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Pedro M. Matias graduated (Licenciatura) in Chemical Engineering (Chemistry and Processes) in 1983 at the Instituto Superior Técnico of the University of Lisbon and obtained a PhD in Crystallography in 1986 at the University of Pittsburgh (USA). He is presently a career Principal Investigator at the ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier of the NOVA University of Lisbon, coordinator of the Biological Chemistry Division and member of the Scientific Council of ITQB NOVA. He is also a member of the Research Unit MOSTMICRO-ITQB, the Associated Laboratory LS4FUTURE and director of the Structural Biology for Drug Development at iBET - Instituto de Biologia Experimental e Tecnológica. He has published to date 103 papers in international peer-reviewed journals and 4 book chapters. He organized 5 National and International Scientific events, supervised 1 PhD thesis and co-supervised 6. He also co-supervised 2 MSc dissertations. His professional activities involved interactions with more than 385 collaborators in the co-authorship of scientific works.
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Identificação

Identificação pessoal

Nome completo
Pedro Manuel Henriques Marques Matias

Nomes de citação

  • Matias, Pedro M

Identificadores de autor

Ciência ID
781D-CE99-A983
ORCID iD
0000-0001-6170-451X
Scopus Author Id
6603792037

Moradas

  • Instituto de Tecnologia Química e Biológica. Apartado 127, 2781-901, OEIRAS, Oeiras, Portugal (Profissional)

Websites

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador independente (B1)
Formação
Grau Classificação
1983/09 - 1986/11
Concluído
 Ph.D. in Crystallography (Doctor of Philosophy)
University of Pittsburgh, PA 15260, EUA, Estados Unidos
""X-ray and Neutron Diffraction Studies of Small Organic Molecules: Deuterionitromethane, Ethylene Carbonate, Isopropyl 1-S-beta-D-Galactopyrano-side monohydrate and Diacetamide (cis-trans )"" (TESE/DISSERTAÇÃO)
 Approved
1977/10 - 1983/06
Concluído
 Chemical Engineering - Chemistry and Processes (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 17
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - Atual Investigador principal (carreira) (Investigação) Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal
2008/03/11 - Atual Investigador principal (carreira) (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1995/11/02 - 2008/03/10 Investigador Auxiliar (carreira) (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1992/11/02 - 1995/11/01 Assistente de Investigação (carreira) (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2014 - Atual Professor Associado (Docente Universitário) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1990/01/01 - 1992/11/01 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/03 - Atual Coordinator of the Macromolecular Crystallography Unit Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2022 - Atual Member of the Institute Council of ITQB NOVA Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015 - Atual Member of the Directive Board Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal
2016 - 2022 Member of the Scientific Council of ITQB NOVA Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016 - 2022 Coordinator of the Biological Chemistry Division Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2008/01/01 - 2023/04/30 Head of the Unit Structural Biology for Drug Development Instituto de Biologia Experimental e Tecnológica, Portugal
Projetos

Bolsa

Designação Financiadores
2019/09/01 - 2023/02/28 IMpaCT - Imaging life from Molecules to cells - building knowledge on Cryo-electron microscopy methodologies at ITQB NOVA
857203
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 European Research Executive Agency
Concluído
2016/01 - 2018/12 Engineering a highly active NiFeSe Hydrogenase for electrocatalytic and photocatalytic applications
Provided by PTCRIS: 141512
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2016/01 - 2018/12 Structure and Function of a Dodecameric Molecular Machine: the human RuvBL1/RuvBL2 Complex and its Role in Disease
grant.Provided by PTCRIS: 140088
Investigador
Fundação para a Ciência e a Tecnologia
2013/06 - 2015/05 Structural and functional insights into centriole biogenesis
127024
Provided by PTCRIS: 127024
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2013/03 - 2015/03 Structural Determinants of Oxygen Tolerance in a NiFeSe Hydrogenase
125671
Provided by PTCRIS: 125671
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2011/03 - 2014/08 Structural determinants of superoxide reduction - A detoxification system essential for life
Provided by PTCRIS: 111940
111940
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2013/06 Engineering mini Superoxide Dismutases with tunable redox properties
98406
Provided by PTCRIS: 98406
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2010/02 - 2013/02 Mind the gap: How extracellular respiration is linked across the periplasmic space to the cytoplasmic oxidation of substrates. A key step in bioenergy harvesting.
98158
Provided by PTCRIS: 98158
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2008/01 - 2011/09 Towards biohydrogen production - study of a high-activity, oxygen-resistant bacterial hydrogenase
Provided by PTCRIS: 70429
70429
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2008/01 - 2011/06 Molecular Adaptation to Extreme Environments: Structural Studies of Proteins Involved in the Synthesis of Osmolytes in (hyper)thermophylic micro-organisms
71142
Provided by PTCRIS: 71142
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2008/01 - 2011/03 Iron Metabolism Study in Deinococcus radiodurans- Novel strategies
Provided by PTCRIS: 67240
67240
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2008/02 - 2011/01 Iron metabolism in sulphate reducing bacteria
Provided by PTCRIS: 67107
67107
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2008/01 - 2009/12 A structural genomics approach to membrane transport proteins from Archaea
66833
Provided by PTCRIS: 66833
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Salgueiro, Bruno A.; Saramago, Margarida; Tully, Mark D.; Issoglio, Federico; Silva, Sara T. N.; Paiva, Ana C. F.; Arraiano, Cecília M.; et al. "SARS-CoV2 Nsp1 is a metal-dependent DNA and RNA endonuclease". BioMetals (2024): http://dx.doi.org/10.1007/s10534-024-00596-z.
    10.1007/s10534-024-00596-z
  2. Fernandes, Andreia; Williamson, Adele; Matias, Pedro M.; Moe, Elin. "Structure/function studies of the NAD+-dependent DNA ligase from the poly-extremophile Deinococcus radiodurans reveal importance of the BRCT domain for DNA binding". Extremophiles 27 3 (2023): http://dx.doi.org/10.1007/s00792-023-01309-z.
    Acesso aberto • Publicado • 10.1007/s00792-023-01309-z
  3. Gouveia, André G.; Salgueiro, Bruno A.; Ranmar, Dean O.; Antunes, Wilson D. T.; Kirchweger, Peter; Golani, Ofra; Wolf, Sharon G.; et al. "Unraveling the multifaceted resilience of arsenic resistant bacterium Deinococcus indicus". Frontiers in Microbiology 14 (2023): http://dx.doi.org/10.3389/fmicb.2023.1240798.
    Acesso aberto • Publicado • 10.3389/fmicb.2023.1240798
  4. Liliana S.O. Silva; Pedro M. Matias; Celia V. Romão; Saraiva LM. "Structural Basis of RICs Iron Donation for Iron-Sulfur Cluster Biogenesis". Frontiers in Microbiology 12 (2021): https://novaresearch.unl.pt/en/publications/5601cd4d-7f65-4776-bc06-392bf3789624.
    10.3389/fmicb.2021.670681
  5. Sónia Zacarias; Adriana Temporão; Philippe Carpentier; Peter van der Linden; Inês A. C. Pereira; Pedro M. Matias. "Exploring the gas access routes in a [NiFeSe] hydrogenase using crystals pressurized with krypton and oxygen". JBIC Journal of Biological Inorganic Chemistry (2020): https://doi.org/10.1007/s00775-020-01814-y.
    10.1007/s00775-020-01814-y
  6. Sousa, Bárbara B.; Sousa, Marcos F. Q.; Marques, Marta C.; Seixas, João D.; Brito, José A.; Matias, Pedro M.; Bernardes, Gonçalo J. L.; Roldão, António. "A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening". Bioprocess and Biosystems Engineering (2020): http://dx.doi.org/10.1007/s00449-020-02421-6.
    10.1007/s00449-020-02421-6
  7. Adrian Ruff; Julian Szczesny; Maria Vega; Sonia Zacarias; Pedro M. Matias; Sébastien Gounel; Nicolas Mano; Inês A. C. Pereira; Wolfgang Schuhmann. "Redox-Polymer-Wired [NiFeSe] Hydrogenase Variants with Enhanced O 2 Stability for Triple-Protected High-Current-Density H 2 -Oxidation Bioanodes". ChemSusChem 13 14 (2020): 3627-3635. https://doi.org/10.1002/cssc.202000999.
    10.1002/cssc.202000999
  8. Seixas, João D.; Sousa, Bárbara B.; Marques, Marta C.; Guerreiro, Ana; Traquete, Rui; Rodrigues, Tiago; Albuquerque, Inês S.; et al. "Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors". RSC Chemical Biology 1 4 (2020): 251-262. http://dx.doi.org/10.1039/d0cb00033g.
    10.1039/d0cb00033g
  9. Sónia Zacarias; Adriana Temporão; Melisa del Barrio; Vincent Fourmond; Christophe Léger; Pedro M. Matias; Inês A. C. Pereira. "A Hydrophilic Channel Is Involved in Oxidative Inactivation of a [NiFeSe] Hydrogenase". ACS Catalysis (2019): 8509-8519. https://doi.org/10.1021/acscatal.9b02347.
    10.1021/acscatal.9b02347
  10. Bruno M Fonseca; Luis Silva; Ines B. Trindade; Elin Moe; Pedro M. Matias; Ricardo Louro; Catarina M. Paquete. "Optimizing Electroactive Organisms: The Effect of Orthologous Proteins". FRONTIERS IN ENERGY RESEARCH 7 (2019): https://novaresearch.unl.pt/en/publications/7aa7ddfc-7cff-4983-bd58-a073df855242.
    10.3389/fenrg.2019.00002
  11. Inês B. Trindade; José M. Silva; Bruno M Fonseca; Teresa Catarino; Masaki Fujita; Pedro M. Matias; Elin Moe; et al. "Structure and reactivity of a siderophore-interacting protein from the marine bacterium Shewanella reveals unanticipated functional versatility". Journal of Biological Chemistry 294 1 (2019): 157-167. https://novaresearch.unl.pt/en/publications/2edefe48-6a7f-4347-bef9-15f45041b387.
    10.1074/jbc.RA118.005041
  12. Sara T. N. Silva; José A. Brito; Rocío Arranz; Carlos Óscar S. Sorzano; Christine Ebel; James Doutch; Mark D. Tully; et al. "X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action". Scientific Reports (2018): https://doi.org/10.1038/s41598-018-31997-z.
    10.1038/s41598-018-31997-z
  13. Romão, Célia V.; Matias, Pedro M.; Sousa, Cristiana M.; Pinho, Filipa G.; Pinto, Ana F.; Teixeira, Miguel; Bandeiras, Tiago M.. "Insights into the Structures of Superoxide Reductases from the Symbionts Ignicoccus hospitalis and Nanoarchaeum equitans". Biochemistry 57 36 (2018): 5271-5281. http://dx.doi.org/10.1021/acs.biochem.8b00334.
    10.1021/acs.biochem.8b00334
  14. Lobo, S.A.L.; Videira, M.A.M.; Pacheco, I.; Wass, M.N.; Warren, M.J.; Teixeira, M.; Matias, P.M.; Romão, C.V.; Saraiva, L.M.. "Desulfovibrio vulgaris CbiKPcobaltochelatase: evolution of a haem binding protein orchestrated by the incorporation of two histidine residues". Environmental Microbiology 19 1 (2017): 106-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983433234&partnerID=MN8TOARS.
    10.1111/1462-2920.13479
  15. Marques, M.C.; Tapia, C.; Gutiérrez-Sanz, O.; Ramos, A.R.; Keller, K.L.; Wall, J.D.; De Lacey, A.L.; Matias, P.M.; Pereira, I.A.C.. "The direct role of selenocysteine in [NiFeSe] hydrogenase maturation and catalysis". Nature Chemical Biology 13 5 (2017): 544-550. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015672149&partnerID=MN8TOARS.
    10.1038/nchembio.2335
  16. Amaral, M.; Kokh, D.B.; Bomke, J.; Wegener, A.; Buchstaller, H.P.; Eggenweiler, H.M.; Matias, P.; et al. "Protein conformational flexibility modulates kinetics and thermodynamics of drug binding". Nature Communications 8 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85039455347&partnerID=MN8TOARS.
    10.1038/s41467-017-02258-w
  17. Clarke, T.L.; Sanchez-Bailon, M.P.; Chiang, K.; Reynolds, J.J.; Herrero-Ruiz, J.; Bandeiras, T.M.; Matias, P.M.; et al. "PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination". Molecular Cell 65 5 (2017): 900-916.e7. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013633978&partnerID=MN8TOARS.
    10.1016/j.molcel.2017.01.019
  18. Colaço, H.G.; Santo, P.E.; Matias, P.M.; Bandeiras, T.M.; Vicente, J.B.. "Roles of Escherichia coli ZinT in cobalt, mercury and cadmium resistance and structural insights into the metal binding mechanism". Metallomics 8 3 (2016): 327-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961244965&partnerID=MN8TOARS.
    10.1039/c5mt00291e
  19. Trindade, I.B.; Fonseca, B.M.; Matias, P.M.; Louro, R.O.; Moe, E.. "A putative siderophore-interacting protein from the marine bacterium Shewanella frigidimarina NCIMB 400: Cloning, expression, purification, crystallization and X-ray diffraction analysis". Acta Crystallographica Section:F Structural Biology Communications 72 (2016): 667-671. http://www.scopus.com/inward/record.url?eid=2-s2.0-84986325474&partnerID=MN8TOARS.
    10.1107/S2053230X16011419
  20. Sousa, C.M.; Carpentier, P.; Matias, P.M.; Testa, F.; Pinho, F.; Sarti, P.; Giuffrè, A.; Bandeiras, T.M.; Romão, C.V.. "Superoxide reductase from Giardia intestinalis: Structural characterization of the first SOR from a eukaryotic organism shows an iron centre that is highly sensitive to photoreduction". Acta Crystallographica Section D: Biological Crystallography 71 (2015): 2236-2247. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946606061&partnerID=MN8TOARS.
    10.1107/S1399004715015825
  21. Zaarur, N.; Xu, X.; Lestienne, P.; Meriin, A.B.; McComb, M.; Costello, C.E.; Newnam, G.P.; et al. "RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils". EMBO Journal 34 18 (2015): 2363-2382. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941732990&partnerID=MN8TOARS.
    10.15252/embj.201591245
  22. Matias, P.M.; Baek, S.H.; Bandeiras, T.M.; Dutta, A.; Houry, W.A.; Llorca, O.; Rosenbaum, J.. "The AAA+ proteins Pontin and Reptin enter adult age: From understanding their basic biology to the identification of selective inhibitors". Frontiers in Molecular Biosciences 2 MAY (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84956964981&partnerID=MN8TOARS.
    10.3389/fmolb.2015.00017
  23. Leite, J.P.; Duarte, M.; Paiva, A.M.; Ferreira-Da-Silva, F.; Matias, P.M.; Nunes, O.C.; Gales, L.. "Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides". PLoS ONE 10 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929379140&partnerID=MN8TOARS.
    10.1371/journal.pone.0123430
  24. Miller, S.P.; Gonçalves, S.; Matias, P.M.; Dean, A.M.. "Evolution of a transition state: Role of lys100 in the active site of isocitrate dehydrogenase". ChemBioChem 15 8 (2014): 1145-1153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901378768&partnerID=MN8TOARS.
    10.1002/cbic.201400040
  25. Borges, N.; Jorge, C.D.; Gonçalves, L.G.; Gonçalves, S.; Matias, P.M.; Santos, H.. "Mannosylglycerate: structural analysis of biosynthesis and evolutionary history". Extremophiles 18 5 (2014): 835-852. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929510245&partnerID=MN8TOARS.
    10.1007/s00792-014-0661-x
  26. Nogly, P.; Matias, P.M.; De Rosa, M.; Castro, R.; Santos, H.; Neves, A.R.; Archer, M.. "High-resolution structure of an atypical -phosphoglucomutase related to eukaryotic phosphomannomutases". Acta Crystallographica Section D: Biological Crystallography 69 10 (2013): 2008-2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885458762&partnerID=MN8TOARS.
    10.1107/S0907444913017046
  27. Rosenbaum, J.; Baek, S.H.; Dutta, A.; Houry, W.A.; Huber, O.; Hupp, T.R.; Matias, P.M.. "The emergence of the conserved AAA+ ATPases pontin and reptin on the signaling landscape". Science Signaling 6 266 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875204484&partnerID=MN8TOARS.
    10.1126/scisignal.2003906
  28. Marques, M.C.; Coelho, R.; Pereira, I.A.C.; Matias, P.M.. "Redox state-dependent changes in the crystal structure of [NiFeSe] hydrogenase from Desulfovibrio vulgaris Hildenborough". International Journal of Hydrogen Energy 38 21 (2013): 8664-8682. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879903914&partnerID=MN8TOARS.
    10.1016/j.ijhydene.2013.04.132
  29. Gonçalves, S.; Miller, S.P.; Carrondo, M.A.; Dean, A.M.; Matias, P.M.. "Induced fit and the catalytic mechanism of isocitrate dehydrogenase". Biochemistry 51 36 (2012): 7098-7115. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866068233&partnerID=MN8TOARS.
    10.1021/bi300483w
  30. Gonçalves, S.; Esteves, A.M.; Santos, H.; Borges, N.; Matias, P.M.. "Three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from thermus thermophilus HB27: A new member of the haloalcanoic acid dehalogenase superfamily". Biochemistry 50 44 (2011): 9551-9567. http://www.scopus.com/inward/record.url?eid=2-s2.0-80155206893&partnerID=MN8TOARS.
    10.1021/bi201171h
  31. Gorynia, S.; Bandeiras, T.M.; Pinho, F.G.; McVey, C.E.; Vonrhein, C.; Round, A.; Svergun, D.I.; et al. "Structural and functional insights into a dodecameric molecular machine - The RuvBL1/RuvBL2 complex". Journal of Structural Biology 176 3 (2011): 279-291. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455176998&partnerID=MN8TOARS.
    10.1016/j.jsb.2011.09.001
  32. Baltazar, C.S.A.; Marques, M.C.; Soares, C.M.; DeLacey, A.M.; Pereira, I.A.C.; Matias, P.M.. "Nickel-iron-selenium hydrogenases - An overview". European Journal of Inorganic Chemistry 7 (2011): 948-962. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951883377&partnerID=MN8TOARS.
    10.1002/ejic.201001127
  33. Pinho, F.G.; Pinto, A.F.; Pinto, L.C.; Huber, H.; Romão, C.V.; Teixeira, M.; Matias, P.M.; Bandeiras, T.M.. "Superoxide reductase from Nanoarchaeum equitans: Expression, purification, crystallization and preliminary X-ray crystallographic analysis". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 5 (2011): 591-595. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955667521&partnerID=MN8TOARS.
    10.1107/S1744309111009432
  34. Romão, C.V.; Ladakis, D.; Lobo, S.A.L.; Carrondo, M.A.; Brindley, A.A.; Deery, E.; Matias, P.M.; et al. "Evolution in a family of chelatases facilitated by the introduction of active site asymmetry and protein oligomerization". Proceedings of the National Academy of Sciences of the United States of America 108 1 (2011): 97-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651075909&partnerID=MN8TOARS.
    10.1073/pnas.1014298108
  35. Gonçalves, S.; Esteves, A.M.; Borges, N.; Santos, H.; Matias, P.M.; Pedro M. Matias; Helena Santos; Nuno Borges. "Crystallization and preliminary X-ray analysis of mannosyl-3- phosphoglycerate phosphatase from Thermus thermophilus HB27". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 3 (2011): 390-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952692197&partnerID=MN8TOARS.
    10.1107/S1744309111002843
  36. Miguel Teixeira; Saraiva LM; Pedro M. Matias; Pinho, F.G.; Romão, C.V.; Pinto, A.F.; Saraiva, L.M.; et al. "Cloning, purification, crystallization and X-ray crystallographic analysis of Ignicoccus hospitalis neelaredoxin". Acta Crystallographica Section F-Structural Biology And Crystallization Com 66 Part 5 (2010): 605-607. https://novaresearch.unl.pt/en/publications/0b08acbf-5bb1-4ffd-8b11-4d52f3fd19cb.
    10.1107/s1744309110012030
  37. Gonçalves, S.; Borges, N.; Esteves, A.M.; Victor, B.L.; Soares, C.M.; Santos, H.; Matias, P.M.. "Structural analysis of Thermus thermophilus HB27 mannosyl-3- phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases". Journal of Biological Chemistry 285 23 (2010): 17857-17868. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952938697&partnerID=MN8TOARS.
    10.1074/jbc.M109.095976
  38. Marques, M.C.; Coelho, R.; De Lacey, A.L.; Pereira, I.A.C.; Matias, P.M.. "The three-dimensional structure of [nifese] hydrogenase from desulfovibrio vulgaris hildenborough: A hydrogenase without a bridging ligand in the active site in its oxidised, "as-isolated" state". Journal of Molecular Biology 396 4 (2010): 893-907. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649271875&partnerID=MN8TOARS.
    10.1016/j.jmb.2009.12.013
  39. Bandeiras, T.M.; Romão, C.V.; Rodrigues, J.V.; Teixeira, M.; Matias, P.M.; Pedro M. Matias; Tiago Miguel Bandeiras; Miguel Teixeira. "Purification, crystallization and X-ray crystallographic analysis of Archaeoglobus fulgidus neelaredoxin". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66 3 (2010): 316-319. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749273980&partnerID=MN8TOARS.
    10.1107/S1744309110000916
  40. Crowley, P.B.; Matias, P.M.; Khan, A.R.; Roessle, M.; Svergun, D.I.. "Metal-mediated self-assembly of a ß-sandwich protein". Chemistry - A European Journal 15 46 (2009): 12672-12680. http://www.scopus.com/inward/record.url?eid=2-s2.0-71549124013&partnerID=MN8TOARS.
    10.1002/chem.200901410
  41. Oliveira, T.F.; Vonrhein, C.; Matias, P.M.; Venceslau, S.S.; Pereira, I.A.C.; Archer, M.. "The crystal structure of Desulfovibrio vulgaris dissimilatory sulfite reductase bound to DsrC provides novel insights into the mechanism of sulfate respiration". Journal of Biological Chemistry 283 49 (2008): 34141-34149. http://www.scopus.com/inward/record.url?eid=2-s2.0-57749097713&partnerID=MN8TOARS.
    10.1074/jbc.M805643200
  42. Gorynia, S.; Matias, P.M.; Bandeiras, T.M.; Donner, P.; Carrondo, M.A.. "Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1-RuvBL2 complex". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64 9 (2008): 840-846. http://www.scopus.com/inward/record.url?eid=2-s2.0-51149096210&partnerID=MN8TOARS.
    10.1107/S174430910802558X
  43. Oliveira, T.F.; Vonrhein, C.; Matias, P.M.; Venceslau, S.S.; Pereira, I.A.C.; Archer, M.; Marques, M.; et al. "Purification, crystallization and preliminary crystallographic analysis of a dissimilatory DsrAB sulfite reductase in complex with DsrC". Journal of Structural Biology 164 2 (2008): 236-239. http://www.scopus.com/inward/record.url?eid=2-s2.0-54049085708&partnerID=MN8TOARS.
    10.1016/j.jsb.2008.07.007
  44. Bandeiras, T.M.; Hillig, R.C.; Matias, P.M.; Eberspaecher, U.; Fanghänel, J.; Thomaz, M.; Miranda, S.; et al. "Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin". Acta Crystallographica Section D: Biological Crystallography 64 4 (2008): 339-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-41949142073&partnerID=MN8TOARS.
    10.1107/S0907444907068217
  45. Crowley, P.B.; Matias, P.M.; Mi, H.; Firbank, S.J.; Banfield, M.J.; Dennison, C.. "Regulation of protein function: Crystal packing interfaces and conformational dimerization". Biochemistry 47 25 (2008): 6583-6589. http://www.scopus.com/inward/record.url?eid=2-s2.0-45749083319&partnerID=MN8TOARS.
    10.1021/bi800125h
  46. Carrondo, M.A.; Bento, I.; Matias, P.M.; Lindley, P.F.. "Crystallographic evidence for dioxygen interactions with iron proteins". Journal of Biological Inorganic Chemistry 12 4 (2007): 429-442. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247626051&partnerID=MN8TOARS.
    10.1007/s00775-007-0213-2
  47. Tatur, J.; Hagen, W.R.; Matias, P.M.. "Crystal structure of the ferritin from the hyperthermophilic archaeal anaerobe Pyrococcus furiosus". Journal of Biological Inorganic Chemistry 12 5 (2007): 615-630. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249874901&partnerID=MN8TOARS.
    10.1007/s00775-007-0212-3
  48. Simplício, A.L.; Matias, P.; Gilmer, J.F.; Clancy, J.M.. "Chiral separation and identification of ß-aminoketones of pharmacological interest by high performance liquid chromatography and capillary electrophoresis". Journal of Chromatography A 1120 1-2 (2006): 89-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744967923&partnerID=MN8TOARS.
    10.1016/j.chroma.2005.12.089
  49. Matias, P.M.; Gorynia, S.; Donner, P.; Carrondo, M.A.. "Crystal structure of the human AAA+ protein RuvBL1". Journal of Biological Chemistry 281 50 (2006): 38918-38929. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846007717&partnerID=MN8TOARS.
    10.1074/jbc.M605625200
  50. Gorynia, S.; Matias, P.M.; Gonçalves, S.; Coelho, R.; Lopes, G.; Thomaz, M.; Huber, M.; et al. "Expression, purification, crystallization and preliminary X-ray analysis of the human RuvB-like protein RuvBL1". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 62 1 (2006): 61-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646869063&partnerID=MN8TOARS.
    10.1107/S1744309105041400
  51. Rodrigues, M.L.; Oliveira, T.; Matias, P.M.; Martins, I.C.; Valente, F.M.A.; Pereira, I.A.C.; Archer, M.. "Crystallization and preliminary structure determination of the membrane-bound complex cytochrome c nitrite reductase from Desulfovibrio vulgaris Hildenborough". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 62 6 (2006): 565-568. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745129677&partnerID=MN8TOARS.
    10.1107/S1744309106016629
  52. Matias, P.M.; Pereira, I.A.C.; Soares, C.M.; Carrondo, M.A.. "Sulphate respiration from hydrogen in Desulfovibrio bacteria: A structural biology overview". Progress in Biophysics and Molecular Biology 89 3 (2005): 292-329. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444385906&partnerID=MN8TOARS.
    10.1016/j.pbiomolbio.2004.11.003
  53. Matias, P.M.; Tatur, J.; Carrondo, M.A.; Hagen, W.R.. "Crystallization and preliminary X-ray characterization of a ferritin from the hyperthermophilic archaeon and anaerobe Pyrococcus furiosus". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61 5 (2005): 503-506. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645487880&partnerID=MN8TOARS.
    10.1107/S1744309105011516
  54. Bento, I.; Matias, P.M.; Baptista, A.M.; Da Costa, P.N.; Van Dongen, W.M.A.M.; Saraiva, L.M.; Schneider, T.R.; Soares, C.M.; Carrondo, M.A.. "Molecular Basis for Redox-Bohr and Cooperative Effects in Cytochrome c 3 from Desulfovibrio desulfuricans ATCC 27774: Crystallographic and Modeling Studies of Oxidized and Reduced High-Resolution Structures at pH 7.6". Proteins: Structure, Function and Genetics 54 1 (2004): 135-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348047621&partnerID=MN8TOARS.
    10.1002/prot.10431
  55. Barros, M.T.; Matias, P.M.; Maycock, C.D.; Ventura, M.R.. "Aziridines as a Protecting and Directing Group. Stereoselective Synthesis of (+)-Bromoxone". Organic Letters 5 23 (2003): 4321-4323. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345359348&partnerID=MN8TOARS.
    10.1021/ol035576i
  56. Macedo, S.; Romão, C.V.; Mitchell, E.; Matias, P.M.; Liu, M.Y.; Xavier, A.V.; LeGall, J.; et al. "The nature of the di-iron site in the bacterio-ferritin from Desulfovibrio desulfuricans". Nature Structural Biology 10 4 (2003): 285-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037389839&partnerID=MN8TOARS.
    10.1038/nsb909
  57. Bento, I.; Teixeira, V.H.; Baptista, A.M.; Soares, C.M.; Matias, P.M.; Carrondo, M.A.. "Redox-Bohr and other cooperativity effects in the nine-heme cytochrome c from Desulfovibrio desulfuricans ATCC 27774: Crystallographic and modeling studies". Journal of Biological Chemistry 278 38 (2003): 36455-36469. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141815636&partnerID=MN8TOARS.
    10.1074/jbc.M301745200
  58. Abreu, I.A.; Lourenço, A.I.; Xavier, A.V.; LeGall, J.; Coelho, A.V.; Matias, P.M.; Pinto, D.M.; et al. "A novel iron centre in the split-Soret cytochrome c from Desulfovibrio desulfuricans ATCC 27774". Journal of Biological Inorganic Chemistry 8 3 (2003): 360-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037326047&partnerID=MN8TOARS.
  59. Matias, P.M.; Coelho, A.V.; Valente, F.M.A.; Plácido, D.; LeGall, J.; Xavier, A.V.; Pereira, I.A.C.; Carrondo, M.A.. "Sulfate respiration in Desulfovibrio vulgaris Hildenborough: Structure of the 16-heme cytochrome c HmcA at 2.5-Å resolution and a view of its role in transmembrane electron transfer". Journal of Biological Chemistry 277 49 (2002): 47907-47916. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037033048&partnerID=MN8TOARS.
    10.1074/jbc.M207465200
  60. Enguita, F.J.; Matias, P.M.; Martins, L.O.; Plácido, D.; Henriques, A.O.; Carrondo, M.A.. "Spore-coat laccase CotA from Bacillus subtilis: Crystallization and preliminary X-ray characterization by the MAD method". Acta Crystallographica Section D: Biological Crystallography 58 9 (2002): 1490-1493. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036713444&partnerID=MN8TOARS.
    10.1107/S0907444902011575
  61. Bonifácio, M.J.; Archer, M.; Rodrigues, M.L.; Matias, P.M.; Learmonth, D.A.; Carrondo, M.A.; Soares-da-Silva, P.. "Kinetics and crystal structure of catechol-O-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application". Molecular Pharmacology 62 4 (2002): 795-805. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036784071&partnerID=MN8TOARS.
    10.1124/mol.62.4.795
  62. Matias, P.M.; Carrondo, M.A.; Coelho, R.; Thomaz, M.; Zhao, X.-Y.; Wegg, A.; Crusius, K.; Egner, U.; Donner, P.. "Structural basis for the glucocorticoid response in a mutant human androgen receptor (ARccr) derived from an androgen-independent prostate cancer". Journal of Medicinal Chemistry 45 7 (2002): 1439-1446. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037187408&partnerID=MN8TOARS.
    10.1021/jm011072j
  63. Louro, R.O.; Bento, I.; Matias, P.M.; Catarino, T.; Baptista, A.M.; Soares, C.M.; Carrondo, M.A.; Turner, D.L.; Xavier, A.V.. "Conformational Component in the Coupled Transfer of Multiple Electrons and Protons in a Monomeric Tetraheme Cytochrome". Journal of Biological Chemistry 276 47 (2001): 44044-44051. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035941269&partnerID=MN8TOARS.
    10.1074/jbc.M107136200
  64. Learmonth, D.A.; Benes, J.; Parada, A.; Hainzl, D.; Beliaev, A.; Bonifácio, M.J.; Matias, P.M.; et al. "Synthesis, anticonvulsant properties and pharmacokinetic profile of novel 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide derivatives". European Journal of Medicinal Chemistry 36 3 (2001): 227-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035310336&partnerID=MN8TOARS.
    10.1016/S0223-5234(01)01220-X
  65. Matias, P.M.; Soares, C.M.; Saraiva, L.M.; Coelho, R.; Morais, J.; Le Gall, J.; Carrondo, M.A.. "[NiFe] hydrogenase from Desulfovibrio desulfuricans ATCC 27774: Gene sequencing, three-dimensional structure determination and refinement at 1.8 Å and modelling studies of its interaction with the tetrahaem cytochrome c3". Journal of Biological Inorganic Chemistry 6 1 (2001): 63-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034846760&partnerID=MN8TOARS.
    10.1007/s007750000167
  66. Coelho, A.V.; Macedo, S.; Matias, P.M.; Thompson, A.W.; LeGall, J.; Carrondo, M.A.. "Structure determination of bacterioferritin from Desulfovibrio desulfuricans by the MAD method at the Fe K-edge". Acta Crystallographica Section D: Biological Crystallography 57 2 (2001): 326-329. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035128171&partnerID=MN8TOARS.
    10.1107/S0907444900015286
  67. Frazão, C.; Silva, G.; Gomes, C.M.; Matias, P.; Coelho, R.; Sieker, L.; Macedo, S.; et al. "Structure of a dioxygen reduction enzyme from Desulfovibrio gigas". Nature Structural Biology 7 11 (2000): 1041-1045. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033767236&partnerID=MN8TOARS.
    10.1038/80961
  68. Costa Pessoa, J.; Cavaco, I.; Correia, I.; Tomaz, I.; Duarte, T.; Matias, P.M.. "Oxovanadium(IV) complexes with aromatic aldehydes". Journal of Inorganic Biochemistry 80 1-2 (2000): 35-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034732818&partnerID=MN8TOARS.
    10.1016/S0162-0134(00)00037-4
  69. Matias, P.M.; Donner, P.; Coelho, R.; Thomaz, M.; Peixoto, C.; Macedo, S.; Otto, N.; et al. "Structural evidence for ligand specificity in the binding domain of the human androgen receptor: Implications for pathogenic gene mutations". Journal of Biological Chemistry 275 34 (2000): 26164-26171. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034714276&partnerID=MN8TOARS.
    10.1074/jbc.M004571200
  70. Matias, P.M.; Coelho, R.; Pereira, I.A.C.; Coelho, A.V.; Thompson, A.W.; Sieker, L.C.; Le Gall, J.; Carrondo, M.A.. "The primary and three-dimensional structures of a nine-haem cytochrome c from Desulfovibrio desulfuricans ATCC 27774 reveal a new member of the Hmc family". Structure 7 2 (1999): 119-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033081499&partnerID=MN8TOARS.
    10.1016/S0969-2126(99)80019-7
  71. Matias, P.M.; Saraiva, L.M.; Soares, C.M.; Coelho, A.V.; LeGall, J.; Carrondo, M.A.. "Nine-haem cytochrome c from Desulfovibrio desulfuricans ATCC 27774: Primary sequence determination, crystallographic refinement at 1.8 and modelling studies of its interaction with the tetrahaem cytochrome c3". Journal of Biological Inorganic Chemistry 4 4 (1999): 478-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032836538&partnerID=MN8TOARS.
    10.1007/s007750050334
  72. Simões, P.; Matias, P.M.; Morais, J.; Wilson, K.; Dauter, Z.; Carrondo, M.A.. "Refinement of the three-dimensional structures of cytochrome C3 from Desulfovibrio vulgaris hildenborough at 1.67 Å resolution and from Desulfovibrio desulfuricans ATCC 27774 at 1.6 Å resolution". Inorganica Chimica Acta 273 1-2 (1998): 213-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-0040598957&partnerID=MN8TOARS.
  73. Costa Pessoa, J.; Duarte, M.T.; Gillard, R.D.; Madeira, C.; Matias, P.M.; Tomaz, I.. "Preparation of [VO(sal-L-Trp)(H2O)] (sal-L-Trp = N-salicylidene-L-tryptophanate) and characterisation of an unusual product obtained from its solutions in water-pyridine". Journal of the Chemical Society - Dalton Transactions 23 (1998): 4015-4020. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748660729&partnerID=MN8TOARS.
  74. Matias, P.M.; Morais, J.; Coelho, A.V.; Meijers, R.; Gonzalez, A.; Thompson, A.W.; Sieker, L.; LeGall, J.; Carrondo, M.A.. "A preliminary analysis of the three-dimensional structure of dimeric di- haem split-Soret cytochrome c from Desulfovibrio desulfuricans ATCC 27774 at 2.5-Å resolution using the MAD phasing method: A novel cytochrome fold with a stacked-haem arrangement". Journal of Biological Inorganic Chemistry 2 4 (1997): 507-514. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030773395&partnerID=MN8TOARS.
    10.1007/s007750050162
  75. Coelho, A.V.; Matias, P.; Fülöp, V.; Thompson, A.; Gonzalez, A.; Carrondo, M.A.. "Desulfoferrodoxin structure determined by MAD phasing and refinement to 1.9-Å resolution reveals a unique combination of a tetrahedral FeS4 centre with a square pyramidal FeSN4 centre". Journal of Biological Inorganic Chemistry 2 6 (1997): 680-689. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031459603&partnerID=MN8TOARS.
    10.1007/s007750050184
  76. Cavaco, I.; Pessoa, J.C.; Duarte, M.T.; Gillard, R.D.; Matias, P.. "Molecular structure of [VO(sal-D,L-Asn)(py)(H2O)] and reaction to produce coumarin-3-carboxamide". Chemical Communications 11 (1996): 1365-1366. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001534843&partnerID=MN8TOARS.
  77. Coelho, A.V.; Matias, P.M.; Sieker, L.C.; Morais, J.; Carrondo, M.A.; Lampreia, J.; Costa, C.; et al. "Preliminary crystallographic analysis and further characterization of a dodecaheme cytochrome c from Desulfovibrio desulfuricans ATCC 27774". Acta Crystallographica Section D: Biological Crystallography 52 6 (1996): 1202-1208. http://www.scopus.com/inward/record.url?eid=2-s2.0-12644312235&partnerID=MN8TOARS.
    10.1107/S090744499600738X
  78. Coelho, A.V.; Matias, P.M.; Carrondo, M.A.; Tavares, P.; Moura, J.J.G.; Moura, I.; Fulop, V.; Hajdu, J.; Le Gall, J.. "Preliminary crystallographic analysis of the oxidized form of a two mono- nuclear iron centres protein from Desulfovibrio desulfuricans ATCC 27774". Protein Science 5 6 (1996): 1189-1191. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030015101&partnerID=MN8TOARS.
  79. Matias, P.M.; Morais, J.; Coelho, R.; Carrondo, M.A.; Wilson, K.; Dauter, Z.; Sieker, L.. "Cytochrome c3 from Desulfovibrio gigas: Crystal structure at 1.8 Å resolution and evidence for a specific calcium-binding site". Protein Science 5 7 (1996): 1342-1354. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029659034&partnerID=MN8TOARS.
  80. Cavaco, I.; Costa Pessoa, J.; Duarte, M.T.; Henriques, R.T.; Matias, P.M.; Gillard, R.D.. "Crystal and molecular structure of [V2O3(sal-L-val)2(H2O)] (sal-L-val = N-salicylidene-L-valinate) and spectroscopic properties of related complexes". Journal of the Chemical Society - Dalton Transactions 9 (1996): 1989-1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748497817&partnerID=MN8TOARS.
  81. Cavaco, I.; Pessoa, J.C.; Luz, S.M.; Duarte, M.T.; Matias, P.M.; Henriques, R.T.; Gillard, R.D.. "N-salicylideneamino-acidate complexes of oxovanadium(IV)-II. Synthesis, characterization and deamination of an n-salicylideneglycylglycinato complex". Polyhedron 14 3 (1995): 429-439. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748501120&partnerID=MN8TOARS.
    10.1016/0277-5387(94)00247-C
  82. Frazao, C.; Dias, J.M.; Matias, P.M.; Romao, M.J.; Carrondo, M.A.; Hervas, M.; Navarro, J.A.; De La Rosa, M.; Sheldrick, G.M.. "Cytochrome c6 from the green alga Monoraphidium braunii. Crystallization and preliminary diffraction studies". Acta Crystallographica - Section D Biological Crystallography 51 2 (1995): 232-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029132455&partnerID=MN8TOARS.
    10.1107/S0907444994005184
  83. Cavaco, I.; Pessoa, J.C.; Costa, D.; Duarte, M.T.; Gillard, R.D.; Matias, P.. "N-salicylideneamino acidate complexes of oxovanadium(IV). Part 1. Crystal and molecular structures and spectroscopic properties". Journal of the Chemical Society, Dalton Transactions 2 (1994): 149-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049081957&partnerID=MN8TOARS.
    10.1039/DT9940000149
  84. Carrondo, M.A.A.F.d.C.T.; Matias, P.M.; Heggie, W.; Page, P.R.. "Molecular structure of 6-methyleneoxytetracycline hydrobromide". Structural Chemistry 5 2 (1994): 73-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-0013108268&partnerID=MN8TOARS.
    10.1007/BF02265348
  85. Morgado, J.; Santos, I.C.; Henriques, R.T.; Fourmigué, M.; Matias, P.; Veiros, L.F.; Calhorda, M.J.; et al. "Molecular metals based on 1,2,7,8-tetrahydrodicyclopenta[cd:lm]perylene and iodine, (CPP)2(I3)1-d". Chemistry of Materials 6 12 (1994): 2309-2316. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242509560&partnerID=MN8TOARS.
  86. Frazao, C.; Morais, J.; Matias, P.M.; Carrondo, M.A.. "Crystallization and preliminary X-ray diffraction analysis of tetra-heme cytochrome c3 from sulfate- and nitrate-reducing Desulfovibrio desulfuricans ATCC 27774". Acta Crystallographica Section D: Biological Crystallography 50 2 (1994): 233-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028054476&partnerID=MN8TOARS.
    10.1107/S0907444993011631
  87. C.T. Carrondo, M.A.A.F.d.; Dias, A.R.; Garcia, M.H.; Matias, P.; Piendade, M.F.M.; Villa de Brito, M.J.. "Indium(III) thiolate-bridged molybdenocene complexes: crystal structure of [InCl2MoCp2(¿-SEt) 22][BPh4] · (CH3)2CO". Journal of Organometallic Chemistry 466 1-2 (1994): 159-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041377401&partnerID=MN8TOARS.
  88. Matias, P.M.; Frazao, C.; Morais, J.; Coll, M.; Carrondo, M.A.. "Structure analysis of cytochrome c 3 from Desulfovibrio vulgaris Hildenborough at 1.9 Å resolution". Journal of Molecular Biology 234 3 (1993): 680-699. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027142037&partnerID=MN8TOARS.
  89. Cavaco, I.; Pessoa, J.C.; Duarte, M.T.; Matias, P.M.; Henriques, R.T.. "Synthesis and structural characterization of a polyoxovanadate coordination complex [V4O8(CH3O)4(bipy)2] with a tetrametallate core". Polyhedron 12 10 (1993): 1231-1237. http://www.scopus.com/inward/record.url?eid=2-s2.0-0006912643&partnerID=MN8TOARS.
  90. Calhorda, M.J.; de C.T. Carrondo, M.A.A.F.; Dias, A.R.; FéIix, V.; Galvão, A.M.; Garcia, M.H.; Matias, P.M.; Villa de Brito, M.J.. "Synthesis, characterization and bonding of fulvalene dimolybdenum(III) and ditungsten(III) cations with one thiolate bridging ligand. Crystal structure of [Mo2(µ-¿5:...". Journal of Organometallic Chemistry 453 2 (1993): 231-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-0009498237&partnerID=MN8TOARS.
  91. Terry, C.J.; Damas, A.M.; Oliveira, P.; Sariava, M.J.M.; Alves, I.L.; Costa, P.P.; Matias, P.M.; Sakaki, Y.; Blake, C.C.F.. "Structure of Met30 variant of transthyretin and its amyloidogenic implications". EMBO Journal 12 2 (1993): 735-741. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027518443&partnerID=MN8TOARS.
  92. Calhorda, M.J.; Dias, A.R.; Duarte, M.T.; Martins, A.M.; Matias, P.M.; Romão, C.C.. "Methylisocyanide derivatives of molybdenocene and tungstenocene: preparation, reactivity and electronic structure: crystal structures of [(¿5-C5H5)2WBr(CNMe)]Br and [(¿5-C5H5)2MoC{N(H)CH3}N(H)C{N(H)CH3}][BF4]2· CH3CN". Journal of Organometallic Chemistry 440 1-2 (1992): 119-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0013671629&partnerID=MN8TOARS.
  93. de C.T. Carrondo, M.A.A.F.; Dias, A.R.; Garcia, M.H.; Matias, P.M.; Robalo, M.P.; Green, M.L.H.; Higgins, J.; Yang, Y.Y.. "Syntheses and reactivity of p-substituted benzonitrile complexes derived from dicyclopentadienyl-molybdenum and -tungsten. Oxidative electrochemistry. The crystal structure of [Mo(¿5-C5H5)2(SC6H5)(p-(CH3)2NC6H4CN)][PF6]". Journal of Organometallic Chemistry 395 3 (1990): 279-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-0040642631&partnerID=MN8TOARS.
  94. Nieto de Castro, C.A.; Fareleira, J.M.N.A.; Matias, P.M.; Ramires, M.L.V.; Canelas Pais, A.A.C.; Varandas, A.J.C.. "Thermophysical properties of alkali metal vapours. Part I. Theoretical calculation of the properties of monatomic systems". Berichte der Bunsengesellschaft/Physical Chemistry Chemical Physics 94 1 (1990): 53-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025262978&partnerID=MN8TOARS.
  95. Matias, P.M.; Jeffrey, G.A.; Wingert, L.M.; Ruble, J.R.. "Single crystal neutron diffraction analysis (15 K) and ab initio molecular orbital calculations for ethylene carbonate". Journal of Molecular Structure: THEOCHEM 184 3-4 (1989): 247-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342296814&partnerID=MN8TOARS.
  96. Matias, P. M.; Jeffrey, G. A.; Ruble, J. R.. "Structures of the E,Z (cis–trans) isomer of diacetamide and the 1:1 complex with acetamide at 123 K. Ab-initio molecular orbital calculations on the Z,Z (trans–trans), E,Z (cis–trans) and E,E (cis–cis) isomers of diacetamide". Acta Crystallographica Section B Structural Science 44 5 (1988): 516-522. http://dx.doi.org/10.1107/s0108768188003520.
    10.1107/s0108768188003520
  97. De Vos, A.M.; Tong, L.; Milburn, M.V.; Matias, P.M.; Jancarik, J.; Noguchi, S.; Nishimura, S.; et al. "Three-dimensional structure of an oncogene protein: Catalytic domain of human c-H-ras p21". Science 239 4842 (1988): 888-893. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023857409&partnerID=MN8TOARS.
  98. Kim, S.-H.; De Vos, A.M.; Tong, L.; Milburn, M.V.; Matias, P.M.; Jancarik, J.; Ohtsuka, E.; Nishimura, S.. "ras Oncogene proteins: Three-dimensional structures, functional implications, and a model for signal transducer". Cold Spring Harbor Symposia on Quantitative Biology 53 1 (1988): 273-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024145902&partnerID=MN8TOARS.
  99. Duda, A.; Buschmann, J.; Bulow, R.; Luger, P.; McMullan, R. K.; Jeffrey, G. A.; Ruble, J.; Matias, P.. "NEW STRUCTURAL STUDIES ON BULLVALENE MOLECULES". Zeitschrift Fur Kristallographie 174 1-4 (1986): 42-44.
  100. Matias, P.M.; Jeffrey, G.A.. "The crystal structure of isopropyl 1-thio-ß-d-galactopyranoside monoydrate at 123 K". Carbohydrate Research 153 2 (1986): 217-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022803262&partnerID=MN8TOARS.
  101. Luger, P.; Buschmann, J.; McMullan, R.K.; Ruble, J.R.; Matias, P.; Jeffrey, G.A.. "Single crystal neutron diffraction refinement of bullvalene at 110 K". Journal of the American Chemical Society 108 24 (1986): 7825-7827. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845375391&partnerID=MN8TOARS.
  102. CARRONDO, MAAFDT; MATIAS, PM; JEFFREY, GA. "BIS(TERT-BUTYLTHIO)BIS(ETA-5-CYCLOPENTADIENYL)MOLYBDENUM(IV), [MO(C5H5)2(C4H9S)2]". ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS 40 JUN (1984): 932-934.
    10.1107/S0108270184006314
Capítulo de livro
  1. Alves, Paula M; Matias, Pedro M; Roque, ACA. "SMALL MOLECULES DRUGS AND BIOPHARMACEUTICALS". In From Life Molecules to Global Health, editado por Fragata, José. Cascais, Portugal: Principia, 2022.
    Publicado
  2. Zacarias, Sónia; Vélez, Marisela; Pita, Marcos; De Lacey, Antonio L.; Matias, Pedro M.; Pereira, Inês A.C.. "Characterization of the [NiFeSe] hydrogenase from Desulfovibrio vulgaris Hildenborough". In Enzymes of Energy Technology, 169-201. Elsevier, 2018.
    10.1016/bs.mie.2018.10.003
  3. Romão, Célia V.; Archer, Margarida; Lobo, Susana A.; Louro, Ricardo O.; Pereira, Inês A. C.; Saraiva, Lígia M.; Teixeira, Miguel; Matias, Pedro M.. "89 Diversity of Heme Proteins in Sulfate Reducing Bacteria". In Handbook of Porphyrin Science (Volume 19), 139-229. World Scientific Publishing Company, 2012.
    10.1142/9789814335508_0016
  4. Sabine Gorynia; Bandeiras, Tiago M.; Matias, Pedro M; Pinho, Filipa G.; McVey, Colin E.; Donner, P.; Carrondo, M.A.; et al. "RuvBL1 and RuvBL2 and Their Complex Proteins Implicated in Many Cellular Pathways". In Macromolecular Crystallography, editado por Carrondo, M.A.; Spadon, P., 55-63. Dordrecht, Países Baixos: Springer, 2012.
    Publicado • 10.1007/978-94-007-2530-0_5
  5. de Vos, A. M.; Tong, L.; Milburn, M. V.; Matias, P. M.; Kim, S.-H.. "Three-Dimensional Structure of ras p21 Proteins". In The Guanine — Nucleotide Binding Proteins, 27-34. Springer US, 1989.
    10.1007/978-1-4757-2037-2_3
Entrada de enciclopédia
  1. Carrondo, Maria Arménia ; Soares, Claudio M.; Matias, Pedro M. "Nine-Heme Cytochrome c". In Handbook of Metalloproteins, editado por Messerschmidt, Albrecht; Huber, Robert; Poulos, Thomas; Wieghardt, Karl. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470028637.met112.
    Publicado • 10.1002/0470028637.met112
Livro
  1. Devos, A. M.; Tong, L.; Milburn, M. V.; Matias, P. M.; Kim, S. H.. 3-DIMENSIONAL STRUCTURE OF RAS P21 PROTEINS. 1989.
Pré-impressão
  1. Trindade, Inês B.; Fonseca, Bruno M.; Catarino, Teresa; Matias, Pedro M.; Moe, Elin; Louro, Ricardo O.. "Flavin-containing siderophore-interacting protein ofShewanella putrefaciensDSM 9451 reveals substrate specificity in ferric-siderophore reduction". 2024. http://dx.doi.org/10.1101/2024.05.13.594011.
    10.1101/2024.05.13.594011
  2. I.B. Trindade; F. Rollo; S. Todorovic; T. Catarino; E. Moe; P.M. Matias; M. Piccioli; R.O. Louro. "The structure of a novel ferredoxin – FhuF, a ferric-siderophore reductase from E. coli K-12 with a novel 2Fe-2S cluster coordination". 2023. https://doi.org/10.1101/2023.07.04.547673.
    10.1101/2023.07.04.547673
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/03/20 A structural overview of RuvBL1, RuvBL2 and their complexes IMpaCT Tomography Workshop
Weizmann Institute of Science (Rehovot, Israel)
2021/12/14 Catching up with the CryoEM Resolution Revolution
ITQB NOVA (virtual) (Oeiras, Portugal)
2019/06/14 Improving the O2 tolerance of a [NiFeSe] hydrogenase 1st National Crystallographic Meeting
Universidade de Aveiro (Aveiro, Portugal)
2019/04/01 Improving the O2 tolerance of a [NiFeSe] hydrogenase 12th International Conference on Hydrogenases and other Redox (Bio)catalysts for Energy Conversion
(Lisboa, Portugal)
2018/07/03 The Portuguese Beam Allocation Group at the ESRF: a 19-year old success history (1999-2018) Encontro Ciência 2018
(Lisboa, Portugal)
2014/11/04 A structural Overview of Pontin (RuvBL1), Reptin (RuvBL2) and their complex(es) PSDI 2014 – 22nd Protein Structure Determination in Industry Conference
Merck KgaA (Cascais)
2013/07/09 Redox State-Dependent Structural Changes in [NiFeSe] Hydrogenase from Desulfovibrio vulgaris Hildenborough 10th International Hydrogenase Conference
(Szeged, Hungria)
2013/02/14 The Portuguese MX Block Allocation Group at the ESRF: a 14-year success history (1999-2013) 2º Encontro Nacional de Utilizadores de Radiação Sincrotrão
(Lisboa)
2012/10/17 A structural Overview of Pontin (RuvBL1), Reptin (RuvBL2) and their complex(es) First International Meeting on Reptin and Pontin
(Bordéus, França)
2011/05/06 The Three Dimensional Structure of a Dodecameric Molecular Machine – The RuvBL1/RuvBL2 Complex INTERBIO Symposium Frontiers in Protein Research
(Oeiras, Portugal)
2010/09/14 Structural Analysis of Thermus thermophilus HB27 Mannosyl-3-Phosphoglycerate Synthase 8th International Congress on Extremophiles
(Ponta Delgada, Portugal)
2006/07/24 Three-dimensional structure of a ferritin from the hyperthermophilic archaeon and anaerobe Pyrococcus furiosus 2006 Annual Meeting of the American Crystallographic Association
American Crystallographic Association (Honolulu)
2005/08/25 The activation process of D.desulfuricans ATCC 27774 [NiFe] Hydrogenase IUCr 2005 - XX Congress of the International Union of Crystallography
International Union of Crystallography (Florença, Itália)
2003/08/26 Sulfate respiration in Desulfovibrio bacteria: a Short Crystallographic Overview ECM-21 - 21st congress of the European Crystallographic Association
European Crystallographic Association (Durban, África do Sul)
2001/07/01 Hydrogen recycling in D.desulfuricans ATCC 27774: crystallographic and molecular modelling studies on the periplasmic electron transfer chain Joint 27th FEBS Meeting and PABMB Meeting
FEBS (Lisboa, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/01/02 - 2023/12/31 Structure and Function of a Dodecameric Molecular Machine: the Human RuvBL1/RuvBL2 Complex and its Role in Disease
Coorientador
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/10/01 - 2023/09/30 Biocatalytic H2 production with a high activity [NiFeSe] hydrogenase
Coorientador
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/09/01 - 2022/03/16 X-ray crystal structure of Human GAPDH with a selective inhibitor
Coorientador
 Bioquímica para a Saúde (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/09/01 - 2020/12/31 Structural and Functional insights into a dodecameric machine
Coorientador
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/09/01 - 2019/11/07 Engineering a [NiFeSe] Hydrogenase for an efficient hydrogen production
Coorientador
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/09/01 - 2019/02/15 Cyclophilin D as a multiple sclerosis and cardiovascular disease drug target
Coorientador
 Bioquímica para a Saúde (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/09/01 - 2018/10/31 CRYSTAL STRUCTURE OF BONE MARROW TYROSINE KINASE FROM CHROMOSOME X WITH COVALENT LIGANDS
Coorientador
 Bioquímica para a Saúde (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/01/01 - 2017/11/27 Structural insights into the human multifunctional protein RuvBL2
Coorientador
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/09/01 - 2014/12/17 Structural and functional studies of a high-activity [NiFeSe] hydrogenase
Coorientador
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2005/09/01 - 2012/05/11 Structural studies on the structure-function relationship in a glycosyltransferase, a phosphatase and an oxidorreductase.
Orientador
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022/07/10 - 2022/07/15 7th European Crystallographic School - ECS7 (2022/07/10 - 2022/07/15)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/03/31 - 2019/04/04 12th International Conference on Hydrogenases and other Redox (Bio)catalysts for Energy Conversion (2019/03/31 - 2019/04/04)
Congresso (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa, Portugal
2016/06/17 - 2016/06/17 5º Encontro Nacional de Utilizadores de Radiação Sincrotrão (2016/06/17)
Encontro (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/01/31 - 2016/02/02 BioStruct-X Workshop on Ensemble Refinement of Protein Crystal Structures (2016/01/31)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/10/10 - 2014/10/12 Second International Workshop on Reptin and Pontin, 10 a 12 de Outubro de 2014, Oeiras, Portugal. (2014/10/10)
Oficina (workshop) (Membro da Comissão Organizadora)
 Instituto de Biologia Experimental e Tecnológica, Portugal
2006/07/02 - 2006/07/07 Eurobic 8, the 8th European Biological Chemistry Conference, 2 a 7 de Julho de 2006, Aveiro, Portugal (2006/07/02)
Congresso (Membro da Comissão Organizadora)
 Universidade de Aveiro, Portugal