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Alexandra Teixeira graduated in Biology-Geology in 2016 and obtained her Master's degree in Health Sciences in 2018, at the Faculty of Medicine - University of Minho. Her master thesis was entitled "Crosstalk between glutaminolysis and autophagy in AML cells" where she mainly focused on the study of the metabolism of AML cell lines (glutaminolysis). In 2018-2020 she worked at INL, as a research associate, with her main research activities in the IMPAct-L project, funded by FCT. This project consisted of combination of different technologies, like Microfluidics, NGS and SERS, for the development of a microfluidic chip for isolation and concentration of AML blasts and respective molecular analyses. In addition, during this period at INL she has been involved in several other projects in different areas, where she explored different techniques and tools, as can be observed in the different publications in which Alexandra Teixeira is co-author. She is currently a FCT scholarship holder as a PhD student at the Faculty of Medicine - University of Minho and is developing her PhD thesis between INL, ICVS (Portugal) and CINBIO (Spain).
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Identificação

Identificação pessoal

Nome completo
Alexandra Catarina Pereira Teixeira

Nomes de citação

  • Teixeira, Alexandra

Identificadores de autor

Ciência ID
B61E-64B9-9605
ORCID iD
0000-0002-5685-625X

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências Médicas e da Saúde - Ciências da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2020/04/01 - 2024/04/01
Concluído
 PhD in Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal

Universidade de Vigo Centro de Investigaciones Biomédicas, Espanha

International Iberian Nanotechnology Laboratory, Portugal
2018
Concluído
 Mestrado em Ciências da Saúde (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"Crosstalk between glutaminolysis and autophagy in AML cells" (TESE/DISSERTAÇÃO)
 17
2016
Concluído
 Biologia-Geologia (Licenciatura)
Universidade do Minho, Portugal
"N/A" (TESE/DISSERTAÇÃO)
 13
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/03/16 - Atual Pós-doutorado (Investigação) International Iberian Nanotechnology Laboratory, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/04/01 - 2024/04/01 PhD student Universidade do Minho Escola de Medicina, Portugal
International Iberian Nanotechnology Laboratory, Portugal
2018/08/01 - 2020/03/31 Research Assistant in a Fellowship (IMPAct-L - POCI-01-0145-FEDER-030782 (c)) International Iberian Nanotechnology Laboratory, Portugal
2016/09/01 - 2019/07/02 Student of Master in Health Sciences Universidade do Minho, Portugal
2013/10/02 - 2016/07/07 Student of Bachelor in Biology and Geology Universidade do Minho, Portugal
Projetos

Projeto

Designação Financiadores
2018/08/01 - 2020/03/31 IMPAct-L - Innovative Microfluidic Platform for Analysis of myeloid Leukemia blasts
POCI-01-0145-FEDER-030782
Bolseiro de Investigação
Em curso
Produções

Publicações

Artigo em revista
  1. António J. N. Oliveira; Jennifer P. Teixeira; Maria S. Relvas; Alexandra Teixeira; André F. Violas; Kevin Oliveira; Sara Abalde-Cela; et al. "Development of a Plasmonic Light Management Architecture Integrated within an Interface Passivation Scheme for Ultrathin Solar Cells". Solar RRL (2024): https://doi.org/10.1002/solr.202400147.
    10.1002/solr.202400147
  2. Ahmed Y.F. Mahmoud; Alexandra Teixeira; Marta Aranda; Maria S. Relvas; Sergio Quintero; Maria Sousa-Silva; Alexandre Chícharo; et al. "Will data analytics revolution finally bring SERS to the clinic?". TrAC Trends in Analytical Chemistry (2023): https://doi.org/10.1016/j.trac.2023.117311.
    10.1016/j.trac.2023.117311
  3. Alexandra Teixeira; Luís Carreira; Sara Abalde-Cela; Belém Sampaio-Marques; Anabela C. Areias; Paula Ludovico; Lorena Diéguez. "Current and Emerging Techniques for Diagnosis and MRD Detection in AML: A Comprehensive Narrative Review". Cancers (2023): https://doi.org/10.3390/cancers15051362.
    10.3390/cancers15051362
  4. Carneiro, Adriana; Piairo, Paulina; Teixeira, Alexandra; Ferreira, Dylan; Cotton, Sofia; Rodrigues, Carolina; Chícharo, Alexandre; et al. "Discriminating Epithelial to Mesenchymal Transition Phenotypes in Circulating Tumor Cells Isolated from Advanced Gastrointestinal Cancer Patients". Cells 11 3 (2022): 376. http://dx.doi.org/10.3390/cells11030376.
    Publicado • 10.3390/cells11030376
  5. Abalde-Cela, Sara; Wu, Lei; Teixeira, Alexandra; Oliveira, Kevin; Diéguez, Lorena. "Multiplexing Liquid Biopsy with Surface-Enhanced Raman Scattering Spectroscopy". Advanced Optical Materials 9 15 (2021): 2001171. http://dx.doi.org/10.1002/adom.202001171.
    10.1002/adom.202001171
  6. "Use of cost-effective technologies for a routine clinical pathology laboratory". Lab on a Chip (2021): http://dx.doi.org/10.1039/d1lc00658d.
    10.1039/d1lc00658d
  7. Teixeira, Alexandra. "Profiling DNA mutation patterns by SERS fingerprinting for supervised cancer classification". Biosensors and Bioelectronics (2020): http://dx.doi.org/10.1016/j.bios.2020.112392.
    10.1016/j.bios.2020.112392
  8. Juan L. Paris; Filipe Coelho; Alexandra Teixeira; L. Diéguez; Bruno Silva; Sara Abalde-Cela. "In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture". Molecules (2020): https://www.mdpi.com/1420-3049/25/14/3277.
    10.3390/molecules25143277
  9. Teixeira, Alexandra; Paris, Juan L.; Roumani, Foteini; Diéguez, Lorena; Prado, Marta; Espiña, Begoña; Abalde-Cela, Sara; Garrido-Maestu, Alejandro; Rodriguez-Lorenzo, Laura. "Multifuntional Gold Nanoparticles for the SERS Detection of Pathogens Combined with a LAMP–in–Microdroplets Approach". Materials 13 8 (2020): 1934. http://dx.doi.org/10.3390/ma13081934.
    10.3390/ma13081934
  10. Teixeira, Alexandra; Hernández-Rodríguez, Juan; Wu, Lei; Oliveira, Kevin; Kant, Krishna; Piairo, Paulina; Diéguez, Lorena; Abalde-Cela, Sara. "Microfluidics-Driven Fabrication of a Low Cost and Ultrasensitive SERS-Based Paper Biosensor". Applied Sciences 9 7 (2019): 1387. http://dx.doi.org/10.3390/app9071387.
    10.3390/app9071387
  11. Sampaio-Marques, Belém; Pereira, Hélder; Santos, Ana R.; Teixeira, Alexandra; Ludovico, Paula. "Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis". Aging 10 12 (2018): 3821-3833. http://dx.doi.org/10.18632/aging.101675.
    10.18632/aging.101675
  12. Pereira, Olga; Teixeira, Alexandra; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; Ludovico, Paula. "Signalling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukaemia cells". Journal of Cellular and Molecular Medicine 22 10 (2018): 4807-4817. http://dx.doi.org/10.1111/jcmm.13737.
    10.1111/jcmm.13737
Poster em conferência
  1. Carneiro, Adriana; Piairo, Paulina; Teixeira, Alexandra; Ferreira, Dylan; Cotton, Sofia; Rodrigues, Carolina; Chícharo, Alexandre; et al. "Microfluidic-based Isolation of Circulating Tumour Cells in Gastrointestinal Cancers". Trabalho apresentado em VII Liquid Biopsy Symposium, 2022.
  2. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, B; et al. ". Isolation and concentration of acute myeloid leukemia blasts in measurable residual disease using a microfluidic system". Trabalho apresentado em NanoPT2021 (online), 2021.
  3. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, B; et al. "Detecção não invasiva de doença residual mínima em leucemia mielóide aguda usando um sistema de microfluídica para o isolamento e concentração de blastos leucémicos em sangue periférico ou em médula óssea". Trabalho apresentado em 3º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2021.
  4. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, B; et al. "Isolation of Acute Myeloid Leukemia Blasts Using a Microfluidic System for Accurate Assessment of Minimal Residual Disease". Trabalho apresentado em EuroNanoForum (online), 2021.
  5. Carneiro, Adriana; Piairo, Paulina; Teixeira, Alexandra; Ferreira, Dylan; Cotton, Sofia; Rodrigues, Carolina; Chícharo, Alexandre; et al. "Microfluidic-based Isolation of Gastrointestinal Circulating Tumour Cells". Trabalho apresentado em EuroNanoForum (online), 2021.
  6. Rodrigues, Carolina; Teixeira, Alexandra; Carneiro, Adriana; Piairo, Paulina; Abalde-Cela, Sara; Diéguez, Lorena. "A Modular Microfluidic Device for the Isolation, Recovery, Encapsulation and Sorting of Circulating Tumour Cells". Trabalho apresentado em 4th PortASAP Meeting (Online), 2021.
  7. Tvarijonaviciute, Asta ; Anfossi, Laura ; di Nardo, Fabio ; Vázquez, Mercedes; Paesani, Daniele; Karopka, Thomas ; Velotta, Raffaele ; et al. "Use of economic technologies for a routine clinical pathology laboratory". Trabalho apresentado em 4th PortASAP Rome 2021 (online), 2021.
  8. Teixeira, Alexandra; Paris, Juan L.; Roumani, Foteini; Diéguez, Lorena; Prado, Marta; Espiña, Begoña; Abalde-Cela, Sara; Garrido-Maestu, Alejandro; Rodriguez-Lorenzo, Laura. "SERS Detection of Pathogens using a LAMP–in–Microdroplets platform". Trabalho apresentado em Nanobiomed Online Conference (NBMO2020), 2020.
  9. Teixeira, Alexandra; Abalde-Cela, Sara; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, B; LUDOVICO, PAULA; Diéguez, Lorena. "Desenvolvimento de uma plataforma de microfluídica para diagnóstico e monitorização de doença residual mínima em leucemia mielóide aguda". Trabalho apresentado em 2º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2020.
  10. Teixeira, Alexandra; Oliveira, Kevin; Fernandes, José Maria; Lopes, Claudia; Piairo, Paulina; Wu, Lei; Rodriguez-Lorenzo, Laura; Diéguez, Lorena; Abalde-Cela, Sara. "Phenotypic characterisation of single cancer cells in microdroplets". Trabalho apresentado em Webminar: Cancer Biology: From Basic to Translational Research, LPCC, 2020, 2020.
  11. Teixeira, Alexandra; Oliveira, Kevin; Abalde-Cela, Sara; Sampaio-Marques, B; LUDOVICO, PAULA; Diéguez, Lorena. "A microfluidics platform for the SERS-based detection of acute myeloid leukemia". Trabalho apresentado em NanoMed Europe (NME), 2019.
  12. Fernandes, José Maria; Oliveira, Kevin; Teixeira, Alexandra; Lopes, Cláudia; Piairo, Paulina; Abalde-Cela, Sara; Diéguez, Lorena. "Cancer single-cell encapsulation and proliferation monitoring in microdroplets.". Trabalho apresentado em NanoMed Europe (NME), 2019.
  13. Oliveira, Kevin; Teixeira, Alexandra; Lopes, Cláudia; Piairo, Paulina; Abalde-Cela, Sara; Diéguez, Lorena. "Development of a microdroplet-based optofluidics platform for the analysis of single cancer cells.". Trabalho apresentado em NanoMed Europe (NME), 2019.
  14. Abalde-Cela, Sara; Teixeira, Alexandra; Oliveira, Kevin; Fernandes, José Maria; Lopes, Cláudia; Kant, Krishna; Wu, Lei; Piairo, Paulina; Diéguez, Lorena. "Surface-enhanced Raman scattering spectroscopy meets microfluidics: towards sensitive, automated and high-throughput integrated tools for diagnosis". Trabalho apresentado em NanoMed Europe (NME), 2019.
  15. Oliveira, Kevin; Teixeira, Alexandra; Lopes, Claudia; Piairo, Paulina; Abalde-Cela, Sara; Diéguez, Lorena. "SERS phenotyping of single cancer cells in microdroplets". Trabalho apresentado em 3rd Annual Meeting CINBIO, 2019.
  16. Teixeira, Alexandra; Hernández-Rodríguez, Juan; Wu, Lei; Oliveira, Kevin; Kant, Krishna; Piairo, Paulina; Diéguez, Lorena. "Low Cost and Ultrasensitive SERS-Based Paper Biosensor for cell type discrimination". Trabalho apresentado em 6th ISCaM Meeting, 2019.
  17. Wu, Lei; Garrido-Maestu, Alejandro; Teixeira, Alexandra; Guerreiro, Joana R. L.; Carvalho, Sandra; Abalde-Cela, Sara; Prado, Marta; Diéguez, Lorena. "Multiplex DNA mutation analysis with SERS-microfluidic platform". Trabalho apresentado em INL Research Group Symposium, 2019.
  18. Pereira, Olga; Teixeira, Alexandra; Fernandes, Sara; Mesquita, Ângela; Sampaio-Marques, B; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Interplay between energetic metabolism and autophagic regulation in acute myeloid leukemia cells". Trabalho apresentado em 1st Meeting on Vesicular Biology, 2018.
  19. Teixeira, Alexandra; Pereira, Olga; Fernandes, Sara; Sampaio-Marques, B; Castro, Isabel; LUDOVICO, PAULA. "Interplay between glutaminolysis and autophagy in acute myeloid leukemia cells". Trabalho apresentado em 1st Meeting on Vesicular Biology, 2018.
  20. Pereira, Hélder; Teixeira, Alexandra; Sampaio-Marques, B; LUDOVICO, PAULA. "Messenger molecules modulating yeast chronological aging". Trabalho apresentado em International Meeting on Yeast Ageing and apoptosis (IMYA), 2018.
  21. Teixeira, Alexandra; Hernández-Rodríguez, Juan; Costa, Luis; Oliveira, Kevin; Kant, Krishna; Wu, Lei; Abalde-Cela, Sara; Diéguez, Lorena. "Microfluidics for the simple and low-cost fabrication of a SERS-based paper sensor with ultra-detection capability". Trabalho apresentado em NanoGateway project conference called "MISSION 10.000", 2018.
  22. Teixeira, Alexandra; Pereira, Olga; Mesquita, Ângela; Fernandes, Sara; Sampaio-Marques, B; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Glutaminolysis and autophagy interplay in acute myeloid leukemia cells". Trabalho apresentado em ESH 4th International Conference on Acute Myeloid Leukemia “Molecular and Translational”: Advances in Biology and Treatment, 2017.
  23. Pereira, Olga; Teixeira, Alexandra; Fernandes, Sara; Mesquita, Ângela; Sampaio-Marques, B; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Energy metabolism in acute myeloid leukemia cells". Trabalho apresentado em SINAL 2017 - 8th Meeting on Signal Transduction., 2017.
  24. Fernandes, Sara; Pereira, Olga; Teixeira, Alexandra; Mesquita, Ângela; Fernandes, Ângela; Sampaio-Marques, B; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Cell signaling pathways and autophagy regulation in acute myeloid leukemia". Trabalho apresentado em SINAL 2017 - 8th Meeting on Signal Transduction., 2017.
  25. Pereira, Olga; Fernandes, Sara; Teixeira, Alexandra; Mesquita, Ângela; Sampaio-Marques, B; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Metabolic cell signalling pathways and autophagy regulation in acute myeloid leukemia cells". Trabalho apresentado em ESH 4th International Conference on Acute Myeloid Leukemia “Molecular and Translational”: Advances in Biology and Treatment, 2017.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/02 Label-free Microfluidic-based isolation of Circulating Tumor cells from Gastrointestinal Cancer Samples Final PortASAP Meeting
COST Action CA 16215 (Tallinn, Estónia)
2022/02 A microfluidic system for isolation and concentration of blasts and enabling a non-invasive detection of minimal residual disease in acute myeloid leukemia Final Meeting of PortASAP
COST Action CA 16215 (Tallinn, Estónia)
2021/09 Isolamento e Recuperação de Células Tumorais Circulantes utilizando um Sistema de Microfluídica Modular Encontro Nacional de Jovens Investigadores em Oncologia, 2021
Liga Portuguesa Contra o Cancro (Porto, Portugal)
2021/09 Otimização de um dispositivo de microfluidica para o isolamento e enurmeração de células tumorais circulantes em cancro digestivo Encontro Nacional de Jovens Investigadores em Oncologia, 2021
Liga Portuguesa Contra o Cancro (Porto, Portugal)
2021 Surface Enhanced Raman Spectroscopy For Viral-Derived Nucleic Acid Detection. 4th PortASAP Meeting (Online)
PortASAP
2020 SERS and microdroplets for multiplex phenotyping of cancer single cells. Nanobiomed Online Conference (NBMO2020)
2020 A microdroplets-based platform for the phenotypic characterisation of single cancer cells 3rd PortASAP Meeting
PortASAP (Creta, Grécia)
2019 Development of an ultrasensitive and low cost paper-based SERS sensor for cell differentiation. 3rd Annual Meeting CINBIO
CINBIO (Vigo, Espanha)
2017 Glutaminolysis and autophagy interplay in acute myeloid leukemia cells SIGNAL 2017 - 8th Meeting on Signal Transduction
(Lisboa, Portugal)