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Vânia Marina Cristóvão Gonçalves graduated in Genetic and Microbial Biology by the Faculty of Sciences of the University of Lisbon in 2003. After one year as an FCT research fellow at the Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA), where she consolidated her post-graduated training, she pursued a PhD in Molecular Biology under the supervision of Dr. Peter Jordan (INSA). In September 2009 she received her PhD degree by the University of Lisbon and in January 2010 was awarded a Post-Doctoral fellowship by the FCT, under the supervision of Dr. Margarida Gama-Carvalho (Faculty of Sciences, University of Lisbon). Since 2015 is working as a staff Researcher in the Oncobiology and Signalling Pathways laboratory of the Human Genetics Department at INSA. Published 16 articles in international journals with an h-index of 13. Has 4 sections of books and organized 5 events. Co-supervised 1 PhD thesis, supervised 3 MSc dissertations and co-supervised 1 more. Has received 4 awards and honors and participates and/or participated in 12 projects, 1 as the Principal investigator. Works in the area of Biological Sciences with emphasis on Molecular Biology, more specifically in Cellular signal transduction pathways regulating alternative splicing in inflammation and cancer. In their professional activities interacted with 97 collaborators in co-authorship of scientific papers.
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Identificação

Identificação pessoal

Nome completo
Vânia Marina Cristóvão Gonçalves

Nomes de citação

  • Gonçalves, Vânia

Identificadores de autor

Ciência ID
7F16-D6F6-6156
ORCID iD
0000-0003-1934-4279
Researcher Id
Q-1749-2015
Scopus Author Id
24773219800

Endereços de correio eletrónico

  • vania.goncalves@insa.min-saude.pt (Profissional)

Telefones

Telefone
  • 217526434 (Profissional)

Moradas

  • Instituto Nacional de Saúde Dr. Ricardo Jorge. Avenida Padre Cruz, 1649-016, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Português (Idioma materno)
Formação
Grau Classificação
2009
Concluído
 PhD in Molecular Biology (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Regulation of alternative splicing of the small GTPase Rac1" (TESE/DISSERTAÇÃO)
 Approved with distinction and honors
2003
Concluído
 Genetic and Microbial Biology Degree (pre-Bologna) (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Mutation screening in genes associated with familiar forms of colorectal and breast cancer " (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/10/01 - Atual Staff Researcher Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2010/01/01 - 2015/09/30 PosDoc Researcher Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
(...)
2005/01/01 - 2008/12/31 PhD student Fundação para a Ciência e a Tecnologia, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2004/01/01 - 2004/12/31 Graduated research student Fundação para a Ciência e a Tecnologia, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2002/09/01 - 2003/07/01 Final project for the graduation thesis Universidade de Lisboa Faculdade de Ciências, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
Projetos

Bolsa

Designação Financiadores
2010/01/01 - 2015/09/30 Identification of splicing regulatory mechanisms for therapeutic manipulation of exon skipping
SFRH/BPD/63395/2009
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2005/01/01 - 2008/12/31 Regulation of alternative splicing of the small GTPase Rac1
SFRH/BD/18262/2004
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2023/04/14 - 2025/04/11 Repurposing of cystic fibrosis orphan drugs in the treatment of colorectal cancer
TF/2023-25/PM
Investigador
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
 Liga Portuguesa Contra o Cancro
Em curso
2020/01/01 - 2023/12/31 Biosystems and Integrative Sciences Institute
UIDB/04046/2020
10.54499/UIDB/04046/2020
Investigador
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Universidade do Minho, Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/10/01 - 2022/09/30 Microenvironmental effects on alternative splicing in malignant progression of colorectal tumor cells
PTDC/BIA-MOL/28386/2017
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2015/01/01 - 2018/12/31 Plurianual grant to BioISI
UID/MULTI/04046/2013
Investigador
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2015/06/01 - 2018/05/31 Tumor cell plasticity through alternative splicing in response to a 3D pro-inflammatory microenvironment
Maratona da Saúde 2014
Investigador
Rádio e Televisão de Portugal SA
Concluído
2016/01/01 - 2017/12/31 Perturbation of the intestinal barrier function in inflammatory blowel disease: role of the Rac1b/cytokine axis
GEDII-06/2013
GEDII-06/2013
Investigador
Concluído
2011/01/01 - 2013/12/31 Strategic Project - UI 4046 - 2011-2012
PEst-OE/BIA/UI4046/2011
Investigador Pós-doutorado
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Universidade do Minho, Portugal

Universidade do Algarve, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2011/12/31 Effects of inflammation on Rac1b, a novel therapeutic target in colorectal tumours
FCG 96495
Investigador Pós-doutorado
Fundação Calouste Gulbenkian
Concluído
2010/01/01 - 2011/02/28 Characterization of post-transcriptional control mechanisms regulating SMN2 gene expression
PROJECT N° 13185 – SR
Investigador Pós-doutorado
Concluído
2004/01/01 - 2004/12/31 Regulation of alternative splicing of the small GTPase Rac1
info:eu-repo/grantAgreement/FCT/POCI/47546/PT
Bolseiro de Integração na Investigação
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Gonçalves, Vânia; Henriques, Andreia F.A; Matos, Paulo; Jordan, Peter. "Ibuprofen disrupts a WNK1/GSK3ß/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells". Oncotarget 11 47 (2020): 4421-4437. http://dx.doi.org/10.18632/oncotarget.27816.
    10.18632/oncotarget.27816
  2. Cláudia Bessa; Paulo Matos; Peter Jordan; Gonçalves Vânia. "Alternative Splicing: Expanding the Landscape of Cancer Biomarkers and Therapeutics". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/23/9032.
    10.3390/ijms21239032
  3. Jordan, Peter; Gonçalves, Vânia; Matos, Paulo. "A New Twist to Ibuprofen: Alternative Action in Alternative Splicing". European Medical Journal 4 2 (2019): 64-71. https://www.emjreviews.com/oncology/article/a-new-twist-to-ibuprofen-alternative-action-in-alternative-splicing/.
    Acesso aberto • Publicado
  4. Alves, Inês Teles Siefers; Condinho, Manuel; Custódio, Sónia; Pereira, Bruna F.; Fernandes, Rafael; Gonçalves, Vânia; da Costa, Paulo J.; et al. "Genetics of personalized medicine: cancer and rare diseases". Cellular Oncology 41 3 (2018): 335-341. http://dx.doi.org/10.1007/s13402-018-0379-3.
    10.1007/s13402-018-0379-3
  5. Goncalves, Vania; Pereira, Joana F S; Jordan, Peter. "Signaling Pathways Driving Aberrant Splicing in Cancer Cells". Genes 9 1 (2017): https://publons.com/publon/4841228/.
    10.3390/GENES9010009
  6. Matos, Paulo; Goncalves, Vania; Jordan, Peter. "Targeting the serrated pathway of colorectal cancer with mutation in BRAF". Biochimica Et Biophysica Acta-Reviews on Cancer 1866 1 (2016): 51-63. https://pubmed.ncbi.nlm.nih.gov/27345584/.
    10.1016/j.bbcan.2016.06.003
  7. Matos, Liliana; Gonçalves, Vânia; Pinto, Eugénia; Laranjeira, Francisco; Prata, Maria João; Jordan, Peter; Desviat, Lourdes R.; Pérez, Belén; Alves, Sandra. "Functional analysis of splicing mutations in the IDS gene and the use of antisense oligonucleotides to exploit an alternative therapy for MPS II". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852 12 (2015): 2712-2721. http://dx.doi.org/10.1016/j.bbadis.2015.09.011.
    10.1016/j.bbadis.2015.09.011
  8. Gonçalves, V.; Jordan, P.. "Posttranscriptional regulation of splicing factor SRSF1 and its role in cancer cell biology". BioMed Research International 2015 (2015): https://www.hindawi.com/journals/bmri/2015/287048/.
    10.1155/2015/287048
  9. Matos, Liliana; Goncalves, Vania; Pinto, Eugenia; Laranjeira, Francisco; Prata, Maria Joao; Jordan, Peter; Desviat, Lourdes R; Perez, Belen; Alves, Sandra. "Data in support of a functional analysis of splicing mutations in the IDS gene and the use of antisense oligonucleotides to exploit an alternative therapy for MPS II.". Data in brief 5 (2015): 810-7. https://pubmed.ncbi.nlm.nih.gov/26693516/.
    10.1016/j.dib.2015.10.011
  10. Gonçalves, Vânia; Henriques, Andreia; Pereira, Joana; Neves Costa, Ana; Moyer, Mary Pat; Moita, Luís Ferreira; Gama-Carvalho, Margarida; Matos, Paulo; Jordan, Peter. "Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells". RNA 20 4 (2014): 474-482. http://dx.doi.org/10.1261/rna.041376.113.
    10.1261/rna.041376.113
  11. Matos, Paulo; Kotelevets, Larissa; Jordan, Peter; Gonçalves, Vânia; Henriques, Andreia; Zerbib, Philippe; Moyer, Mary Pat; Chastre, Eric. "Ibuprofen Inhibits Colitis-Induced Overexpression of TumorRelated Rac1b". Neoplasia 15 1 (2013): 102-111. http://dx.doi.org/10.1593/neo.121890.
    10.1593/neo.121890
  12. Gonçalves, Vânia; Matos, Paulo; Jordan, Peter. "Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways". Human Molecular Genetics 18 19 (2009): 3696-3707. http://dx.doi.org/10.1093/hmg/ddp317.
    10.1093/hmg/ddp317
  13. Gonçalves, Vânia; Theisen, Patrícia; Antunes, Ofélia; Medeira, Ana; Ramos, José Silva; Jordan, Peter; Isidro, Glória. "A missense mutation in the APC tumor suppressor gene disrupts an ASF/SF2 splicing enhancer motif and causes pathogenic skipping of exon 14". Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 662 1-2 (2009): 33-36. http://dx.doi.org/10.1016/j.mrfmmm.2008.12.001.
    10.1016/j.mrfmmm.2008.12.001
  14. Gonçalves, Vânia; Matos, Paulo; Jordan, Peter. "The ß-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression". RNA 14 12 (2008): 2538-2549. http://dx.doi.org/10.1261/rna.1253408.
    10.1261/rna.1253408
  15. Matos, Paulo; Oliveira, Carla; Velho, Sérgia; Gonçalves, Vânia; da Costa, Luís Teixiera; Moyer, Mary Pat; Seruca, Raquel; Jordan, Peter. "B-RafV600E Cooperates With Alternative Spliced Rac1b to Sustain Colorectal Cancer Cell Survival". Gastroenterology 135 3 (2008): 899-906. http://dx.doi.org/10.1053/j.gastro.2008.05.052.
    10.1053/j.gastro.2008.05.052
  16. Isidro, G.; Matos, S.; Gonçalves, V.; Cavaleiro, C.; Antunes, O.; Marinho, C.; Soares, J.; Boavida, M.G.. "Novel MLH1 mutations and a novel MSH2 polymorphism identified by SSCP and DHPLC in Portuguese HNPCC families". Human Mutation 22 5 (2003): 419-420. http://dx.doi.org/10.1002/humu.9192.
    10.1002/humu.9192
Capítulo de livro
  1. Jordan, Peter; Gonçalves, Vânia; Fernandes, Sara; Marques, Tânia; Pereira, Marcelo; Gama-Carvalho, Margarida. "Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease". In Advances in Experimental Medicine and Biology, 1-27. Springer International Publishing, 2019.
    10.1007/978-3-030-19966-1_1
  2. Matos, Paulo; Gonçalves, Vânia; Jordan, Peter. "Therapeutic Approaches Targeting the Serrated Pathway of Colorectal Cancer Characterized by Mutation in the BRAF Gene and Overexpression of GTPase Rac1b". In Therapeutic Targets for Inflammation and Cancer, 233-255. WORLD SCIENTIFIC, 2017.
    10.1142/9789813148574_0011
  3. Gonçalves, Vânia; Jordan, Peter. "The deleterious effect of missense mutations on pre-mRNA splicing". In Advances in Genetics Research, 141-152. Estados Unidos: Nova Science Publishers Inc, 2011.
    Publicado
  4. Jordan, Peter; Gonçalves, Vânia; Matos, Paulo. "Alternative splicing changes regulation and signalling properties of the small GTPase Rac1". In Alternative Splicing and Cancer, 45-65. Índia: Transworld Research Network, 2006.
    Publicado
Poster em conferência
  1. Bizarro, Inês; Jordan, Peter; Gonçalves, Vânia. "Regulation of the Alternative Splicing of RAC1b in tumor cells". Trabalho apresentado em 27th Annual Meeting of the SPGH, 2023.
  2. Alves, Bárbara; Pereira, Joana FS; Ferrão, José; Vieira, Luís; Matos, Paulo; Jordan, Peter; Gonçalves, Vânia. "Il-6 induces the overexpression of genes involved in the regulation of apoptosis and cell-cell adhesion in polarized colorectal cancer cells.". Trabalho apresentado em 27th Annual Meeting of the SPGH, 2023.
  3. Bizarro, Inês; Jordan, Peter; Gonçalves, Vânia. "Regulation of the Alternative Splicing of RAC1b in tumor cells". Trabalho apresentado em 5th International Caparica Conference in Splicing, 2023.
  4. Pereira JFS; Bessa C; Gonçalves, Vânia; Matos P; Jordan P. "Pro-Inflammatory Cytokines induce changes in expression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells". Trabalho apresentado em The Biochemistry Global Summit, IUBMB-FEBS-PABMB, 2022.
  5. Pereira JFS; Bessa C; Gonçalves, Vânia; Matos P; Jordan P. "Pro-Inflammatory Cytokines induce changes in expression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells". Trabalho apresentado em 5th ASPIC International Congress, 2022.
  6. Pereira JFS; Bessa C; Gonçalves, Vânia; Matos P; Jordan P. "A pro-inflammatory microenvironment triggers overexpression of tumor-related RAC1B in polarized colorectal cancer cells". Trabalho apresentado em The Structural Microenvironment: Breaking down the walls of cancer, 2022.
  7. Gonçalves, Vânia. "A pro-inflammatory microenvironment triggers overexpression of tumor-related RAC1B in polarized colorectal cancer cells". Trabalho apresentado em 25th Annual Meeting of SPGH - Sociedade Portuguesa de Genética Humana, 2021.
  8. Gonçalves, Vânia. "A pro-inflammatory microenvironment triggers overexpression of tumor-related RAC1B in polarized colorectal cancer cells". Trabalho apresentado em Goodbye Flat Biology: Next Generation Cancer Models, 2021.
  9. Gonçalves, Vânia. "Targeting tumour-related alternative splice variant RAC1B with anti-sense oligonucleotides". Trabalho apresentado em 1st Symposium on Oligonucleotide Technologies and Therapeutics@Portugal – OTP2021, 2021.
  10. Gonçalves, Vânia. "Ibuprofen Inhibits Overexpression of Tumor-Related RAC1B through SRSF1". Trabalho apresentado em EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment, 2020.
  11. Gonçalves, Vânia. "Signal Transduction Pathways Regulating the Alternative Splicing of Tumor-Related RAC1b". Trabalho apresentado em 23th Annual Meeting of SPGH - Sociedade Portuguesa de Genética Humana, 2019.
  12. Gonçalves, Vânia. "Microenvironment-induced changes in expression of tumor-promoting RAC1B in colorectal cells grown as polarized 2D or 3D models". Trabalho apresentado em Goodbye Flat Biology: Advancing 3D-based Models for Cancer Biology and Drug Discovery, 2019.
  13. Gonçalves, Vânia. "Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transduction Pathways". Trabalho apresentado em VIII National RNA Meeting: ptRNA2019, 2019.
  14. Gonçalves, Vânia. "Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transduction Pathways". Trabalho apresentado em 22th Annual Meeting of the Portuguese Society of Human Genetics, 2018.
  15. Gonçalves, Vânia. "Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transduction Pathways". Trabalho apresentado em SINAL 2018 – 9th Meeting on Signal Transduction, 2018.
  16. Gonçalves, Vânia. "Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transduction Pathways". Trabalho apresentado em 2nd International Caparica Conference in Splicing, 2018.
  17. Gonçalves, Vânia. "Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transduction Pathways". Trabalho apresentado em 3rd ASPIC International Congress, 2018.
  18. Gonçalves, Vânia. "Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transduction Pathways". Trabalho apresentado em 21th Annual Meeting of the Portuguese Society of Human Genetics, 2017.
  19. Gonçalves, Vânia. "Signal Transduction Pathways Regulating Alternative Splicing of RAC1b". Trabalho apresentado em ESMO Annual Congress 2017, 2017.
  20. Gonçalves, Vânia. "Signal Transduction Pathways Regulating Alternative Splicing of RAC1b". Trabalho apresentado em SINAL 2017 - 8th Meeting on Signal Transduction, 2017.
  21. Gonçalves, Vânia. "Regulation of Alternative Splicing by Signal Transduction Pathways: Lessons from Studying Variant RAC1b in Colon Cancer". Trabalho apresentado em 20a Reunião Anual da Sociedade Portuguesa de Genética Humana, 2016.
  22. Gonçalves, Vânia. "Ibuprofen Inhibits Overexpression of Tumor-Related Rac1b through SRSF1". Trabalho apresentado em 1st International Caparica Conference in Splicing, 2016.
  23. Gonçalves, Vânia. "Ibuprofen Inhibits Overexpression of Tumor-Related Rac1b through SRSF1". Trabalho apresentado em 2nd ASPIC International Congress, 2016.
  24. Gonçalves, Vânia. "Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells". Trabalho apresentado em 1st ASPIC International Congress, 2014.
  25. Gonçalves, Vânia. "Alternative splicing of tumour-related Rac1b is regulated by upstream signalling pathways". Trabalho apresentado em Molecular Biology in Portugal and at EMBL (and EMBL Alumni), 2013.
  26. Gonçalves, Vânia. "Ibuprofen inhibits colitis-induced overexpression of tumour-related Rac1b". Trabalho apresentado em 1st Cancer Research Center of Lyon (CRCL) Symposium, 2013.
  27. Gonçalves, Vânia. "Alternative splicing of tumour-related Rac1b is regulated by upstream signalling pathways". Trabalho apresentado em SINAL 2012 - 6th National Meeting on Cell Signaling, 2012.
  28. Gonçalves, Vânia. "Alternative splicing of tumour-related Rac1b is regulated by upstream signalling pathways". Trabalho apresentado em 1st Post-EURASNET Symposium on “Regulation of Gene Expression through RNA Splicing”, 2012.
  29. Gonçalves, Vânia. "Integrated Approach to assess the pathogenicity of two unclassified variants in the APC gene". Trabalho apresentado em 14a Reunião Anual da Sociedade Portuguesa de Genética Humana, 2010.
  30. Gonçalves, Vânia. "Antagonistic SR proteins regulate alternative splicing of tumour-related Rac1b downstream of the PI3-kinase and Wnt pathways". Trabalho apresentado em SINAL2009- 3rd National Meeting on Signal Transduction, 2009.
  31. Gonçalves, Vânia. "Antagonism between SRp20 and ASF/SF2 is involved in regulating alternative splicing of Rac1b in colorectal cancer cells". Trabalho apresentado em First International EURASNET Conference on Alternative Splicing, 2008.
  32. Gonçalves, Vânia. "Activation of the beta-catenin/TCF4 pathway modifies alternative splicing". Trabalho apresentado em SINAL2008- 2nd National Meeting on Signal Transduction, 2008.
  33. Gonçalves, Vânia. "Rac1b and B-Raf cooperate in maintaining transformation of colorectal cancer cells". Trabalho apresentado em Frontiers of cellular, developmental and molecular biology, ELSO 2007, 2007.
  34. Sosa-García, Bernadette; Vázquez-Rivera, Viviana; Dutil, Julie; Cress, William D.; Santiago-Cardona, Pedro. "Signalling pathways involved in the regulation of alternative splicing of the small GTPase Rac1". Trabalho apresentado em SINAL2007 - 1st National Meeting on Signal Transduction, 2007.
  35. Gonçalves, Vânia. "Regulation of alternative splicing of the small GTPase Rac1". Trabalho apresentado em pre-mRNA processing and disease, EMBO Conference Series, 2007.
  36. Gonçalves, Vânia. "Rac1, but not Rac1b, stimulates RelB-mediated gene transcription in colorectal cancer cells". Trabalho apresentado em FASEB Summer Research Conferences, Regulation and Function of Small GTPases, 2006.
  37. Gonçalves, Vânia. "Rac1 alternative splicing: regulation and oncogenic potential". Trabalho apresentado em Dia do Jovem Investigador, 2006.
  38. Korn, W. Michael. "Regulation of alternative splicing of the small GTPase Rac1". Trabalho apresentado em FEBS-ELSO Advanced Lecture Course, Molecular Mechanisms in Signal Transduction and Cancer, 2005.
  39. Gonçalves, Vânia; Isidro, G.; Matos, S.; Claudino, S.; Gonçalves, Vânia; Pedro, S.; Marinho, C.; et al. "Análise Comparativa dos Métodos SSCP e DHPLC na Pesquisa de Mutações no Gene hMLH1 em Famílias Portuguesas com HNPCC". Trabalho apresentado em 6ª Reunião Anual da Sociedade Portuguesa de Genética Humana, 2002.
Resumo em conferência
  1. Pereira, Joana FS; Bessa, Cláudia; Gonçalves, Vânia; Matos, Paulo; Jordan, Peter. "A pro-inflammatory microenvironment triggers overexpression of tumor-related RAC1B in polarized colorectal cancer cells". Trabalho apresentado em 25th Annual Meeting of the Portuguese Society of Human Genetics, 2022.
    Publicado • DOI: 10.1097/MD.0000000000029313
  2. Gonçalves, Vânia. "Proceedings of the 22nd Annual Meeting of the Portuguese Society of Human Genetics". 2019.
    10.1097/md.0000000000015772
  3. Gonçalves, V.; Matos, P.; Henriques, A.A.; Pereira, J.; Jordan, P.. "41PSignal transduction pathways regulating alternative splicing of tumor-related RAC1b". 2017.
    10.1093/annonc/mdx361.037
  4. Gonçalves, Vânia. "Signal transduction pathways regulating alternative splicing of tumour-related RAC1b". 2017.
Tese / Dissertação
  1. Gonçalves, Vânia. "Regulation of alternative splicing of the small GTPase Rac1". Doutoramento, Universidade de Lisboa Faculdade de Ciências, 2009.
  2. Gonçalves, Vânia. "Pesquisa de mutações constitucionais em genes críticos para formas familiares de cancro colorectal e cancro da mama". Licenciatura, Universidade de Lisboa Faculdade de Ciências, 2003.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/07 Ibuprofen disrupts a WNK1/GSK3ß/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells SPLICING 2021 – 4th International Caparica Conference in Splicing
(online)
2021/04/08 Ibuprofen disrupts a WNK1/GSK3ß/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells BioISI Research Seminar
BioSystems & Integrative Sciences Institute - BioISI (Portugal)
2020/07/15 Ibuprofen Inhibits Overexpression of Tumor-Related RAC1B through SRSF1 SPLICING 2020 - 3rd International Caparica Conference in Splicing (online)
(Caparica, Portugal)
2019/10/19 Signal Transduction Pathways Regulating the Alternative Splicing of Tumor-Related RAC1b SINAL2019 - 10th Meeting in Signal Transduction
(Olhão, Portugal)
2017/05/08 Lessons from Colon Cancer: How Signal Transduction Pathways Regulate Alternative Splicing of RAC1b 2o Dia do Jovem Investigator do Instituto Nacional de Saúde Doutor Ricardo Jorge
Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisboa, Portugal)
2013/12/07 Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells SINAL2013 - 7th National Meeting on Cell Signaling
(Aveiro, Portugal)
2011/11 Alternative splicing of tumour-related Rac1b is regulated by upstream signalling pathways Protein Kinases Regulating RNA Splicing
(Roskoff, França)
2009/11/05 Antagonistic SR proteins regulate alternative splicing of tumour-related Rac1b downstream of the PI3-kinase and Wnt pathways RNA 2009 – V Encontro Nacional de RNA
(Carcavelos, Portugal)
2007/11/09 Antagonism between SRp20 and ASF/SF2 is involved in regulating alternative splicing of Rac1b in colorectal cancer cells RNA2007 - IV Congresso Nacional de RNA
(Vimeiro, Portugal)
2005/12/16 Regulation of alternative splicing of the small GTPase Rac1 RNA2005 – 2a Reunião de RNólogos Portugueses
(Lisboa, Portugal)
2005/11/12 Regulation of alternative splicing of the small GTPase Rac1 9a Reunião Científica Anual da Sociedade Portuguesa de Genética Humana
Sociedade Portuguesa de Genética Humana (Cascais, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/09/19 - 2023/12/21 Regulation of the alternative splicing of RAC1B in tumor cells
Orientador de Inês Bizarro
 Bioquimica e Biomedicina (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/01 - 2021/02/26 RAC1B alternative splicing regulation in colorectal cancer cells
Orientador de Telma Rosado
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2019 Effect of an inflammatory microenvironment on alternative splicing-mediated gene expression plasticity in colorectal cells
Coorientador
 Biologia (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/09 - 2018/09 Regulation of the alternative splicing of RAC1b in tumour cells
Orientador de Cláudia Rodrigues
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2015 Inflammatory bowel disease as a risk factor for the development of colorectal cancer: evaluation of the inflammatory effect on colorectal epithelial differentiation markers
Coorientador
 Bolsa INSA/BRJ/DGH/2012 (Iniciação científica)
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2010 - 2011 Effect of the oncogene BRAF and GTPase RAC1b on the expression of genes involved in the senescence state of human colon cells
Coorientador
 Biologia Celular e Biotecnologia (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2013 - Atual Ciclos de Seminários Anuais do Departamento de Genética Humana do Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisboa (Cycles of Annual Seminars of the Department of Human Genetics of the National Institute of Health Doutor Ricardo Jorge, Lisbon) (2013)
Seminário (Presidente da Comissão Organizadora)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2023/09 - 2023/11 Member of the organizing committee of the 27th Annual Meeting of the SPGH (2023/11/23 - 2023/11/25)
Congresso (Membro da Comissão Organizadora)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Sociedade Portuguesa de Genética Humana, Portugal
2022/11/08 - 2022/11/08 Member of the organizing committee of the 3rd Young investigator day (2022/11/08 - 2022/11/08)
Congresso (Membro da Comissão Organizadora)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2017/11/16 - 2017/11/18 21st annual meeting of SPGH (Sociedade Portuguesa de Genética Humana) (Portuguese Society of Human Genetics) (2017/11/16 - 2017/11/18)
Congresso (Membro da Comissão Organizadora)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2009/11/05 - 2009/11/06 RNA 2009 - V Encontro Nacional de RNA (V National RNA Meeting) (2009/11/05 - 2009/11/06)
Congresso (Membro da Comissão Organizadora)
 Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/12/21 Regulation of the alternative splicing of RAC1B in tumor cells
Orientador
 Inês Bizarro (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/11/09 Revisão Sistemática das mutações no gene mTOR em cancro e determinação de hotspots mutacionais
Arguente
 Ana Rita Serralha de Vargas (Mestrado)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2023/05/18 Non canonical translation of UPF1 protein (up-frameshift 1) and its relevance in tumorigenesis of colorectal cancer
Arguente
 Adriana Antunes Elias (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/07/22 mTOR expression regulation and new anticancer applications for apigenin
Arguente principal
 Renata Wellenakamp de Carvalho Freire de Cervantes (Mestrado)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2021/02/26 RAC1B alternative splicing regulation in colorectal cancer cells
Orientador
 Telma Filipa Almas Rosado (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 Regulation of the alternative splicing of RAC1b in tumour cells
Orientador
 Cláudia Alexandra da Silva Rodrigues (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 Interplay between Rac1b and Sodium Iodide symporter expression in thyroid and breast cancers
Arguente principal
 Liliana Mónica Santos Capinha (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2019/10/18 - 2019/10/19 Member of the scientific committee to evaluate the best poster of SINAL2019 - 10th Meeting in Signal Transduction
Avaliador

Membro de associação

Nome da associação Tipo de participação
2017 - Atual Sociedade Portuguesa de Genética Humana (Portuguese Society of Human Genetics)
2014 - Atual Associação Portuguesa de Investigação em Cancro: ASPIC (Portuguese Association for Cancer Research)
2014 - Atual The European Association for Cancer Research:EACR
2004 - Atual Ordem dos Biólogos (Order of Biologists)

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2019/07/15 - 2019/07/25 Evaluation of 2 projects for the call "Single cell approaches for the study of oncogenic processes" INSERM, França
2014 - 2014 Call for the award of a Research Grant (BI) within the scope of the EJA Project - EUCERD Joint Action: working for rare diseases Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2023/06 - 2023/06 Cancers mdpi
2022/05 - 2022/05 International Journal of Molecular Sciences mdpi
2021/10 - 2021/10 Gene elsevier
2020/09 - 2020/09 Genes mdpi
2020/06 - 2020/06 Aging
2020/01 - 2020/06 Cells (2073-4409) mdpi
2019/05/20 - 2019/05/23 Cells (2073-4409) mdpi
2018/10/25 - 2018/10/28 Advances in Experimental Medicine and Biology
2015/10/27 - 2015/11/02 JSM Genetics and Genomics
Distinções

Prémio

2021 Excellent Shotgun Presentation Prize
Associação Científica Proteomass, Portugal
2006 Young investigator award for the best poster communication
Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal

Outra distinção

2016 Honourable Mention for the poster communication
Sociedade Portuguesa de Genética Humana, Portugal
1999 Honourable Mention for completing the 1st year of the Graduation in Biology with best scores
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal