Daniel Freitas Chavarria (471E-8468-DEF7)

Curriculum Vitae

Daniel Freitas Chavarria

Daniel Chavarria obtained his BSc (2012) and MSc (2014) in Biochemistry from the Faculty of Sciences, University of Porto (FCUP, Portugal), and a PhD in Pharmaceutical Sciences (2020) from the Faculty of Pharmacy, University of Porto (FFUP, Portugal). His PhD was labeled as European Doctorate, and his PhD Thesis received an award of excellence from the Paul Ehrlich MedChem Euro-PhD in Medicinal Chemistry. During his PhD, Daniel developed projects in drug discovery at CIQUP-IMS/FCUP (Portugal) in collaboration with CNC-UC (Portugal) and UCIBIO-REQUIMTE (Portugal). Part of his PhD was performed at USC (Spain) under the supervision of Prof. Eugenio Uriarte. As a post-doc researcher, he also performed 2 secondments: one at Mediagnost GmbH (Germany), funded by project H2020-MSCA-RISE-2016-734719 and supervised by Dr Andrea Normann, and the other at the University of Montpellier (France), funded by project MitoTARGET4AD (2022.15117.CBM) and supervised by Prof Tangui Maurice. Daniel is currently a post-doc researcher at CIQUP-IMS. His current research interests fall within the area of CNS drug discovery. In particular, he aims to develop new drug candidates able to regulate pathophysiological processes associated with neurodegenerative diseases, namely chronic neuroinflammation, oxidative and nitrosative stress, mitochondrial dysfunction, ferroptosis, and neurotransmitter depletion. Daniel Chavarria was the principal investigator (PI) of project NOXIOUS (EXPL/BIA-BQM/0492/2021, 18 months, 50K). This exploratory project, focused on the development of targeted covalent inhibitors to unravel NOX2 crystal structure, counted with the collaboration of Prof. Andrea Mattevi (UniPV, Italy). He is also Co-PI of project DeFend (2022.04633.PTDC, 18 months, 50K), which aims at developing mitochondria-targeted iron chelators to treat Friedreich's Ataxia. Project DeFend is being performed in collaboration with Dr. António Currais (Salk institute, USA). Since the beginning of his scientific career, Daniel authored 28 peer-reviewed scientific publications in international high impact factor journals (12 as first author), some of which were published with collaborations from Italy, Spain, France, and Germany (h index ~11). He attended 18 national and international scientific meetings that resulted in 15 oral communications (6 as first author), 40 conference posters (15 as first author, 2 as last author), 3 conference abstracts, and 4 international scientific awards for best communications. He also attended 3 workshops and 2 training schools within the area of drug discovery and was actively involved in the organization of 4 international science dissemination activities (scientific meetings, workshops) and one course in Medicinal Chemistry. He was integrated in 14 research projects from national (FCT, NORTE2020) and European (FEDER) agencies. He is/was also the reviewer of research manuscripts (e.g.: RSC Medicinal Chemistry, Scientific Reports, Expert Opinion on Drug Discovery) and the guest editor of 2 special issues (Molecules). Finally, in addition to research, Daniel Chavarria is involved in teaching activities at FCUP, supervision/tutoring of national PhD (2), MSc (3) and BSc students (5), BSc/MSC fellows (2), mentoring of international Post-doc reserachers (1), PhD (1) and MSc students (2), and in public exams of students (6).

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Identificação

Identificação pessoal

Nome completo: Daniel Freitas Chavarria

Nomes de citação

Chavarria, Daniel

Identificadores de autor

Ciência ID: 471E-8468-DEF7
ORCID iD: 0000-0002-7010-9808
Scopus Author Id: 57189521654

Endereços de correio eletrónico

danielfchavarria@gmail.com (Profissional)
daniel.chavarria@fc.up.pt (Profissional)

Moradas

Rua do Campo Alegre, s/n, 4169-007, Porto, Porto, Portugal (Profissional)

Websites

https://drugdiscoveryup.pt/ (Profissional)
https://www.researchgate.net/profile/Daniel-Chavarria-4 (Rede social)
https://www.scopus.com/authid/detail.uri?authorId=57189521654 (Profissional)

Domínios de atuação

Ciências Exatas - Química - Química Orgânica
Ciências Médicas e da Saúde - Medicina Básica - Química Médica
Ciências Médicas e da Saúde - Medicina Básica - Toxicologia
Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)

Formação

	Grau	Classificação
2015/09 - 2020/01/17 Concluído	PhD in Pharmaceutical Sciences (Doutoramento) Especialização em Toxicology Universidade do Porto Faculdade de Farmácia, Portugal "Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders" (TESE/DISSERTAÇÃO)	Approved
2018/12/05 - 2018/12/07 Concluído	3rd MuTaLig Training School "CA15135 multi-targeting Biophysical Training School" (Outros) Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie IME Bereich Translationale Medizin Aussenstelle ScreeningPort, Alemanha
2017/05/02 - 2017/05/06 Concluído	37th Edition of the European School of Medicinal Chemistry (ESMEC) (Outros) Università degli Studi di Urbino Carlo Bo Dipartimento di Scienze Biomolecolari, Itália
2012/09 - 2014/09 Concluído	Biochemistry (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Desenvolvimento de Novos Antioxidantes Lipofílicos como Solução Terapêutica para Doenças Neurodegenerativas" (TESE/DISSERTAÇÃO)	18
2009/09 - 2012/09 Concluído	Biochemistry (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Synthesis of chromone amides: a contribution for the development of monoamine oxidase B (MAO-B) inhibitors" (TESE/DISSERTAÇÃO)	16

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2020/03/16 - Atual	Investigador Contratado (Investigação)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2023/11/19 - 2023/12/03	Investigador visitante (Investigação)	Université de Montpellier, França

2022/04/01 - 2022/04/30	Investigador visitante (Investigação)	Universidade do Porto Faculdade de Ciências, Portugal
	Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH, Alemanha
2018/07/02 - 2019/06/04	Investigador visitante (Investigação)	Universidade de Santiago de Compostela, Espanha

2011/10 - 2012/06	Estagiário de Investigação (Investigação)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2015/09 - 2020/01/17	PhD student, FCT Grant SFRH/BD/108119/2015	Universidade do Porto Faculdade de Farmácia, Portugal

2015/03/01 - 2015/06/30	Research Grant, Project "Development of Functional Materials"	Universidade do Porto Centro de Investigação em Química, Portugal

Projetos

Projeto

	Designação	Financiadores
2021/01/01 - Atual	Plurianual Funding of the Associated Laboratory Institute of Molecular Sciences LA/P/0056/2020 Investigador Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2024 - 2027	IMPULSE: IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN 101132028 Investigador	European Commission
2023/03/01 - 2025/02/28	MitoTARGET4AD: Improving Nature for a Novel Disruptive Treatment for Alzheimer's Disease 2022.15117.CBM Investigador Universidade do Porto Faculdade de Ciências, Portugal Université de Montpellier, França	Fundação para a Ciência e a Tecnologia
2023/01 - 2024/06	DeFend: De-ironing Friedreich's Ataxia with innovative mitochondria-targeted chelators 2022.04633.PTDC 2022.04633.PTDC Co-Investigador Responsável (Co-IR) Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2020/01/01 - 2023/12/31	CIQUP - Financiamento Plurianual da Unidade de I&D CIQUP - Centro de Investigação em Química da Universidade do Porto UIDB/00081/2020 Investigador Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia
2022/02/01 - 2023/07/31	NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure EXPL/BIA-BQM/0492/2021 Investigador responsável Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2022/07/01 - 2023/06/30	MitoBOOST v2.0 - A Proof of Concept for the Use of Mitochondria-Targeted Polyphenols to Treat Non-Alcoholic Fatty Liver Disease CENTRO-01-0145-FEDER-181226 Investigador Universidade de Coimbra, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Agência para a Competitividade e Inovação IP Concluído
2021/06/01 - 2023/05/31	PT-OPENSCREEN - NORTE-01-0145-FEDER-085468: Infraestrutura Nacional para a Química Biológica e Genética NORTE-01-0145-FEDER-085468 Investigador Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal Universidade do Minho, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Em curso
2018/07/26 - 2022/07/25	ABFISH: Development of new antibiotics for aquaculture POCI-01-0145-FEDER-028397 Investigador Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/07/26 - 2020/01/17	COMT4brain: Development of centrally-active and safe catechol O-methyltransferase inhibitors POCI-01-0145-FEDER-029164 Bolseiro de Doutoramento Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/07/26 - 2020/01/17	SkinShield - Redox-active phytochemicals triggering mitochondrial hormesis: developing a new generation of cosmetic active ingredients PTDC/BIA-MOL/28607/2017 POCI-01-0145-FEDER-02860 Bolseiro de Doutoramento Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/04/01 - 2019/09/30	MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria PTDC/DTP-FTO/2433/2014 Bolseiro de Doutoramento Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/06/01 - 2019/05/31	SAM: Sustainable Advanced Materials (SAM) Norte-01-0145-FEDER-000028 Bolseiro de Doutoramento	Fundação para a Ciência e a Tecnologia Concluído
2015/09/01 - 2018/02/28	TOX-OER - Learning Toxicology through Open Educational Resources 2015-1-ES01-KA203-015957 Colaboration Universidade do Porto Faculdade de Farmácia, Portugal	Erasmus Plus Concluído
2015/03/01 - 2015/06/30	Development of Functional Materials NORTE-07-0124-FEDER-000065 Bolseiro de Mestrado Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista	Amorim, Ricardo; Chavarria, Daniel; Soares, Pedro; Benfeito, Sofia; Cagide, Fernando; Teixeira, José; Oliveira, Paulo; Borges, Fernanda. "Decreasing the Burden of Non-Alcoholic Fatty Liver Disease: from Therapeutic Targets to Drug Discovery Opportunities". European Journal of Medicinal Chemistry (2024): Submetido Gil-Martins, Eva; Cagide-Fagín, Fernando; Martins, Daniel; Borer, Ana; Barbosa, Daniel José; Fernandes, Carlos; Chavarria, Daniel; et al. Autor correspondente: Silva, Renata. "Mechanistic Insights into the Neurotoxicity of 2,5-Dimethoxyphenethylamines (2C) and Corresponding N-(2-methoxybenzyl)phenethylamine (NBOMe) Drugs". Journal of Xenobiotics 14 2 (2024): 772-797. http://dx.doi.org/10.3390/jox14020044. 10.3390/jox14020044 Sequeira, Lisa; Benfeito, Sofia; Fernandes, Carlos; Gaspar, Alexandra; Lima, Inês; Peixoto, Joana; Alves, Catarina; et al. Autor correspondente: Chavarria, Daniel. "Drug development for Alzheimer’s and Parkinson’s disease: where do we go now?". Pharmaceutics 16 6 (2024): 708. Publicado • 10.20944/preprints202404.0437.v1 Albertini, Claudia; Petralla, Sabrina; Massenzio, Francesca; Monti, Barbara; Rizzardi, Nicola; Bergamini, Christian; Uliassi, Elisa; et al. "Targeting Lewy body dementia with neflamapimod-rasagiline hybrids". Archiv der Pharmazie 2024 (2024): e2300525. http://dx.doi.org/10.1002/ardp.202300525. Publicado • 10.1002/ardp.202300525 Giovannuzzi, Simone; Chavarria, Daniel; Provensi, Gustavo; Leri, Manuela; Bucciantini, Monica; Carradori, Simone; Bonardi, Alessandro; et al. "Dual inhibitors of brain carbonic anhydrases and monoamine oxidase B efficiently protect against amyloid-ß-induced neuronal toxicity, oxidative stress and mitochondrial dysfunction". Journal of Medicinal Chemistry (2024): Publicado • 10.1021/acs.jmedchem.4c00045 Martins, Daniel; Gil-Martins, Eva; Cagide, Fernando; Fonseca, Catarina; Benfeito, Sofia; Fernandes, Carlos; Chavarria, Daniel; et al. "Unraveling the In Vitro Toxicity Profile of Psychedelic 2C Phenethylamines and Their N-Benzylphenethylamine (NBOMe) Analogues". Pharmaceuticals 16 8 (2023): 1158. http://dx.doi.org/10.3390/ph16081158. Publicado • 10.3390/ph16081158 Vicente-Zurdo, David; Brunetti, Leonardo; Piemontese, Luca; Guedes, Beatriz; Cardoso, Sandra M.; Chavarria, Daniel; Borges, Fernanda; et al. "Rivastigmine-benzimidazole Hybrids as Promising Multitarget Metal-modulating Compounds for Potential Treatment of Neurodegenerative Diseases". International Journal of Molecular Sciences 24 9 (2023): 8312. Publicado • 10.3390/ijms24098312 Costa, Inês; Barbosa, Daniel José; Benfeito, Sofia; Silva, Vera; Chavarria, Daniel; Borges, Fernanda; Remião, Fernando; Silva, Renata. "Molecular mechanisms of ferroptosis and their involvement in brain diseases". Pharmacology & Therapeutics 244 (2023): 108373. http://dx.doi.org/10.1016/j.pharmthera.2023.108373. Publicado • 10.1016/j.pharmthera.2023.108373 Chavarria, Daniel; Borges, Anabela; Benfeito, Sofia; Sequeira, Lisa; Ribeiro, Marta; Oliveira, Catarina; Borges, Fernanda; Simões, Manuel; Cagide, Fernando. "Phytochemicals and quaternary phosphonium ionic liquids: connecting the dots to develop a new class of antimicrobial agents". Journal of Advanced Research 54 (2023): 251-279. http://dx.doi.org/10.1016/j.jare.2023.02.004. Publicado • 10.1016/j.jare.2023.02.004 Soares, Pedro; Chavarria, Daniel; Silva, Catia; Silva, Filomena S.G.; Oliveira, Paulo J.; Borges, Fernanda. "Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities". Ageing Research Reviews 83 (2023): 101790. http://dx.doi.org/10.1016/j.arr.2022.101790. 10.1016/j.arr.2022.101790 Benfeito, Sofia; Chavarria, Daniel; Fernandes, Carlos; Barreiro, Sandra; Cagide, Fernando; Sequeira, Lisa; Teixeira, José; et al. "Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks". Journal of Medicinal Chemistry 66 3 (2023): 1835-1851. http://dx.doi.org/10.1021/acs.jmedchem.2c01630. 10.1021/acs.jmedchem.2c01630 Chavarria, Daniel; Benfeito, Sofia; Soares, Pedro; Lima, Carla; Garrido, Jorge; Serrão, Paula; Soares-da-Silva, Patrício; et al. Autor correspondente: Borges, Fernanda. "Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor". European Journal of Medicinal Chemistry 243 (2022): 114740. http://dx.doi.org/10.1016/j.ejmech.2022.114740. 10.1016/j.ejmech.2022.114740 Albertini, Claudia; Salerno, Alessandra; Atzeni, Silvia; Uliassi, Elisa; Massenzio, Francesca; Maruca, Annalisa; Rocca, Roberta; et al. "Riluzole-Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis". ACS Chemical Neuroscience (2022): http://dx.doi.org/10.1021/acschemneuro.2c00261. 10.1021/acschemneuro.2c00261 Catalano, Raffaella; Procopio, Francesca; Chavarria, Daniel; Benfeito, Sofia; Alcaro, Stefano; Borges, Fernanda; Ortuso, Francesco. "Molecular Modeling and Experimental Evaluation of Non-Chiral Components of Bergamot Essential Oil with Inhibitory Activity against Human Monoamine Oxidases". Molecules 27 8 (2022): 2467. http://dx.doi.org/10.3390/molecules27082467. 10.3390/molecules27082467 Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Maruca, Annalisa; Rocca, Roberta; Gil Martins, Eva; Barreiro, Sandra; et al. "Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Quid Est Veritas?". Journal of Medicinal Chemistry 64 15 (2021): 11169-11182. http://dx.doi.org/10.1021/acs.jmedchem.1c00510. 10.1021/acs.jmedchem.1c00510 Chavarria, Daniel; Da Silva, Ophelie Da; Benfeito, Sofia; Barreiro, Sandra; Garrido, Jorge; Cagide, Fernando; Soares, Pedro; et al. "Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases". Antioxidants 10 2 (2021): 329. http://dx.doi.org/10.3390/antiox10020329. 10.3390/antiox10020329 Chavarria, Daniel; Fernandes, Carlos; Aguiar, Brandon; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Oliveira, Paulo J.; Uriarte, Eugenio; Borges, Fernanda. "Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues". Molecules 24 23 (2019): 4405. http://dx.doi.org/10.3390/molecules24234405. Acesso aberto • Publicado • 10.3390/molecules24234405 Mesiti, Francesco; Chavarria, Daniel; Gaspar, Alexandra; Alcaro, Stefano; Borges, Fernanda. "The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease". European Journal of Medicinal Chemistry 181 (2019): 111572. http://dx.doi.org/10.1016/j.ejmech.2019.111572. Publicado • 10.1016/j.ejmech.2019.111572 Chavarria, Daniel; Fernandes, Carlos; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Oliveira, Paulo J.; Borges, Fernanda. "Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid". Organic & Biomolecular Chemistry 17 44 (2019): 9646-9654. http://dx.doi.org/10.1039/c9ob01875a. Publicado • 10.1039/c9ob01875a Teixeira, José; Chavarria, Daniel; Borges, Fernanda; Wojtczak, Lech; Wieckowski, Mariusz R.; Karkucinska-Wieckowska, Agnieszka; Oliveira, Paulo J.. "Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease". Current Medicinal Chemistry 26 19 (2019): 3376-3406. http://dx.doi.org/10.2174/0929867324666170529101810. Publicado • 10.2174/0929867324666170529101810 Chavarria, Daniel; Cagide, Fernando; Pinto, Miguel; Gomes, Lígia R.; Low, John N.; Borges, Fernanda. "Development of piperic acid-based monoamine oxidase inhibitors: Synthesis, structural characterization and biological evaluation". Journal of Molecular Structure 1182 (2019): 298-307. http://dx.doi.org/10.1016/j.molstruc.2019.01.060. Publicado • 10.1016/j.molstrue.2010.01.060 Chavarria, D; Fernandes, C; Silva, V; Silva, C; Gil Martins, E; Soares, P; Silva, T; et al. "Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies". European Journal of Medicinal Chemistry (2019): 10.1016/j.ejmech.2019.111770 Garrido, E. Manuela P.J.; Cerqueira, Ana S.; Chavarria, Daniel; Silva, Tiago; Borges, Fernanda; Garrido, Jorge M.P.J.. "Microencapsulation of caffeic acid phenethyl ester and caffeic acid phenethyl amide by inclusion in hydroxypropyl-ß-cyclodextrin". Food Chemistry 254 (2018): 260-265. http://dx.doi.org/10.1016/j.foodchem.2018.02.007. 10.1016/j.foodchem.2018.02.007 Reis, Joana; Cagide, Fernando; Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Gaspar, Alexandra; Uriarte, Eugenio; et al. "Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors". Journal of Medicinal Chemistry 59 12 (2016): 5879-5893. http://dx.doi.org/10.1021/acs.jmedchem.6b00527. Publicado • 10.1021/acs.jmedchem.6b00527 Chavarria, Daniel. "Discovery of the first A1 adenosine receptor ligand based on chromone scaffold". RSC Advances (2016): 10.1039/c6ra02347a Chavarria, Daniel; Silva, Tiago; Magalhães e Silva, Diogo; Remião, Fernando; Borges, Fernanda. "Lessons from black pepper: piperine and derivatives thereof". Expert Opinion on Therapeutic Patents 26 2 (2015): 245-264. http://dx.doi.org/10.1517/13543776.2016.1118057. Publicado • 10.1517/13543776.2016.1118057 Cagide, F; Gaspar, A; Reis, J; Chavarria, Daniel; Vilar, S; Hripcsak, G; Uriarte, E; et al. "Navigating in chromone chemical space: discovery of novel and distinct A3 adenosine receptor ligands". RSC Advances (2015): 10.1039/C5RA14988F Gomes, Ligia R.; Low, John Nicolson; Cagide, Fernando; Chavarria, Daniel; Borges, Fernanda. "New insights in the discovery of novel h-MAO-B inhibitors: structural characterization of a series of N-phenyl-4-oxo-4H-chromene-3-carboxamide derivatives". Acta Crystallographica Section E 71 5 (2015): 547-554. http://dx.doi.org/10.1107/s2056989015007859. Publicado • 10.1107/S2056989015007859 Chavarria, Daniel; Silva, Tiago; Martins, Daniel; Bravo, Joana; Summavielle, Teresa; Garrido, Jorge; Borges, Fernanda. "Exploring the cinnamic acid scaffold: development of promising neuroprotective lipophilic antioxidants". MedChemComm 6 6 (2015): 1043-1053. http://dx.doi.org/10.1039/c5md00018a. Publicado • 10.1039/C5MD00018A Soares, Pedro; Fernandes, Carlos; Chavarria, Daniel; Borges, Fernanda. "Microwave-Assisted Synthesis of 5-Phenyl-2-hydroxyacetophenone Derivatives by a Green Suzuki Coupling Reaction". Journal of Chemical Education 92 3 (2014): 575-578. http://dx.doi.org/10.1021/ed400498w. 10.1021/ed400498w
Capítulo de livro	Tiago Silva; Chavarria, Daniel; Lisa Sequeira; Maria Fernanda Martins Borges. "Recycling vanillin into ferulic acid-based antioxidants". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. Reino Unido: Royal Society of Chemistry, 2015. Publicado
Poster em conferência	Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Recent Advances in the Discovery of Isoform-Selective NOX Inhibitors". Trabalho apresentado em Encontro Ciência 2024, 2024. Lima, Carla; Soares, Letícia; Alves, Catarina; Chavarria, Daniel; Sequeira, Lisa; Cagide, Fernando; Borges, Fernanda; Benfeito, Sofia. "Getting around on Friedrich ataxia: development of new mitochondriotropic strategies". Trabalho apresentado em Encontro Ciência 2024, 2024. Lima, Carla; Alves, Catarina; Chavarria, Daniel; Sequeira, Lisa; Cagide, Fernando; Borges, Fernanda; Benfeito, Sofia. "De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators". Trabalho apresentado em XIII Meeting Paul Ehrlich Euro-PhD Network & COST ACTION, 2024. Ceramella, Jessica; Iacopetta, Domenico; Mariconda, Annaluisa; D'amato, Assunta; Chavarria, Daniel; Procopio, Francesca; Ortuso, Francesco; et al. "New Au and Ag NHC complexes with N-Boc-protected proline as promising candidates for neurodegenerative diseases". Trabalho apresentado em XIII Meeting Paul Ehrlich Euro-PhD Network & COST ACTION, 2024. Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Insights into the development of isoform-selective, non-interfering NOX inhibitors". Trabalho apresentado em XIII Meeting Paul Ehrlich Euro-PhD Network & COST ACTION, 2024. Dias, Inês; Bon, Leo; Chavarria, Daniel; Borges, Fernanda; Chaves, Sílvia; Santos, Maria Amélia. "Exploring rivastigmine-indole hybrids with anti-neurodegenerative multitarget ability: biometal modulation and MAO inhibition". Trabalho apresentado em CQE Days 2024, 2024. Lima, Inês; Castelôa, Mariana; Chavarria, Daniel; Conde, Carlos; Pombinho, António; Borges, Fernanda. "High throughput screening of heterocyclic compounds to identify new spindle assembly checkpoint inhibitors". Trabalho apresentado em IJUP - Investigação Jovem da Universidade do Porto (17ª edição), 2024. Soares, Letícia; Lima, Carla; Chavarria, Daniel; Sequeira, Lisa; Alves, Catarina; Borges, Fernanda; Benfeito, Sofia. "Development of new iron chelators targeting mitochondia with potential application in Friedreich ataxia". Trabalho apresentado em IJUP - Investigação Jovem da Universidade do Porto (17ª edição), 2024. Dias, Inês; Bon, Leo; Emmanuel, Marlene; Vogt, Paul; Chavarria, Daniel; Borges, Fernanda; Guerreiro-Oliveira, Catarina; et al. "Novel Rivastigmine derivatives as promising multi-target compounds for potential treatment of Alzheimer's disease". Trabalho apresentado em AD/PD 2024 - International Conference on Alzheimer's and Parkinson's Diseases and related Neurological Disorders, 2024. Chavarria, Daniel; Barreiro, Sandra; Aguiar, Brandon; Carneiro, Aitor; Crucitti, David; Borges, Fernanda; Matos, Maria João. "Evaluation of Physicochemical features and biological activity of propargylamine-containing compounds for Parkinson's disease". Trabalho apresentado em International Symposium on Advances in Synthetic and Medicinal Chemistry, Zagreb, Croatia, 2023. Castelôa, Mariana; Lima, Carla; Benfeito, Sofia; Aguiar, Brandon; Soares, Pedro; Borges, Fernanda; Chavarria, Daniel. "Fine-tuning the reactivity and drug-like profile of potential covalent NOX2 inhibitors". Trabalho apresentado em XII Meeting of the Paul Ehrlich Euro-PhD Network, Thessaloniki, Greece, 2023. Raffellini, Lorenzo; Chavarria, Daniel; Cirone, Italo; Borges, Fernanda; Manera, Clementina; Rapposelli, Simona. "Synthesis and evaluation of novel neuroprotective multitarget compounds based on urolithin scaffold". Trabalho apresentado em XII Meeting of the Paul Ehrlich Euro-PhD Network, Thessaloniki, Greece, 2023. Barreiro, Sandra; Benfeito, Sofia; Fernandes, Carlos; Chavarria, Daniel; Cagide, Fernando; Sequeira, Lisa; Teixeira, José; et al. "Nitrogen-based cationic carriers as a game changer in the development of mitochondriotropic antioxidants". Trabalho apresentado em MitoPorto - Mitochondrial physiology, redox biology, and genetics, 2023. Albuquerque, Bárbara; Benfeito, Sofia; Chavarria, Daniel; Serrão, Paula; Borges, Fernanda; Soares-da-Silva, Patrício. "Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors". Trabalho apresentado em XVI Encontro de Jovens Investigadores da UP (IJUP), 2023. Silva, Vera; Benfeito, Sofia; Lima, Carla; Chavarria, Daniel; Gonçalves, Tiago; Costa, Inês; Remião, Fernando; Borges, Fernanda; Silva, Renata. "3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson's disease". Trabalho apresentado em II TOXRUN International Congress 2023, 2023. Castelôa, Mariana; Soares, Pedro; Benfeito, Sofia; Lima, Carla; Borges, Fernanda; Chavarria, Daniel. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, 2022. Benfeito, Sofia; Fernandes, Carlos; Chavarria, Daniel; Barreiro, Sandra; Cagide, Fernando; Silva, Catia; Teixeira, José; et al. "Synthesis and in vitro evaluation of versatile cell-penetrating mitochondriotropic antioxidants". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, 2022. Procopio, Francesca; Catalano, Raffaella; Chavarria, Daniel; Benfeito, Sofia; Alcaro, Stefano; Borges, Fernanda; Ortuso, Francesco. "Non-Chiral Components of Bergamot Essential Oil: Identification of a Novel, Selective Human Monoamine Oxidase B Inhibitor". Trabalho apresentado em X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Silva, Vera; Benfeito, Sofia; Costa, Inês; Lima, Carla; Chavarria, Daniel; Remião, Fernando; Borges, Fernanda; Silva, Renata. "Evaluation of cytotoxic and neuroprotective profile of potential dual-acting ligands for the treatment of Parkinson's disease". Trabalho apresentado em X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Chavarria, Daniel; Borges, Anabela; Benfeito, Sofia; Fernandes, Carlos; Oliveira, Catarina; Ribeiro, Marta; Simões, Manuel; Borges, Fernanda; Cagide, Fernando. "Quaternary phosphonium conjugates: a new class of antimicrobial agents?". Trabalho apresentado em X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Chavarria, Daniel; Benfeito, Sofia; Garrido, Jorge; Serrão, Paula; Soares-da-Silva, Patrício; Remião, Fernando; Oliveira, Paulo; Borges, Fernanda. "Tackling dopamine depletion and oxidative stress with innovative caffeic acid derivatives". Trabalho apresentado em X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Arrighi, Francesca; Guglielmi, Paolo ; Chavarria, Daniel; Oliveira, Catarina; Pontecorvi, Virginia ; Granese, Arianna ; Berrino, Emanuela ; et al. "Design, synthesis and human monoamine oxidase inhibitory activity of 2-aroylbenzofuran-3-ol and 2-aroylbenzofuran derivatives: a new route towards hMAOs inhibition.". Trabalho apresentado em X Meeting of the Paul Ehrlich Euro-PhD Network, 2022. Soares, Pedro; Fernandes, Carlos; Sousa, Sérgio; Alfenim, Ana; Chavarria, Daniel; Cagide, Fernando; Borges, Fernanda. "Development of Innovative Multitarget Drugs for Amyotrophic lateral sclerosis by targeting neuroinflammation and modulating iron dysregulation (virtual Event)". Trabalho apresentado em XXVI EFMC International Symposium on Medicinal Chemistry, 2021. Catalano, Raffaella; Maruca, Annalisa; Rocca, Roberta; Borges, Fernanda; Benfeito, Sofia; Chavarria, Daniel; Alcaro, Stefano; Ortuso, Francesco. "Phytocompounds and their metabolites profiling, as promising multi-target agents for the treatment of Alzheimer's disease (virtual event)". Trabalho apresentado em Paul Ehrlich Virtual Meeting 2021, 2021. Salermo, A.; Albertini, C.; Atzeni, S.; Uliassi, F.S.G.; Massenzio, F.; Monti, B.; Chavarria, Daniel; et al. "Combining riluzole/dexpramipexole and rasagiline in new multi-target-directed ligands in the context of Amyotrophic Lateral Sclerosis". Trabalho apresentado em 13th Young Medicinal Chemist Virtual Symposium, 2021. Chavarria, Daniel; Fernandes, Carlos; Silva, Vera; Gil-Martins, Eva; Silva, Renata; Remião, Fernando; Borges, Fernanda. "Design and development of piperine derivatives acting as potent MAO-B inhibitors and mild P-gp inhibitors". Trabalho apresentado em 4th WG meeting – Final status of WG activities within the MuTaLig COST Action, 2020. Monjane, Sandra; Silva, Vera; Martins, Eva-Gil; Chavarria, Daniel; Borges, Fernanda; Silva, Renata; Fernandes, Carlos. "Descoberta de Novas Entidades Químicas como Potenciais Moduladores da Glicoproteína-P". Trabalho apresentado em XV CICLO DE CONFERÊNCIAS DO IUCS - 2019, Porto, Portugal, 2019. Monjane, Sandra; Silva, Vera; Martins, Eva-Gil; Chavarria, Daniel; Borges, Fernanda; Silva, Renata; Fernandes, Carlos. "Descoberta de Novas Entidades Químicas como Potenciais Moduladores da Glicoproteína-P". Trabalho apresentado em IV Congresso da Associação Portuguesa de Ciências Forenses, Porto, Portugal, 2019. Chavarria, Daniel; Fernandes, Carlos; Cagide, Fernando; Remião, Fernando; Oliveira, Paulo Jorge; Borges, Fernanda. "Searching for New Neuroprotective Agents: Design, Synthesis and Biological Evaluation of Piperine-derived Cationic Compounds". Trabalho apresentado em 26th Young Research Fellows Meeting (YRFM), Paris, France, 2019. Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Silva, Tiago; Alcaro, Stefano; Borges, Fernanda. "Evaluation of benzopyrone pharmacophore features on MAO-B inhibition". Trabalho apresentado em 26th Young Research Fellows Meeting (YRFM), 2019. Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Silva, Tiago; Alcaro, Stefano; Borges, Fernanda. "Design and Development of Dual -Target Ligands Based on Benzopyran for the Treatment of Parkinson’s Disease". Trabalho apresentado em 3rd Annual meeting - MuTaLig COST ACTION (CA15135), Valleta, Malta, 2018. Chavarria, Daniel; Fernandes, Carlos; Cagide, Fernando; Remião, Fernando; Oliveira, Paulo Jorge; Borges, Fernanda. "Development of piperine-based triphenylphosphonium conjugates as a therapeutic solution for Alzheimer’s disease". Trabalho apresentado em 3rd Annual meeting - MuTaLig COST ACTION (CA15135), 2018, Valletta, Malta, 2018. Mesiti, Francesco; Gaspar, Alexandra; Chavarria, Daniel; Silva, Tiago; Alcaro, Stefano; Borges, Fernanda. "Mapping the Pharmacophore of Benzopyrone MAO-B Inhibitors". Trabalho apresentado em 8th meeting of Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, 2018. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Development of Novel Phenolic and Thiophenolic Antioxidants based on Hydroxycinnamic Acid Scaffold". Trabalho apresentado em 8th meeting of Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, 2018. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Hydroxycinnamic acid derivatives and sulfured analogues: from synthesis to antioxidant properties". Trabalho apresentado em 2nd WG meeting – Status of WG activities of the MuTaLig COST Action (CA15135), Tenerife, Spain, 2018. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Natural products in drug discovery: enhancing the antioxidant profile of hydroxycinnamic acids". Trabalho apresentado em EpiChemBio (CM1406) and MuTaLig COST (CA15135) actions joint meeting, Porto, Portugal, 2017. Garrido, Emanuela P.J.; Cerqueira, Ana S.; Chavarria, Daniel; Silva, Tiago; Borges, Fernanda; Garrido, Jorge. "Microencapsulation as a strategy to improve the ADMET properties of bioactive caffeic acid derivatives". Trabalho apresentado em EpiChemBio (CM1406) and MuTaLig COST (CA15135) actions joint meeting, Porto, Portugal, 2017. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Design, synthesis and neuroprotective properties of new hydroxycinnamic acid-based antioxidants". Trabalho apresentado em 7th meeting of Paul Ehrlich MedChem EuroPhD Network, Vienna, Austria, 2017. Chavarria, Daniel; Silva, Tiago; Fernandes, Carlos; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Effect of the acid strength on the antioxidant profile of natural and synthetic antioxidants". Trabalho apresentado em 37th Edition of the European School of Medicinal Chemistry (ESMEC), Urbino, Italy, 2017. Silva, Tiago; Martins, Daniel; Sequeira, Lisa; Chavarria, Daniel; Garrido, Jorge; Borges, Fernanda. "Optimizing nature: development of novel antioxidants based on ferulic acid". Trabalho apresentado em 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept, Budapest, Hungary, 2016. Cagide, Fernando; Reis, Joana; Chavarria, Daniel; Vilar, Santiago; Hripcsak, George; Uriarte, Eugenio; Kachler, Sonja; Klotz, Karl-Norbert; Borges, Fernanda. "Design and development of novel and selective A3 adenosine receptor ligands based on chromone-2-carboxamide". Trabalho apresentado em 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept, Budapest, Hungary, 2016. Chavarria, Daniel; Silva, Tiago; Garrido, Jorge; Remião, Fernando; Borges, Fernanda. "Insights on the development of novel neuroprotective agents: a comparative study between ferulic acid and related sulfanyl derivatives". Trabalho apresentado em 6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich's magic bullet concept, Budapest, Hungary, 2016. Chavarria, Daniel; Silva, Tiago; Garrido, E. Manuela; Garrido, Jorge; Borges, Fernanda. "Electrochemical and antioxidant activity of diene derivatives inspired on natural hydroxycinnamic acids". Trabalho apresentado em XX Meeting of the Portuguese Electrochemical Society (XXSNSPE), Braga, Portugal, 2015. Chavarria, Daniel; Silva, Tiago; Summavielle, Teresa; Borges, Fernanda. "Development of Novel Neuroprotective Antioxidants Inspired on Hydroxycinnamic Acid Scaffold". Trabalho apresentado em V Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Krakow, Poland, 2015. Cagide, Fernando; Gaspar, Alexandra; Chavarria, Daniel; Martins, Daniel; Magalhães e Silva, Diogo; Milhazes, Nuno; Vilar, Santiago; et al. "Development of new adenosine receptors ligands based on chromone scaffold: adventures in the design and optimization process". Trabalho apresentado em V Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Krakow, Poland., 2015. Chavarria, Daniel; Silva, Tiago; Summavielle, Teresa; Borges, Fernanda. "Neuroprotective Properties of Lipophilic Antioxidants Based on Hydroxycinnamic Acid Template". Trabalho apresentado em 2nd Symposium on Medicinal Chemistry of University of Minho, Braga, Portugal., 2015. Gaspar, Alexandra; Cagide, Fernando; Reis, Joana; Chavarria, Daniel; Kachler, Sonja; Klotz, Karl-Norbert; Borges, Fernanda. "Development of A3 adenosine receptor ligands by an analogue-based approach". Trabalho apresentado em Young Research Fellows Meeting (YRFM), Paris, France, 2015. Chavarria, Daniel; Cagide, Fernando; Gaspar, Alexandra; Borges, Fernanda. "Microwave Organic Reactions Applied to the Synthesis of Novel Monoamine Oxidase Inhibitors". Trabalho apresentado em V Encontro de Jovens Investigadores da UP (IJUP), 2012.
Resumo em conferência	Silva, Vera; Benfeito, Sofia; Lima, Carla; Chavarria, Daniel; Gonçalves, Tiago; Costa, Inês; Remião, Fernando; Borges, Fernanda; Silva, Renata. "3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson's disease". Trabalho apresentado em Revista Científica Internacional RevSALUS, Porto, 2023. Aceite para publicação Castelôa, Mariana; Soares, Pedro; Benfeito, Sofia; Lima, Carla; Borges, Fernanda; Chavarria, Daniel. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Publicado Benfeito, Sofia; Fernandes, Carlos; Chavarria, Daniel; Barreiro, Sandra; Cagide, Fernando; Silva, Catia; Teixeira, José; et al. "Synthesis and in vitro evaluation of versatile cell-penetrating mitochondriotropic antioxidants". Trabalho apresentado em XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Publicado
Tese / Dissertação	Chavarria, Daniel. "Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders". Doutoramento, Universidade do Porto Faculdade de Farmácia, 2020. Chavarria, Daniel. "Desenvolvimento de Novos Antioxidantes Lipofílicos como Solução Terapêutica para Doenças Neurodegenerativas". Mestrado, Universidade do Porto Faculdade de Ciências, 2014. https://repositorio-aberto.up.pt/handle/10216/82718.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/06/17	Design, Synthesis and human monoamine oxidase inhibitory activity of 2-aroylbenzofuran derivatives: a new route towards hMAOs inhibition	XIII Meeting Paul Ehrlich Euro-PhD Network & COST ACTION Sapienza university of Rome (Rome, Itália)
2024/04/24	Propargylamine-containing compounds for neurodegenerative diseases: biological activity, physicochemical properties and docking studies	4th MMCS: Harnessing the Power of New Drug Modalities (Barcelona, Espanha)
2024/02/07	Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors	54th Meeting of the Portuguese Society of Pharmacology NOVA Medical School (Lisbon, Portugal)
2022/07/04	Brick by brick: pharmacophore mapping of chromone-based MAO-B inhibitors	29th Young Research Fellows Meeting, Nantes, France. Nantes Université (Nantes, França)
2021/12/09	New Potential MAO-B/p38 MAPK Dual Inhibitors Targeting Neuroinflammation in Alzheimer's Disease. (Virtual event)	2nd International Conference on Neuroprotection by Drugs, Nutraceuticals, and Physical Activity Università di Bologna (Itália)
2021/10/07	Tackling antimicrobial resistance with novel phytochemical-based conjugates: a structure-activity-toxicity study.	E-Conference on Innovation in Microbial Control (Porto, Portugal)
2021/07/26	Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders	Paul Ehrlich Virtual Meeting Università degli Studi "Magna Graecia" di Catanzaro (Catanzaro, Itália)
2021/07/26	Mapping chromone-3-phenylcarboxamide pharmacophore: quid est veritas?	Paul Ehrlich Virtual Meeting 2021 Università degli Studi "Magna Graecia" di Catanzaro (Catanzaro, Itália)
2020/03/05	Mapping the benzopyran chromone-3-carboxamide pharmacophore: structure-activity-toxicity and efflux transport studies	4th WG meeting - Final status of WG activities within the MuTaLig COST Action Faculty of Pharmacy, Ege University (Izmir, Turquia)
2020/02/22	Synthesis and structure-activity relationship study of piperine derivatives with MAO-B and P-gp inhibitory activities	II Workshop meeting CIQUP Faculty of Sciences, University of Porto (Porto, Portugal)
2019/06/13	Lessons from black pepper: moving from one to multitarget-directed ligands by diversity-oriented synthesis	IX Meeting of the Paul Ehrlich Euro-PhD Network & 4th Annual meeting – MuTaLig COST Action meeting University "Magna Græcia" of Catanzaro (Catanzaro, Itália)
2019/06/13	Looking for the Pharmacophore of Benzopyran MAO-B Inhibitors	IX Meeting of the Paul Ehrlich Euro-PhD Network & 4th Annual meeting – MuTaLig COST Action meeting Università degli Studi "Magna Graecia" di Catanzaro (Catanzaro, Itália)
2019/02/23	Development of Dual-Target Agents Based on Piperine Scaffold	3rd WG meeting – Activities of young investigators within the WG MuTaLig COST Action (CA15135) University of Paris Descartes (Paris, França)
2019/02/23	Design and development of new chemical entities for the treatment of Parkinson disease	3rd WG meeting – Activities of young investigators within the WG MuTaLig COST Action (CA15135) Faculté de Pharmacie de Paris, Université Paris DESCARTES (Paris, França)
2015/07/02	Antioxidants: from Nature to drug prototypes.	International Workshop on "Biochemistry, Physiology and Pharmacology of Oxidative Stress Sapienza University of Rome (Roma, Itália)
2015/05/13	Exploring Cinnamic Acid Scaffold: Development of Promising Neuroprotective Lipophilic Antioxidants	VIII Encontro de Jovens Investigadores da UP (IJUP) Universidade do Porto (Porto, Portugal)
2015/03/27	Finding a therapeutic solution for neurodegenerative diseases: design and synthesis of novel neuroprotective agents	III ENEQUI – “Ilumina o teu conhecimento! Sociedade Portuguesa de Química (Aveiro, Portugal)
2014/06/04	Biology-oriented development of lipophilic antioxidants with neuroprotective activity	8th International Conference on Polyphenols Applications – ISANH Polyphenols 2014 International Society of Antioxidants in Nutrition and Health (ISANH) (Lisboa, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2023/09 - Atual	Synthesis and evaluation of novel Spindle Assembly Checkpoint inhibitors Orientador	Bioquímica (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2023/04/03 - Atual	De-ironing Friedreich's Ataxia with innovative mitochondria-targeted chelators Coorientador	Química (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal
2022/10/01 - Atual	Bona fide NOX2 inhibitors: a new therapeutic solution for neurodegenerative diseases? Orientador	Química (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal
2024/02/19 - 2024/07/27	Desenvolvimento de inibidores da NOX2 para regulação da neuroinflamação crónica em doenças neurodegenerativas Orientador	Bioquímica (Outra) Universidade do Porto Faculdade de Ciências, Portugal
2023/02/17 - 2023/07/04	Desenvolvimento de novos inibidores da NOX2 baseados na estrutura do VAS2870 Orientador	Química (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2021/02/15 - 2021/07/31	Development of selective NOX2 inhibitors Orientador	Química (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2020/02 - 2020/07	Evaluation of drug-like properties of innovative multitarget-directed ligands for treatment of Parkinson's disease Coorientador	Bioengenharia (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/04 - 2016/07	Desenvolvimento de novos antioxidantes tendo como base modelos naturais Coorientador	Química (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2023/06/26 - 2023/07/12	Co-organizer/Trainer of the international course "Drug Discovery 2030: A Roadmap for a New Decade". This course aimed to improve, via virtual classes and a week of intensive training, the participants skills in Medicinal Chemistry and Chemistry Biology. This course was funded with support from the European Commission and implemented within the framework of Blended Intensive Programmes (BIPs), a new format of Erasmus+ mobility. https://drugdiscovery2030.pt/ (2023/06/26 - 2023/07/12) Outro (Coorganizador)	Universidade do Porto Faculdade de Ciências, Portugal
2021/05/07 - 2021/05/21	Co-organizer of the "First Webinar on Medicinal Chemistry". Three-day webinar (May 7th, 14th and 21st) organized within the framework of the Medicinal Chemistry curricular unit and opened to the scientific community. The webinar was aimed to bring together renowned researchers from academy and industry that exchanged and shared their experiences on aspects of Drug Discovery and Development. (2021/05/07 - 2021/05/21) Oficina (workshop) (Coorganizador)	Universidade do Porto Faculdade de Ciências, Portugal
2018/06/12 - 2018/06/14	Member of the Local Organizing Committee during the "8th meeting of Paul Ehrlich MedChem EuroPhD Network" (2018/06/12 - 2018/06/14) Congresso (Membro da Comissão Organizadora)	Universidade do Porto Faculdade de Ciências, Portugal
2017/09/22 - 2017/09/24	Member of the Local Organizing Committee during the "EpiChemBio and MuTaLig COST actions joint meeting" (2017/09/22 - 2017/09/24) Congresso (Membro da Comissão Organizadora)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2016/06/29 - 2016/07/01	Member of the Local Organizing Committee during the "10th World Congress on Polyphenols Applications" (2016/06/29 - 2016/07/01) Congresso (Membro da Comissão Organizadora)	Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2022/11/16 - 2022/11/18	XXVI Encontro Galego-Portugués de Química Conferência	Universidade de Santiago de Compostela Facultade de Química, Espanha
2022/10/17 - 2022/10/17	How to protect a research result via patent and how to accommodate this protection in the proposal budget for funding Oficina (workshop)	UPTEC Associação de Transferência de Tecnologia da Asprela, Portugal
2022/06/14 - 2022/06/16	X Meeting of the Paul Ehrlich Euro-PhD Network Conferência	Universitat Ramon Llull IQS, Espanha
2021/10/07 - 2021/10/08	E-Conference on Innovation in Microbial Control Conferência	Universidade do Porto Faculdade de Engenharia, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2021/07/26 - 2021/07/28	Paul Ehrlich Virtual Meeting 2021 Conferência	Università degli Studi Magna Graecia di Catanzaro, Itália
2020/12/01 - 2020/12/01	Webinar "Back to basics: Fundamental concepts of HPLC and UHPLC" (1 h). Organisation's name: VWR (part of Avantor). Outro
2020/07/16 - 2020/07/16	Webinar "Improving cell-based assays and their future in drug discovery" (1h). Organisation's name: ICBAS/FFUP library, University of Porto, Portugal Outro
2020/03/05 - 2020/03/06	4th WG meeting - Final status of WG activities within the MuTaLig COST Action (CA15135) Conferência	Ege Üniversitesi Eczacilik Fakültesi, Turquia
2020/02/22 - 2020/02/22	II workshop meeting CIQUP Conferência	Universidade do Porto Faculdade de Ciências, Portugal
2019/06/13 - 2019/06/15	IX Meeting of the Paul Ehrlich Euro-PhD Network & 4th Annual meeting – MuTaLig COST Action meeting Conferência	Università degli Studi Magna Graecia di Catanzaro, Itália
2019/02/23 - 2019/02/24	3rd WG meeting - Activities of young investigators within the WG MuTaLig COST Action (CA15135) Conferência	Université de Paris UFR de Pharmacie, França
2019/02/20 - 2019/02/22	26th Young Research Fellows Meeting (YRFM) Conferência	Université de Paris UFR de Pharmacie, França
2018/10/18 - 2018/10/19	3rd Annual meeting - MuTaLig COST ACTION (CA15135) Conferência	University of Malta, Malta
2018/07/12 - 2018/07/14	8th meeting of Paul Ehrlich MedChem EuroPhD Network Conferência	Universidade do Porto Faculdade de Ciências, Portugal
2018/03/15 - 2018/03/16	2nd WG meeting - Status of WG activities of the MuTaLig COST Action (CA15135) Conferência	Universidad de La Laguna, Espanha
2018/02/16 - 2018/02/20	"Project TOX-OER (Learning Toxicology through Open Educational Resources)". This project was funded with support from the European Commission and implemented in the framework of Erasmus+ programme under the Action KA2 -Cooperation for Innovation and the Exchange of Good Practices Strategic Partnerships for Higher Education-. Main activity: Preparation of contents in Portuguese for the "Module 7.1.: Patents and Patent Application" (http://moodle.toxoer.com/) Outro	Project TOX-OER (Learning Toxicology through Open Educational Resources) Universidade do Porto Faculdade de Farmácia, Portugal
2017/11/27 - 2017/11/27	Participation in seminar (4 h). Dissemination of the Toxicology course MOOC (Massive Open Online Course). This initiative was promoted within the scope of the project Erasmus+ TOX-OER - Learning Toxicology through Open Educational Resources. Seminário	Dissemination of the Toxicology course MOOC (Massive Open Online Course) Universidade do Porto Faculdade de Farmácia, Portugal
2017/09/22 - 2017/09/24	EpiChemBio (CM1406) and MuTaLig COST (CA15135) actions joint meeting Conferência	Universidade do Porto Faculdade de Ciências, Portugal
2017/08/25 - 2017/08/27	7th meeting of Paul Ehrlich MedChem EuroPhD Network Conferência	Technischen Universität Wien, Áustria
2016/11/18 - 2016/11/20	6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept Conferência	Semmelweis Egyetem, Hungria
2016/05/18 - 2016/05/18	Participation in training initiative (4 h). Outro	Introdução à escrita de um artigo científico: artigo original e artigo de revisão Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Farmácia, Portugal
2016/04/27 - 2016/04/27	Participation in training initiative (4 h). Outro	Introdução ao EndNote X7: da criação de uma biblioteca à escrita de um documento Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Farmácia, Portugal
2016/03/16 - 2016/03/16	Participation in training initiative (4 h). Outro	Web of Science e Scopus: pesquisa em bases de dados de citações Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Farmácia, Portugal
2015/07/03 - 2015/07/05	V Meeting of the Paul Ehrlich MedChem Euro-PhD Network Conferência	Uniwersytet Jagiellonski w Krakowie, Polónia
2015/05/13 - 2015/05/15	VIII Encontro de Jovens Investigadores da UP (IJUP) Conferência	Universidade do Porto, Portugal
2014/05/30 - 2014/05/30	Participation in workshop (1 day) Oficina (workshop)	3rd workshop on Medicinal Chemistry - Drug Design and Development: Understanding the R&D Process Universidade do Porto Faculdade de Ciências, Portugal
2013/10 - 2014/01	Participation in english course (30 h) Outro	English course, Level B2.1 (Vantage) Universidade do Porto Faculdade de Ciências, Portugal
2013/03/22 - 2013/03/24	Participation in meeting (3 days) Encontro	VI ENEBIOQ - Encontro Nacional de Estudantes de Bioquímica Universidade de Aveiro, Portugal
2012/02/17 - 2012/02/19	V Encontro de Jovens Investigadores da UP (IJUP) Conferência	Universidade do Porto, Portugal
2011/09/08 - 2011/09/09	Participation in workshop (2 days) Oficina (workshop)	New-indigo workshop - Antitumour and antiparasitic drugs Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2023/07/27	Desenvolvimento de novos inibidores da NOX2 baseados na estrutura do VAS2870 Orientador	Vera Lúcia Pinheiro Amaral (Outro) Universidade do Porto Faculdade de Ciências, Portugal
2023/07/21	Desenvolvimento de novas estratégias para o tratamento da resistência a antibióticos Arguente principal	Joana Parreira Quadros Ferreira (Outro) Universidade do Porto Faculdade de Ciências, Portugal
2023/02/17	NOX2 como alvo terapêutico para desenvolvimento de novos fármacos para as doenças neurodegenerativas Orientador	Andreia Ferreira (Outro) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2021/11/15	In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer Arguente principal	Mariana Antunes Castelôa (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2021/07/13	Development of selective NOX2 inhibitors Orientador	Inês Filipa Cabral Real Libânio (Outro) Universidade do Porto Faculdade de Ciências, Portugal
2020/07/22	Design and development of cationic nanoparticles for the delivery of a catechol O-methyltransferase inhibitor to the brain Arguente principal	Rúben Faria Correia (Outro) Universidade do Porto Faculdade de Ciências, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2024/05/08 - 2024/05/10	IJUP2024 - Investigação Jovem na Universidade do Porto (Representative for Chemistry)	University of Porto

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2022/09/15 - 2023/05/31	Molecules, "Advances in Drug Discovery Research in Europe"; https://www.mdpi.com/journal/molecules/special_issues/2PSM2TE9VP	MDPI AG
2020/07/07 - 2021/01/31	Molecules, "Recent Advances in CNS Drug Discovery"; https://www.mdpi.com/journal/molecules/special_issues/CNS_Drug	MDPI AG

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2020/02 - Atual	Invited professor of Medicinal Chemistry	Biochemistry (Mestrado)	Universidade do Porto Faculdade de Ciências, Portugal
2024/02/17 - 2024/07/27	Projeto/estágio (BIOQ3003)	Bioquímica	Universidade do Porto Faculdade de Ciências, Portugal
2023/02 - 2023/07	Projeto/estágio (Q208)	Química (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2021/02 - 2021/07	Projeto/estágio (Q208)	Química (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2023/04/04	Portuguese researchers develop antioxidant to fight neurodegenerative diseases	SIC Notícias
2023/04/04	FCUP develops antioxidant with potential to fight neurodegenerative diseases	Jornal de Notícias
2023/04/04	Newly developed antioxidant with potential to fight neurodegenerative diseases	Diário de Notícias
2023/04/04	Portuguese researchers develop antioxidant with potential to fight neurodegenerative diseases	CNN Portugal
2023/04/04	How Lego Chemistry can help to fight neurodegenerative diseases	Notícias U.Porto and FCUP

Tutoria

	Tópico	Nome do aluno
2024/02 - 2024/07	Desenvolvimento de novas moléculas para o tratamento de doenças associadas o stress oxidativo	Teresa Baptista Rocha
2023/04/12 - 2023/12/21	In vitro evaluation of bioactivity (antioxidant, enzyme inhibition) of plant extracts. Role: mentor	Jessica Ceramella (Post doc researcher, University of Calabria, Italy)
2023/03/01 - 2023/06/02	Enzymatic assays for the evaluation of the activity of acetylcholinesterase and monoamine oxidase B inhibitors. International mobility of PhD student. Role: Supervisor	Michele Collucia (PhD in Pharmaceutical Sciences, University of Rome, Italy)
2022/10/15 - 2023/05/14	Design and synthesis of new chemical entities based on VAS2870. BSc fellowship. Project NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure (EXPL/BIA-BQM/0492/2021) (7 months). Role: supervisor	Carla Patrícia Costa Lima
2022/10/06 - 2023/02/02	Insights into the discovery of new neuroprotective agents. International mobility of MSc under the ERASMUS+ programme. Role: Mentor	Sara Bertolami (MSc in Pharmaceutical Chemistry and Technology, University of Pisa, Italy)
2022/05/01 - 2022/09/30	Tailoring VAS27870 scaffold to develop new covalent NOX2 inhibitors. MSc fellowship (5 months). Project NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure (EXPL/BIA-BQM/0492/2021). Role: Supervisor	Mariana Antunes Castelôa
2020/02/20 - 2020/04/20	Synthesis and biological evaluation of urolithin derivatives for neurodegenerative diseases. International mobility of MSc under the ERASMUS+ programme. Role: Mentor	Giulia Fusi (MSc in Pharmaceutical Chemistry and Technology, University of Pisa, Italy)

Distinções

Prémio

2024	Best article Prize (Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier) in IACOBUS-Papers cross-border scientific collaboration between the northern reg Xunta de Galicia, Espanha
2022	Award for best poster presentation (X Meeting of the Paul Ehrlich Euro-PhD Network, 2022, July 14-16th, Barcelona, Spain) Universitat Ramon Llull IQS, Espanha
2020	Award for 2nd best poster presentation (4th WG meeting - Final status of WG activities within the MuTaLig COST Action (CA15135), 2020, March 5th-6th, Izmir, Turkey) Ege Üniversitesi Izmir Arastirma ve Uygulama Merkezi, Turquia
2020	Best award for oral presentation (4th WG meeting - Final status of WG activities within the MuTaLig COST Action (CA15135), 2020, March 5th-6th, Izmir, Turkey) Ege Üniversitesi Izmir Arastirma ve Uygulama Merkezi, Turquia

Título

2021	Award of excellence from the Paul Ehrlich MedChem Euro-PhD in Medicinal Chemistry Università degli Studi Magna Graecia di Catanzaro, Itália
2020	European Doctorate Universidade do Porto Faculdade de Farmácia, Portugal

Outra distinção

2022	Mobility grant, funded by project H2020-MSCA-RISE-2016-734719 European Commission Directorate-General for Research and Innovation, Bélgica
2020	Conference grant to attend the 4th WG meeting - Final status of WG activities within the MuTaLig COST Action European Cooperation in Science and Technology, Bélgica
2019	Conference Grant for Early Career Investigators (ECI) and PhD students from Inclusiveness Target Countries (ITC) European Cooperation in Science and Technology, Bélgica
2018	Full grant, CA15135 Multi-Targeting Biophysical Training School, 2nd edition (EU) European Cooperation in Science and Technology, Bélgica
2018	Conference grant to attend the 2nd WG meeting - Status of WG activities of the MuTaLig COST Action (CA15135) European Cooperation in Science and Technology, Bélgica