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Zach Hensel completed his PhD in Molecular Biophysics at Johns Hopkins University in the laboratory of Dr. Jie Xiao, where he studied single-molecule biophysics problems in gene regulation in E. coli. He then completed postdoctoral work in projects linking single-molecule microscopy and computational biophysics at the Okinawa Institute of Science and Technology (OIST). Since 2017, Dr. Hensel runs the Single Molecule Microbiology lab at ITQB NOVA, within the MOSTMICRO research unit. His lab studies gene regulation and cell division at the single-molecule level in living microbial cells, with a focuses on imaging single mRNA and protein molecules and on investigating structures of protein complexes predicted by deep learning. The lab has built two hybrid commercial/DIY microscope for single-molecule imaging. His interests include advances in rapid and reproducible dissemination of scientific results (i.e. preprints and executable research articles).
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Identificação

Identificação pessoal

Nome completo
Zachary Jay Hensel

Nomes de citação

  • Hensel, Zach
  • Zach Hensel

Identificadores de autor

Ciência ID
6A11-3CB3-F87F
ORCID iD
0000-0002-4348-6229

Websites

  • https://zach-hensel.github.io/ (Profissional)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1) Utilizador independente (B1)
Japonês Utilizador independente (B1) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador independente (B1)
Formação
Grau Classificação
2012/05/24
Concluído
 Molecular Biophysics (Doctor of Philosophy)
Johns Hopkins University School of Medicine, Estados Unidos
"Single-molecule studies of stochastic gene regulation by the lambda repressor CI in live E. coli cells" (TESE/DISSERTAÇÃO)
 N/A
2005/05
Concluído
 Physics (Bachelor)
University of Illinois at Urbana-Champaign, Estados Unidos
"Chiral liquid crystals in suspensions of Salmonella flagella" (TESE/DISSERTAÇÃO)
 3.99/4.0
2005
Concluído
 Cinema Studies (Bachelor)
University of Illinois at Urbana-Champaign, Estados Unidos
"An introduction to lo-fi cinema" (TESE/DISSERTAÇÃO)
 3.99/4.0
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/01/03 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/04/01 - 2016/12/31 Independent Postdoctoral Researcher, Deans Research Group Advisors: Dr. Ken Peach (04-2015—01-2016), Dr. Gordon Arbuthnott (02-2016—12-2016) Okinawa Kagaku Gijutsu Daigakuin Daigaku, Japão
2012/10/01 - 2015/03/31 Postdoctoral Researcher, Integrative Systems Biology Unit Advisor: Dr. Tatiana Marquez Lago Okinawa Kagaku Gijutsu Daigakuin Daigaku, Japão
Projetos

Bolsa

Designação Financiadores
2023/04/01 - Atual MOSTMICRO-ITQB Exploratory Project
ICA35303
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Em curso
2017/04/01 - 2022/12/31 ITQB-OIST Joint Research Agreement
NA
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Concluído
2021/09/16 - 2022/09/15 Prediction of the structure of bacterial cell-division complexes
GCP20210916
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Google Inc
Concluído

Projeto

Designação Financiadores
2023/09/01 - Atual Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
10.54499/LA/P/0087/2020
Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade Nova de Lisboa, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Centro de Estudos Comparatistas, Portugal

BioResources 4 Sustainability, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 Molecular, Structural and Cellular Microbiology
UID/CBQ/04612/2019
Universidade Nova de Lisboa, Portugal

Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Alexander Crits-Christoph; Joshua I. Levy; Jonathan E. Pekar; Stephen A. Goldstein; Reema Singh; Zach Hensel; Karthik Gangavarapu; et al. "Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic". Cell (2024): http://dx.doi.org/10.1016/j.cell.2024.08.010.
    10.1016/j.cell.2024.08.010
  2. Simon Schäper; António D. Brito; Bruno M. Saraiva; Georgia R. Squyres; Matthew J. Holmes; Ethan C. Garner; Zach Hensel; Ricardo Henriques; Mariana G. Pinho. "Cell constriction requires processive septal peptidoglycan synthase movement independent of FtsZ treadmilling in Staphylococcus aureus". Nature Microbiology (2024): https://doi.org/10.1038/s41564-024-01629-6.
    10.1038/s41564-024-01629-6
  3. Liv Zimmermann; Xiaohan Zhao; Jana Makroczyova; Moritz Wachsmuth-Melm; Vibhu Prasad; Zach Hensel; Ralf Bartenschlager; Petr Chlanda. "SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle". Nature Communications (2023): https://doi.org/10.1038/s41467-023-43666-5.
    10.1038/s41467-023-43666-5
  4. Brooke M. Britton; Remy A. Yovanno; Sara F. Costa; Joshua McCausland; Albert Y. Lau; Jie Xiao; Zach Hensel. Autor correspondente: Zach Hensel. "Conformational changes in the essential E. coli septal cell wall synthesis complex suggest an activation mechanism". Nature Communications (2023): https://doi.org/10.1038/s41467-023-39921-4.
    10.1038/s41467-023-39921-4
  5. Letra-Vilela, Ricardo; Quiteres, Ricardo; Murtinheira, Fernanda; Crevenna, Alvaro; Hensel, Zach; Herrera, Federico. Autor correspondente: Hensel, Zach. "New tools for the visualization of glial fibrillary acidic protein in living cells". Experimental Results 1 (2020): https://doi.org/ggnnvq.
    10.1017/exp.2020.1
  6. João P. N. Silva; Soraia Vidigal Lopes; Diogo J. Grilo; Zach Hensel. Autor correspondente: Zach Hensel. "Plasmids for Independently Tunable, Low-Noise Expression of Two Genes". mSphere (2019): https://doi.org/gf3vhf.
    10.1128/mSphere.00340-19
  7. Sarvenaz Sarabipour; Humberto J. Debat; Edward Emmott; Steven J. Burgess; Benjamin Schwessinger; Zach Hensel. Autor correspondente: Zach Hensel. "On the value of preprints: An early career researcher perspective". PLOS Biology 17 2 (2019): e3000151-e3000151. https://doi.org/gfw8hd.
    10.1371/journal.pbio.3000151
  8. Xiaona Fang; Qiong Liu; Christopher Bohrer; Zach Hensel; Wei Han; Jin Wang; Jie Xiao. "Cell fate potentials and switching kinetics uncovered in a classic bistable genetic switch". Nature Communications 9 1 (2018): https://doi.org/gdwxjt.
    10.1038/s41467-018-05071-1
  9. Hensel, Z.. "A plasmid-based Escherichia coli gene expression system with cell-to-cell variation below the extrinsic noise limit". PLoS ONE 12 10 (2017): https://doi.org/gcg8pf.
    10.1371/journal.pone.0187259
  10. Hensel, Zachary; Marquez-Lago, Tatiana T. "Cell-cycle-synchronized, oscillatory expression of a negatively autoregulated gene in E. coli". arXiv q-bio (2015): https://doi.org/10.48550/arXiv.1506.08596.
  11. Hensel, Z.; Xiao, J.. "Single-molecule methods for studying gene regulation in vivo". Pflugers Archiv European Journal of Physiology 465 3 (2013): 383-395. https://doi.org/gdxw5j.
    10.1007/s00424-013-1243-y
  12. Hensel, Z.; Fang, X.; Xiao, J.. "Single-molecule imaging of gene regulation in vivo using cotranslational activation by cleavage (CoTrAC)". Journal of Visualized Experiments 73 (2013): https://doi.org/gfb8nv.
    10.3791/50042
  13. Hensel, Z.; Weng, X.; Lagda, A.C.; Xiao, J.. "Transcription-Factor-Mediated DNA Looping Probed by High-Resolution, Single-Molecule Imaging in Live E. coli Cells". PLoS Biology 11 6 (2013): https://doi.org/gbdb2z.
    10.1371/journal.pbio.1001591
  14. Hensel, Z.; Feng, H.; Han, B.; Hatem, C.; Wang, J.; Xiao, J.. "Stochastic expression dynamics of a transcription factor revealed by single-molecule noise analysis". Nature Structural and Molecular Biology 19 8 (2012): 797-802. https://doi.org/f358fm.
    10.1038/nsmb.2336
  15. Feng, H.; Hensel, Z.; Xiao, J.; Wang, J.. "Analytical calculation of protein production distributions in models of clustered protein expression". Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 85 3 (2012): https://doi.org/gfb8vm.
    10.1103/PhysRevE.85.031904
  16. Fu, G.; Huang, T.; Buss, J.; Coltharp, C.; Hensel, Z.; Xiao, J.. "In Vivo structure of the E. coli FtsZ-ring revealed by photoactivated localization microscopy (PALM)". PLoS ONE 5 9 (2010): 1-16. https://doi.org/drrw4v.
    10.1371/journal.pone.0012680
  17. Hensel, Z.; Xiao, J.. "A mechanism for stochastic decision making by bacteria". ChemBioChem 10 6 (2009): 974-976. https://doi.org/bzbk92.
    10.1002/cbic.200800824
  18. Barry, E.; Hensel, Z.; Dogic, Z.; Shribak, M.; Oldenbourg, R.. "Entropy-driven formation of a chiral liquid-crystalline phase of helical filaments". Physical Review Letters 96 1 (2006): https://doi.org/b2rbcd.
    10.1103/PhysRevLett.96.018305
Poster em conferência
  1. Ruilan Xu; João Ramalheira Ferreira; Hensel, Zach. Autor correspondente: Hensel, Zach. "(Flash talk and poster) Fluorescence microscopy in E. coli confirms protein-protein interaction essential in persistent M. tuberculosis infection". Trabalho apresentado em 91st Harden Conference: Single Molecule Bacteriology III, 2024.
  2. Ruilan Xu; João Ramalheira Ferreira; Hensel, Zach. Autor correspondente: Ruilan Xu. "Mycobacterium tuberculosis FtsB and PerM interact via a C-terminal helix in FtsB to modulate cell division". Trabalho apresentado em Single Molecule Localization Microscopy Symposium, 2024.
  3. Sara F. Costa; Margarida A. Pereira; Hensel, Zach. Autor correspondente: Hensel, Zach. "Imaging transcription elongation and mRNA localization in E. coli using newly reported fluorescent proteins". Trabalho apresentado em Single Molecule Localization Microscopy Symposium, 2024.
  4. Zach Hensel. "Detecting the expression of single messenger RNAs and the protein molecules they encode in living E. coli cells". Trabalho apresentado em Spanish & Portuguese Advanced Optical Microscopy Meeting, 2019.
  5. Zach Hensel. "Low-noise expression system for single-molecule mRNA visualization in live E. coli cells". Trabalho apresentado em Cutting Edge Developments in RNA Biology for the Control of Gene Expression, 2017.
  6. Zach Hensel. "Single-molecule tracking in living cells reveals disruption of non-specific DNA binding upon translation inhibition". Trabalho apresentado em Seeing is Believing EMBO EMBL Symposium, 2017.
  7. Zach Hensel. "Cell-cycle-synchronized oscillations of an autoregulated gene in E. coli: Testing possible biomolecular mechanisms by stochastic simulation". Trabalho apresentado em Biochemistry and Molecular Biology Meeting (BMB2015), 2015.
  8. Zach Hensel. "Oscillations in expression of a negatively autoregulated gene in E. coli are synchronized to the cell cycle by gene doubling". Trabalho apresentado em Cellular Dynamics and Models Meeting. Cold Spring Harbor Laboratory., 2015.
Pré-impressão
  1. João Ramalheira Ferreira; Ruilan Xu; Zach Hensel. Autor correspondente: Zach Hensel. "Mycobacterium tuberculosis FtsB and PerM interact via a C-terminal helix in FtsB to modulate cell division". 2024. https://doi.org/10.1101/2024.03.11.584518.
    10.1101/2024.03.11.584518
  2. Zach Hensel. Autor correspondente: Zach Hensel. "Secondary structure of the SARS-CoV-2 genome is predictive of nucleotide substitution frequency". 2024. https://doi.org/10.1101/2024.02.27.581995.
    10.1101/2024.02.27.581995
  3. F. Débarre; Z. Hensel. Autor correspondente: F. Débarre. "A critical reexamination of recovered SARS-CoV-2 sequencing data". 2024. https://doi.org/10.1101/2024.02.15.580500.
    10.1101/2024.02.15.580500
  4. Zach Hensel. "Secondary structure of the SARS-CoV-2 genome is predictive of nucleotide substitution frequency". 2024. https://doi.org/10.7554/eLife.98102.
    10.7554/eLife.98102
  5. Alexander Crits-Christoph; Joshua I. Levy; Jonathan E. Pekar; Stephen A. Goldstein; Reema Singh; Zach Hensel; Karthik Gangavarapu; et al. "Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic". 2023. https://doi.org/10.1101/2023.09.13.557637.
    10.1101/2023.09.13.557637
  6. Simon Schäper; António D. Brito; Bruno M. Saraiva; Georgia Squyres; Matthew J. Holmes; Ethan C. Garner; Zach Hensel; Ricardo Henriques. "Processive movement of Staphylococcus aureus essential septal peptidoglycan synthases is independent of FtsZ treadmilling and drives cell constriction". 2023. http://dx.doi.org/10.1101/2023.06.29.547026.
    10.1101/2023.06.29.547026
  7. Hensel, Zach. "Predicted binding interface between coronavirus nsp3 and nsp4". 2022. http://dx.doi.org/10.1101/2022.03.05.483145.
    10.1101/2022.03.05.483145
  8. Brooke M. Britton; Remy A. Yovanno; Sara F. Costa; Joshua McCausland; Albert Y. Lau; Jie Xiao; Zach Hensel. Autor correspondente: Zach Hensel. "Conformational changes in the essential E. coli septal cell wall synthesis complex suggest an activation mechanism". 2022. https://doi.org/10.1101/2022.11.27.518129.
    10.1101/2022.11.27.518129
Website
  1. Hensel, Zach. North America sub-lineages of B.1.617.2 with Spike A222V, V1264L, often N1074S, and sometimes additional Spike mutations (SARS-CoV-2 lineage AY.26 proposal). 2021. https://github.com/cov-lineages/pango-designation/issues/188.
  2. Hensel, Zach; Robinson, Ashley. A new sub-lineage of AY.3 concentrated in Mississippi, USA (SARS-CoV-2 lineage AY.3.1 proposal). 2021. https://github.com/cov-lineages/pango-designation/issues/147.
  3. Hensel, Zach. B.1.617.2 sub-lineage with ORF1a: I3731V (SARS-CoV-2 lineage AY.3 proposal). 2021. https://github.com/cov-lineages/pango-designation/issues/121.

Propriedade Intelectual

Patente
  1. Zach Hensel; Dr. Jie Xiao. 2017. "Co-translational activation of a transcription factor by proteolytic cleavage and methods of use". Estados Unidos.
    Concedida/Emitida

Outros

Outra produção
  1. Letter: Preprints are good for science and good for the public. Nature 560, 553. 2018. Sarabipour, Sarvenaz; Wissink, Erin M.; Burgess, Steven J.; Hensel, Zach; Debat, Humberto; Emmott, Edward; Akay, Alper; Akdemir, Kadir C.; Schwessinger, Benjamin.
    https://doi.org/gd3xpk
  2. Preprint: Maintaining confidence in the reporting of scientific outputs. 2018. Sarvenaz Sarabipour; Erin M Wissink; Steven J Burgess; Zach Hensel; Humberto Debat; Edward Emmott; Alper Akay; Kadir Akdemir; Benjamin Schwessinger. https://doi.org/hj23.
    10.7287/peerj.preprints.27098v1
Técnica de investigação
  1. Plasmids for single-molecule mRNA imaging in E. coli (inducible expression of fluorescent RNA-binding proteins). Distributed freely through AddGene at https://www.addgene.org/Zach_Hensel/. Investigador. Zach Hensel.
    Investigador
  2. Plasmids for low-noise gene expression. Available freely from AddGene at https://www.addgene.org/Zach_Hensel/. Investigador. Zach Hensel.
    Investigador
  3. Plasmid for single-molecule detection of protein expression. Available from AddGene at https://www.addgene.org/47311/. Investigador. Zach Hensel.
    Investigador
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/11/24 Live-cell imaging, localization and tracking of single mRNA molecules in E. coli cells Spanish & Portuguese Advanced Optical Microscopy Meeting
Instituto Gulbenkian de Ciência (Remote) (Oeiras, Portugal)
2021/05/21 Immortalization and aggregation in live-cell mRNA imaging in E. coli Invited seminar
Center for Integrative Biology (Remote) (Toulouse, França)
2021/05/04 Single-molecule mRNA FISH in bacteria 2nd DelNAM Summer School "FISHing for Bacteria"
University of Porto (Porto, Portugal)
2020/02/06 Imaging single mRNAs and their encoded proteins in living Escherichia coli Single Molecule Biophysics 2020
(Les Houches, França)
2019/09/05 Progress towards counting single transcription and translation events in living bacteria at the same time Seminar
Dr. Ulf Landegren (Uppsala, Suécia)
2018/09/12 Improved tools for single-molecule mRNA and protein detection in living E. coli Harden Conference: Single-molecule bacteriology
Biochemical Society (Oxford, Reino Unido)
2017/02/02 Microbiology at the nanoscale: Counting and tracking single molecules in living cells Advanced Integrated Microsystems program workshop
(Lisbon, Portugal)
2017/01/10 Single Molecule Microbiology: observing single molecules within living microbial cells for applications in molecular and synthetic biology MOSTMICRO Scientific Advisory Board meeting
(Lisbon, Portugal)
2016/02/19 Cell-cycle-synchronized oscillations of an autoregulated transcription factor in E. coli: single-molecule fluorescence measurements & computational investigations into biomolecular mechanisms Departmental Seminar
Dr. Floyd Reed (Honolulu, Estados Unidos)
2016/02/15 Exploring oscillatory Cro expression in E. coli by stochastic simulation Winter Q-Bio Meeting
(Honolulu, Estados Unidos)
2016/01/29 Gene oscillations in E. coli OIST Internal Seminar Series
(Onna-son, Japão)
2012/03/05 Single-molecule studies of stochastic gene regulation by the lambda repressor in live E. coli cells Thesis defense seminar
Johns Hopkins University School of Medicine Department of Biophysics and Biophysical Chemistry (Baltimore, Estados Unidos)
2010/09/11 A closer look at bacteriophage ¿ lysogeny: Single-molecule studies of gene expression and DNA looping in living cells Institute of Biophysical Research Retreat
Johns Hopkins University (Baltimore, Estados Unidos)
2010/08/26 Mechanism of transcription autoregulation of the ¿ repressor revealed by single-molecule imaging in live E. coli cells Molecular Genetics of Bacteria and Phages Meeting
Cold Spring Harbor Laboratory (Cold Spring Harbor, Estados Unidos)
2009/03/02 A single-molecule study of gene regulation in real time Annual meeting
Biophysical Society (Boston, Estados Unidos)
2007/02/28 Bioindustrial processing of lignocellulose: Structure, catalysis, and remaining challenges Departmental seminar
John Hopkins University School of Medicine Department of Biophysics and Biophysical Chemistry (Baltimore, Estados Unidos)
2005/01/28 Chiral liquid crystals in suspensions of Salmonella flagella Undergraduate thesis defense presentation
University of Illinois at Urbana Champaign Department of Physics (Urbana, Estados Unidos)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/10/01 - 2024/12/03 Studying Mycobacterium tuberculosis PerM-FtsB interaction under oxidative stress
Orientador
 Post-graduate program in Practical Research (Iniciação científica)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2024/01/22 - 2024/07/18 Imaging transcription and mRNA localization in E. coli using newly reported fluorescent proteins
Orientador
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/05/25 - 2023/09/15 Understanding the role of gene expression regulation in controlling cell division in Staphylococcus aureus
Coorientador de Sara Maria Francisco da Costa
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022/01/12 - 2022/06/24 Quantifying E. coli transcription rate and mRNA localization in changing growth conditions using single-molecule microscopy in living cells
Orientador de Leonardo Pina
 Cell and Molecular Biology (Iniciação científica)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Characterization on the protein-protein interactions of M. tuberculosis divisome proteins, expressed in E. coli
Orientador de João Pedro Ramalheira de Araújo Ferreira
 Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/10/06 - 2021/12/13 Improved techniques for single-molecule mRNA detection and tracking in living E. coli cells
Orientador de Maria Inês Costa de Sousa
 Masters degree in Molecular Biotechnology (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade de Aveiro, Portugal
2019/10/07 - 2021/11/20 Post-graduate research projection: Improved techniques for single-molecule mRNA detection and tracking in living E. coli cells
Orientador de Cleusia Manuel
 ITQB NOVA Curso de Pós-Graduação (Curso de aperfeiçoamento / especialização)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/12/13 - 2019/12/13 The mechanism of the Legionella VipA protein in altering actin dynamics during infection
Coorientador de Ana Teresa Carrilho Carvalho
 Bioquímica para a Saúde (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/11/25 - 2019/11/26 Developing new molecular tools to study and visualize the intermediate filament GFAP in living cells
Coorientador de Ricardo Jorge Pinheiro Quiteres
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/08/05 - 2019/08/30 New fluorescent protein mutants for improved single-molecule mRNA detection (summer internship)
Orientador de Inês Neto Silva Rosa Mendes
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/08/05 - 2019/08/30 Deep learning for E. coli cell segmentation in timelapse imaging (summer internship)
Orientador de Joana Luísa Góis Valério
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/11/15 - 2018/12/15 Low-noise gene expression system and mRNA tracking (internship)
Orientador de Diogo Grilo
 1-month undergraduate research internship (Iniciação científica)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/11/14 - 2018/11/14 Engineering low-noise gene expression systems for single-molecule experiments
Orientador de João Pedro Nunes Silva
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/07/10 - 2017/08/10 Stochastic simulation of bacteriophage infection (summer internship)
Orientador de João Pedro Ramalheira Ferreira
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/07/10 - 2017/08/10 Single-molecule tracking of DNA-binding proteins labeled with synthetic dyes in living E. coli (summer internship)
Orientador de Pedro Ladino
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018/07/23 - Atual ITQB Summer Science: Week-long course in laboratory skills and career development for undergraduate students looking to enter the workforce. In 2018 and 2019 I hosted one student in my laboratory and also helped organize and co-present a session on career planning/development. (2018/07/23)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/01/22 - 2020/01/24 ITQB PhD Meeting: Faculty Advisor. In this roll I advised the students on organizing invited speakers and co-coordinated evaluations for student poster and oral presentations. (2020/01/22 - 2020/01/24)
Conferência (Membro da Comissão Organizadora)
2017/11/09 - 2018/09/21 ITQB Preprint Journal club: I organized an experimental journal club at ITQB that ran for about one year. We choose articles from the preprint literature to read and discuss, and post collaborative preprint peer reviews online. (2017/11/09 - 2018/09/21)
Outro (Coorganizador)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2024/10/17 - Atual (Remote) Career development roundtable for students and postdoctoral scholars at the Okinawa Institute of Science and Technology
Mesa-redonda
 Alumni Stories Mixer
Okinawa Institute of Science and Technology Promotion Corp, Japão
2023/07/23 - Atual I helped organize a table at ITQB Open Day 2023 presenting fluorescence and microscopy topics to an audience of local residents who visited our institute to learn about our work and the subjects we work on.
Exposição
 ITQB Open Day
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2023/07/20 - Atual I co-presented a workshop on CV preparation and scientific career paths for students in the one-week SummerScience program. SummerScience 2023
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/01/01 - 2016/12/31 Community outreach at the Okinawa Institute of Science and Technology (OIST): Between 2014 and 2016 I contributed to OIST's community education/outreach by (1) presenting my work to students at the elementary and high school levels in public events such as the OIST Children's School of Science and (2) volunteering as a photographer for the OIST Summer Festival.
Exposição
 Various
Okinawa Institute of Science and Technology Promotion Corp, Japão
2009/07/01 - 2011/07/01 For 3 years I helped organize our lab's presentation for the Fun With Science Summer Camp in which we gave Baltimore-area elementary students hands on experiences with fluorescent proteins.
Festival
 Fun With Science Summer Camp
Johns Hopkins University School of Medicine, Estados Unidos

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/12/17 Opponent for Masters thesis defense in molecular genetics and biomedicine.
Arguente principal
 Ana Rita Luazes Sequeira (Mestrado)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/04/12 Bioimage analysis using machine learning
Vogal
 Bruno Saraiva (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/07/16 Study of the single cell response of Staphylococcus aureaus to cell wall targeting antibiotics
Vogal
 Ana Raquel Ramos Pereira (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018/04/01 - 2020/01/23 biOverlay

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2022 - 2023 PhD Program Application Evaluation Committee, Molecular Biosciences
Membro
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017 - 2018 PhD Program Application Evaluation Committee, Biology at the Host Microbe Interface
Membro
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023/09/20 - Atual Fundamentals of light microscopy and image processing (Short Course) Lecture: Basic principles of widefield and widefield Super Resolution microscopy (Outros) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2023/03/20 - 2023/03/24 Mechanisms of Gene Expression (Molecular Biosystems and Plants4Life PhD programs) (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/03/01 - 2021/03/05 Mechanisms of Gene Expression/Gene Expression and Systems Biology (Molecular Biosystems, Plants4Life, and Biology at the Host-Microbe Interface PhD units) (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/02/11 - 2019/02/15 Mechanisms of Gene Expression/Gene Expression and Systems Biology (Molecular Biosystems and Biology at the Host-Microbe Interface PhD units) (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/03/05 - 2018/03/09 Mechanisms of Gene Expression/Gene Expression and Systems Biology (Molecular Biosciences and Biology at the Host-Microbe Interface PhD programs) (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/04/01 - 2017/04/01 "Co-localization and conformation of nucleic acids in vivo: proximity ligation and fluorescence microscopy methods" (Guest Lecture in Plant Cell and Developmental Biology Unit II, ITQB NOVA coordinated by C. Miguel, R. Abranches) (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006 - 2006 Teaching assistant (leading discussion sections, grading, test administration) for an undergraduate biophysics course taught by Richard Cone Cellular and Molecular Physiology Johns Hopkins University, Estados Unidos
2003 - 2005 Teaching assistant positions for 3 courses in the UIUC Physics department in various subjects. Teaching discussion sections of approximately 30 students. Physics X199D (general; continuing education), Thermodynamics and Quantum Mechanics, and Physics 101 (Bachelor) University of Illinois at Urbana-Champaign, Estados Unidos

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2024/09/19 Interviewed for article discussing a recent paper I co-authored investigating COVID-19 pandemic origins (Crits-Christoph et al, Cell, 2024). New Scientist
2023/05/24 Interviewed regarding my analysis of correlation in sequencing data from environmental sampling of Huanan Market in Wuhan China. The Atlantic (online article)

Membro de associação

Nome da associação Tipo de participação
2017/10/09 - Atual ASAPbio In this organization I participate in discussing the evolving publishing ecosystem focusing on preprints and open access
2017/12/08 - 2018/01/15 eLife Early Career Ambassadors My focus in the organization was on preprints; together with other ambassadors I published letters and articles on how preprints affect early career researchers in Nature, PLOS Biology and in preprint

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023 - Atual PhD committee member for Fernando Jorge Neiva Ferreira Nunes (Molecular Biosciences) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2023 - Atual PhD committee member for Dominik Alwardt (Molecular Biosciences) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/12/15 - Atual PhD committee for António Brito
Membro
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/01/18 - Atual Thesis committee member for Cristiana Santos
Membro
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019 - Atual ITQB NOVA Bacterial Imaging Cluster, Scientific Advisor https://www.itqb.unl.pt/bic/team-and-contacts
Consultor
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016 - Atual OIST Researcher Community (ORC) representative to the OIST Faculty Assembly (elected by peer researchers) Okinawa Institute of Science and Technology Promotion Corp, Japão
2017/08/11 - 2023/04 PhD committee member for Sara Handem
Membro
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2022/07/26 - Atual Evaluation of final report and oral presentation: Post-graduate Program on Research Practice Level 1 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2017 - Atual Invited peer review for iScience, Nature Methods, PLOS Computational Biology, eLife, PLOS ONE, and Nucleic Acids Research

Tutoria

Tópico Nome do aluno
2017/04/01 - Atual Supervision of Masters and PhD Rotation Students Various (11 students)
2023/07/24 - 2023/08/04 NuBioq FCT UNL Undergraduate Research Internship Carolina Nobre
2023/07/17 - 2023/07/21 ITQB SummerScience Internship Ana Mesquita
2023/01 - 2023/02 NuBioq FCT UNL Undergraduate Research Internship Luisa Guerriero
Distinções

Prémio

2017 LabArchives Grant Award
2009 Biophysical Society Travel Award
2005 Robert E. Hetrick Outstanding Senior Thesis
2004 Certificate of Teaching Excellence
2003 James Scholar Research Grant

Outra distinção

2022 Finalist, Amyris Innovation BIG Impact Award
Amyris Biotechnologies Inc, Estados Unidos

Universidade Católica Portuguesa, Portugal