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I am a Microbiologist with an MSc in Molecular Biology and Genetics from the Faculdade de Ciências Universidade de Lisboa (2008). As an undergraduate I conducted my research work at Instituto Nacional de Saúde Dr. Ricardo Jorge (Portugal) with Dra. Mafalda Bourbon, and at MRC-CSC Imperial College London (UK) with Prof. Anne Soutar to study of Familial Hypercholesterolaemia and perform in vitro cell biology and biochemical studies for characterizing patient mutations. In 2008 I was selected for the prestigious internship program InoVContacto, run by the Portuguese Government to work as an R&D scientist in a biotech company, Fluxome Sciences A/S, in Denmark. In 2009 I was awarded a competitive individual fellowship from FCT and obtained my PhD degree at the University of Copenhagen Biologisk Institut (Denmark) in 2014, under the supervision of Prof. Michael Lisby. During my PhD studies I started working in the field of genomic instability studying the effect of SUMOylation, a post-translational modification, in the spatiotemporal regulation of DNA double-strand break (DSB) repair and telomere maintenance. To further my research in the genomic instability field, I moved to CABIMER in Seville, to join Prof. Andrés Aguilera for my postdoc and work on the role of R-loops and transcription-replication conflicts in genomic instability and their implication in DNA damage response. As a postdoc I led two main projects and participated in several others, implemented a new line of research in the Aguilera lab and created new tools to allow sophisticated cellular and molecular biology studies at specific DSB sites. During this period, I continued to produce high quality results published in several articles and Methods paper. In 2022 I made the decision to return to my home country, Portugal, having joined Dr. Helder Maiato’s lab at i3S/University of Porto, a leading scientist in the field of cell division, where I continue to develop my research in the molecular mechanisms associated with chromosome instability and cancer, with a particular focus on breast cancer and translational research.
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Identificação

Identificação pessoal

Nome completo
Sónia Cristina Pinela da Silva

Identificadores de autor

Ciência ID
9316-A5D3-EE72
ORCID iD
0000-0003-3700-3072
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=Fn2tlGIAAAAJ
Researcher Id
F-2447-2016

Websites

Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/01/16 - Atual Pós-doutorado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/01 - 2021/11/30 Pós-doutorado (Investigação) Fundación de Investigación de la Universidad de Sevilla, Espanha
Centro Andaluz de Biología Molecular y Medicina Regenerativa, Espanha
(...)
2014/02/01 - 2015/05/31 Investigador (Investigação) Københavns Universitet Biologisk Institut, Dinamarca
2006/11 - 2007/08 Estagiário de Investigação (Investigação) Instituto do Emprego e Formação Profissional, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2006/01 - 2006/10 Estagiário de Investigação (Investigação) Imperial College Faculty of Medicine - Hammersmith Campus, Reino Unido

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2019 - 2020 Assistente (Docente Universitário) Universidad de Sevilla Departamento de Genética, Espanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2008/06 - 2009/02 Estágio INOV Contacto AICEP - Agência para o Investimento e Comércio Externo de Portugal, Portugal
Fluxome Sciences SA, Dinamarca
Produções

Publicações

Artigo em boletim informativo
  1. Rocha, Teresa; Alves, Ana Catarina; Medeiros, Ana; Francisco, Vânia; Silva, Sónia; Guiomar, Sofia; Paixão, Eleanora; et al. "Perfil de risco cardiovascular de estudantes do ensino secundário", Boletim Epidemiológico Observações, 2012, http://repositorio.insa.pt/bitstream/10400.18/878/5/Observa%C3%A7%C3%B5es%20Vol%201%20N%2012012.pdf.
Artigo em revista
  1. Maiato, Helder; Silva, Sónia. "Double-checking chromosome segregation". Journal of Cell Biology 222 5 (2023): http://dx.doi.org/10.1083/jcb.202301106.
    Publicado • 10.1083/jcb.202301106
  2. Esther Marchena-Cruz; Lola P. Camino; Jay Bhandari; Sónia Silva; José Javier Marqueta-Gracia; Shahad A. Amdeen; Cristina Guillén-Mendoza; et al. "DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops". Cell Reports 42 3 (2023): 112148-112148. http://dx.doi.org/10.1016/j.celrep.2023.112148.
    10.1016/j.celrep.2023.112148
  3. Sonia Jimeno; Rosario Prados-Carvajal; María Jesús Fernández-Ávila; Sonia Silva; Domenico Alessandro Silvestris; Martín Endara-Coll; Guillermo Rodríguez-Real; et al. "ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair". Nature Communications (2021): https://doi.org/10.1038/s41467-021-25790-2.
    10.1038/s41467-021-25790-2
  4. Gaetana, Sessa; Gómez-González, Belén ; Silva, Sónia; Pérez-Calero, Carmen ; Beaurepere, Romane; Barroso, Sonia ; Martineau, Sylvain; et al. Autor correspondente: Carreira, Aura. "BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair.". The EMBO journal 40 7 (2021): e106018. https://www.embopress.org/doi/abs/10.15252/embj.2020106018.
    Publicado • 10.15252/embj.2020106018
  5. Silva S; Camino LP; Aguilera A. "Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.". Proceedings of the National Academy of Sciences of the United States of America (2018): http://europepmc.org/abstract/med/30301808.
    10.1073/pnas.1807258115
  6. Juan Lafuente-Barquero; Francesca Storici; Sarah Luke-Glaser; Marco Graf; Sonia Silva; Belén Gómez-González; Arianna Lockhart; et al. "The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage". PLOS Genetics 13 12 (2017): e1007136-e1007136. https://doi.org/10.1371/journal.pgen.1007136.
    10.1371/journal.pgen.1007136
  7. Churikov, D.; Charifi, F.; Eckert-Boulet, N.; Silva, S.; Simon, M.-N.; Lisby, M.; Géli, V.; Silva, Sónia. "SUMO-Dependent Relocalization of Eroded Telomeres to Nuclear Pore Complexes Controls Telomere Recombination". Cell Reports 15 6 (2016): 1242-1253. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964650731&partnerID=MN8TOARS.
    10.1016/j.celrep.2016.04.008
  8. Silva, S.; Altmannova, V.; Eckert-Boulet, N.; Kolesar, P.; Gallina, I.; Hang, L.; Chung, I.; et al. "SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination". DNA Repair 42 (2016): 11-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964433786&partnerID=MN8TOARS.
    10.1016/j.dnarep.2016.04.001
  9. Kolesar, P.; Altmannova, V.; Silva, S.; Lisby, M.; Krejci, L.. "Pro-recombination Role of Srs2 Protein Requires SUMO (Small Ubiquitin-like Modifier) but Is Independent of PCNA (Proliferating Cell Nuclear Antigen) Interaction". J Biol Chem 291 14 (2016): 7594-607.
    10.1074/jbc.M115.685891
  10. Silva, Sonia; Altmannova, Veronika; Luke-Glaser, Sarah; Henriksen, Peter; Gallina, Irene; Yang, Xuejiao; Choudhary, Chunaram; et al. "Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance.". Genes & development 30 6 (2016): 700-17. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:26966248&KeyUID=MEDLINE:26966248.
    10.1101/gad.276204.115
  11. Gallina, Irene; Colding, Camilla; Henriksen, Peter; Beli, Petra; Nakamura, Kyosuke; Offman, Judith; Mathiasen, David P.; et al. "Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control". Nature Communications 6 (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352720000023&KeyUID=WOS:000352720000023.
    10.1038/ncomms7533
  12. Gallina, Irene; Colding, Camilla S.; Henriksen, Peter; Beli, Petra; Nakamura, Kyosuke; Offman, Judith; Mathiasen, David P.; et al. "Regulation of homologous recombination". Yeast 32 (2015): S32-S32. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000361466200009&KeyUID=WOS:000361466200009.
  13. Rocha, Teresa; Rocha, Evangelista; Alves, Ana Catarina; Medeiros, Ana Margarida; Francisco, Vania; Silva, Sonia; Gaspar, Isabel Mendes; Rato, Quiteria; Bourbon, Mafalda. "Cardiovascular risk profile of high school students: A cross-sectional study". Revista Portuguesa De Cardiologia 33 9 (2014): 525-534. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000343196100005&KeyUID=WOS:000343196100005.
    10.1016/j.repc.2014.01.024
  14. Silva, S.; Alves, A. C.; Patel, D.; Malho, R.; Soutar, A. K.; Bourbon, M.. "In vitro functional characterization of missense mutations in the LDLR gene". Atherosclerosis 225 1 (2012): 128-134. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000310354000019&KeyUID=WOS:000310354000019.
    10.1016/j.atherosclerosis.2012.08.017
  15. Medeiros, A. M.; Alves, A. C.; Francisco, V.; Silva, S.; Bourbon, M.; Portuguese FH Study. "Familial hypercholesterolaemia - an oportunity for preventive medicine". European Heart Journal 30 (2009): 374-374. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000208702603278&KeyUID=WOS:000208702603278.
  16. Bourbon, M.; Alves, A. C.; Medeiros, A. M.; Silva, S.; Soutar, A. K.; Investigators Portuguese FH Study. "Familial hypercholesterolaemia in Portugal". Atherosclerosis 196 2 (2008): 633-642. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000253743800018&KeyUID=WOS:000253743800018.
    10.1016/j.atherosclerosis.2007.07.019
  17. Silva, S.; Patel, D.; Bourbon, M.; Soutar, A. K.. "Functional characterization of point mutations in the LDLR gene found in Portuguese patients with clinical diagnosis of familial hypercholesterolaemia.". Atherosclerosis Supplements 8 1 (2007): 213-213. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000247869100858&KeyUID=WOS:000247869100858.
    10.1016/S1567-5688(07)71810-X
Capítulo de livro
  1. Silva, Sónia; Cristina Guillén-Mendoza; Andrés Aguilera. Autor correspondente: Andrés Aguilera. "RNase H1 Hybrid-Binding Domain-Based Tools for Cellular Biology Studies of DNA:RNA Hybrids in Mammalian Cells". 115-125. Springer {US, 2022.
    10.1007/978-1-0716-2477-7_8
  2. Silva, S.; Gallina, I.; Eckert-Boulet, N.; Lisby, M.. "Live cell microscopy of DNA damage response in saccharomyces cerevisiae". 2012.
    10.1007/978-1-61779-998-3-30