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Identificação

Identificação pessoal

Nome completo
Angela Moreira Borralho Relógio

Nomes de citação

  • Relógio, Angela

Identificadores de autor

Ciência ID
7718-BBA3-6EE2
ORCID iD
0000-0002-9165-2439

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador proficiente (C1)
Formação
Grau Classificação
2016
Concluído
 Professor (Título de Habilitação de Coordenação Científica)
Charité Universitätsmedizin Berlin, Alemanha
 Summa cum laude
2003
Concluído
 n/a (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
"Analysis of Alternative pre-mRNA Splicing Regulation using DNA Microarrays" (TESE/DISSERTAÇÃO)
 19/20
2003
Concluído
 Ciências Biomédicas (Doutoramento)
Especialização em Especialidade: Biologia Celular e Molecular
Universidade de Lisboa, Portugal
"Analysis of Alternative Pre-mrna Splicing Regulation Using Dna Microarrays" (TESE/DISSERTAÇÃO)
 19/20
1998
Concluído
 Engenharia Física-Tecnológica (Licenciatura)
Universidade de Lisboa, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 17/20
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/04/01 - Atual Professor Catedrático (Docente Universitário) MSH Medical School Hamburg, Alemanha
MSH Medical School Hamburg, Alemanha

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/04/01 - Atual Director de Unidade Orgânica MSH Medical School Hamburg, Alemanha
MSH Medical School Hamburg, Alemanha
Projetos

Bolsa

Designação Financiadores
2012 - 2014 Circadian regulation in Cancer
Habilitaion Stipendium
Investigador responsável
Charité Universitätsmedizin Berlin, Alemanha
Concluído
2004 - 2006 Splicing in Cancer progression
SFRH/BPD/12009/2003
EMBL Heidelberg Genome Biology, Alemanha

Projeto

Designação Financiadores
2021/09/01 - Atual TimeTeller
TimeTeller
Investigador responsável
Berlin Institute of Health at Charité, Alemanha
Em curso
2017 - 2022 Circadian Clock:Driver of Tumourigenesis
07/2019
Investigador responsável
Charité Universitätsmedizin Berlin, Alemanha
Concluído
2020 - 2021 Treatment timing in cancer
A tool for corcadian rhythms
Investigador responsável
Berlin Institute of Health at Charité, Alemanha
Concluído
2019 - 2021 Non-invasive methods for clock profilling
Non-Invasive Methods
Investigador responsável
Stiftung Charité, Alemanha
Concluído
2014 - 2020 CIRSPLICE
eBIO-M2-011
Investigador responsável
Charité Universitätsmedizin Berlin, Alemanha
Concluído
Produções

Publicações

Artigo em revista
  1. Muege Yalcin; Deeksha Malhan; Alireza Basti; Ana Rita Peralta; Joaquim J. Ferreira; Angela Relógio. "A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes". Cancers (2021): https://www.mdpi.com/2072-6694/13/23/5978.
    10.3390/cancers13235978
  2. "A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer.". Computational and structural biotechnology journal (2021): https://europepmc.org/articles/PMC8477139.
    10.1016/j.csbj.2021.08.051
  3. Basti, A.; Yalçin, M.; Herms, D.; Hesse, J.; Aboumanify, O.; Li, Y.; Aretz, Z.; et al. "Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day". BMJ Open Sport and Exercise Medicine 7 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85100968590&partnerID=MN8TOARS.
    10.1136/bmjsem-2020-000876
  4. Gaspar, L.S.; Hesse, J.; Yalçin, M.; Santos, B.; Carvalhas-Almeida, C.; Ferreira, M.; Moita, J.; et al. "Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea". EBioMedicine 65 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85101588732&partnerID=MN8TOARS.
    10.1016/j.ebiom.2021.103248
  5. Furtado A; Astaburuaga R; Costa A; Duarte AC; Gonçalves I; Cipolla-Neto J; Lemos MC; et al. "The Rhythmicity of Clock Genes is Disrupted in the Choroid Plexus of the APP/PS1 Mouse Model of Alzheimer's Disease.". Journal of Alzheimer's disease : JAD (2020): http://europepmc.org/abstract/med/32741824.
    10.3233/jad-200331
  6. Alireza Basti; Rita Fior; Müge Yal¿in; Vanda Póvoa; Rosario Astaburuaga; Yin Li; Julian Naderi; Miguel Godinho Ferreira; Angela Relógio. "The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in A Zebrafish Xenograft Colon Cancer Model". Cancers (2020): https://www.mdpi.com/2072-6694/12/4/853.
    10.3390/cancers12040853
  7. Müge Yalçin; Rukeia El-Athman; Koliane Ouk; Josef Priller; Angela Relógio. "Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease". Cancers (2020): https://www.mdpi.com/2072-6694/12/4/963.
    10.3390/cancers12040963
  8. Furtado, A.; Astaburuaga, R.; Costa, A.; Duarte, A.C.; Goncalves, I.; Cipolla-Neto, J.; Lemos, M.C.; et al. "The Rhythmicity of Clock Genes is Disrupted in the Choroid Plexus of the APP/PS1 Mouse Model of Alzheimer's Disease". Journal of Alzheimer's Disease 77 2 (2020): 795-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-85091469905&partnerID=MN8TOARS.
    10.3233/JAD-200331
  9. Hesse, J.; Malhan, D.; Yalçin, M.; Aboumanify, O.; Basti, A.; Relógio, A.. "An optimal time for treatment-predicting circadian time by machine learning and mathematical modelling". Cancers 12 11 (2020): 1-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-85094207246&partnerID=MN8TOARS.
    10.3390/cancers12113103
  10. Li, Y.; Basti, A.; Yalçin, M.; Relógio, A.. "Circadian Dysregulation of the TGFß/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells". iScience 23 10 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85091571655&partnerID=MN8TOARS.
    10.1016/j.isci.2020.101551
  11. Parascandolo, A.; Bonavita, R.; Astaburuaga, R.; Sciuto, A.; Reggio, S.; Barra, E.; Corcione, F.; et al. "Effect of naive and cancer-educated fibroblasts on colon cancer cell circadian growth rhythm". Cell Death and Disease 11 4 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85083972242&partnerID=MN8TOARS.
    10.1038/s41419-020-2468-2
  12. Mazzoccoli, G.; Vinciguerra, M.; Carbone, A.; Relógio, A.. "The circadian clock, the immune system, and viral infections: The intricate relationship between biological time and host-virus interaction". Pathogens 9 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078985992&partnerID=MN8TOARS.
    10.3390/pathogens9020083
  13. Rosario Astaburuaga; Orlando Daniel Quintanar Haro; Tobias Stauber; Angela Relógio. "A Mathematical Model of Lysosomal Ion Homeostasis Points to Differential Effects of Cl- Transport in Ca2+ Dynamics". Cells (2019): https://www.mdpi.com/2073-4409/8/10/1263.
    10.3390/cells8101263
  14. Nikolai Genov; Stefano Castellana; Felix Scholkmann; Daniele Capocefalo; Mauro Truglio; Jessica Diana Rosati; Elisa Maria Turco; et al. "A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/18/4585.
    10.3390/ijms20184585
  15. El-Athman R; Knezevic D; Fuhr L; Relógio A. "A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events.". International journal of molecular sciences (2019): http://europepmc.org/abstract/med/31443305.
    10.3390/ijms20163977
  16. Relógio, Angela. "The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes". Cancers (2019): http://dx.doi.org/10.3390/cancers11070988.
    10.3390/cancers11070988
  17. Relógio, Angela. "The importance of determining circadian parameters in pharmacological studies.". British journal of pharmacology (2019): https://doi.org/10.1111/bph.14712.
    10.1111/bph.14712
  18. Genov N; Basti A; Abreu M; Relógio A. "Temporal Splicing Switches in Elements of the TNF-Pathway Identified by Computational Analysis of Transcriptome Data for Human Cell Lines.". International journal of molecular sciences (2019): http://europepmc.org/abstract/med/30857150.
    10.3390/ijms20051182
  19. Astaburuaga, R.; Basti, A.; Li, Y.; Herms, D.; Relógio, A.. "Circadian regulation of physiology: Relevance for space medicine". REACH 14-15 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068511097&partnerID=MN8TOARS.
    10.1016/j.reach.2019.100029
  20. Genov, N.; Basti, A.; Abreu, M.; Astaburuaga, R.; Relógio, A.. "A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85069964626&partnerID=MN8TOARS.
    10.1038/s41598-019-47343-w
  21. Fuhr, L.; El-Athman, R.; Scrima, R.; Cela, O.; Carbone, A.; Knoop, H.; Li, Y.; et al. "The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer". EBioMedicine 33 (2018): 105-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049588993&partnerID=MN8TOARS.
    10.1016/j.ebiom.2018.07.002
  22. Abreu, M.; Basti, A.; Genov, N.; Mazzoccoli, G.; Relógio, A.. "The reciprocal interplay between TNFa and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85050947899&partnerID=MN8TOARS.
    10.1038/s41598-018-29847-z
  23. El-Athman, R.; Fuhr, L.; Relógio, A.. "A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer". EBioMedicine 33 (2018): 68-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048933315&partnerID=MN8TOARS.
    10.1016/j.ebiom.2018.06.012
  24. Castellana, S.; Mazza, T.; Capocefalo, D.; Genov, N.; Biagini, T.; Fusilli, C.; Scholkmann, F.; et al. "Systematic analysis of mouse genome reveals distinct evolutionary and functional properties among circadian and ultradian genes". Frontiers in Physiology 9 AUG (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85052054046&partnerID=MN8TOARS.
    10.3389/fphys.2018.01178
  25. El-Athman, R.; Relógio, A.. "Escaping Circadian Regulation: An Emerging Hallmark of Cancer?". Cell Systems (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044139127&partnerID=MN8TOARS.
    10.1016/j.cels.2018.03.006
  26. Relógio, Angela. "The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity.". PLOS Biology (2017): https://www.ncbi.nlm.nih.gov/pubmed/29216180.
    10.1371/journal.pbio.2002940
  27. Scrima, R.; Cela, O.; Merla, G.; Augello, B.; Rubino, R.; Quarato, G.; Fugetto, S.; et al. "Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay". Biochimica et Biophysica Acta - Bioenergetics 1857 8 (2016): 1344-1351. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963579212&partnerID=MN8TOARS.
    10.1016/j.bbabio.2016.03.035
  28. Cela O; Scrima R; Pazienza V; Merla G; Benegiamo G; Augello B; Fugetto S; et al. "Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos.". (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000371940500009&KeyUID=WOS:000371940500009.
    10.1016/j.bbamcr.2015.12.018
  29. Lehmann R; Childs L; Thomas P; Abreu M; Fuhr L; Herzel H; Leser U; Relógio A. "Assembly of a comprehensive regulatory network for the mammalian circadian clock: a bioinformatics approach.". (2015): http://europepmc.org/abstract/med/25945798.
    10.1371/journal.pone.0126283
  30. Fuhr L; Abreu M; Pett P; Relógio A. "Circadian systems biology: When time matters.". (2015): http://europepmc.org/abstract/med/26288701.
    10.1016/j.csbj.2015.07.001
  31. Abreu, M. T.; Relogio, A.. "Circadian regulation of the immune system: a role in tumourigenesis". Febs Journal 282 (2015): 184-185. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000362570603084&KeyUID=WOS:000362570603084.
  32. Fuhr, L.; Relogio, A.. "Analysis and identification of circadian-regulated metabolic pathways in tumourigenesis". Febs Journal 282 (2015): 184-184. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000362570603082&KeyUID=WOS:000362570603082.
  33. Relogio, A.. "Deregulation of circadian time and its correlation with tumour progression". Febs Journal 282 (2015): 14-14. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000362570600035&KeyUID=WOS:000362570600035.
  34. Relógio A; Thomas P; Medina-Pérez P; Reischl S; Bervoets S; Gloc E; Riemer P; et al. "Ras-mediated deregulation of the circadian clock in cancer.". (2014): http://europepmc.org/abstract/med/24875049.
    10.1371/journal.pgen.1004338
  35. Relogio, A.; Westermark, P. O.; Wallach, T.; Schellenberg, K.; Kramer, A.; Herzel, H.. "Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops". Plos Computational Biology 7 12 (2011): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000299167800029&KeyUID=WOS:000299167800029.
    10.1371/journal.pcbi.1002309
  36. Bozek K; Relógio A; Kielbasa SM; Heine M; Dame C; Kramer A; Herzel H. "Regulation of clock-controlled genes in mammals.". (2009): http://europepmc.org/abstract/med/19287494.
    10.1371/journal.pone.0004882
  37. Meister, S.; Agianian, B.; Turlure, F.; Relogio, A.; Morlais, I.; Kafatos, F. C.; Christophides, G. K.. "Anopheles gambiae PGRPLC-Mediated Defense against Bacteria Modulates Infections with Malaria Parasites". Plos Pathogens 5 8 (2009): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000270804500027&KeyUID=WOS:000270804500027.
    10.1371/journal.ppat.1000542
  38. Relógio A; Ben-Dov C; Baum M; Ruggiu M; Gemund C; Benes V; Darnell RB; Valcárcel J. "Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells.". (2005): http://europepmc.org/abstract/med/15546866.
    10.1074/jbc.M411976200
  39. Relógio A; Schwager C; Richter A; Ansorge W; Valcárcel J; Relógio, A.; Schwager, C.; et al. "Optimization of oligonucleotide-based DNA microarrays.". Nucleic acids research 30 11 (2002): http://europepmc.org/abstract/med/12034852.
    10.1093/nar/30.11.e51
Capítulo de livro
  1. El-Athman, R.; Mazuch, J.; Fuhr, L.; Abreu, M.; Genov, N.; Relógio, A.. "Methods for the visualization of circadian rhythms: From molecules to organisms". 231-258. 2017.

Outros

Outra produção
  1. Systematic analysis of mouse genome reveals distinct evolutionary and functional properties among circadian and ultradian genes. 2018. Castellana S; Mazza T; Kappler M; Capocefalo D; Genov N; Biagini T; Fusilli C; et al. http://europepmc.org/abstract/PPR/PPR16677.
    10.1101/197111