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Joana Lérias has a background in Veterinary Medicine and a Ph.D. in System’s Biology by the Faculty of Sciences of the University of Lisbon which included 1 year and a half as a visiting Ph.D. student at Regensburg University (Regensburg, Germany). The PhD was focused on the development of new therapies for Cystic fibrosis, namely the study of ion channels that may overcome the channel function deficit associated with such a disease. After completion of the Ph.D., she moved to Prof. Markus Maeurer's laboratory at the Champalimaud Center for the Unknown, the ImmunoSurgery/ImmunoTherapy Laboratory, that is mainly focused on the use of the immune system as a tool for anti-cancer treatments. Indeed, in this laboratory, she gained vast experience in primary cell culture, immunohistology, flow cytometry, microdissections, fluorescence microscopy and several biomolecular techniques. During her career, she also developed strong interpersonal skills and good communication and writing skills, which include several oral and poster presentations, two awards, and eleven scientific publications (nine as the first author). As a PostDoctoral Researcher, she has supervised two students: one of a Laboratorial rotation from the NOVA Biomedical Research Master’s degree for 2 months (January-February 2020) and one Bachelor in Cell and Molecular Biology internship for 3 months (January-March 2020) as the main supervisor.
Identificação

Identificação pessoal

Nome completo
Joana Lerias

Nomes de citação

  • Lerias, Joana
  • Joana R Lérias

Identificadores de autor

Ciência ID
F31D-E19F-8302
ORCID iD
0000-0002-9874-5259

Endereços de correio eletrónico

  • joana.lerias@research.fchampalimaud.org (Profissional)

Moradas

  • Champalimaud Center for the Unknown Avenida Brasília, 1400-038 , 1400-038 , Lisboa, Portugal (Profissional)

Domínios de atuação

  • Ciências Agrárias - Ciências Veterinárias
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Médicas e da Saúde - Medicina Básica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Alemão Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
2018/03/01
Concluído
Biologia (Doutoramento)
Especialização em Especialidade: Biologia de Sistemas
Universidade de Lisboa Faculdade de Ciências, Portugal
"Anoctamin I - A member of a novel family of ion channels with extended functions and significance in disease" (TESE/DISSERTAÇÃO)
Aprovado com distinção
2006/09/15 - 2012/05/10
Concluído
Medicina Veterinária (Mestrado integrado)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
"Expression and characterization of calreticulin gene isolated from Rhipicephalus annulatus after Babesia bigemina infection" (TESE/DISSERTAÇÃO)
15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2018/03/15 - Atual Pós-doutorado (Investigação) Fundação Champalimaud, Portugal
Centro Champalimaud, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2016/06/01 - 2017/09/27 Visiting Phd student Universität Regensburg, Alemanha
Universität Regensburg, Alemanha
Projetos

Bolsa

Designação Financiadores
2014/01/13 - 2018/01/13 Anoctamin 1 - A Member of A Novel Family of Ion Channels with Extended Functions and Significance in Disease
SFRH/BD52489/2014
Bolseiro de Doutoramento
Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/01/01 - 2013/12/31 Lactation and milk production in Goat (Capra hircus): identifying molecular markers underlying adaptation to seasonal weight loss
Bolseiro de Investigação
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. "The polarity and specificity of antiviral T lymphocyte responses determine susceptibility to SARS-CoV-2 infection in cancer patients and healthy individuals". Cancer Discovery (2022):
    Aceite para publicação • 10.1158/2159-8290.CD-21-1441
  2. de Sousa, Eric; Ligeiro, Dário; Joana R Lérias; Zhang, Chao; Chiara Agrati; Osman, Mohamed; El-Kafrawy, Sherif A; et al. "Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants.". Int J Infect Dis 98 (2020): 454-459.
    Publicado • 10.1016/j.ijid.2020.07.016
  3. Lérias, Joana R.; Paraschoudi, Georgia; de Sousa, Eric; Martins, João; Condeço, Carolina; Figueiredo, Nuno; Carvalho, Carlos; et al. "Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies". Frontiers in Cell and Developmental Biology 7 (2020): http://dx.doi.org/10.3389/fcell.2019.00362.
    10.3389/fcell.2019.00362
  4. Lérias, Joana R.; de Sousa, Eric; Paraschoudi, Georgia; Martins, João; Condeço, Carolina; Figueiredo, Nuno; Carvalho, Carlos; et al. "Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future Opportunities". Frontiers in Microbiology 10 (2020): http://dx.doi.org/10.3389/fmicb.2019.02924.
    10.3389/fmicb.2019.02924
  5. Joana R. Lérias; Georgia Paraschoudi; Inês Silva; João Martins; Eric de Sousa; Carolina Condeço; Nuno Figueiredo; et al. "Clinically Relevant Immune Responses against Cytomegalovirus: Implications for Precision Medicine". International Journal of Molecular Sciences 20 8 (2019): 1986-1986. https://doi.org/10.3390/ijms20081986.
    10.3390/ijms20081986
  6. Benedetto, Roberta; Ousingsawat, Jiraporn; Cabrita, Inês; Pinto, Madalena; Lérias, Joana R.; Wanitchakool, Podchanart; Schreiber, Rainer; Kunzelmann, Karl. "Plasma membrane–localized TMEM16 proteins are indispensable for expression of CFTR". Journal of Molecular Medicine 97 5 (2019): 711-722. http://dx.doi.org/10.1007/s00109-019-01770-4.
    10.1007/s00109-019-01770-4
  7. Joana Lérias; Madalena Pinto; Roberta Benedetto; Rainer Schreiber; Margarida Amaral; Massimo Aureli; Karl Kunzelmann. "Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1". Cellular Signalling 44 (2018): 10-19. https://doi.org/10.1016/j.cellsig.2018.01.008.
    10.1016/j.cellsig.2018.01.008
  8. Lérias, Joana R.; Pinto, Madalena C.; Botelho, Hugo M.; Awatade, Nikhil T.; Quaresma, Margarida C.; Silva, Iris A.L.; Wanitchakool, Podchanart; et al. "A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865 2 (2018): 421-431. http://dx.doi.org/10.1016/j.bbamcr.2017.11.009.
    10.1016/j.bbamcr.2017.11.009
  9. Lérias, Joana R.; Kilminster, Tanya; Scanlon, Tim; Milton, John; Oldham, Chris; Greeff, Johan C.; Martins, Luísa L.; Mourato, Miguel P.; Almeida, André M.. "The fat-tail of Damara sheep: an assessment of mineral content as influenced by weight loss". Animal Production Science 56 9 (2016): 1492. http://dx.doi.org/10.1071/an14852.
    10.1071/an14852
  10. Lérias, Joana R; Peña, Raquel; Hernández-Castellano, Lorenzo E; Capote, Juan; Castro, Noemí; Argüello, Anastasio; Araújo, Susana S; et al. "Establishment of the biochemical and endocrine blood profiles in the Majorera and Palmera dairy goat breeds: the effect of feed restriction". Journal of Dairy Research 82 4 (2015): 416-425. http://dx.doi.org/10.1017/s0022029915000412.
    10.1017/s0022029915000412
  11. Antunes, Sandra; Merino, Octávio; Lérias, Joana; Domingues, Nuno; Mosqueda, Juan; de la Fuente, José; Domingos, Ana. "Artificial feeding of Rhipicephalus microplus female ticks with anti calreticulin serum do not influence tick and Babesia bigemina acquisition". Ticks and Tick-borne Diseases 6 1 (2015): 47-55. http://dx.doi.org/10.1016/j.ttbdis.2014.09.003.
    10.1016/j.ttbdis.2014.09.003
  12. Lérias, Joana R; Hernández-Castellano, Lorenzo E; Suárez-Trujillo, Aridany; Castro, Noemí; Pourlis, Aris; Almeida, André M. "The mammary gland in small ruminants: major morphological and functional events underlying milk production – a review". Journal of Dairy Research 81 3 (2014): 304-318. http://dx.doi.org/10.1017/s0022029914000235.
    10.1017/s0022029914000235
  13. Lérias, Joana R.; Hernández-Castellano, Lorenzo E.; Morales-delaNuez, Antonio; Araújo, Susana S.; Castro, Noemí; Argüello, Anastasio; Capote, Juan; Almeida, André M.. "Body live weight and milk production parameters in the Majorera and Palmera goat breeds from the Canary Islands: influence of weight loss". Tropical Animal Health and Production 45 8 (2013): 1731-1736. http://dx.doi.org/10.1007/s11250-013-0423-2.
    10.1007/s11250-013-0423-2
Tese / Dissertação
  1. Lérias, Joana Ramos Rapaz, 1988-. "Anoctamin 1-A member of a novel family of ion channels with extended functions and significance in disease". Doutoramento, 2018. http://hdl.handle.net/10451/35037.
  2. Lérias, Joana Ramos Rapaz. "Expression and characterization of calreticulin gene isolated from Rhipicephalus annulatus after Babesia bigemina infection". Mestrado, 2012. http://hdl.handle.net/10400.5/4420.

Outros

Outra produção
  1. Effect of polyclonal antibodies applied by artificial feeding to Rhipicephalus microplus ticks. Ticks are obligate haematophagous ectoparasites that can transmit a wide variety of pathogens being considered the principal vectors of disease among animals. The piroplasms Babesia bigemina and B. bovis are transmited mainly by Rhipicephalus microplus and R. annulatus ticks. Acaricides are still the most common method of tick control despite the disadvantages presented by them. Anti-tick vaccines. 2018. Antunes, Sandra; Lérias, Joana; Merino, Octávio; do Rosário, Virgílio; de la Fuente, José; Domingos, Ana. http://anaisihmt.com/index.php/ihmt/article/view/191.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/10/28 Changes in TIL recognition caused by Clostridium difficile infection 7th Annual Immunogenomics Conference
Champalimaud Foundation (Lisbon, Portugal)
2018/11/08 Tumor-infiltrating lymphocytes (TIL) for the adoptive treatment of patients with pancreatic cancer 33rd Annual Meeting of the Society for Immunotherapy of Cancer (SITC)
Society for Immunotherapy of Cancer (Washington DC, Estados Unidos)
2017/11/07 Anoctamin 1 - Identification of Novel Traffic Regulators and their significance for Cystic Fibrosis 31st North American Cystic Fibrosis Conference
Cystic Fibrosis Foundation (Indianapolis, Estados Unidos)
2017/09/02 Anoctamin 1 and CFTR relationship with tethering proteins family of extended synaptotagmins CF’s Got Talent
CF Trust (Nottingham, Reino Unido)
2017/06/02 Anoctamin 1 activation is increased by G-protein coupled receptors expression 5th International Symposium of the Collaborative Research Centre Sonderforschungsbereich 699 (Integrative kidney physiology – from molecules to disease)
Regensburg University (Regensburg, Alemanha)
2017/04/03 Anoctamin 1 traffic and function is enhanced by tethering proteins family of extended synaptotagmins 14th ECFS Basic Science Conference
European Cystic Fibrosis Society (Albufeira, Portugal)
2016/04/02 Anoctamin 1 - a member of a novel family of ion channels with extended functions and significance in disease 13th ECFS Basic Science Conference
European Cystic Fibrosis Society (Pisa, Itália)
2014/11/03 First characterization of the goat mammary gland proteome secretory tissue using shotgun proteomics Final Showcase Meeting of Farm Animal Proteomics
Cost Action FA1002 (Milão, Itália)
2014/08/02 Effect of body weight loss in biochemical and endocrine blood metabolites of Majorera and Palmera goat breeds from the Canary Islands 1st Dairycare Conference: Health and Welfare of Dairy Animals
Dairy Cost Action (Copenhaga, Dinamarca)
2014/04/02 An assessment of selected biochemical and endocrine parameters of Majorera and Palmera goats from the Canary Islands subjected to weight loss VI Congress of the Portuguese Society of Veterinary Sciences
Portuguese Society of Veterinary Sciences (Oeiras, Portugal)
2013/04/03 Seasonal weight loss in dairy goats from the Canary Islands: towards an integrated omics approach? 3rd Meeting of COST Action FA-1002 Farm Animal Proteomics
COST Action FA1002 (Kosice, Eslováquia)
2013/04/03 Seasonal Weight Loss in dairy goats from the Canary Islands: assessment of production losses BSAS Annual Meeting 2013
British Society of Animal Science (Nottingham, Reino Unido)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2020/01/06 - 2020/06/23 Individualized expansion of T-cells from patients with epithelial cancer
Orientador
Licenciatura em Biologia Celular e Molecular (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/01/01 - 2020/03/01 The use of IL-6 and IL-17 as novel biomarkers to predict complication after colorectal surgery
Orientador
Investigação Biomédica (Outra)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2019/11/28 - 2019/11/30 7th Annual Immunogenomics Conference
Conferência
7th Annual Immunogenomics Conference
HudsonAlpha Institute for Biotechnology, Estados Unidos

Fundação Champalimaud, Portugal
2019/11/14 - 2019/11/15 Meeting of Postdocs from Lisbon Lisbon Area Posdoc Meeting
2019/03/27 - 2019/03/29 Workshop on dentritic cells and their impact in anti-tumoral immunotherapy.
Congresso
5th Workshop on Dentritic Cell Biology: Anti-tumoral immunotherapy, from biology to the clinic
Fundação Champalimaud, Portugal
2018/11/08 - 2018/11/11 33rd Annual Meeting of the Society for Immunotherapy of Cancer (SITC)
Conferência
33rd Annual Meeting of the Society for Immunotherapy of Cancer (SITC)
Society for Immunotherapy of Cancer, Estados Unidos
2017/09/07 - 2017/09/09 UK Cystic Fibrosis Conference
Conferência
UK Cystic Fibrosis Conference
Cystic Fibrosis Trust, Reino Unido
2017/06/04 - 2017/06/07 5th International Symposium of the Collaborative Research Centre
Congresso
5th International Symposium of the Collaborative Research Centre
2017/03/29 - 2017/04/01 14th ECFS Basic Science Conference 14th ECFS Basic Science Conference
European Cystic Fibrosis Society, Dinamarca
2016/03/30 - 2016/04/02 13th ECFS Basic Science Conference
Conferência
13th ECFS Basic Science Conference
European Cystic Fibrosis Society, Dinamarca
2014/08/01 - 2014/08/03 Dairy Care Cost Action FA1308 Conference Dairy Care Cost Action FA1308 Conference
Dairy Care Cost Action, Dinamarca
2014/04/01 - 2014/04/01 VI Congress of the Portuguese Society of Veterinary Sciences
Congresso
VI Congress of the Portuguese Society of Veterinary Sciences
Sociedade Portuguesa de Ciências Veterinárias, Portugal
2013/04/04 - 2013/04/05 Farm Animal Proteomics Conference
Congresso
Farm Animal Proteomics Conference
Dairy Care Cost Action, Dinamarca
Distinções

Prémio

2014 Poster prize 1st award
Dairy Care Cost Action FA1308 , Dinamarca