskeleton.". The Journal of biological chemistry (2014): http://europepmc.org/abstract/med/24662291.
    10.1074/jbc.M113.546754
  37. Boesmans W; Rocha NP; Reis HJ; Holt M; Vanden Berghe P. "The astrocyte marker Aldh1L1 does not reliably label enteric glial cells.". Neuroscience letters (2014): http://europepmc.org/abstract/med/24589880.
    10.1016/j.neulet.2014.02.042
  38. Kiessling V; Ahmed S; Domanska MK; Holt MG; Jahn R; Tamm LK. "Rapid fusion of synaptic vesicles with reconstituted target SNARE membranes.". Biophysical journal (2013): http://europepmc.org/abstract/med/23663838.
    10.1016/j.bpj.2013.03.038
  39. Ahmed S; Holt M; Riedel D; Jahn R. "Small-scale isolation of synaptic vesicles from mammalian brain.". Nature protocols (2013): http://europepmc.org/abstract/med/23619891.
    10.1038/nprot.2013.053
  40. Park Y; Hernandez JM; van den Bogaart G; Ahmed S; Holt M; Riedel D; Jahn R. "Controlling synaptotagmin activity by electrostatic screening.". Nature structural & molecular biology (2012): http://europepmc.org/abstract/med/22940675.
    10.1038/nsmb.2375
  41. Matta S; Van Kolen K; da Cunha R; van den Bogaart G; Mandemakers W; Miskiewicz K; De Bock PJ; et al. "LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.". Neuron (2012): http://europepmc.org/abstract/med/22998870.
    10.1016/j.neuron.2012.08.022
  42. Owald D; Khorramshahi O; Gupta VK; Banovic D; Depner H; Fouquet W; Wichmann C; et al. "Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly.". Nature neuroscience (2012): http://europepmc.org/abstract/med/22864612.
    10.1038/nn.3183
  43. Ghosh SK; Castorph S; Konovalov O; Salditt T; Jahn R; Holt M. "Measuring Ca2+-induced structural changes in lipid monolayers: implications for synaptic vesicle exocytosis.". Biophysical journal (2012): http://europepmc.org/abstract/med/22455922.
    10.1016/j.bpj.2012.01.006
  44. Koch M; Holt M. "Coupling exo- and endocytosis: an essential role for PIP2 at the synapse.". Biochimica et biophysica acta (2012): http://europepmc.org/abstract/med/22387937.
    10.1016/j.bbalip.2012.02.008
  45. Castorph S; Schwarz Henriques S; Holt M; Riedel D; Jahn R; Salditt T. "Synaptic vesicles studied by dynamic light scattering.". The European physical journal. E, Soft matter (2011): http://europepmc.org/abstract/med/21706281.
    10.1140/epje/i2011-11063-2
  46. van den Bogaart G; Thutupalli S; Risselada JH; Meyenberg K; Holt M; Riedel D; Diederichsen U; et al. "Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation.". Nature structural & molecular biology (2011): http://europepmc.org/abstract/med/21642968.
    10.1038/nsmb.2061
  47. Groemer TW; Thiel CS; Holt M; Riedel D; Hua Y; Hüve J; Wilhelm BG; Klingauf J. "Amyloid precursor protein is trafficked and secreted via synaptic vesicles.". PloS one (2011): http://europepmc.org/abstract/med/21556148.
    10.1371/journal.pone.0018754
  48. Matthew Holt; S K Ghosh; S Castorph; O Konovalov; R Jahn; M Holt; T Salditt. "In vitro study of interaction of synaptic vesicles with lipid membranes". New Journal of Physics 12 10 (2010): 105004-105004. http://dx.doi.org/10.1088/1367-2630/12/10/105004.
    10.1088/1367-2630/12/10/105004
  49. Castorph S; Riedel D; Arleth L; Sztucki M; Jahn R; Holt M; Salditt T. "Structure parameters of synaptic vesicles quantified by small-angle x-ray scattering.". Biophysical journal (2010): http://europepmc.org/abstract/med/20371319.
    10.1016/j.bpj.2009.12.4278
  50. van den Bogaart G; Holt MG; Bunt G; Riedel D; Wouters FS; Jahn R. "One SNARE complex is sufficient for membrane fusion.". Nature structural & molecular biology (2010): http://europepmc.org/abstract/med/20139985.
    10.1038/nsmb.1748
  51. Rummel A; Häfner K; Mahrhold S; Darashchonak N; Holt M; Jahn R; Beermann S; et al. "Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.". Journal of neurochemistry (2009): http://europepmc.org/abstract/med/19650874.
    10.1111/j.1471-4159.2009.06298.x
  52. Hosoi N; Holt M; Sakaba T. "Calcium dependence of exo- and endocytotic coupling at a glutamatergic synapse.". Neuron (2009): http://europepmc.org/abstract/med/19640480.
    10.1016/j.neuron.2009.06.010
  53. Holt M; Riedel D; Stein A; Schuette C; Jahn R. "Synaptic vesicles are constitutively active fusion machines that function independently of Ca2+.". Current biology : CB (2008): http://europepmc.org/abstract/med/18485705.
    10.1016/j.cub.2008.04.069
  54. Takamori S; Holt M; Stenius K; Lemke EA; Grønborg M; Riedel D; Urlaub H; et al. "Molecular anatomy of a trafficking organelle.". Cell (2006): http://europepmc.org/abstract/med/17110340.
    10.1016/j.cell.2006.10.030
  55. Holt M; Varoqueaux F; Wiederhold K; Takamori S; Urlaub H; Fasshauer D; Jahn R. "Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression.". The Journal of biological chemistry (2006): http://europepmc.org/abstract/med/16621800.
    10.1074/jbc.m513838200
  56. Holt M; Jahn R. "Neuroscience. Synaptic vesicles in the fast lane.". Science (New York, N.Y.) (2004): http://europepmc.org/abstract/med/15044796.
    10.1126/science.1096747
  57. Holt M; Cooke A; Neef A; Lagnado L. "High mobility of vesicles supports continuous exocytosis at a ribbon synapse.". Current biology : CB (2004): http://europepmc.org/abstract/med/14761649.
    10.1016/j.cub.2003.12.053
  58. Holt, M.; Cooke, A.; Neef, A.; Lagnado, L.. "High Mobility of Vesicles Supports Continuous Exocytosis at a Ribbon Synapse". Current Biology 14 3 (2004): 173-183. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242310783&partnerID=MN8TOARS.
    10.1016/S0960-9822(03)00973-4
  59. Holt M; Cooke A; Wu MM; Lagnado L. "Bulk membrane retrieval in the synaptic terminal of retinal bipolar cells.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2003): http://europepmc.org/abstract/med/12598621.
    10.1523/jneurosci.23-04-01329.2003
  60. O'Brien JA; Holt M; Whiteside G; Lummis SC; Hastings MH. "Modifications to the hand-held Gene Gun: improvements for in vitro biolistic transfection of organotypic neuronal tissue.". Journal of neuroscience methods (2001): http://europepmc.org/abstract/med/11640958.
    10.1016/s0165-0270(01)00457-5
Capítulo de livro
  1. Francisco Pestana; T. Grant Belgard; Thierry Voet; Matthew G. Holt. "Studying the Role of Astrocytes at Synapses Using Single-Cell Transcriptomics". 2024.
    10.1007/978-1-0716-3742-5_9
  2. Grønborg, M.; Holt, M.; Richter, F.; Takamori, S.; Riedel, D.; Jahn, R.; Urlaub, H.. "Proteome analysis of synaptic vesicles". In Proteomics of the nervous system. Wiley, 2008.
    Publicado
Poster em conferência
  1. Pereira, Maria João; Ayana, Rajagopal; Holt, Matthew; Arckens, Lutgarde. "Manipulating astrocytic activity as a gateway to modulate adult neuroplasticity". Trabalho apresentado em XVI European Meeting on Glial Cells in Health and Disease, 2023.
  2. Pereira, Maria João; Holt, Matthew; Arckens, Lutgarde. "Star Power - Elucidating the mechanisms by which astrocytes promote neuroplasticity in adulthood". Trabalho apresentado em Leuven Brain Institute (LBI) Scientific meeting, 2022.
  3. Pereira, Maria João; Holt, Matthew; Arckens, Lutgarde. "Star Power - Elucidating the mechanisms by which astrocytes promote adult brain plasticity". Trabalho apresentado em VI Symposium of the Portuguese Glia Network, 2022.
  4. Machado, João Luís; Viana, João Filipe; Veiga, Alexandra; Teixeira, Eduardo; Abreu, Daniela Sofia; Wahis, Jerôme; Liu, Chen; Holt, Matthew; Oliveira, João Filipe. "Morphological analysis of astrocytes in different preparations". Trabalho apresentado em FENS Forum 2022 July 9 ¿ 13 in Paris, 2022.
Pré-impressão
  1. Jérôme Wahis; Cansu Akkaya; Andre M. Kirunda; Aline Mak; Karen Zeise; Jens Verhaert; Hayk Gasparyan; Sargis Hovhannisyan; Matthew G. Holt. "The astrocyte a1-adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex". 2023. https://doi.org/10.1101/2023.05.02.538934.
    10.1101/2023.05.02.538934
  2. Lidia YSHII; Loriana Mascali; Lubna Kouser; Pierre Lemaitre; Marika Marino; James Dooley; Oliver Burton; et al. "The AppNL-G-F mouse model of Alzheimer’s disease is refractory to regulatory T cell treatment". 2022. http://dx.doi.org/10.1101/2022.03.11.483903.
    10.1101/2022.03.11.483903
  3. "AAV mediated delivery of a novel anti-BACE1 VHH reduces Abeta in an Alzheimer’s disease mouse model". 2019. http://dx.doi.org/10.1101/698506.
    10.1101/698506
Tese / Dissertação
  1. Machado, Maria Eugénia Freire Torres Alves. "Vectored immunoprophylaxis to produce anti-BACE1 nanobodies for treatment of Alzheimer's disease". Mestrado, 2019. http://hdl.handle.net/10451/40536.

Outros

Outra produção
  1. Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain. 2022. Lemaitre, P.; Tareen, S.; Pasciuto, E.; Mascali, L.; Martirosyan, A.; Callaerts-Vegh, Z.; Dooley, J.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85128987197&partnerID=MN8TOARS.
    10.1101/2022.03.01.482519
  2. Flexible, fast and selective genetic manipulation of the vertebrate CNS with misPiggy. 2018. Slezak, M.; de Vin, F.; Shinmyo, Y.; Batiuk, M.Y.; Rincon, M.Y.; Pando, C.M.; Urschitz, J.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095644876&partnerID=MN8TOARS.
    10.1101/481580
  3. Astrocytes integrate local sensory and brain-wide neuromodulatory signals. 2018. Slezak, M.; Kandler, S.; Van Veldhoven, P.P.; Bonin, V.; Holt, M.G.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095660573&partnerID=MN8TOARS.
    10.1101/381434
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/11 Career development talk
University of Amsterdam (Amsterdam, Países Baixos)
2024/11 Invited talk Swammerdam Lecture
University of Amsterdam (Amsterdam, Países Baixos)
2024/07 Invited talk Scuola Internazionale Superiore di Studi Avanzati
Scuola Internazionale Superiore di Studi Avanzati (Trieste, Itália)
2024/04 Invited talk
University of Padova (Padova, Itália)
2024/03 Invited talk Gordon Research Conference: Antibody Biology and Engineering
(Itália)
2024/02 Invited talk
Institut du Cerveau et de la Moelle épinière (França)
2023/11 Keynote talk: The emerging concept of astrocyte heterogeneity: Consequences for CNS function Astrocytes and ApoE mini-symposium
(Leuven, Bélgica)
2023/09 Keynote talk: AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer’s disease model Nanobody Symposium
(Paris, França)
2023/08 Astrocyte heterogeneity and interactions with local circuits International Society for Neurochemistry Satellite Meeting
(Portugal)
2023/05 Career development talk (ERC information session) FENS Regional Meeting
(Algarve, Portugal)
2023/05 New tools to study the brain in health and disease FENS Regional Meeting
(Portugal)
2022/11 Molecular Heterogeneity of Astrocytes: Potential Implications for Development and Function i3S Neuro Day
(Porto, Portugal)
2022/10 Keynote Talk: “Molecular Heterogeneity of Astrocytes: Potential Implications for Development and Function” Portuguese Glia Meeting
(Porto, Portugal)
2022/10 Astrocytes: Master regulators of inhibition and plasticity i3S Group Leaders’ Seminar Series
(Porto, Portugal)
2022/09 Invited Talk ITN AstroTech Workshop
(Porto, Portugal)
2022/07 AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer’s disease model Alzheimer’s Association International Conference
(Estados Unidos)
2022/07 The emerging concept of astrocyte heterogeneity: consequences for CNS function FENS Forum
(França)
2022/07 Astrocytes: Master regulators of inhibition and plasticity? FENS Glia Satellite
(Paris, França)
2022/06 Astrocytes: Master regulators of inhibition and plasticity?
Institute of Molecular Medicine (Lisbon, Portugal)
2022/06 Spatial Transcriptomics: mapping gene expression and cell populations in the brain Dutch Neuroscience Society
(Tiel, Países Baixos)
2022/05 Experiences of an ERA Chair Science Europe Workshop on Widening Participation and Spreading
2022/05 Astrocytes: Master regulators of inhibition and plasticity? Belgian Neuroscience Society
(Brussels, Bélgica)
2021/06 Mapping transcriptome heterogeneity in the CNS with single cell resolution using highly multiplexed spatial transcriptomics American Society for Neurochemistry - Advances in Genome Biology and Technology
(Florida, Estados Unidos)
2020/11 Invited talk Neuroscience Ireland Young Investigators Symposium
(Irlanda)
2020/10 Invited talk Neurophotonics Virtual Mini-Symposium
2020/09 Invited talk
University of Maastricht (Maastricht, Países Baixos)
2020/09 Invited talk OpenBox Science Symposium, Virtual Conference
2020/02 Career development talk Careers in neuroscience symposium
University of Luxembourg (Luxemburgo)
2020/02 Invited talk
University of Luxembourg (Luxemburgo)
2020/01 Invited talk Resolve Life Sciences (formerly Qiagen)
(Alemanha)
2019/12 Invited talk
Vrije Universiteit Brussels (Bélgica)
2019/07 Invited talk
Ludwig Maximilians-Universiteit (Alemanha)
2019/07 Invited talk European Glia Conference
(Portugal)
2019/06 Invited talk Lowlands Neuroscience Meeting
(Bélgica)
2019/03 Invited talk Gordon Research Conference, Glial Biology: Functional Interactions Among Glia and Neurons
(Estados Unidos)
2019/02 Invited talk
University of Osnabrück (Alemanha)
2018/09 Invited talk
University of Lausanne (Lausanne, Suiça)
2017/07 Invited talk Cajal Neuroscience School
(França)
2017/05 Invited talk Thierry Latran Meeting
(Eslovénia)
2017/01 Invited talk
University of Amsterdam (Amsterdam, Países Baixos)
2016/05 Invited talk Thierry Latran Meeting
(Itália)
2016/05 Invited talk Janssen Pharma
(Bélgica)
2016/03 Career development talk (ERC information session)
University of Utrecht (Utrecht, Países Baixos)
2016/03 Invited talk
University of Utrecht (Utrecht, Países Baixos)
2015/11 Invited talk
University of Maastricht (Maastricht, Países Baixos)
2015/04 Invited talk KU Leuven Biomedical Congress
(Bélgica)
2015/03 Invited talk
KU Leuven Stem Cell Institute (Bélgica)
2014/10 Invited talk
Bogaziçi University (Turquia)
2014/09 Invited talk
VIB Neurogenetics Unit (Bélgica)
2014/06 Invited talk
Scripps Research Institute (Estados Unidos)
2013/05 Invited talk Neuronus Conference
(Polónia)
2013/01 Invited talk
University of Lausanne (Lausanne, Suiça)
2012/11 Invited talk
Université Libre de Bruxelles (Brussels, Bélgica)
2012/05 Career development talk (ERC information session) Leadnet Conference
Max Planck Society (Berlin, Alemanha)
2012/03 Invited talk International Astrocyte Summer School
(Itália)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024 - Atual Development of Cas9-based tools for astrocyte-specific manipulation
Orientador de Rafaela Seixas
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023 - Atual Identification of astrocyte-secreted factors involved in synapse formation
Orientador de João Baltar Guimarães
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023 - Atual Development of TurboID-based systems for secretome analysis
Orientador de Luísa Florido
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023 - Atual Implementation of TurboID-based systems for surface proteome analysis
Orientador de Carlos Pinto
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - Atual Establishing the molecular basis and function of the astrocyte-neuron interplay at the inhibitory tripartite synapse.
Orientador de Domenico Natale
Associatie KU Leuven, Bélgica
2021 - Atual Critical periods and brain plasticity – astrocytes as key modulators of cortical wiring.
Orientador de Maria João Pereira
Associatie KU Leuven, Bélgica
2020 - Atual Investigating the protocadherin system in astrocytes: a cross species study on their involvement in formation of brain circuitry.
Orientador de Francisco Pestana
Associatie KU Leuven, Bélgica
2019 - Atual Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador de Dr. Sarah van Veen
Associatie KU Leuven, Bélgica
2017 - Atual Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador
Associatie KU Leuven, Bélgica
2023/11/06 - 2024/03/01 Generation and in vitro validation of CRISPR/Cas9-based knockout of proteins in astrocytes
Orientador de Julia Oster
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - 2022/09 Optimized AAV systems for vectored immunoprophylaxis as a therapeutic strategy to treat CNS disease.
Orientador de Marika Marino
Associatie KU Leuven, Bélgica
2021 - 2022 Investigating cell type heterogeneity in the brain using machine learning techniques.
Orientador de Hayk Gasparyan
Yerevan State University, Arménia
2021 - 2022 Single image dehazing.
Orientador de Sargis Hovhannisyan
Yerevan State University, Arménia
2021 - 2022 Solving the problems of classification and segmentation of brain cells.
Orientador de Razmik Aleksanyan
Yerevan State University, Arménia
2021 - 2022 Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador de Dr. Çansu Akkaya
Associatie KU Leuven, Bélgica
2017 - 2022 Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador de Dr. Araks Martirosyan
Associatie KU Leuven, Bélgica
2019 - 2021 Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador de Dr. Lidia Yshii
Associatie KU Leuven, Bélgica
2020 - 2020/12 Characterizing the missing cellular component in visual cortex plasticity.
Coorientador de Maroussia Hennes
Associatie KU Leuven, Bélgica
2020 - 2020/09 Target specific routing of visual information by the superior colliculus.
Coorientador de Chen Li
Associatie KU Leuven, Bélgica
2020 - 2020 Optimisation of an rAAV-based tool for the treatment of CNS disorders.
Orientador de Jens Verhaert
UC Leuven-Limburg, Bélgica
2020 - 2020 Studying neuromodulatory functions of astrocytes using cell-type specific genetic tools.
Orientador de Thomas Alkins
UC Leuven-Limburg, Bélgica
2020 - 2020 Solving the problems of classification and segmentation of brain cells.
Orientador de Razmik Aleksanyan
Yerevan State University, Arménia
2018 - 2019 Vectored immunoprophylaxis in the CNS.
Orientador de Eugénia Machado
Universidade de Lisboa, Portugal
2018 - 2019 Astrocytes as mediators in noradrenergic modulation of long-term potentiation in visual cortex.
Orientador de Aline Mak
Vrije Universiteit Amsterdam, Países Baixos
2018 - 2019 Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador de Dr. Jordan Koeppen
Associatie KU Leuven, Bélgica
2017 - 2019 Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador de Dr. Melina Figueiredo
Associatie KU Leuven, Bélgica
2016 - 2019 Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador de Dr. Melvin Rincon
Associatie KU Leuven, Bélgica
2018 - 2018/11 Study of astrocyte heterogeneity using single cell transcriptomics.
Orientador de Mykhailo Batiuk
Associatie KU Leuven, Bélgica
2017 - 2018 Development of new systems for enhanced gene therapy in the central nervous system.
Orientador de Shelly Fripont
Associatie KU Leuven, Bélgica
2017 - 2017 Validation of effective silencing of p53 with a p53 shRNA strategy.
Orientador de Catherine Marneffe
Université de Namur, Bélgica
2014 - 2017 Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador de Dr. Sandra Duqué
Associatie KU Leuven, Bélgica
2016 - 2016 AAV9-based delivery of anti-SOD1 nanobodies into the CNS has no therapeutic benefit in a SOD1G93A mouse model.
Orientador de Ori Roethler
Vrije Universiteit Amsterdam, Países Baixos
2012 - 2016 Postdoctoral Researcher in Dr. Matthew Holt's lab.
Orientador de Dr. Michal Slezak
Associatie KU Leuven, Bélgica
2015 - 2015 Visualization of Ca2+ responses in neurons and astrocytes.
Orientador de Vicky Leuris
Plantijn Technical School, Bélgica
2014 - 2015 The role of inflammation and glial Notch in the control of behaviour in Drosophila and mice.
Coorientador de Sedef Dalbeyer
Associatie KU Leuven, Bélgica
2014 - 2014 Implementation of organotypic slice culture system to study astrocyte function.
Orientador
Vrije Universiteit Amsterdam, Países Baixos
2014 - 2014 Implementation of organotypic slice culture system to study astrocyte function.
Orientador de Ana Sobornova
Vrije Universiteit Amsterdam, Países Baixos
2014 - 2014 Expression and purification of recombinant proteins in mammalian tissue culture cells.
Orientador de Tom Mertens
Plantijn Technical School, Bélgica
2013 - 2014 A novel tool for astrocyte specific expression of genetic manipulations.
Orientador de Arno Vandebroek
Associatie KU Leuven, Bélgica
2013 - 2014 TU tagging to measure gene expression.
Orientador de Ilayda Hasakiogullari
Universiteit Hasselt, Bélgica
2013 - 2013 Co-purification of astrocyte process with synaptosomes.
Orientador de Liese Vandevyvere
Plantijn Technical School, Bélgica

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/06/30 - 2023/06/30 Neural Cell Biology (NCBio) Stakeholder Hub Kick-Off Meeting (2023/06/30 - 2023/06/30)
Encontro (Membro da Comissão Organizadora)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/10/18 - 2022/11/18 VI Portuguese Glia Meeting (2022/10/18 - 2022/10/18)
Encontro (Coorganizador)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/11/04 - 2022/11/04 Meeting of the i3S Program of Neurobiology and Neurologic Diseases (2022/11/04 - 2022/11/04)
Encontro (Coorganizador)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - 2022 Symposium in Single Cell Sequencing and Spatial Transcriptomics, Dutch Neuroscience Meeting (2022 - 2022)
Simpósio (Coorganizador)
2017/05 - 2017/05 VIB Training Course on Gene Regulation and Tools for Transcriptional Profiling (2017/05 - 2017/05)
Oficina (workshop) (Coorganizador)
 Vlaams Instituut voor Biotechnologie, Bélgica
2016/09 - 2016/09 VIB Training Course on Single Cell Analysis (2016/09 - 2016/09)
Oficina (workshop) (Coorganizador)
 Vlaams Instituut voor Biotechnologie, Bélgica
2016/09 - 2016/09 VIB Conference on Single Cell Analysis (Brain Mosaic) (2016/09 - 2016/09)
Conferência (Coorganizador)
 Vlaams Instituut voor Biotechnologie, Bélgica
2012/09 - 2012/09 VIB Training Course on ‘Omics Technologies (2012/09 - 2012/09)
Oficina (workshop) (Outra)
 Vlaams Instituut voor Biotechnologie, Bélgica

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2017/07 - 2017/07 Instructor at the FENS Summer School “Advanced Neuroscience Techniques”
Oficina (workshop)
Federation of European Neuroscience Societies, Bélgica
2015/09 - 2015/09 Speaker at the Annalis Ultracentrifuge Training Symposium
Simpósio
2013/04 - 2013/04 Speaker at the Brain Train Integrative Neuroscience School on Brain Function and Disease
Conferência

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022/12 Systematic profiling of microRNA-132 functional targetome and its therapeutic potential in Alzheimer's disease.
Arguente
 Hannah Walgrave (Doutoramento)
2022/11 Modelling amyotrophic lateral sclerosis: Human iPSC-derived astrocytes and neuromuscular junctions in microfluidic devices.
Arguente
 Katarina Dittlau (Doutoramento)
2022/11 Decoding gene regulation in the fly brain.
Arguente
 Jasper Janssens (Doutoramento)
2022/09 Radial astrocytes in the developing retinotectal system promote escape behavior through the detection and modulation of neuronal activity.
Arguente
 Nick Benfey (Doutoramento)
2021/12 Unraveling the role of PREPL, a serine hydrolase deleted in a Prader-Willi-like syndrome.
Arguente
 Karen Rosier (Doutoramento)
2021/08 Stress-dependent mental disorders: a molecular and structural basis.
Arguente
 Dorien Vandael (Doutoramento)
2021/07 Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum.
Arguente
 Tingting Zhang (Doutoramento)
2021/03 Nanobodies to cross the blood-brain barrier.
Arguente
 Yessica Wouters (Doutoramento)
2021/03 The role of nucleocytoplasmic transport in C9orf72 amyotrophic lateral sclerosis.
Arguente
 Joni Vanneste (Doutoramento)
2020/10 Mapping the cell-surface proteome underlying synapse type-specific identity.
Arguente
 Nuno Apóstolo (Doutoramento)
2020/01 The role of TNFAIP3/A20 in neurolupus.
Arguente
 Carmen Daems (Doutoramento)
2019/01 Exploration and modulation of oligodendrocyte dysfunction in ALS.
Arguente
 Caroline Eykens (Doutoramento)
2019 Molecular mechanisms of synaptic vesicle rejuvenation: Skywalker and epilepsy.
Arguente
 Ina Maes (Doutoramento)
2018/11 Hsp90 mediates membrane deformation and exosome release.
Arguente
 Yu Chun Wang (Doutoramento)
2018/10 BACE2 distribution in the brain and identification of its substrates.
Arguente
 Iryna Voytyuk (Doutoramento)
2018/02 The synapse to nucleus signalling is impaired in Fragile X syndrome.
Arguente
 Laura D’Andrea (Doutoramento)
2017/09 Investigation of a genetic and environmental modifier of sporadic Alzheimer’s disease.
Arguente
 Isabel Salas (Doutoramento)
2016/10 Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine induced peripheral neuropathies and inhibits tumor progression in vivo.
Arguente
 Lawrence Van Helleputte (Doutoramento)
2016/09 Modulation of tau pathology propagation.
Arguente
 Sara Calafate (Doutoramento)
2016/01 Exploring the mechanism and therapeutic potential of the ephrin system in ALS.
Arguente
 Lies Schoonaert (Doutoramento)
2016/01 Dynamic properties of the alkaline vesicle population at hippocampal synapses.
Arguente
 Mareike Röther (Doutoramento)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2023 - 2024 Member of the ATIP-Avenir Evaluation Board (CNRS-Inserm)
Membro
 Centre National de la Recherche Scientifique, França Centre National de la Recherche Scientifique
2023 - 2023 Member of the ERA-NET NEURON initiative pre-selection panel for ‘Transnational Research Projects on Mechanisms of Resilience and Vulnerability to Environmental Challenges in Mental Health’ run with DFG
Membro
 Deutsche Forschungsgemeinschaft, Alemanha Deutsche Forschungsgemeinschaft
2023 - 2023 Member of the Collège de France Scientific Evaluation board (Inserm)
Membro
 Collège de France, França
2022 - 2022 Elected Member of the Sapienza Academic Network
Membro
 Sapienza Università Editrice, Itália
2021 - 2021 Member of the panel for the “Synapses Under Stress” Research Unit
Membro
 Deutsche Forschungsgemeinschaft, Alemanha Deutsche Forschungsgemeinschaft
2021 - 2021 Member of the “Talent Stars” selection panel for junior PIs.
Membro
 Università degli Studi di Padova, Itália
2017 - 2017 Member of the “Astrocyte Heterogeneity” panel
Membro
 Deutsche Forschungsgemeinschaft, Alemanha Deutsche Forschungsgemeinschaft

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2012 - Atual Ad hoc review on glia Agence nationale de la recherche, França
2012 - Atual Ad hoc review on glia Alzheimer Nederland, Países Baixos
2012 - Atual Ad hoc review on glia Association Européenne contre les Leucodystrophies, França
2012 - Atual Ad hoc review on glia Biotechnology and Biological Sciences Research Council, Reino Unido
2012 - Atual Ad hoc review on glia UK Dementia Research Institute, Reino Unido
2012 - Atual Ad hoc review on glia Wellcome Trust, Reino Unido
2012 - Atual Ad hoc review on glia Düsseldorf University Internal Funds, Alemanha
2012 - Atual Ad hoc review on glia (Consolidator Panel and Synergy Panel) European Research Council, Bélgica
2012 - Atual Ad hoc review on glia European Science Foundation, França
2012 - Atual Ad hoc review on glia Fédération pour la recherche sur le cerveau, França
2012 - Atual Ad hoc review on glia Fondation pour la Recherche Médicale, França
2012 - Atual Ad hoc review on glia Fondazione Cariplo, Itália
2012 - Atual Ad hoc review on glia Israeli Science Foundation, Israel
2012 - Atual Ad hoc review on glia Medical Research Council UK, Reino Unido
2012 - Atual Ad hoc review on glia Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Países Baixos
2012 - Atual Ad hoc review on glia Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Suiça
2012 - Atual Ad hoc review on glia Fondation Thierry Latran, França

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2024 - Atual Faculty Member of the International Astrocyte School, Bertinoro, Italy
2024 - Atual Synapse Assembly, Structure, and Function PhD course (Doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023 - Atual Neuroscience Ph.D. lectures on astrocyte biology (Doutoramento) Universidade do Porto, Portugal
2022 - Atual Molecular and Cellular Biology Ph.D. lectures on glial biology (Doutoramento) Universidade do Porto, Portugal
2019 - Atual Topics in Neurodegeneration (Master) Associatie KU Leuven, Bélgica
2012 - Atual Advanced Biology of the Cell/Neuron (Master) Associatie KU Leuven, Bélgica
2012 - Atual Hot Topics in the Biology of the Cell/Neuron (Master) Associatie KU Leuven, Bélgica
2012 - 2022 Organizer of the VIB-CBD institutional lecture series VIB-KU Leuven Center for Brain & Disease Research, Bélgica

Membro de associação

Nome da associação Tipo de participação
2012 - Atual Elected Member of the “Sapienza Academic Network” based at Sapienza University, Rome.

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2018 - Atual Member of the oversight panel for gene therapy trials run by the Dementia Research Institute, UK.
Membro
 UK Dementia Research Institute, Reino Unido
2016 - Atual Member of the management committees for the KU Leuven and VIB FACS facilities.
Membro
 Associatie KU Leuven, Bélgica
2012 - Atual Member of the evaluation panel for the "Synapses Under Stress" Research Unit.
Membro
 Deutsche Forschungsgemeinschaft, Alemanha
2012 - Atual Member of the “Talent Stars” selection panel for junior PIs.
Membro
 Università degli Studi di Padova, Itália
2002 - Atual Member of the "Astrocyte Heterogeneity" evaluation panel
Membro
 Deutsche Forschungsgemeinschaft, Alemanha
2015 - 2016 Member of the VIB Group Leader’s Management Committee (with responsibility for selection of students admitted to the VIB Ph.D. program)
Membro
 VIB - KU Leuven Center for Brain & Disease Research, Bélgica

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2023 - Atual Member of Editorial Board of Brain Organoid and Systems Neuroscience Elsevier B.V.
2022/10/07 - Atual Member of Editorial Board of GLIA (1098-1136) Wiley Periodicals, LLC.
2021 - Atual Frontiers in Cell and Developmental Biology (2296-634X) Frontiers
2019 - Atual Frontiers in Cellular Neuroscience (1662-5102) Frontiers
2019 - Atual Editorial board member of Brain Sciences (2076-3425 ) MDPI
2019 - Atual Editorial board member of Frontiers in Cellular Neuroscience (1662-5102) Frontiers
2012 - Atual Acta Neuropathologica Communications (2051-5960) BMC
2012 - Atual Brain Behavior and Immunity (1090-2139) Elsevier B.V.
2012 - Atual Brain Structure and Function (1863-2661) Springer
2012 - Atual Biophysical Journal (1542-0086) Cell Press
2012 - Atual Cell (1097-4172) Cell Press
2012 - Atual Cell Calcium (0143-4160) Elsevier B.V.
2012 - Atual Cell Reports (2211-1247) Cell Press
2012 - Atual Current Opinion in Neurobiology (1873-6882) Elsevier B.V.
2012 - Atual Developmental Cell (1878-1551) Cell Press
2012 - Atual eLife (2050-084X) eLife Sciences Publications, Ltd
2012 - Atual EMBO Journal (1460-2075) EMBO Press
2012 - Atual EMBO Molecular Medicine (1757-4684) EMBO Press
2012 - Atual European Journal of Neuroscience (1460-9568) Federation of European Neuroscience Societies and John Wiley & Sons Ltd
2012 - Atual FEBS Journal (1742-4658) FEBS Press
2012 - Atual Glia (1098-1136) Wiley Periodicals, LLC.
2012 - Atual iScience (2589-0042) Cell Press
2012 - Atual Journal of Cell Biology (0021-9525) Rockefeller University Press
2012 - Atual Journal of Cellular Biochemistry (1097-4644) Wiley Periodicals, LLC.
2012 - Atual Journal of Cellular Physiology (1097-4644) Wiley Periodicals, LLC.
2012 - Atual Journal of Neuroscience (1529-2401) Society for Neuroscience
2012 - Atual Journal of Neuroscience Research (1097-4547) Wiley Periodicals, LLC.
2012 - Atual JoVE (1940-087X) MyJove Corp.
2012 - Atual Molecular Psychiatry (1476-5578) Nature Portofolio
2012 - Atual Molecular Therapy (Nucleic Acids) (2162-2531) Cell Press
2012 - Atual Nature (1476-4687) Nature Portfolio, Springer Nature
2012 - Atual Nature Communications (2041-1723) Nature Portofolio
2012 - Atual Nature Neuroscience (1546-1726) Nature Portofolio
2012 - Atual Neurobiology of Disease (1095-953X) Elsevier B.V.
2012 - Atual Neuroscience (1873-7544) Elsevier B.V.
2012 - Atual Plos One (1932-6203) PLOS
2012 - Atual Plos Pathogens (1553-7374 ) PLOS
2012 - Atual PNAS (1091-6490) National Academy of Sciences
2012 - Atual Science (0036-8075) AAAS
2012 - Atual Scientific Reports (2045-2322) Nature Portofolio
2012 - Atual Theranostics (1838-7640) Ivyspring International Publisher
2012 - Atual Trends in Cell Biology (1879-3088) Cell Press
2022 - 2022 Frontiers in Cell and Developmental Biology - Editor of Astrogliogenesis special topic (2296-634X) Frontiers

Tutoria

Tópico Nome do aluno
2023/09 - Atual Identification of astrocyte cell surface proteins involved in synapse formation Dr. Maria Joana Pinto (post-doc)
2022 - 2022 Analysis of cell differentiation pathways using RNA Velocity analysis. Arabo Apresyan (Institute of Molecular Biology NAS RA, Armenia)
2020 - 2020 Effect of Noradrenergic Signalling on Astrocytes and Synaptic Plasticity. Leon Kremers (Tübingen, Germany]
2019 - 2019 Development of genetic strategies for astrocyte-specific alpha1a-adrenoceptor silencing. Andre Kirunda (Northeastern University, Boston, USA)
2019 - 2019 Vectored immunoprophylaxis in the CNS. Laura Manjarres Madrid (CES University, Colombia)
2018 - 2019 Tracing astrocyte development. Carola Kusserow (University of Freiburg, Germany)
2018 - 2018 Development of genetic strategies for astrocyte-specific alpha1a-adrenoceptor silencing. Karen Zeise (Northeastern University, Boston, USA)
2017 - 2017 Development of novel in utero electroporation systems. Carmen Menacho Pando (Universitat Autònoma de Barcelona, Spain)
2017 - 2017 Development of transposon-based genetic tools. Ana Toledano (Universidad Autonoma de Madrid, Spain)
2017 - 2017 Development of TRAP-based methodologies to study local translation in astrocytes.2017 Sarah Neshat (Northeastern University, Boston, USA)
2016 - 2016 Development of transposon-based lineage tracing tools. Busra Kirpat (Bilkent University, Turkey)
Distinções

Prémio

2022 ERA Chair in Neural Cell Biology
EU Framework Programme for Research and Innovation Spreading Excellence and Widening Participation, Bélgica
2015 ERC Proof-of-Concept Grant
European Research Council, Bélgica
2011 ERC Starting Grant
European Research Council, Bélgica
2010 Fellowship from the Neurocure consortium
German Elite University Initiative, Alemanha
2008 Bombannes-Institut Laue-Langevin Prize for “Scattering Methods Applied to Soft Condensed Matter”
2003 Postdoctoral stipend of the Max Planck Society
Max-Planck-Gesellschaft zur Förderung der Wissenschaften, Alemanha
1998 Ph.D. fellowship from the Medical Research Council
Medical Research Council UK, Reino Unido
1998 Glaxo Wellcome Prize for Biochemistry for distinguished performance in undergraduate studies
Glaxo Wellcome, Reino Unido
1994 Full faculty scholarships at the University of Liverpool. Awarded to top 1% of students in the faculty.
University of Liverpool, Reino Unido

Outra distinção

2012 ESRF annual research highlight for work on structure-function analysis of synaptic vesicles
ESRF, França