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Sandrina Nóbrega Pereira concluded a BSc in Biochemistry at the University of Coimbra (2003) and a PhD in Biology, specialization of Cell Biology in 2009 from the same University with work conducted at Oscar Marin lab in the Instituto de Neurociencias (Alicante, Spain). During her PhD, she developed a solid background in Biochemical and Cell Biology, which allowed the identification of key players that regulate the migration of interneuronal populations in the developing mouse brain including a ground-breaking discovery in Neuron (1st author and cover). Sandrina made an extensive post-doc training in Cancer Metabolism, Ageing and Stem Cells Biology first at the CNIO (Madrid, Spain) at Manuel Serrano lab (2009-2013) and subsequently at the GIIM (Lisbon, Portugal) at Sérgio Dias and MC Fonseca labs (2013-2020), where she revealed the impact of metabolic adaptations as therapeutic strategies in Cancer and Ageing. Importantly, she had two career breaks (between 2011 and 2014) due to maternity leave of 3 children, which significantly impacted her research productivity. In 2018, Sandrina was appointed a non-permanent employment contract as Invited Assistant Professor at the Department of Medical Sciences, University of Aveiro (DCM-UA), and in 2020, she was awarded an Assistant Researcher (2020.00355.CEECIND, 6 year contract, more than 271k€ gross salary) at UA, where she started an independent research line in nutrient signaling and metabolic plasticity in cancer and regenerative biology. Over the past 7 years, she has been able to attract 6 competitive grants as Principal or Co-Principal Investigator from European and Portuguese entities (FCT, ERA-CVD, Horizon 2020 EU) with an overall budget of more than 657k€ and has participant in several international projects and networks (ReTuBi Twinning 2016, EpiLipidNET CA19105, CorEuStem CA20140, GreenLabs Portugal). Sandrina has published 30 articles in peer-reviewed journals (28 indexed to SCOPUS, 6 with Journal 5y-IF higher than 10), including Nat Cell Biol, Neuron, Nat. Commun., and 1 book chapter, with 1467 citations and h-index of 16. During her trajectory, she spent more than 10 years working abroad (2002-2013) in European leading institutes and a top pharmaceutical company (IN, CNIO, Janssen Pharmaceutical). She has more than 40 communications in national and international scientific meetings and 22 oral communications as invited speaker in ad hoc seminars, has mentored and supervised 35 undergraduates, 13 MSc or BSc students, 4 PhD students, 3 research fellows and 1 post-doc, and has participated as jury member in 18 MSc thesis. Sandrina has an extensive participation in several pedagogical activities and knowledge transfer to the academic community, including coordination of pedagogical projects (teacher responsible regent for 3 curricular units at UA, Eco-Escolas Ensino Superior DCM, bandeira verde 2022), participation in mobility and training actions (Erasmus+ program, Spain, 2022), lecturer in prestigious graduate programs (PT, ES) and teaching university classes (BSc Biomedical Sciences and Integrated Master in Medicine, DCM-UA, 2018-present). Sandrina has been involved in several management institutional activities at iBiMED and DCM-UA since 2018, including current holding positions (DCM Commission for Co-operation, Dissemination and Transfer of Knowledge, iBiMED Scientific Council) and participation in the coordination and management of teams in scientific resources (COVID UA Task Force implementation 2020, iBiMED Flow cytometry facility Animal Models Platform Commission). Additionally, she is actively engaged sustainability actions in biomedical research (iBIMED Greenlab, funding member), outreaching and dissemination activities to the general public (institutional visits to iBiMED/DCM, scientific internships and lecturers of cancer literacy to high school students).
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Identificação

Identificação pessoal

Nome completo
Sandrina Nóbrega Pereira

Nomes de citação

  • Nóbrega-Pereira, Sandrina

Identificadores de autor

Ciência ID
A211-DF5C-7A77
ORCID iD
0000-0002-9652-1382

Endereços de correio eletrónico

  • sandrina.pereira@ua.pt (Profissional)
  • sandrina.pereira@ua.pt (Profissional)

Telefones

Telemóvel
  • 912242449 (Pessoal)

Moradas

  • DCM-UA, Campus universitário de santiago, Agra do crasto - edifício 30, 3810-193, Aveiro, Aveiro, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Medicina Clínica - Oncologia
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia do Desenvolvimento
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Medicina Básica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2010/03/15 - 2010/04/15
Concluído
 Course of Laboratory Animal Sciences for Researchers (Postgraduate Certificate)
Especialização em Title on Animal Handling category B and C, acredited by the Spanish Healthcare Continuing Education System and FELASA
Centro Nacional de Investigaciones Oncológicas, Espanha
2003/10/01 - 2009/02/26
Concluído
 Doutoramento em Biologia, na especialidade de Biologia Celular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Cellular and Molecular Mechanisms Controlling the Migration of Telencephalic Interneurons: a Role for Postmitotic Nkx2-1 in Neuronal Migration." (TESE/DISSERTAÇÃO)
 Aprovado com Distinção e Louvor
2004
Concluído
 Biologia (Doutoramento)
Especialização em Especialidade: Biologia Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mecanismos Moleculares e Celulares Que Controlam a Migração de Interneurónios no Córtex Cerebral" (TESE/DISSERTAÇÃO)
1998/09/15 - 2003/07/18
Concluído
 Licenciatura em Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"mGlu1 receptor autoradiography – receptor distribution and development of an ex vivo occupancy model in rat." (TESE/DISSERTAÇÃO)
 16/20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/06/01 - 2027/05/31 Investigador Auxiliar (carreira) (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Aveiro Instituto de Biomedicina, Portugal
2019/07/01 - 2021/05/31 Investigador Contratado (Investigação) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2018/08/01 - 2019/06/30 Investigador Contratado (Investigação) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2013/08/01 - 2018/07/31 Pós-doutorado (Investigação) Instituto de Medicina Molecular, Portugal
2009/05/02 - 2013/07/31 Pós-doutorado (Investigação) Centro Nacional de Investigaciones Oncológicas, Espanha
2004/04/01 - 2009/02/26 Estagiário de Investigação (Investigação) Instituto de Neurociencias, Espanha
2003/09/01 - 2009/02/26 Estagiário de Investigação (Investigação) CNC.IBILI, Portugal
2002/08/01 - 2003/07/18 Estagiário de Investigação (Investigação) Janssen Pharmaceutica NV, Bélgica

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/10/01 - 2021/05/31 Professor Auxiliar Convidado (Docente Universitário) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
Projetos

Bolsa

Designação Financiadores
2023 - 2026 Transient pluripotent states as novel reservoirs of cancer-specific antigens
2022/01199/PTDC
Co-Investigador Responsável (Co-IR)
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2023 - 2024 Non-coding transcripts associated to DNA damage repair promote breast cancer chemotherapy resistance
Dr Dário Cruz Oncology Research Scholarship
Co-Investigador Responsável (Co-IR)
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Centro
Concluído
2021 - 2024 Clinical-Pathological Characterization of PALOP`S Cancer – INCUBATOR
INCUBATOR
Investigador
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Obra Social La Caixa
Em curso
2022/01/17 - 2023/08/17 Metabolic barriers in cell transdifferentiation: a road back for cardiac regeneration
EXPL/BIA-CEL/0358/2021
Investigador responsável
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2023 The role of long non-coding RNAs on the molecular circuitry and metabolic adaptation of breast cancer” (RNAMETCANCER)
PTDC/BTM-TEC/28534/2017
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022/09 - 2022/10 R&D project/unit Verão com Ciência of the UID 4501
UID 4501
Orientador
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2019/04/01 - 2022/03/30 INNOVATION: Investigating long non-coding RNA regulated pathways driving cardiac regeneration
ERA-CVD/0001/2018
10.54499/ERA-CVD/0001/2018
Investigador responsável
Universidade de Aveiro Instituto de Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/06/01 - 2019/11/30 The non-coding transcriptome in stemness and aging
Provided by PTCRIS: 138613
Investigador Pós-doutorado
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016 - 2019 ReTuBi, Towards Outstanding Research and Training in Tumour Biology.
692322
Investigador Pós-doutorado
Instituto de Medicina Molecular, Portugal
 EU Framework Programme for Research and Innovation Euratom
Concluído
2017 - 2018 A inibição da PKM2 em tumores luminais da mama consegue modificar a sua sensibilidade a inibidores de ciclinas?
20180033
Orientador
Instituto de Medicina Molecular, Portugal
 Faculty of Medicine from the University of Lisbon
Concluído
2016 - 2017 The impact of PGC-1a and mitochondrial metabolism in the response of VEGFR-2 positive Acute Myeloid Leukemia variants to chemotherapy.
20170007
Orientador
Instituto de Medicina Molecular, Portugal
 Faculty of Medicine from the University of Lisbon
Concluído
2015 - 2016 O papel da reprogramação metabólica e respiração mitocondrial no fenótipo agressivo de cancro da mama induzido por hipercolesterolemia.
20160012
Orientador
Instituto de Medicina Molecular, Portugal
 Faculty of Medicine from the University of Lisbon
Concluído
2013/05 - 2015/10 Cerebrospinal fluid metabolome: an instructive niche for CNS metastasis
PTDC/BIM-ONC/1242/2012.
Investigador Pós-doutorado
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2014 - 2015 Resistência terapêutica em cancro da mama associada a alterações metabólicas.
20150029
Orientador
Instituto de Medicina Molecular, Portugal
 Faculty of Medicine from the University of Lisbon
Concluído
2010 - 2014 Common Mechanisms Underlying Cancer and Aging.
ERC-AG/233270
Investigador Pós-doutorado
Centro Nacional de Investigaciones Oncológicas, Espanha
 European Research Council
Concluído
2010 - 2013 New mouse models to study the interplay between cancer and aging
SAF2008-02959
Investigador Pós-doutorado
Centro Nacional de Investigaciones Oncológicas, Espanha
 Ministerio de Ciencia, Innovación y Universidades
Concluído
2010 - 2012 Cancer Biology (OncoBIO)
CSD2007-00017
Investigador Pós-doutorado
Centro Nacional de Investigaciones Oncológicas, Espanha
 Spanish Ministry of Education and Science
Concluído

Projeto

Designação Financiadores
2021/06/01 - 2027/05/31 Unraveling the impact of host nutrition and metabolite signaling in gene expression programs and cell plasticity: re-defining strategies for Cancer and Regenerative Biology.
2020.00355.CEECIND/CP1589/CT0024
10.54499/2020.00355.CEECIND/CP1589/CT0024
2020.00355.CEECIND
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2025/12/31 Institute of Molecular Medicine João Lobo Antunes
LA/P/0082/2020
10.54499/LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019 - 2021/05/31 The role of long non-coding RNAs on the molecular circuitry and metabolic adaptation of breast cancer.
PTDC/BTM-TEC/28534/2017 LISBOA-01-0145-FEDER-02853
Investigador
Gulbenkian Institute for Molecular Medicine, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/06/01 - 2019/11/30 O transcriptoma não codificante em envelhecimento e pluripotência
PTDC/BIM-MED/0032/2014
Universidade de Aveiro, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/08/01 - 2019/06/30 Understanding the role of mitochondrial metabolism in the acquisition of the agressive phenotype induced by LDL-cholesterol in triple negative breast cancer cells
Decree-Law nr 57/2016
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Desativado
2013/08/01 - 2018/07/31 CHOLESTEROL LEVELS SELECT TUMOR POPULATIONS WITH ALTERED METABOLIC AND GENETIC FEATURES?
SFRH/BPD/91159/2012
Bolseiro de Pós-Doutoramento
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Desativado
2011 - 2013 METABOLIC INTERVENTIONS TO PREVENT CANCER AND AGEING: ROLE OF THE PENTOSE PHOSPHATE PATHWAY ENZYME GLUCOSE-6-PHOSPHATE DEHYDROGENASE.
Convocatoria 2011, modalidad A
Bolseiro de Pós-Doutoramento
Centro Nacional de Investigaciones Oncológicas, Espanha
 Spanish Association Against Cancer Scientific Foundation
Desativado
2009 - 2011 A role for Glucose-6-Phosphate Dehydrogenase in conferring protection against oxidative stress, cancer and ageing in mice
2009 CALL
Bolseiro de Pós-Doutoramento
Centro Nacional de Investigaciones Oncológicas, Espanha
 Centro Nacional de Investigaciones Oncológicas
Concluído
2003 - 2007 Cellular and Molecular Mechanisms Controlling the Migration of Telencephalic Interneurons: a Role for Postmitotic Nkx2-1 in Neuronal Migration
SFRH/BD/11827/2003
Bolseiro de Doutoramento
Instituto de Neurociencias, Espanha

Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2021 - 2025 EpiLipidNET – CA19105 – Pan-European Network in Lipidomics and Epilipidomics COST Action
CA19105
Investigador
European Cooperation in Science and Technology, Bélgica
 European Union
Em curso
2021 - 2025 CorEuStem Network – CA20140 – The European Network for Stem Cell Core Facilities COST Action
CA20140
Investigador
European Union
Em curso
2021 - 2022 Metabolic-driven histone marks remodeling during transdifferentiation of fibroblasts into induced cardiac-like myocytes (iCLMs).
EPIC-XS project 346 and 421
Investigador responsável
Istituto Europeo di Oncologia, Itália
 Horizon 2020
Em curso
Produções

Publicações

Artigo em revista
  1. Santos, Francisco; Correia, Magda; Dias, Rafaela; Bola, Bárbara; Noberini, Roberta; Ferreira, Rita S.; Trigo, Diogo; et al. "Age-associated metabolic and epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes". Aging Cell 24 2 (2024): https://doi.org/10.1111/acel.14371.
    10.1111/acel.14371
  2. Pessoa, João; Nóbrega-Pereira, Sandrina; de Jesus, Bruno Bernardes. "Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?". Aging 16 12 (2024): 10657-10665. https://doi.org/10.18632/aging.205975.
    10.18632/aging.205975
  3. Ana Maria Capela; Carlota Tavares-Marcos; Hugo F. Estima-Arede; Sandrina Nóbrega-Pereira; Bruno Bernardes de Jesus. "NORAD-Regulated Signaling Pathways in Breast Cancer Progression". Cancers (2024): https://doi.org/10.3390/cancers16030636.
    10.3390/cancers16030636
  4. Júlia Tavares e Silva; João Pessoa; Sandrina Nóbrega-Pereira; Bruno Bernardes de Jesus. "The Impact of Long Noncoding RNAs in Tissue Regeneration and Senescence". Cells (2024): https://doi.org/10.3390/cells13020119.
    10.3390/cells13020119
  5. Alves-Vale, Catarina; Capela, Ana Maria; Tavares-Marcos, Carlota; Domingues-Silva, Beatriz; Pereira, Bruno; Santos, Francisco; Gomes, Carla Pereira; et al. "Expression of NORAD correlates with breast cancer aggressiveness and protects breast cancer cells from chemotherapy". Molecular Therapy - Nucleic Acids 33 (2023): 910-924. https://doi.org/10.1016/j.omtn.2023.08.019.
    10.1016/j.omtn.2023.08.019
  6. Sandrina Nóbrega-Pereira; Francisco Santos; Miguel Oliveira Santos; Teresa L. Serafim; Ana Patrícia Lopes; Diogo Coutinho; Filipa S. Carvalho; et al. "Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration". Cancer Res Commun . 26;3 4 (2023): 709-724. doi: 10.1158/2767-9764.CRC-22-0394.
    Publicado • 10.1158/2767-9764.c.6563219.v2
  7. Trigo, Diogo; Nadais, André; Carvalho, Ana; Morgado, Bárbara; Santos, Francisco; Nóbrega-Pereira, Sandrina; da Cruz e Silva, Odete A.B.. "Mitochondria dysfunction and impaired response to oxidative stress promotes proteostasis disruption in aged human cells". Mitochondrion 69 (2023): 1-9. http://dx.doi.org/10.1016/j.mito.2022.10.002.
    10.1016/j.mito.2022.10.002
  8. Correia, Magda; Santos, Francisco; da Silva Ferreira, Rita; Ferreira, Rita; Bernardes de Jesus, Bruno; Nóbrega-Pereira, Sandrina. "Metabolic Determinants in Cardiomyocyte Function and Heart Regenerative Strategies". Metabolites 12 6 (2022): 500. http://dx.doi.org/10.3390/metabo12060500.
    10.3390/metabo12060500
  9. Santos, Francisco; Capela, Ana Maria; Mateus, Francisca; Nóbrega-Pereira, Sandrina; Bernardes de Jesus, Bruno. "Non-coding antisense transcripts: fine regulation of gene expression in cancer". Computational and Structural Biotechnology Journal 20 (2022): 5652-5660. http://dx.doi.org/10.1016/j.csbj.2022.10.009.
    10.1016/j.csbj.2022.10.009
  10. Correia, Magda; Bernardes de Jesus, Bruno; Nóbrega-Pereira, Sandrina. "Novel insights linking lncRNAS and metabolic with implications for cardiac regeneration.". Frontiers in Physiology 12 (2021): https://doi.org/10.3389/fphys.2021.586927.
    Publicado
  11. Santos, Francisco; Correia, Magda; Nóbrega-Pereira, Sandrina; Bernardes de Jesus, Bruno. "Age-Related Pathways in Cardiac Regeneration: A Role for lncRNAs?". Frontiers in Physiology 11 (2021): http://dx.doi.org/10.3389/fphys.2020.583191.
    10.3389/fphys.2020.583191
  12. Bruno Bernardes de Jesus; Bruno Miguel Neves; Manuela Ferreira; Sandrina Nóbrega-Pereira. "Strategies for Cancer Immunotherapy Using Induced Pluripotency Stem Cells-Based Vaccines". Cancers 12 12 (2020): 3581-3581. https://doi.org/10.3390/cancers12123581.
    10.3390/cancers12123581
  13. Cian J. Lynch; Raquel Bernad; Ana Martínez-Val; Marta N. Shahbazi; Sandrina Nóbrega-Pereira; Isabel Calvo; Carmen Blanco-Aparicio; et al. "Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases". Nature Cell Biology 22 10 (2020): 1223-1238. https://doi.org/10.1038/s41556-020-0573-1.
    10.1038/s41556-020-0573-1
  14. Gomes, Carla Pereira; Nóbrega-Pereira, Sandrina; Domingues-Silva, Beatriz; Rebelo, Kenny; Alves-Vale, Catarina; Marinho, Sérgio Pires; Carvalho, Tânia; Dias, Sérgio; Bernardes de Jesus, Bruno. "An antisense transcript mediates MALAT1 response in human breast cancer". BMC Cancer 19 1 (2019): http://dx.doi.org/10.1186/s12885-019-5962-0.
    10.1186/s12885-019-5962-0
  15. Santos, Francisco; Moreira, Cristiana; Nóbrega-Pereira, Sandrina; Bernardes de Jesus, Bruno. "New Insights into the Role of Epithelial–Mesenchymal Transition during Aging". International Journal of Molecular Sciences 20 4 (2019): 891. http://dx.doi.org/10.3390/ijms20040891.
    10.3390/ijms20040891
  16. Pereira, Sandrina; Dias, Sérgio. "VEGF signaling in acute leukemia: mitochondrial connections". Oncoscience (2018): 54. http://dx.doi.org/10.18632/oncoscience.400.
    Publicado • 10.18632/oncoscience.400
  17. Rodrigues, Neidy V.; Correia, Daniel V.; Mensurado, Sofia; Nóbrega-Pereira, Sandrina; deBarros, Ana; Kyle-Cezar, Fernanda; Tutt, Andrew; et al. "Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human V¿9Vd2 T Cells". Cancer Immunology Research 6 4 (2018): 448-457. http://dx.doi.org/10.1158/2326-6066.cir-17-0327.
    Publicado • 10.1158/2326-6066.cir-17-0327
  18. Lynch, Cian J.; Bernad, Raquel; Calvo, Isabel; Nóbrega-Pereira, Sandrina; Ruiz, Sergio; Ibarz, Nuria; Martinez-Val, Ana; et al. "The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity". Cell Reports 22 2 (2018): 396-410. http://dx.doi.org/10.1016/j.celrep.2017.12.062.
    Publicado • 10.1016/j.celrep.2017.12.062
  19. Nóbrega-Pereira, Sandrina; Caiado, Francisco; Carvalho, Tânia; Matias, Inês; Graça, Gonçalo; Gonçalves, Luís G.; Silva-Santos, Bruno; Norell, Haakan; Dias, Sérgio. "VEGFR2¿ Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy". Cancer Research 78 3 (2017): 731-741. http://dx.doi.org/10.1158/0008-5472.can-17-1166.
    Publicado • 10.1158/0008-5472.can-17-1166
  20. Fernandez-Marcos, Pablo J.; Nóbrega-Pereira, Sandrina. "NADPH: new oxygen for the ROS theory of aging". Oncotarget 7 32 (2016): http://dx.doi.org/10.18632/oncotarget.10744.
    Publicado • 10.18632/oncotarget.10744
  21. Nóbrega-Pereira, Sandrina; Fernandez-Marcos, Pablo J.; Brioche, Thomas; Gomez-Cabrera, Mari Carmen; Salvador-Pascual, Andrea; Flores, Juana M.; Viña, Jose; Serrano, Manuel. "G6PD protects from oxidative damage and improves healthspan in mice". Nature Communications 7 1 (2016): http://dx.doi.org/10.1038/ncomms10894.
    Publicado • 10.1038/ncomms10894
  22. Villar-Cerviño, V.; Kappeler, C.; Nóbrega-Pereira, S.; Henkemeyer, M.; Rago, L.; Nieto, M.A.; Marín, O.. "Molecular mechanisms controlling the migration of striatal interneurons". Journal of Neuroscience 35 23 (2015): 8718-8729. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930911567&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.4317-14.2015
  23. Borrell, Víctor; Cárdenas, Adrián; Ciceri, Gabriele; Galcerán, Joan; Flames, Nuria; Pla, Ramón; Nóbrega-Pereira, Sandrina; et al. "Slit/Robo Signaling Modulates the Proliferation of Central Nervous System Progenitors". Neuron 76 2 (2012): 338-352. http://dx.doi.org/10.1016/j.neuron.2012.08.003.
    Publicado • 10.1016/j.neuron.2012.08.003
  24. Nóbrega-Pereira, S.; Gelman, D.; Bartolini, G.; Pla, R.; Pierani, A.; Marín, O.. "Origin and molecular specification of globus pallidus neurons". Journal of Neuroscience 30 8 (2010): 2824-2834. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649122694&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.4023-09.2010
  25. Gelman, D. M.; Martini, F. J.; Nobrega-Pereira, S.; Pierani, A.; Kessaris, N.; Marin, O.. "The Embryonic Preoptic Area Is a Novel Source of Cortical GABAergic Interneurons". Journal of Neuroscience 29 29 (2009): 9380-9389. http://dx.doi.org/10.1523/jneurosci.0604-09.2009.
    Publicado • 10.1523/jneurosci.0604-09.2009
  26. Nobrega-Pereira, S.; Marin, O.. "Transcriptional Control of Neuronal Migration in the Developing Mouse Brain". Cerebral Cortex 19 suppl 1 (2009): i107-i113. http://dx.doi.org/10.1093/cercor/bhp044.
    Publicado • 10.1093/cercor/bhp044
  27. Nóbrega-Pereira, Sandrina; Kessaris, Nicoletta; Du, Tonggong; Kimura, Shioko; Anderson, Stewart A.; Marín, Oscar. "Postmitotic Nkx2-1 Controls the Migration of Telencephalic Interneurons by Direct Repression of Guidance Receptors". Neuron 59 5 (2008): 733-745. http://dx.doi.org/10.1016/j.neuron.2008.07.024.
    Publicado • 10.1016/j.neuron.2008.07.024
  28. Lavreysen, H.; Pereira, S.N.; Leysen, J.E.; Langlois, X.; Lesage, A.S.J.. "Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: A quantitative autoradiographic study using [3H]R214127". Neuropharmacology 46 5 (2004): 609-619. http://www.scopus.com/inward/record.url?eid=2-s2.0-1442275398&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2003.11.014
  29. Lavreysen, H.; Wouters, R.; Bischoff, F.; Nóbrega Pereira, S.; Langlois, X.; Blokland, S.; Somers, M.; Dillen, L.; Lesage, A.S.J.. "JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist". Neuropharmacology 47 7 (2004): 961-972. http://www.scopus.com/inward/record.url?eid=2-s2.0-8844229596&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2004.08.007
Artigo em revista (magazine)
  1. Nóbrega-Pereira, Sandrina. "iBiMED GreenLab: an example of good sustainability practices at the University of Aveiro", United Nations Academic Impact (UNAI)., 2024, https://www.un.org/en/academic-impact/ibimed-greenlab-example-good-sustainability-practices-university-aveiro.
  2. Nóbrega-Pereira, Sandrina. "A investigação no Departamento de Ciências Médicas da Universidade de Aveiro", Perspectiva Atual., 2023, http://perspetivaatual.pt/index.php/2023/12/22/a-investigacao-no-departamento-de-ciencias-medicas-da-universidade-de-aveiro/.
  3. Helguero, Luisa; Nóbrega-Pereira, Sandrina. Autor correspondente: Nóbrega-Pereira, Sandrina. "Dia Mundial Contra o Cancro uma luta de todos", Notícias UA, 2022
Capítulo de livro
  1. Nóbrega-Pereira, Sandrina; Bernardes de Jesus B.. "Cellular reprogramming and aging". In Springer Learning Series Concepts and Applications of Stem Cell Biology: a Guide for Students!. 2020.
    No prelo
Poster em conferência
  1. Gomes, Carla P.; Nóbrega-Pereira, Sandrina; Silva, B.; Carvalho, T.; Bernardes de Jesus, B.. "A natural antisense lncRNA transcript mediates the impact of MALAT1 in human breast cancer". Trabalho apresentado em VIII National RNA Meeting: ptRNA2019, 2019.
Tese / Dissertação
  1. Nóbrega-Pereira, Sandrina. "Cellular and Molecular Mechanisms Controlling the Migration of Telencephalic Interneurons: a Role for Postmitotic Nkx2-1 in Neuronal Migration.". Doutoramento, Universidade de Coimbra, 2009.
  2. Nóbrega-Pereira, Sandrina. "mGlu1 receptor autoradiography – receptor distribution and development of an ex vivo occupancy model in rat.". Licenciatura, Universidade de Coimbra, 2003.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2025/02/20 The use of direct cellular reprogramming of fibroblasts into induced cardiomyocytes as a cardiac regenerative therapy Envision Biomed
Engineering in Medicine and Biological Sciences (EMBS) (Aveiro, Portugal)
2024/12/11 Age-associated metabolic and epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes iBiMED Scientific Advisory Board visit, Montebelo Vista-Alegre Ihavo
iBiMED (Ilhavo, Portugal)
2024/11/26 Age-associated metabolic and epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes Workshop In vitro models of cardiovascular diseases
FMUP (Porto, Portugal)
2024/05/27 Metabolic and age-associated epigenetic barriers during direct reprogramming of mouse fibroblasts into induced cardiomyocytes MIA-Portugal Ageing Spring School 2024
University of Coimbra (Coimbra, Portugal)
2024/05/14 Bandeira Verde Eco-Escolas no Departamento de Ciências Médicas 2º Encontro Sustentabilidade UA
University of Aveiro (Aveiro, Portugal)
2023/06/28 iBiMED GreenLab: BOAS PRÁTICAS AMBIENTAIS EM LABORATÓRIO 2º Workshop sobre Boas Práticas de Gestão de Resíduos Perigosos e Hospitalares
University of Aveiro (Aveiro, Portugal)
2023/05/25 Mitochondria and lipids in cancer cell migration VI iBiMED Symposium
iBiMED (Aveiro, Portugal)
2023/05/17 iBiMED Green lab Encontro Sustentabilidade UA.
University of Aveiro (Aveiro, Portugal)
2023/03/17 iBiMED GreenLab: promoting sustainable biomedical research XIII JNCB’23
XIII JNCB’23 (Aveiro, Portugal)
2023/01/13 Metabolic signaling in cancer and cell plasticity III Metabolism Aging and Disease Meeting, CIBB/CNC
(Coimbra, Portugal)
2022/12/20 Metabolic signaling in cancer and cell plasticity Mechanisms of Tumour Suppression and Senescence Symposium, Institute for Research in Biomedicine (IRB)
(Barcelona, Espanha)
2022/11/30 Mitochondria and lipids in breast cancer cell plasticity Educar, para que a Prevenção do Cancro da Próstata, seja uma prioridade na saúde do homem nos PALOPs” International Conference, INCUBATOR-Faculdade de Ciência e Tecnologia-UNICV, virtual
(Santiago, Cabo Verde)
2022/10/07 Metabolic and epigenetic barriers in direct cardiac conversion INNOVATION in Cardiac Regeneration symposium. DCM/UA
(Aveiro, Portugal)
2022/04/26 Metabolic Signaling in Cancer and Cell Plasticity Center for Research in Molecular Medicine and Chronic Disease (CiMUS)
(Santiago de Compostela, Espanha)
2021/01/29 Metabolic signaling in cancer and cell plasticity Ad Hoc Seminar
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2020/12/10 The G6PD enzyme as a new approach to the Free Radical Theory of Aging AGING: Unveiling the mysteries of time (Online event)
NECiB/UA (Aveiro, Portugal)
2019/09/05 The role of mitochondrial metabolism in breast cancer aggressiveness induced by hipercolesterolemia. 2nd FEBS Advanced Lecture Course on Oncometabolism
FEBS (Luso, Portugal)
2018/11/20 VEGFR2 Reprograms Mitochondrial Metabolism and the response of Leukemia to Chemotherapy Signalling Afternoon (invited speaker)
Institute of Biomedicine (iBiMED), University of Aveiro (Aveiro, Portugal)
2018/11/08 Mitochondrial metabolism in breast cancer aggressiveness induced by hypercolesterolemia Metabolism Club (internal seminar)
Instituto de Medicina Molecular (Lisbon, Portugal)
2018/10/17 Metabolic selection of tumor phenotypes 10 Simpósio de Metabolismo (invited speaker)
Faculdade de Medicina da Universidade do Porto (Porto, Portugal)
2018/06/11 The role of mitochondrial metabolism in breast cancer aggressiveness induced by hypercholesterolemia 8th International Conference on Tumor Microenvironment (selected oral presentation)
ICMS (Lisbon, Portugal)
2018/03/14 Metabolic adaptations in cancer and aging Ad Hoc seminar
Institute of Biomedicine (iBiMED), University of Aveiro (Aveiro, Portugal)
2017/10/20 Metabolic adaptations in cancer and aging Ad Hoc seminar
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2015/05/13 Metabolic adaptations of cancer cells under selective pressures Oncobiology club (internal seminar)
Instituto de Medicina Molecular (Lisbon, Portugal)
2009/10/02 A Role for Nkx2-1 in Neuronal Migration Ad Hoc seminar
Instituto de Microbiología Bioquímica (Salamanca, Espanha)
2008/04/14 Postmitotic Nkx2-1 Controls the Migration of Telencephalic Interneurons by Direct Repression of Guidance Receptors Ad Hoc seminar
Centro Nacional de Investigaciones Oncologicas (Madrid, Espanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024 - Atual Exploring cardiac fibroblast’s metabolism towards effective heart regeneration in advanced 3D cardiac models (PhD, Bolsas de Doutoramento UA, 6ª edição)
Orientador
 PhD Program in Biomedicine (Doutoramento)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2024 - Atual A new technology to induce tumor cell death and boost cancer immunotherapies (PhD, Bolsas de Doutoramento UA, 6ª edição)
Coorientador
 PhD Program in Biomedicine (Doutoramento)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021 - Atual Induced Pluripotent Stem Cells (iPSC)-based Cancer Immunotherapy (UI/BD/151373/2021) PhD
Coorientador
 PhD program in Biomedicine (Doutoramento)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2024 - 2025 Nutrient sensing in cell reprogramming, pluripotency and ESC-based immunotherapies (Master)
Coorientador
 Master Degree in Molecular Biomedicine (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2024 - 2025 Validation of hits from a Natural compound library that potentiate direct cardiac conversion (Master)
Orientador
 Master Degree in Biochemistry (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
2023 - 2024 Exploring the impacto f dietary lipids on IPSCs pluripotency (Master)
Orientador
 Master Degree in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023 - 2024 Identifying new molecular modulators of direct cardiac conversion (Master)
Orientador
 Master Degree in Molecular Biomedicine, (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019/05 - 2024 Exploiting the role of long non-coding RNAs in the direct conversion of fibroblasts into functional cardiomyocytes and neurons (PhD)
Coorientador
 PhD Program in Biochemistry (Doutoramento)
Universidade de Aveiro Departamento de Química, Portugal
2022 - 2023 Metabolic and energetic reprogramming driving direct cardiac conversion of mouse fibroblasts into induced cardiac-like myocytes (Master)
Orientador
 Master in Molecular Biomedicine (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022 - 2023 RNA transcripts in human breast cancer (Master)
Coorientador
 Master Degree in Molecular Biomedicine (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022 - 2023 Nutritional and aging-associated barriers to direct cardiac conversion (Master)
Orientador
 Master Degree in Molecular Biomedicine (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021 - 2022/11/25 Metabolic barriers in the transdifferentiation of fibroblasts into induced cardiac-like myocytes (Master)
Orientador
 Master in Molecular Biomedicine (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2020 - 2021 Cell-specific targeted nanosystem to modulate the tumor microenvironment (Master)
Orientador
 Integrated Master in Biomedical Engineering (Mestrado)
Universidade de Aveiro Departamento de Física, Portugal
2020 - 2021 Exploiting metabolic targets in the direct conversion of fibroblasts into functional cardiomyocytes (Master)
Coorientador
 Master in biology of differentiation and reproduction, University of Naples “Federico II” – Naples (Erasmus) (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - 2020 Exploiting the role of long non-coding RNAs in the direct conversion of fibroblasts into functional cardiomyocytes (Master)
Coorientador
 Master in Molecular and Cell Biology (Mestrado)
Universidade de Aveiro Departamento de Biologia, Portugal
2018 - 2019/06 Using zebrafish as a system model to study LDL-induced breast cancer aggressiveness (Master)
Coorientador
 Integrated Master in Medicine, Faculty of Medicine from the University of Lisbon (Mestrado)
Faculty of Medicine from the University of Lisbon, Portugal
2017 - 2019/05 Mitochondrial Adaptations in breast cancer cell migration - influence of lipid environment and respose to Taxanes (Master)
Coorientador
 Master in Oncobiology (Mestrado)
Faculty of Medicine from the University of Lisbon, Portugal
2016 - 2017 The role of mitochondrial metabolism in breast cancer aggressive phenotype induced by hypercholesterolemia (Master)
Coorientador
 Integrated Master in Medicine, Faculty of Medicine from the University of Lisbon (Mestrado)
Faculty of Medicine from the University of Lisbon, Portugal
2016 - 2017 The role of mitochondrial adaptations in the acquisition of the phenotype induced by LDL in breast cancer (Master)
Coorientador
 Master Degree in Biopharmaceutical Sciences (Mestrado)
Faculty of Medicine from the University of Lisbon, Portugal

Faculty of Pharmacy from the University of Lisbon, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019 - Atual Hosting guest speakers (2019)
Conferência (Outra)
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2025/05/22 - 2025/05/23 VIII iBiMED Symposium – Biomedicine beyond boundaries (2025/05/22 - 2025/05/23)
Simpósio (Membro da Comissão Científica)
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2024/06/07 - 2024/06/07 Lipids and Cell Plasticity: Implications for Tissue Regeneration, Cancer, and Immunology (organized within the scope of the EpiLipidNET – CA19105 linked activities). (2024/06/07 - 2024/06/07)
Simpósio (Membro da Comissão Organizadora)
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2024/05/23 - 2024/05/24 VII iBiMED Symposium - Sharing Science, Inspiring Progress (2024/05/23 - 2024/05/24)
Simpósio (Membro da Comissão Científica)
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2023/09/23 - 2023/09/23 GREEN LABS PORTUGAL SYMPOSIUM: Promoting Sustainability in Research (2023/09/23 - 2023/09/23)
Simpósio (Membro da Comissão Científica)
 Universidade de Coimbra, Portugal
2022/10/07 - 2022/10/07 INNOVATION in Cardiac Regeneration symposium (2022/10/07 - 2022/10/07)
Simpósio (Coorganizador)
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2022/10/06 - 2022/10/06 ERA-CVD INNOVATION F2F Meeting 2022, internal scientific meeting of members of the European project consortium (2022/10/06 - 2022/10/06)
Encontro (Coorganizador)
 Universidade de Aveiro Instituto de Biomedicina, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/04/03 - 2032/04/06 Organoids as Tools for Fundamental Discovery and Translation (Virtual). Keystone Symposium
Simpósio
 Organoids as Tools for Fundamental Discovery and Translation (Virtual). Keystone Symposium
2024/07/10 - 2024/07/13 Systemic lipids impact ex vivo cell reprogramming into pluripotency by metabolic and epigenetic landscape transitions ISSCR 2024
International Society for Stem Cell Research, Estados Unidos
2023/10/11 - 2023/10/13 Metabolic and epigenetic barriers in direct reprogramming of fibroblasts into induced cardiomyocytes
Congresso
 ETRS-SPCE 2023
2023/07/08 - 2023/07/12 Metabolic and epigenetic barriers in the direct reprogramming of mouse fibroblasts into induced cardiomyocytes
Congresso
 FEBS 2023
Federation of European Biochemical Societies, Reino Unido
2023/06/14 - 2023/06/17 Strategies for cancer immunotherapy using induced pluripotent stem cells (iPSCs) and Embryonic Stem cells (ESC)
Congresso
 ISSCR 2023
International Society for Stem Cell Research, Estados Unidos
2023/06/14 - 2023/06/17 #27 Metabolic and epigenetic barriers in direct reprogramming of fibroblasts into induced cardiomyocytes
Congresso
 ISSCR 2023
International Society for Stem Cell Research, Estados Unidos
2023/03/11 - 2023/03/11 O Cancro visto ao Microscópio - À conversa com os cientistas, Round-table, Moderator.
Mesa-redonda
 O Cancro visto ao Microscópio - À conversa com os cientistas
Universidade de Aveiro, Portugal
2022/11/10 - 2022/11/12 Metabolic and epigenetic barriers in the direct reprogramming of fibroblasts into induced cardiomyocytes.
Conferência
 CNIC Conference 2022- Cardiac Regeneration: from Mechanisms to Therapy
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Espanha
2022/04/05 - 2022/04/09 Single Cell Biology: Pushing New Frontiers in the Life Sciences (Virtual). Keystone Symposium
Simpósio
 Single Cell Biology: Pushing New Frontiers in the Life Sciences (Virtual). Keystone Symposium
2022/04 - 2022/04 Mitochondrial metabolism drives LDL-cholesterol induced breast cancer cell migration and metastasis formation (poster)
Congresso
 Cell Symposia: Metabolites in Signaling and Disease 2022
Elsevier BV, Países Baixos
2022/03/25 - 2022/03/27 Erasmus+ program, mobilty for teaching staff, Faculty of Phamacy of the University Santiago de Compostela
Oficina (workshop)
Universidade de Santiago de Compostela, Espanha
2021/10 - 2021/10 LDL-cholesterol favors breast cancer cell migration and invasion by remodeling of mitochondrial metabolism (poster )
Congresso
 Biology of Cancer: Microenvironment & Metastasis (Virtual)
Cold Spring Harbor Laboratory, Estados Unidos
2021/10 - 2021/10 Exploiting the role of metabolic cues during the conversion of mouse fibroblasts into induced cardiomyocytes (poster)
Congresso
 Stem Cells: from basic science to clinical translation (Virtual)
International Society for Stem Cell Research, Estados Unidos
2021/10 - 2021/10 Aging and nutrient signaling in transdifferentiation of fibroblasts into iCLMs (oral presentation)
Encontro
 ERA CVD Meeting Report (virtual)
Medizinische Hochschule Hannover, Alemanha
2021/05 - 2021/05 Strategies for cancer immunotherapy using induced pluripotency stem cells-based vaccines (poster)
Congresso
 Cancer Stem Cells: Advances in Biology and Clinical Translation (Virtual).
Keystone Symposia on Molecular and Cellular Biology, Estados Unidos
2020/09/11 - 2020/09/11 Mitochondrial metabolism in breast cancer aggressive induced by hipercolesterolemia (poster)
Congresso
 Mechanisms & Models of Cancer (virtual)
Cold Spring Harbor Laboratory, Estados Unidos
2020/09 - 2020/09 Teaching + Program, transforming a Course Unit into b-learning. Team Based Learning (TBL), ARS platforms, Padlet, Google drive.
Conferência
 Teaching + Program, transforming a Course Unit into b-learning
Universidade de Aveiro, Portugal
2018/12/05 - 2018/12/06 The role of mitochondrial metabolism in breast cancer aggressiveness induced by hipercolesterolemia (poster)
Simpósio
 Symposia on Tumour Biology: from basic biology to disease
ReTuBi Project , Portugal
2018/10/09 - 2018/10/11 The role of mitochondrial metabolism in breast cancer aggressiveness induced by hipercolesterolemia (poster)
Encontro
 Mechanisms to Therapies, Innovations in Cancer Metabolism
European Association For Cancer Research, Reino Unido
2018/05/10 - 2018/05/11 VEGFR2-mediated reprogramming of mitochondrial metabolism regulates the sensitivity of acute myeloid leukemia to chemotherapy (highlighted poster)
Congresso
 3rd ASPIC International Congress
Associaçao Portuguesa de Investigaçao em Cancro, Portugal
2017 - 2018 Scientific dissemination activities to high school students (Escola Secundária de Camões and Escola Básica e Secundária Passos Manuel, Lisbon)
Seminário
 The Biology of Cancer in one hour
ReTuBi Project , Portugal

Instituto de Medicina Molecular, Portugal
2017/11/13 - 2017/11/13 Scientific dissemination event for cancer patient’s associations
Mesa-redonda
 Oncologia: Conversas com cientistas
ReTuBi Project , Portugal

Instituto de Medicina Molecular, Portugal
2017/10/09 - 2017/10/11 VEGFR2 signaling regulates the sensitivity of Acute Myeloid Leukemia to chemotherapy by reprogramming mitochondrial metabolism (poster)
Simpósio
 Champalimaud Research Symposium
Centro Champalimaud, Portugal
2017/05/26 - 2017/05/26 Mitochondrial metabolism in breast cancer aggressive phenotype induced by hypercholesterolemia (poster)
Simpósio
 MitoPorto International Symposium
2017/02/22 - 2017/02/24 Career development and soft skills for young scientists - From Lisbon to the World, ReTuBi Project Framework
Oficina (workshop)
 Career development and soft skills for young scientists - From Lisbon to the World
ReTuBi Project , Portugal
2016/10/04 - 2016/10/06 VEGFR2 signaling regulates chemotherapy resistance through reprogramming of mitochondrial metabolism in Acute Myeloid Leukemia (poster)
Congresso
 EMBO Cancer CIC bioGune Translational Research in Cancer Metabolism
European Molecular Biology Laboratory, Alemanha
2016/04/28 - 2016/04/29 VEGFR2 signaling regulates chemotherapy resistance through reprogramming of mitochondrial metabolism in Acute Myeloid Leukemia (poster)
Congresso
 2nd ASPIC International Congress
Associaçao Portuguesa de Investigaçao em Cancro, Portugal
2015/09/28 - 2015/09/30 Acquisition of chemotherapy resistance in acute myeloid leukemia: interplay between lipid metabolism and VEGF receptor signaling (poster)
Encontro
 Metastasis Initiation: Mechanistic and Therapeutic Opportunities,
Centro Nacional de Investigaciones Oncológicas, Espanha
2014/11/07 - 2014/11/07 Glucose-6-Phosphate Dehydrogenase Overexpression Protects Against Chronic Oxidative Stress And Increases Lifespan in Mouse (poster)
Encontro
 Energy Homeostasis and Metabolic Disease
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Espanha
2013/10/30 - 2013/10/30 Making Sense of the Science: a Course on Effective Scientific Writing
Oficina (workshop)
 Workshop Making Sense of the Science: a Course on Effective Scientific Writing - Grant Writing by Judith A. Swan
Instituto de Medicina Molecular, Portugal
2012/09/06 - 2012/09/24 Flow Cytometer Seminar Series
Seminário
 CNIO, Madrid, Spain
Centro Nacional de Investigaciones Oncológicas, Espanha
2010/09/28 - 2010/10/02 A Role for Glucose-6-Phosphate Dehydrogenase in Conferring Protection Against Oxidative Stress and Aging in Mice (poster)
Congresso
 Molecular Genetics of Aging
Cold Spring Harbor Laboratory, Estados Unidos
2010/07/01 - 2010/07/01 Cellular Reprogramming and Induced Pluripotent Stem Cells (iPS)
Simpósio
 Network of Cellular Therapy and Spanish Society for Gene and Cellular Therapy
2009/11/02 - 2009/11/04 CNIO Cancer Conference: The Energy of Cancer
Conferência
 CNIO Cancer Conference: The Energy of Cancer
Centro Nacional de Investigaciones Oncológicas, Espanha
2008/05/19 - 2008/05/21 Barcelona Biomed Conferences: Metastasis Genes and Functions
Conferência
 Barcelona Biomed Conferences: Metastasis Genes and Functions
Institut de Recerca Biomèdica, Espanha
2007/10/31 - 2007/11/03 Postmitotic Nkx2-1 Controls the Segregation of Cortical and Striatal Interneurons in the Developing Telencephalon (poster)
Encontro
 37th Annual Meeting
Society for Neuroscience, Estados Unidos
2006/07/18 - 2006/07/26 Modern Technologies in Gene Expression Detection and Data Integration, Debrecen, Hungary
Oficina (workshop)
 Modern Technologies in Gene Expression Detection and Data Integration
2006/07/08 - 2006/07/12 Postmitotic Nkx2-1 Expression Controls the Segregation of Striatal and Cortical Interneurons in the Developing Telencephalon (poster)
Congresso
 5th Forum of European Neuroscience
Federation of European Neuroscience Societies, Bélgica
2005/09/01 - 2005/09/04 EMBO Young Investigator PhD Course, EMBL
Oficina (workshop)
 EMBO Young Investigator PhD Course
European Molecular Biology Laboratory, Alemanha
2005/05/12 - 2005/05/15 Cortical Development: Neural Stem Cells to Neural Circuits, Santorini, Greece
Conferência
 Cortical Development: Neural Stem Cells to Neural Circuits
2005/01/28 - 2005/02/01 II International Workshop in Morphological Interpretation in Neuroembriology
Oficina (workshop)
 II International Workshop in Morphological Interpretation in Neuroembriology
Universidad de Murcia, Espanha

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/12/06 Identifying new molecular modulators of direct cardiac conversion
Orientador
 Inês Loureiro (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2024/12 The Role of Ube3A in Presynaptic Differentiation
Presidente do júri
 Inês Conceição Denis Bruno (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2024/10 Transient pluripotent states as new reservoirs of cancer-specific antigens
Arguente principal
 Rafaela Dias (Outro)
Universidade de Aveiro, Portugal
2024/09/10 Exploring the impacto f dietary lipids on IPSCs pluripotency
Orientador
 Nathan James Hunter (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/12/20 Nutritional and aging-associated barriers to cell reprogramming
Orientador
 Rafaela Dias (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2023/12/14 Metabolic and energetic shifts driving direct cardiac conversion of mouse fibroblasts into induced cardiomyocytes
Orientador
 Bárbara Bola (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2023/12 Effect of hepatic ischemia-reperfusion injury on the proteome of lung mitochondria
Arguente principal
 Carolina Martins Godinho (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
2023/12 Metabolic characterization of homotypic and heterotypic in vitro models of pancreatic adenocarcinoma
Arguente principal
 Diogo Filipe Martins Lopes (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
2023/12 Production of Photo-engineered Cell-Rich Materials Exhibiting Living
Arguente principal
 José Carlos Almeida Pinto (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
2023/12 Pyrazoles and Indazoles: Potential PARP-1/PI3K dual inhibitors for cancer therapy
Arguente principal
 Inês Martins Bastos (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
2023/10 In human evidence of the therapeutic efficacy of CDK4/6 inhibitors plus RANK pathway inhibition in Triple Negative Breast Cancer
Arguente principal
 Rúben Marcelo Simão Nunes (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2023 Development of a "circuit-on-a-chip" to study Neurodevelopmental Diseases
Arguente
 Mariana Raquel da Silva Carvalho (Outro)
Universidade de Aveiro Departamento de Física, Portugal
2022/11/25 Metabolic barriers in the transdifferentiation of fibroblasts into induced cardiac-like myocytes
Orientador
 Rita da Silva Ferreira (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022/02 Regulation of LDL expression in breast cancer cells and its implication in tumour progression
Arguente principal
 Pedro Miguel da Silva Marreiros (Mestrado)
Universidade de Lisboa, Portugal
2021/12 Different strategies to promote neuronal differentiation using the BRI2 protein
Presidente do júri
 Maria Isabela Pinho Santos (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021/11 Cell-specific targeted nanosystem to modulate the tumor microenvironment
Orientador
 Sofia Ponce Dias (Mestrado)
Universidade de Aveiro Departamento de Física, Portugal
2021/02/24 Development of a hydrogel of platelet lysates to induce nerve regeneration
Presidente do júri
 Joana Filipa Ribeiro Correia (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019/12/13 Unravelling the interplay between influenza A virus and transfer RNA-modifying enzymes.
Presidente do júri
 Alexandre Miguel Manana Nunes (Mestrado)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019/07/22 LDL favours metastatic spread of triple negative breast cancer.
Arguente principal
 Miguel Esteves de Oliveira Santos (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 YB-1 expression in breast cancer: modulation of receptor status and therapeutic implications.
Arguente principal
 Patricia Alves (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2022 - Atual Review Editor on the Editorial Board of Cardiovascular Biologics and Regenerative Medicine Frontiers in Cardiovascular Medicine
2021 - Atual Metabolites, Guest Editor at Special Issue (“Interplay Between Nutrient and Metabolic Signaling in Cell Identity”) MDPI

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021 - Atual Biomedicine Laboratories 3 (regency in 2023) Bachelor of Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021 - Atual Advanced Course in Scientific Research (Curricular Unit Coordinator) New technologies and experimental models in biomedicine (Coordinator) (Pós-Graduação) Universidade de Aveiro, Portugal
2019 - Atual Hallmarks of Ageing: Mitochondrial dysfunction, PhD Program in Biomedicine PhD Program in Biomedicine (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2025/02 - 2025/06 Molecular Mechanisms of Ageing (teacher responsible, regency) Bachelor of Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2024/09 - 2024/11 Fundamentals of Medical Sciences Fundamentals of Medical Sciences (Mestrado integrado) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2023 - 2023 Organic and Functional Systems II Bachelor of Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022 - 2023 Research in Biomedicine Biomedical Sciences Bachelor degree (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022/04 - 2022/04 Metabolic reprogramming in cancer progression, MSc in Biological Bases of Cancer MSc in Biological Bases of Cancer, (Master) Universidad de Salamanca Facultad de Medicina, Espanha
2019 - 2022 Biomedicine Laboratories 2 Bachelor of Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018 - 2022 Molecular Biology of Cancer: deregulation of cellular energetics, MSc in Cell and Molecular Biology Master Programme in Cell and Molecular Biology (Mestrado) Faculdade de Ciências de Tecnologia da Universidade de Coimbra, Portugal
2019 - 2021 Organic and Functional Systems I Bachelor of Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018 - 2020 Biopathology, Bachelor in Biomedicine Biomedical Sciences Bachelor degree (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019/02/11 - 2019/06 Organic and Functional Systems IV Bachelor of Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018 - 2019 Organic and Functional Systems III Bachelor of Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018/09/17 - 2018/09/20 Cancer Progression: Focus on stemness, invasion, metabolism and metastasis ReTuBi Project Framework Second Joint Summer School (Outros) ReTuBi Project , Portugal
2018/09 - 2018/09 Clinical Training, component of Systems Medicine Bachelor of Biomedical Sciences (Licenciatura) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2015/04/22 - 2015/04/22 Metabolism in cancer and aging, IGC PhD in Integrative Biology and Biomedicine IGC PhD Programme – Integrative Biology and Biomedicine (Curso de doutoramento (conclusão de unidades curriculares)) Instituto Gulbenkian de Ciência, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2023/12/13 90 segundos de Ciência, Podcast. ep. 1678 sandrina pereira – investigação estuda o papel dos lípidos na metastização de células tumorais em cancro da mama triplo negativo 90 segundos de Ciência, Podcast (UTQB NOVA, FCSH, Antena 1).
2022 Opinion article at UA website, entitled World Cancer Day: a fight for all Noticias UA
2021 Global hyperactivation of enhancers stabilizes human and mouse naïve pluripotency through inhibition of CDK8/19 Mediator kinases. research@ua vol. 11 report 2020
2020 INNOVATION: Investigating long non-coding RNA regulated pathways driving cardiac regeneration research@ua vol. 10 report 2019

Membro de associação

Nome da associação Tipo de participação
2018 - 2019 EACR (European Association for Cancer Research) membership

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2024 - Atual DCM Commission for Co-operation, Dissemination and Transfer of Knowledge
Membro
 Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022 - Atual iBiMED Scientific Council
Membro
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2022 - Atual Flocy - Flow cytometry facility at iBiMED
Coordenador
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2021 - Atual iBiMED GREENLAB initiative
Coordenador
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2021 - Atual Portuguese Flow Cytometry network – PT-FlowCyt (working group Outreaching)
Coordenador
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2020 - Atual Implementation and participation in the COVID UA diagnostic Task Force (qPCR data analysis and reporting)
Membro
 Universidade de Aveiro Instituto de Biomedicina, Portugal
2022 - 2023 Eco-Escolas para o Ensino Superior, Department of Medical Sciences, UA
Coordenador
 Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2021 - 2021 Election Commission, Department of Medical Sciences, UA
Membro
 Universidade de Aveiro Departamento de Ciências Médicas, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023 - Atual Juri member (surrogate) for the recruitment of 1 laboratory technician under an open-ended employment contract (ref. CND-CTTRI-15-SGRH/2023) Universidade de Aveiro Instituto de Biomedicina, Portugal
2023 - Atual Grants reviewer ITC Conference Grants (CG) and Short-Term Scientific Mission Grant (STSM), COST Action CA19105 Universidade de Aveiro, Portugal
2021 - Atual Jury Solidarity of Stories Ajudaris 2021 (from basic school students) AJUDARIS, CSA-Solidarity Center (IPSS – Private Institution of Social Solidarity), Portugal
2024 - 2024 Jury member (1st alternate member) for the recruitment of 1 Senior Technician (CND-CTTRI-122-SGRH/2024) Universidade de Aveiro Instituto de Biomedicina, Portugal
2024 - 2024 Jury member for the award of 1 research grant (BI) under the Diamond Photonics Platforms for Synaptic Connectivity Assessment in Healthy and Parkinson Disease Neuronal Models project (LCF/PR/HP20/52300001) Universidade de Aveiro Instituto de Biomedicina, Portugal
2023 - 2023 Juri member for the recruitment of 1 technical assistant under an open-ended employment contract (ref. CND-CTTRI-130-SGRH/2022) Universidade de Aveiro Instituto de Biomedicina, Portugal
2023 - 2023 Juri member (surrogate) for the recruitment of 1 higher technician under an open-ended employment contract (ref. CND-CTTRI-229-SGRH/2022) Universidade de Aveiro Instituto de Biomedicina, Portugal
2023 - 2023 Juri member (surrogate) for the evaluation of student applications for the Master's Degree in Medical Imaging Technology, Department of Medical Sciences, University of Aveiro. Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2023 - 2023 Juri member (surrogate) for the evaluation of student applications for the Master's Degree in Molecular Biomedicine, Department of Medical Sciences, University of Aveiro. Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2022 - 2022 Juri member for the recruitment of 6 Research Initiation Scholarship(s) (BII) under the R&D project/unit Verão com Ciência of the UID 4501 Universidade de Aveiro Instituto de Biomedicina, Portugal
2021 - 2021 Juri member for the recruitment of 1 postdoctoral researcher under an unfixed-term contract (ref. iMM/CT/33-2021) Universidade de Aveiro Instituto de Biomedicina, Portugal

Processo legal

Descrição da atividade Caso
2013/12/27 - 2014/08/24 Career break due to pregnancy risk and maternity leave of baby twins according to the Portuguese Legislation with the duration of 7 months and 24 days
2011/05/16 - 2011/11/01 Career break due to medical, maternity leave and breast feeding license according to the Spanish Legislation with the duration of 5 months and 16 days

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2022 - Atual MDPI Metabolites MDPI
2022 - Atual Cardiovascular Biologics and Regenerative Medicine Frontiers in Cardiovascular Medicine
2019 - Atual Elsevier Editorial Systems journal Nutrition, Metabolism & Cardiovascular Diseases. Elsevier
2019 - Atual Elsevier Editorial Systems journal Free Radical Biology & Medicine Elsevier
2019 - Atual MDPI International Journal of Molecular Sciences MDPI
2019 - Atual Cellular Reprogramming, Mary Ann Liebert, Inc., publishers Mary Ann Liebert, Inc., publishers

Tutoria

Tópico Nome do aluno
2023 - Atual Orientation of academic work of 1 Post-Doctoral researcher João Pessoa
2019/09 - Atual UA Mentoring Program 1st year students, Biomedical Sciences Bachelor degree
2024/12 - 2025/05 Laboratory rotation (undergraduate) Gonçalo Pires
2024/07 - 2024/12 Scientific internships for high-school students 4 students
2024/04 - 2024/06 Laboratory rotations (undergraduate) Joana Barrosa, Ana Rita Mendes, Maria Almeida, Carolina Maio, Bárbara and Bruna
2024/05 - 2024/05 Laboratory rotation (graduate) Inês Rios
2024/01 - 2024/04 Research fellows Carlota Marcos, Júlia Silva and Rafaela Dias
2023/03 - 2023/06 Laboratory rotations (undergraduate) Maria Pinheiro, Rute Dionisio, Sofia Xavier
2023/03 - 2023/04 Laboratory rotations (graduate) Inês Loureiro, Eva Feliz and Catarina Gomes
2023/02 - 2023/02 Scientific internships (high-school students) 2 high-school students (10º-12º)
2022/12 - 2022/12 Scientific internships (high-school students) 2 high-school students (10º-12º)
2022 - 2022 Laboratory rotations (graduate) Rafaela Dias, Bárbara Bola
2022 - 2022 Laboratory rotations (undergraduate) Yuliya Kinash, Inês Domingos, Vanessa Araújo
2022 - 2022 Laboratory rotation (graduate) Júlia Silva
2022 - 2022 Estágios Científicos da Associação Nacional de Estudantes de Medicina (ANEM) Marta Serra
2019 - 2020 Laboratory rotation (undergraduate) Alexandra Santos, Claudia Martins, Vladimir Ghilas, Diana Sousa
2019/09 - 2019/12 Erasmus Student Mobility traineeship (graduate) Augustina Miselkaite
2014 - 2018 Mentor in the Science Educational Program “Educaçao pela Ciência”, GAPIC, FMUL Mafalda Teixeira, Beatriz Morgado, Inês Hartley, Madalena Correira
2016 - 2017 Laboratory internship, oncobiology subject (undergraduate) Diogo Lopes, Filipe da Silva Pereira, Ana Catarina Bravo
2016/07 - 2016/07 Laboratory internship (undergraduate) Inês Hartley
2016 - 2016 Laboratory internship (graduate) Rafael Carecho
Distinções

Prémio

2023 3rd prize of best scientific picture in the photography exposition "O Cancro visto ao Microscópio", Fábrica da Ciência Viva, Aveiro
Universidade de Aveiro, Portugal
2022 Best Poster Award at Dia dos Mestrados, DCM/UA (supervisor)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 Best Short Talk Award
2nd FEBS Advanced Lecture Course on Oncometabolism, Portugal
2013 Post-doctoral fellowship FCT
Fundação para a Ciência e a Tecnologia, Portugal
2011 Post-doctoral fellowship AECC
Spanish Association Against Cancer Scientific Foundation, Espanha
2009 Post-doctoral fellowship Caja Navarra-CNIO
Centro Nacional de Investigaciones Oncológicas, Espanha
2007 Research fellowship CSIC
Consejo Superior de Investigaciones Científicas, Espanha
2003 Doctoral fellowship FCT
Fundação para a Ciência e a Tecnologia, Portugal
2002 Fellowship for undergraduate students undertaken an internship in industry
Leonardo da Vinci Community , Portugal
2002 PRODEP fellowship for undergraduate students